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Found 3200 Enz. Inhib. hit(s) with Target = 'Macrophage colony-stimulating factor 1 receptor'
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50381703(CHEMBL1970317)
Affinity DataKi:  2nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50381716(ABT-348 | ILORASERTIB | US8722890, 1 | US8722890, ...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50381719(CHEMBL2022856)
Affinity DataKi:  3.20nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50388873(CHEMBL1964441)
Affinity DataKi:  5nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50388874(CHEMBL1967720)
Affinity DataKi:  5nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50388880(CHEMBL1979577)
Affinity DataKi:  7.90nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50601865(CHEMBL5180946)
Affinity DataKi:  8nMAssay Description:Binding affinity to CSF1R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50520846(CHEMBL4461911)
Affinity DataKi:  129nMAssay Description:Inhibition of human CSF1R using poly[Glu:Tyr] (4:1) as substrate after 120 mins in presence of [gamma-33P]-ATP by filtration methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50567869(CHEMBL4878007)
Affinity DataKi:  166nMAssay Description:Inhibition of human FMS using KKKSPGEYVNIEFG as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counting based radiomet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50020310(CHEMBL3288854)
Affinity DataKi:  230nMAssay Description:Binding affinity to FMS (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50463483(CHEMBL4245242)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50463479(CHEMBL4249925)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50402020(CHEMBL2205426)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of recombinant CSF1R after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50321368(4-cyano-N-(4-(1,3-dimethyl-2-oxohexahydropyrimidin...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM27912(8-(4-ethylphenyl)-N-methoxy-2-{[4-(1-methylpiperid...)
Affinity DataIC50:  0.300nMpH: 7.5 T: 2°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50377072(CHEMBL438533)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50377072(CHEMBL438533)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM27915(8-(4,4-dimethylcyclohexyl)-N-methoxy-2-{[4-(1-meth...)
Affinity DataIC50:  0.400nMpH: 7.5 T: 2°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM27913(8-(3-ethylphenyl)-N-methoxy-2-{[4-(1-methylpiperid...)
Affinity DataIC50:  0.400nMpH: 7.5 T: 2°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50377071(CHEMBL402337)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of FMSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50321373(4-cyano-N-(4-(2-(cyanoimino)-1,3-dimethylhexahydro...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM27909(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-{[4-(1-m...)
Affinity DataIC50:  0.400nMpH: 7.5 T: 2°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM98644(US8497376, 20)
Affinity DataIC50:  0.410nMpH: 7.5Assay Description:An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM238106(US9394289, 2)
Affinity DataIC50:  0.420nMpH: 7.5 T: 2°CAssay Description:An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM98627(US8497376, 8)
Affinity DataIC50:  0.420nMpH: 7.5Assay Description:An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM98621(US8497376, 2)
Affinity DataIC50:  0.430nMpH: 7.5Assay Description:An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor [555-568](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM198857(BDBM198884 | US9221797, 20)
Affinity DataIC50:  0.440nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM119049(CHEMBL3086320 | US8674100, 20 | US8674100, 69)
Affinity DataIC50:  0.440nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM98624(US8497376, 5)
Affinity DataIC50:  0.470nMpH: 7.5Assay Description:An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM238129(US9394289, 25)
Affinity DataIC50:  0.490nMpH: 7.5 T: 2°CAssay Description:An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM27896(8-(2,3-dihydro-1H-inden-5-yl)-N-ethoxy-2-({4-[2-(4...)
Affinity DataIC50:  0.5nMpH: 7.5 T: 2°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50240227(CHEMBL4084391)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity was determined against HSV-1 Ribonucleoside diphosphate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50321365(4-cyano-N-(2-cyclohexenyl-4-(1-methyl-2,6-dioxopip...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM27906(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-5-oxo-2-{[...)
Affinity DataIC50:  0.5nMpH: 7.5 T: 2°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM238109(US9394289, 5)
Affinity DataIC50:  0.5nMpH: 7.5 T: 2°CAssay Description:An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM27897(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Affinity DataIC50:  0.5nMpH: 7.5 T: 2°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50240209(CHEMBL4068526)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of human CSF1R using poly[Glu:Tyr] (4:1) as substrate incubated for 2 hrs in presence of [33gammaP]ATP by P81 ion exchange chromatographic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50321367(4-cyano-N-(2-cyclohexenyl-4-(1,3-dimethyl-2-oxohex...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM119049(CHEMBL3086320 | US8674100, 20 | US8674100, 69)
Affinity DataIC50:  0.510nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor [555-568](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM198857(BDBM198884 | US9221797, 20)
Affinity DataIC50:  0.510nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50579499(CHEMBL4847875)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of wild-type human partial length CSF1R (I564 to S939 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM595657(US11591328, Compound 10)
Affinity DataIC50:  0.550nMAssay Description:CSF1R: The specific operation is as follows: Set the concentration gradient of the test compound and dilute the test compound to the working concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM238121(US9394289, 17)
Affinity DataIC50:  0.560nMpH: 7.5 T: 2°CAssay Description:An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of CSF1R (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM119032(US8674100, 45)
Affinity DataIC50:  0.600nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor [555-568](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM198873(US9221797, 45)
Affinity DataIC50:  0.600nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50233716(5-cyano-N-(4-(4-(2-hydroxyethyl)piperazin-1-yl)-2-...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50443154(CHEMBL3085973 | US8674100, 147)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM119049(CHEMBL3086320 | US8674100, 20 | US8674100, 69)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50393560(CHEMBL2158300 | US8697716, 48)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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