Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) for PDB: 3S7S
TargetAromatase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50398447(Aromasin | EXEMESTANE)
Affinity DataIC50: 15nMAssay Description:Inhibition of aromatase in human breast tumorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAromatase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50398447(Aromasin | EXEMESTANE)
Affinity DataIC50: 23nMAssay Description:Inhibition of aromatase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAromatase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50398447(Aromasin | EXEMESTANE)
Affinity DataIC50: 43nMAssay Description:Inhibition of CYP19 in human placental microsome using [1beta-3H]-androstenedione as substrate after 15 mins in presence of NADPH by liquid scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAromatase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50398447(Aromasin | EXEMESTANE)
Affinity DataIC50: 50nMAssay Description:Inhibition of human placental microsome aromatase using [1beta-3H] androstenedione as substrate after 15 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAromatase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50398447(Aromasin | EXEMESTANE)
Affinity DataIC50: 50nMAssay Description:Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAromatase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50398447(Aromasin | EXEMESTANE)
Affinity DataIC50: 50.1nMAssay Description:Inhibition of human placental aromatase using [3H]-1beta-androstenedione as substrate after 16 hrs by [3H]-water methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAromatase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50398447(Aromasin | EXEMESTANE)
Affinity DataIC50: 230nMAssay Description:Inhibition of aromatase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAromatase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50398447(Aromasin | EXEMESTANE)
Affinity DataIC50: 900nMAssay Description:Inhibition of human placental microsome aromatase expressed in human MCF7 cells using [1beta-3H] androstenedione as substrate after 1 hr by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAromatase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50398447(Aromasin | EXEMESTANE)
Affinity DataKi:  0.950nMAssay Description:Binding affinity to aromatase (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAromatase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50398447(Aromasin | EXEMESTANE)
Affinity DataKi:  10nMAssay Description:Competitive inhibition of human aromatase extracted from placental microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAromatase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50398447(Aromasin | EXEMESTANE)
Affinity DataKi:  26nMAssay Description:Irreversible inhibition of human aromatase extracted from placental microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAromatase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50398447(Aromasin | EXEMESTANE)
Affinity DataKi:  26nMAssay Description:Competitive inhibition of human placental microsome aromatase using varying levels of [1beta2beta3H]-androstenedione as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAromatase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50398447(Aromasin | EXEMESTANE)
Affinity DataKi:  26nMAssay Description:Inhibition of human placental microsome aromatase using [3H]androstenedione as substrate preincubated for 32 mins in presence of NADPH followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)