Compile Data Set for Download or QSAR
Found 3 Enz. Inhib. hit(s) for PDB: 4WT6
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50061611(CHEMBL3394069 | US9321756, 16)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(NC4CCCC4)n3)c2c1
Show InChI InChI=1S/C20H20N6S/c21-20-26-25-19(27-20)12-8-9-16-14(10-12)15(11-22-16)17-6-3-7-18(24-17)23-13-4-1-2-5-13/h3,6-11,13,22H,1-2,4-5H2,(H2,21,26)(H,23,24)
Affinity DataIC50: 12nMAssay Description:Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50061611(CHEMBL3394069 | US9321756, 16)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(NC4CCCC4)n3)c2c1
Show InChI InChI=1S/C20H20N6S/c21-20-26-25-19(27-20)12-8-9-16-14(10-12)15(11-22-16)17-6-3-7-18(24-17)23-13-4-1-2-5-13/h3,6-11,13,22H,1-2,4-5H2,(H2,21,26)(H,23,24)
Affinity DataIC50: 12.4nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50061611(CHEMBL3394069 | US9321756, 16)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(NC4CCCC4)n3)c2c1
Show InChI InChI=1S/C20H20N6S/c21-20-26-25-19(27-20)12-8-9-16-14(10-12)15(11-22-16)17-6-3-7-18(24-17)23-13-4-1-2-5-13/h3,6-11,13,22H,1-2,4-5H2,(H2,21,26)(H,23,24)
Affinity DataIC50: 111nMAssay Description:Inhibition of PIM1 in human U2OS cells assessed as phosphorylation of BADMore data for this Ligand-Target Pair