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Found 2918 Enz. Inhib. hit(s) with Target = 'Focal adhesion kinase 1'
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50554439(CHEMBL4752642)
Affinity DataKi:  0.230nMAssay Description:Covalent inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50554449(CHEMBL4750273)
Affinity DataKi:  0.400nMAssay Description:Covalent inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50554448(CHEMBL4783568)
Affinity DataKi:  0.470nMAssay Description:Covalent inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50554446(CHEMBL4777260)
Affinity DataKi:  2.60nMAssay Description:Covalent inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Pol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50020310(CHEMBL3288854)
Affinity DataKi:  530nMAssay Description:Binding affinity to FAK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50341519((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50463479(CHEMBL4249925)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50463484(CHEMBL4248525)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50463483(CHEMBL4245242)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50513279(CHEMBL4554455)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of human recombinant N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50590475(CHEMBL5170906)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50590490(CHEMBL5198068)
Affinity DataIC50:  0.108nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50590479(CHEMBL5196177)
Affinity DataIC50:  0.117nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50590489(CHEMBL5176233)
Affinity DataIC50:  0.124nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50590488(CHEMBL5206909)
Affinity DataIC50:  0.153nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50590483(CHEMBL5187385)
Affinity DataIC50:  0.161nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50590484(CHEMBL5190968)
Affinity DataIC50:  0.192nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50590485(CHEMBL5177776)
Affinity DataIC50:  0.194nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50590474(CHEMBL5176990)
Affinity DataIC50:  0.213nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50590477(CHEMBL5204729)
Affinity DataIC50:  0.275nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50590482(CHEMBL5186801)
Affinity DataIC50:  0.296nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM155552(US9012461, 28)
Affinity DataIC50:  0.300nMpH: 7.4Assay Description:A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50590487(CHEMBL5199835)
Affinity DataIC50:  0.315nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50590476(CHEMBL5178369)
Affinity DataIC50:  0.315nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFocal adhesion kinase 1 [410-689](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM418652(4-{[4-({3- [methyl(methylsulfonyl)amino]benzyl} am...)
Affinity DataIC50:  0.380nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM155547(US9012461, 23)
Affinity DataIC50:  0.390nMpH: 7.4Assay Description:A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50568532(CHEMBL4742157)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50246239(CHEMBL487229 | N-methyl-N-(2-((2-(1-oxoisoindolin-...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of GST-tagged FAK (unknown origin) assessed as inhibition of poly-Glu-Tyr phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM418817(N-methyl-4-({4-[({3- [methyl(methylsulfonyl)amino]...)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of recombinant FAK (unknown origin) by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50592745(CHEMBL5188373)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50207359(CHEMBL3892377)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of NH2-terminal His6-tagged FAK kinase domain (410 to 689 residues) (unknown origin) expressed in baculovirus infected sf9 cells using p(G...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50207351(CHEMBL3965256)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of NH2-terminal His6-tagged FAK kinase domain (410 to 689 residues) (unknown origin) expressed in baculovirus infected sf9 cells using p(G...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50590486(CHEMBL5177168)
Affinity DataIC50:  0.514nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50590473(CHEMBL5192604)
Affinity DataIC50:  0.579nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFocal adhesion kinase 1 [410-689](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM418606(N-[3-({[2-anilino-5- (trifluoromethyl)pyrimidin-4-...)
Affinity DataIC50:  0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFocal adhesion kinase 1 [410-689](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM418607(N-[3-({[2-anilino-5- (trifluoromethyl)pyrimidin-4-...)
Affinity DataIC50:  0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFocal adhesion kinase 1 [410-689](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM418609(N-methyl-4-({4-[({2- [methyl(methylsulfonyl)amino]...)
Affinity DataIC50:  0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFocal adhesion kinase 1 [410-689](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM418610(N-methyl-4-({4-[({6-methyl-2- [methyl(methylsulfon...)
Affinity DataIC50:  0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFocal adhesion kinase 1 [410-689](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM418624(N-[2-(([2-anilino-5- (trifluoromethyl)pyrimidin-4-...)
Affinity DataIC50:  0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFocal adhesion kinase 1 [410-689](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM418634(N-[5-({[2-anilino-5- (trifluoromethyl)pyrimidin-4-...)
Affinity DataIC50:  0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFocal adhesion kinase 1 [410-689](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM418649(N-methyl-4-{[4-({2- [methyl(methylsulfonyl)amino]b...)
Affinity DataIC50:  0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFocal adhesion kinase 1 [410-689](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM418650(N-ethyl-4-({4-[({3- [methyl(methylsulfonyl)amino]p...)
Affinity DataIC50:  0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFocal adhesion kinase 1 [410-689](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM418651(US10450297, Example 98 | ethyl [4-({4-[({2- [methy...)
Affinity DataIC50:  0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFocal adhesion kinase 1 [410-689](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM418653(N-methyl-4-{[4-({3- [methyl(methylsulfonyl)amino]b...)
Affinity DataIC50:  0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFocal adhesion kinase 1 [410-689](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM418655(N-methyl-4-({4-[({6-methyl-4- [methyl(methylsulfon...)
Affinity DataIC50:  0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFocal adhesion kinase 1 [410-689](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM418656(N-[3-({[2-{[4-(aminomethyl)phenyl]amino}- 5-(trifl...)
Affinity DataIC50:  0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFocal adhesion kinase 1 [410-689](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM418659(4-{[4-({2-methyl-6- [methyl(methylsulfonyl)amino]b...)
Affinity DataIC50:  0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFocal adhesion kinase 1 [410-689](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM418597(US10450297, Example 40 | methyl 4-({4-[({2- [methy...)
Affinity DataIC50:  0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFocal adhesion kinase 1 [410-689](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM418603(3-methoxy-4-{[4-{[3- (methylsulfonyl)benzyl]amino}...)
Affinity DataIC50:  0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFocal adhesion kinase 1 [410-689](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM418604(3-methoxy-4-({4-[({2- [methyl(methylsuffonyl)amino...)
Affinity DataIC50:  0.590nMAssay Description:The in vitro activity of the compounds of the compounds of the invention may be determined by the following procedure. More particularly, the followi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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