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Report error Found 9 Enz. Inhib. hit(s) for PDB: 3PT6
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataIC50:  71nMAssay Description:Inhibition of recombinant human DNMT1 using poly(dl-dC) as substrate by hotspot assayMore data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataIC50:  200nMAssay Description:Inhibition of DNMT1 (unknown origin)More data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataIC50:  600nMAssay Description:Inhibition of DNMT1 (unknown origin) using biotinylated substrate using [3H]-SAM after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human recombinant DNMT1More data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataIC50:  900nMAssay Description:Inhibition of full length N-terminal His6-tagged human DNMT1 after 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataIC50:  941nMAssay Description:Inhibition of human Dnmt1 using oligonucleotide 2 as substrate after 5000 sec by micro plate reader based real-time break-light assayMore data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant DNMT1 expressed in baculovirus infected high five insect cellsMore data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human recombinant DNMT1 expressed in baculovirus-insect cell system by scintillation countingMore data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human recombinant DNMT1 expressed in Sf9 cells assessed as incorporation of [3H]S-adenosyl methionine into hemimethylated oligonucleoti...More data for this Ligand-Target Pair