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Report error Found 14 Enz. Inhib. hit(s) for PDB: 1GW6
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataKi:  320nMAssay Description:Competitive inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using varying levels of L-arginine-7-amino-4-M...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  266nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged LTA4H expressed in Escherichia coli BL21 DE3 cells assessed as reduction in amino-...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using L-arginine-7-amino-4-Methylcoumarine as substrate pr...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  500nMAssay Description:Inhibition of aminopeptidase activity of human leukotriene A4 hydrolase by Dixon plot analysisMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  500nMAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory activity against Leukotriene A4 hydrolase from human leukocytesMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human recombinant leukotriene A4 hydrolaseMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of human LTA4H epoxide hydrolase activity using LTA4 as substrate incubated for 15 mins prior to substrate addition measured after 10 mins...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  1.01E+4nMAssay Description:Inhibition of recombinant C-terminal His-tagged human LTA4H aminopeptidase activity expressed in Escherichia coli using L-alanine-4-nitro-anilide hyd...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of recombinant C-terminal His-tagged human LTA4H epoxide hydrolase activity expressed in Escherichia coli assessed as reduction in LTB4 pr...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM50046325((S)-2-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyryla...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of amidase activity of LTA4 hydrolase purified from human leukocytesMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataKd:  2.05E+3nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 25 degC by ITC methodMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataKd:  4.63E+3nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 15 degC by ITC methodMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataKd:  5.15E+3nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 35 degC by ITC methodMore data for this Ligand-Target Pair