BindingDB PrimarySearch

Report error Found 3 Enz. Inhib. hit(s) for PDB: 3V04

Dual specificity mitogen-activated protein kinase kinase 1(Human)
Argenta Discovery

Curated by ChEMBL

BDBM50420692(CHEMBL2087076)

IC50: 13nMAssay Description:Inhibition of MEK1-mediated ERK1 phosphorylation after 30 mins by HTRF assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

Dual specificity mitogen-activated protein kinase kinase 1(Human)
Argenta Discovery

Curated by ChEMBL

BDBM50420692(CHEMBL2087076)

EC50: 0.400nMAssay Description:Inhibition of MEK1-mediated ERK1 phosphorylation in human A375 cells after 2 hrs by immunoblotting methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

Dual specificity mitogen-activated protein kinase kinase 1(Human)
Argenta Discovery

Curated by ChEMBL

BDBM50420692(CHEMBL2087076)

EC50: 0.200nMAssay Description:Inhibition of MEK1-mediated ERK1 phosphorylation in human HCT116 cells after 2 hrs by immunoblotting methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)