TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: <0.5nMAssay Description:Binding affinity to BH3 binding groove of BclXLMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 0.600nMAssay Description:Binding affinity to Bcl-XL assessed as inhibition of Bcl-XL-BAD derived peptide interactionMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Displacement of fluorescein labeled BAD peptide from Bcl-XL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Displacement of fluorescein labeled BAD peptide from Bcl-XL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 100nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 250nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 250nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 300nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 360nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 460nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 490nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 530nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 560nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 638nMAssay Description:Displacement of FAM-Bak BH3 peptide from human Bcl-xL by FP-based binding assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 660nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 800nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 820nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 820nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 870nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 970nMAssay Description:Inhibition of Bak peptide binding to human recombinant Bcl-XlMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.00E+3nMAssay Description:Inhibition of BH3 peptide binding to human recombinant BCL-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.08E+3nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.11E+3nMAssay Description:Binding affinity to human Bcl-xL protein by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.20E+3nMAssay Description:Displacement of FAM-Bim peptide from human Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.28E+3nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.30E+3nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.32E+3nMAssay Description:Binding affinity to human Bcl-xL protein by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.74E+3nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.80E+3nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 2.30E+3nMAssay Description:Inhibition of Bak peptide binding to human recombinant Bcl-XlMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 2.40E+3nMAssay Description:Inhibition of Bak peptide binding to human recombinant Bcl-XlMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 2.55E+3nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 3.21E+3nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 4.53E+3nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 5.25E+3nMAssay Description:Inhibition of Bak peptide binding to human recombinant Bcl-XlMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 8.70E+3nMAssay Description:Inhibition of Bak peptide binding to human recombinant Bcl-XlMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.60E+4nMAssay Description:Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assayMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 5.84E+4nMAssay Description:Inhibition of Bak peptide binding to human recombinant Bcl-XlMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.04E+5nMAssay Description:Inhibition of Bak peptide binding to human recombinant Bcl-XlMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.12E+5nMAssay Description:Inhibition of Bak peptide binding to human recombinant Bcl-XlMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.34E+5nMAssay Description:Inhibition of Bak peptide binding to human recombinant Bcl-XlMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.76E+5nMAssay Description:Inhibition of Bak peptide binding to human recombinant Bcl-XlMore data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Astex Therapeutics
Curated by ChEMBL
Astex Therapeutics
Curated by ChEMBL
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair