Compile Data Set for Download or QSAR
maximum 50k data
Found 99 Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase LCK'
LigandPNGBDBM25191(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Affinity DataKi:  20nM ΔG°:  -43.5kJ/mole IC50:  59nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25979(BMCL18324 Compound 1 | N-[4-methoxy-3-(4-methylpip...)
Affinity DataKi:  2.80E+3nM ΔG°:  -31.4kJ/mole IC50:  8.40E+3nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25980(BMCL18324 Compound 3 | CHEMBL270164 | N-(3-cyanoph...)
Affinity DataKi: >5.40E+3nM ΔG°: >-29.8kJ/mole IC50: >1.60E+4nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25981(BMCL18324 Compound 17 | CHEMBL273158 | D3RKN_78 | ...)
Affinity DataKi: >5.40E+3nM ΔG°: >-29.8kJ/mole IC50: >1.60E+4nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26166(2,4-dianilino pyrimidine, 23 | 3-({4-[(5-hydroxy-2...)
Affinity DataIC50:  8.5nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26180(2,4-dianilino pyrimidine, 37 | 3-({4-[(5-methyl-1H...)
Affinity DataIC50:  12nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26145(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Affinity DataIC50:  13nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26186(2,4-dianilino pyrimidine, 43 | 3-({4-[(5-methyl-1H...)
Affinity DataIC50:  19nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  31nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26185(2,4-dianilino pyrimidine, 42 | 3-{[4-(1H-indazol-4...)
Affinity DataIC50:  33nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25116(1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]...)
Affinity DataIC50:  40nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26152(2,4-dianilino pyrimidine, 9 | 3-({4-[(4-hydroxy-2-...)
Affinity DataIC50:  40nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26149(2,4-dianilino pyrimidine, 6 | 3-({4-[(2-bromo-5-hy...)
Affinity DataIC50:  41nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26167(2,4-dianilino pyrimidine, 24 | 3-({4-[(5-methoxy-2...)
Affinity DataIC50:  54nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26182(2,4-dianilino pyrimidine, 39 | 3-({4-[(7-methyl-1H...)
Affinity DataIC50:  55nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25191(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Affinity DataIC50:  59nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13242(2-[(butylcarbamoyl)amino]-4-methyl-N-(2,4,6-trimet...)
Affinity DataIC50:  70nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13242(2-[(butylcarbamoyl)amino]-4-methyl-N-(2,4,6-trimet...)
Affinity DataIC50:  70nMAssay Description:In vitro inhibition of murine Lck kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26147(2,4-dianilino pyrimidine, 4 | 3-({4-[(3-hydroxy-5-...)
Affinity DataIC50:  73nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26156(2,4-dianilino pyrimidine, 13 | 3-({4-[(5-methoxy-2...)
Affinity DataIC50:  86nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26151(2,4-dianilino pyrimidine, 8 | 3-({4-[(2-methylphen...)
Affinity DataIC50:  89nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13241(4-methyl-2-[(phenylcarbamoyl)amino]-N-(2,4,6-trime...)
Affinity DataIC50:  90nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26157(2,4-dianilino pyrimidine, 14 | 3-({4-[(5-amino-2-m...)
Affinity DataIC50:  97nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13244(2-[(benzylcarbamoyl)amino]-4-methyl-N-(2,4,6-trime...)
Affinity DataIC50:  100nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26179(2,4-dianilino pyrimidine, 36 | 3-{[4-(1H-indazol-4...)
Affinity DataIC50:  100nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26153(2,4-dianilino pyrimidine, 10 | 3-({4-[(2-hydroxy-6...)
Affinity DataIC50:  100nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26146(2,4-dianilino pyrimidine, 3 | 3-({4-[(3-hydroxyphe...)
Affinity DataIC50:  130nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50307127((3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-I...)
Affinity DataIC50:  150nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13240(2-[[(Methylamino)-carbonyl]amino]-4-methyl-N-(2,4,...)
Affinity DataIC50:  170nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13240(2-[[(Methylamino)-carbonyl]amino]-4-methyl-N-(2,4,...)
Affinity DataIC50:  170nMAssay Description:In vitro inhibition of murine Lck kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26148(2,4-dianilino pyrimidine, 5 | 3-({4-[(3-hydroxy-4-...)
Affinity DataIC50:  190nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26154(2,4-dianilino pyrimidine, 11 | 3-({4-[(5-fluoro-2-...)
Affinity DataIC50:  270nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13224(2-N-benzene-4-methyl-5-N-(2,4,6-trimethylphenyl)-1...)
Affinity DataIC50:  320nMAssay Description:In vitro inhibition of murine Lck kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13224(2-N-benzene-4-methyl-5-N-(2,4,6-trimethylphenyl)-1...)
Affinity DataIC50:  320nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26168(2,4-dianilino pyrimidine, 25 | 3-({4-[(2,4-difluor...)
Affinity DataIC50:  350nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM26155(2,4-dianilino pyrimidine, 12 | 3-({4-[(5-chloro-2-...)
Affinity DataIC50:  380nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50298225(CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US10544104...)
Affinity DataIC50:  460nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26176(2,4-dianilino pyrimidine, 33 | 3-{[4-(1H-1,2,3-ben...)
Affinity DataIC50:  490nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13223(2-acetamido-4-methyl-N-(2,4,6-trimethylphenyl)-1,3...)
Affinity DataIC50:  510nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26181(2,4-dianilino pyrimidine, 38 | 3-({4-[(6-methyl-1H...)
Affinity DataIC50:  520nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26175(2,4-dianilino pyrimidine, 32 | 3-{[4-(quinolin-5-y...)
Affinity DataIC50:  560nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)
Affinity DataIC50:  570nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229961(1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazo...)
Affinity DataIC50:  660nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13222(2-[[(Methoxy)carbonyl]-amino]-4-methyl-N-(2,4,6-tr...)
Affinity DataIC50:  720nMAssay Description:In vitro inhibition of murine Lck kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13222(2-[[(Methoxy)carbonyl]-amino]-4-methyl-N-(2,4,6-tr...)
Affinity DataIC50:  720nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50248765(1-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrol...)
Affinity DataIC50:  750nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26150(2,4-dianilino pyrimidine, 7 | 3-[(4-{[5-hydroxy-2-...)
Affinity DataIC50:  880nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26165(2,4-dianilino pyrimidine, 22 | 3-({4-[(2,4-difluor...)
Affinity DataIC50:  1.10E+3nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26158(2,4-dianilino pyrimidine, 15 | 3-({2-[(3-carbamoyl...)
Affinity DataIC50:  1.30E+3nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26177(2,4-dianilino pyrimidine, 34 | 3-{[4-(1H-indazol-7...)
Affinity DataIC50:  1.40E+3nMAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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