Compile Data Set for Download or QSAR
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Found 31 Enz. Inhib. hit(s) with Target = 'Geranylgeranyl transferase type-1 subunit beta [A2V]/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha'
LigandPNGBDBM14014((5S)-31-oxo-20-oxa-2,6,11,13-tetraazahexacyclo[19....)
Affinity DataIC50:  5.5nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
LigandPNGBDBM14713(GGTI-DU40 | N-[(1S)-1-carbamoyl-2-phenylethyl]-4-{...)
Affinity DataIC50:  8.24nMpH: 7.7 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase or GGTase-1 in vitro using purified recombinant mammalian enzymes to catalyze the reactions between [3H]...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14016((5S)-6-methyl-31-oxo-20-oxa-2,6,11,13-tetraazahexa...)
Affinity DataIC50:  32nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14015((5R)-31-oxo-20-oxa-2,6,11,13-tetraazahexacyclo[19....)
Affinity DataIC50:  35nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14017((5R)-6-methyl-31-oxo-20-oxa-2,6,11,13-tetraazahexa...)
Affinity DataIC50:  39nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14012((5S)-7,31-dioxo-20-oxa-2,6,11,13-tetraazahexacyclo...)
Affinity DataIC50:  94nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14013((5R)-7,31-dioxo-20-oxa-2,6,11,13-tetraazahexacyclo...)
Affinity DataIC50:  150nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14023((1R,2R,5R)-30-oxo-19-oxa-2,6,10,12-tetraazahexacyc...)
Affinity DataIC50:  390nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14009((20S)-19,20,21,22-Tetrahydro-19-oxo-5H-18,20-ethan...)
Affinity DataIC50:  650nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
LigandPNGBDBM14008((11R)-32-oxo-25-oxa-8,12,16,18-tetraazahexacyclo[2...)
Affinity DataIC50:  810nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14003((20R)-17-(3-Chlorophenyl)-19,20,21,22-tetrahydro-1...)
Affinity DataIC50:  820nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14025((1R,2R,5R)-30-oxo-19,24-dioxa-2,6,10,12-tetraazahe...)
Affinity DataIC50:  1.10E+3nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14001((6R)-27-oxo-2-phenyl-20-oxa-3,7,11,13-tetraazapent...)
Affinity DataIC50:  1.60E+3nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14011((5S)-6-methyl-30-oxo-19-oxa-2,6,10,12-tetraazahexa...)
Affinity DataIC50:  2.20E+3nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14024((1R,2R,5S)-30-oxo-19-oxa-2,6,10,12-tetraazahexacyc...)
Affinity DataIC50:  2.20E+3nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14010((20R)-19,20,21,22-Tetrahydro-19-oxo-5H-18,20-ethan...)
Affinity DataIC50:  3.90E+3nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
LigandPNGBDBM14021((1S,2S,5S)-29-oxo-19-oxa-2,6,10,12-tetraazahexacyc...)
Affinity DataIC50:  4.00E+3nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14001((6R)-27-oxo-2-phenyl-20-oxa-3,7,11,13-tetraazapent...)
Affinity DataIC50:  5.80E+3nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14003((20R)-17-(3-Chlorophenyl)-19,20,21,22-tetrahydro-1...)
Affinity DataIC50:  7.00E+3nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14007((6R)-24-bromo-27-oxo-20-oxa-3,7,11,13-tetraazapent...)
Affinity DataIC50:  9.20E+3nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14026((1R,2R,5S)-30-oxo-19,24-dioxa-2,6,10,12-tetraazahe...)
Affinity DataIC50:  1.50E+4nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14018((17R, 20R)-19,20,21,22-Tetrahydro-19-oxo-17H-15,-1...)
Affinity DataIC50:  1.80E+4nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14022((1R,2R,5R)-6-methyl-29-oxo-19-oxa-2,6,10,12-tetraa...)
Affinity DataIC50: >2.00E+4nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14020((1R,2R,5S)-29-oxo-19-oxa-2,6,10,12-tetraazahexacyc...)
Affinity DataIC50: >2.00E+4nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14019((1S,2S,5R)-29-oxo-19-oxa-2,6,10,12-tetraazahexacyc...)
Affinity DataIC50:  2.00E+4nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13999((6S)-27-oxo-20-oxa-3,7,11,13-tetraazapentacyclo[19...)
Affinity DataIC50: >2.00E+4nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14000((6R)-23-chloro-27-oxo-20-oxa-3,7,11,13-tetraazapen...)
Affinity DataIC50: >2.00E+4nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14005((20R)-19,20,21,22-Tetrahydro-5-methyl-19-oxo-17H-1...)
Affinity DataIC50: >2.00E+4nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14005((20R)-19,20,21,22-Tetrahydro-5-methyl-19-oxo-17H-1...)
Affinity DataIC50: >2.00E+4nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13998((20R)-19,20,21,22-Tetrahydro-19-oxo-17H-18,20-etha...)
Affinity DataIC50: >2.00E+4nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14434(6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl...)
Affinity DatapH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of GGTase-1 in vitro using purified human enzyme to catalyze the reaction between [3H] GGPP and a biotinylated pe...More data for this Ligand-Target Pair