Compile Data Set for Download or QSAR
maximum 50k data
Found 739 Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B'
LigandPNGBDBM50395892(CHEMBL2163772)
Affinity DataKi:  10nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395887(CHEMBL2163770)
Affinity DataKi:  90nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395894(CHEMBL2163771)
Affinity DataKi:  700nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395888(CHEMBL2163769)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395893(CHEMBL1165662)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University Of Newcastle

LigandPNGBDBM5566(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)
Affinity DataKi:  2.50E+3nM ΔG°:  -32.5kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University Of Newcastle

LigandPNGBDBM5485(6-(cyclohexylmethoxy)-9H-purin-2-amine | CHEMBL269...)
Affinity DataKi:  5.00E+3nM ΔG°:  -30.8kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7453(1-aza-9-oxafluorene deriv. 7b | 4-methoxy-3-phenyl...)
Affinity DataKi:  5.30E+3nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395890(CHEMBL2163774)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395889(CHEMBL2163768)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395891(CHEMBL2163773)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50191929(2-(4-(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50191913(CHEMBL384350 | N-(2-methyl-4-(2-(pyrrolidin-1-yl)e...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50191918(CHEMBL212552 | N-(2-methyl-4-(2-(piperidin-1-yl)et...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50191924(CHEMBL377449 | N-(2-methyl-4-(2-morpholinoethyl)ph...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50191922(CHEMBL212299 | trans-N1-(4-(1H-pyrrolo[2,3-b]pyrid...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin) after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University Of Newcastle

LigandPNGBDBM139540(US10189849, staurosporine | US10307427, Staurospor...)
Affinity DataIC50:  2.63nMAssay Description:Compounds of the present disclosure were tested in a 10-dose IC50 mode with a 3-fold serial dilution starting from 0.5 μM, and the control compo...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50191925(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-o-tolylpyrimid...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50338873(CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Cyclin B-cyclin-dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University Of Newcastle

LigandPNGBDBM5595(2-arylamino-pyrimidine deriv. 9e | 4-{[4-amino-6-(...)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University Of Newcastle

LigandPNGBDBM7478(2-chloro-4-[(2-{[(1R)-1-(hydroxymethyl)-2-methylpr...)
Affinity DataIC50:  6nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-33P] ATP. 33...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7478(2-chloro-4-[(2-{[(1R)-1-(hydroxymethyl)-2-methylpr...)
Affinity DataIC50:  6nMAssay Description:Inhibition of cyclin dependent kinase 1-cyclinBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University Of Newcastle

LigandPNGBDBM5545(4-(6-Cyclohexylmethoxy-2-ylamino)-N-methylbenzenes...)
Affinity DataIC50:  9nMAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University Of Newcastle

LigandPNGBDBM7501(4-{(Z)-[4,6-dihydroxy-7-(1-methylpiperidin-4-yl)-3...)
Affinity DataIC50:  9nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence ATP/ [gamma-32P] ATP. 32P incorpo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50191914(CHEMBL212833 | N-(2-chlorophenyl)-4-(1H-pyrrolo[2,...)
Affinity DataIC50:  9nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University Of Newcastle

LigandPNGBDBM5544(4-{[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino}benz...)
Affinity DataIC50:  9.5nMAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University Of Newcastle

LigandPNGBDBM5544(4-{[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino}benz...)
Affinity DataIC50:  9.5nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University Of Newcastle

LigandPNGBDBM10642(2-[({2-[(1-hydroxy-3-methylbutan-2-yl)amino]-9-(pr...)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against Cyclin D1-cyclin-dependent kinase 4 by measuring the phosphorylation of RbINGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50191919(CHEMBL380301 | N-(2-bromophenyl)-4-(1H-pyrrolo[2,3...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50191912(CHEMBL385478 | N-cyclohexyl-4-(1H-pyrrolo[2,3-b]py...)
Affinity DataIC50:  14nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50:  18nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50366800(OLOMOUCINE II)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169892(3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl...)
Affinity DataIC50:  21nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7491((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)
Affinity DataIC50:  22nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7238((3Z)-3-(1H-imidazol-5-ylmethylidene)-5-methoxy-2,3...)
Affinity DataIC50:  22nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University Of Newcastle

LigandPNGBDBM7491((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)
Affinity DataIC50:  22nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University Of Newcastle

LigandPNGBDBM7264(2,3-dimethoxy-9-nitropaullone | 4,5-dimethoxy-14-n...)
Affinity DataIC50:  24nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University Of Newcastle

LigandPNGBDBM7263(9-cyanopaullone | 9-oxo-8,18-diazatetracyclo[9.7.0...)
Affinity DataIC50:  24nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7263(9-cyanopaullone | 9-oxo-8,18-diazatetracyclo[9.7.0...)
Affinity DataIC50:  24nMAssay Description:Inhibition of CDK1/cyclin B expressed in M phase starfish oocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University Of Newcastle

LigandPNGBDBM7492(3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2...)
Affinity DataIC50:  25nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50191928(1-(3-(2-(cyclohexylamino)pyrimidin-4-yl)-1H-pyrrol...)
Affinity DataIC50:  31nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
University Of Newcastle

LigandPNGBDBM7262(14-nitro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Affinity DataIC50:  35nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7262(14-nitro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Affinity DataIC50:  35nMAssay Description:Inhibition of CDK1/cyclin B expressed in M phase starfish oocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7262(14-nitro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Affinity DataIC50:  35nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50191916(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-p-tolylpyrimid...)
Affinity DataIC50:  40nMAssay Description:Inhibition of CDK1/cyclinB by Flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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