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Found 6 Enz. Inhib. hit(s) with Target = 'Tyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321C]'
TargetTyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321C](Mus musculus (Mouse))
National Institutes Of Health

LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50:  580nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321C](Mus musculus (Mouse))
National Institutes Of Health

LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50:  710nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321C](Mus musculus (Mouse))
National Institutes Of Health

LigandPNGBDBM50438863(10-(4-Hydroxyphenyl)-2,4-dioxo-pyrimido[4,5-b]quin...)
Affinity DataIC50:  1.10E+3nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
TargetTyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321C](Mus musculus (Mouse))
National Institutes Of Health

LigandPNGBDBM50438865(2,4-Dioxo-10-phenyl-pyrimido[4,5-b]quinoline-8-car...)
Affinity DataIC50:  3.70E+3nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321C](Mus musculus (Mouse))
National Institutes Of Health

LigandPNGBDBM50438870(8-Chloro-10-(4-hydroxyphenyl)pyrimido[4,5-b]quinol...)
Affinity DataIC50:  3.50E+4nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321C](Mus musculus (Mouse))
National Institutes Of Health

LigandPNGBDBM50438882(10-Phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dion...)
Affinity DataIC50: >1.11E+5nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed