Compile Data Set for Download or QSAR
Found 3457 Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 3A'
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50282059(CHEMBL433452 | quinuclidine derivative)
Affinity DataKi: >0nMAssay Description:Binding affinity at 5-hydroxytryptamine 3 receptor in rat entorhinal cortex by [3H]-BRL-43694 displacement.More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50417287(Aloxi | Aurothioglucose | PALONOSETRON | PALONOSET...)
Affinity DataKi:  0.0316nMAssay Description:Binding affinity to 5HT3A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50004276(1-Isopropyl-2-oxo-1,2-dihydro-quinoline-4-carboxyl...)
Affinity DataKi:  0.0320nMAssay Description:Ability to displace [3H]quipazine binding to 5-hydroxytryptamine 3 receptor sites in NG 108-15.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50060242(5-[3-(3,5-Dichloro-phenyl)-2-oxo-imidazolidin-1-yl...)
Affinity DataKi:  0.0380nMAssay Description:In vitro affinity for 5-hydroxytryptamine 3 (5-HT3) receptor by displacement of [3H]BRL-43694 from rat entorhinal cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50417287(Aloxi | Aurothioglucose | PALONOSETRON | PALONOSET...)
Affinity DataKi:  0.0400nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50459886(CHEMBL261010)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]granisetron from human 5-HT3A receptor expressed in HEK293 cells by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50288283(4-Amino-N-(S)-1-aza-bicyclo[2.2.2]oct-3-yl-5-chlor...)
Affinity DataKi:  0.0500nMAssay Description:Compound was tested for its binding affinity towards 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50397290(CHEMBL475331 | VUF-10147)
Affinity DataKi:  0.0513nMAssay Description:Displacement of [3H]granisetron from 5HT3A receptor expressed in HEK293 cells after 24 hrs by scintillation counting in presence of quipazineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50288283(4-Amino-N-(S)-1-aza-bicyclo[2.2.2]oct-3-yl-5-chlor...)
Affinity DataKi:  0.0520nMAssay Description:Compound was tested in vitro for its antagonistic activity against 5-hydroxytryptamine 3 receptor in rat CNS.More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50334454(CHEMBL1643895 | Ramosetron | US9045501, Ramosetron)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity to human 5HT3A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50334454(CHEMBL1643895 | Ramosetron | US9045501, Ramosetron)
Affinity DataKi:  0.0600nM ΔG°:  -58.3kJ/molepH: 7.5 T: 2°CAssay Description:The relative affinity of the various compounds for the human 5-HT3 receptor was measured in a radioligand binding assay, using a scintillation proxim...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50167011(4-(4-Methyl-piperazin-1-yl)-2,3-dihydro-1H-cyclope...)
Affinity DataKi:  0.0708nMAssay Description:Rat 5-hydroxytryptamine 3 receptor (5-HT3) antagonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50288283(4-Amino-N-(S)-1-aza-bicyclo[2.2.2]oct-3-yl-5-chlor...)
Affinity DataKi:  0.0750nMAssay Description:Compound was tested for its binding affinity towards 5-hydroxytryptamine 3 receptor in whole rat brain using [125I]-DAIZAC as the radioligand.More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50042715(1-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-...)
Affinity DataKi:  0.0750nMAssay Description:The binding affinity of the compound was measured on histamine H1 receptor using [3H]- mepyramine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50166996(2-(4-Methyl-piperazin-1-yl)-3-propyl-quinoline-4-c...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [3H]granisetron from 5-hydroxytryptamine 3 receptor of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50063263(6-(4-Methyl-piperazin-1-yl)-7,8,9,10-tetrahydro-ph...)
Affinity DataKi:  0.0977nMAssay Description:Rat 5-hydroxytryptamine 3 receptor (5-HT3) antagonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50288587(2-(4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-ylc...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity at 5-hydroxytryptamine 3 receptor in rat entorhinal cortex by [3H]BRL-43694 displacement.More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50063264(6-Piperazin-1-yl-7,8,9,10-tetrahydro-phenanthridin...)
Affinity DataKi:  0.100nMAssay Description:Rat 5-hydroxytryptamine 3 receptor (5-HT3) antagonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50167002(3-Methyl-2-(4-methyl-piperazin-1-yl)-quinoline-4-c...)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]granisetron from 5-hydroxytryptamine 3 receptor of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50056419(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Affinity DataKi:  0.110nMAssay Description:In vitro relaxation of carbachol pre-contracted rat oesophageal TMM.More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50083190(6-Chloro-1H-benzoimidazole-4-carboxylic acid (1-az...)
Affinity DataKi:  0.130nMAssay Description:In vitro affinity at serotonergic 5-hydroxytryptamine 3 receptor by radioligand binding assay, using [3H]-LY 278584 in rat cerebral cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50214492(CHEMBL145725 | RS-16566)
Affinity DataKi:  0.145nMAssay Description:Binding affinity for 5-hydroxytryptamine 3 receptor by displacement of [3H](R)-zacopride from ondansetron-treated NG-108-15 cell membranesMore data for this Ligand-Target Pair
In DepthDetails
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50280507(6-Amino-2-(R)-1-aza-bicyclo[2.2.2]oct-3-yl-benzo[d...)
Affinity DataKi:  0.150nMAssay Description:Antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor of isolated guinea pig ileum (GPI)More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50282053(4-Amino-2-(1-aza-bicyclo[2.2.2]oct-3-yl)-benzo[de]...)
Affinity DataKi:  0.150nMAssay Description:Binding affinity at 5-hydroxytryptamine 3 receptor in rat entorhinal cortex by [3H]-BRL-43694 displacement.More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50280507(6-Amino-2-(R)-1-aza-bicyclo[2.2.2]oct-3-yl-benzo[d...)
Affinity DataKi:  0.150nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-BRL 43694 as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50000453(CHEMBL540055)
Affinity DataKi:  0.160nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50000523(CHEMBL544784)
Affinity DataKi:  0.160nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50307815(4-Hydroxy-1-methyl-N-[(3-endo)-9-methyl-9-azabicyc...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]granisetron from human 5HT3A receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50167013(4-Methyl-2-(4-methyl-piperazin-1-yl)-quinoline-3-c...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]granisetron from 5-hydroxytryptamine 3 receptor of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50056419(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Affinity DataKi:  0.182nMAssay Description:Binding affinity for 5-hydroxytryptamine 3 receptor by displacement of [3H]-BRL 43694 from NG-108-15 cell membranesMore data for this Ligand-Target Pair
In DepthDetails
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50000485((S)-2-(5-chlorospiro[2,3-dihydrobenzo[b]furan-2,1'...)
Affinity DataKi:  0.190nMAssay Description:Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50231569(Cilansetron | KC-9946)
Affinity DataKi:  0.190nMAssay Description:The binding affinity was measured on 5-hydroxytryptamine 3 receptor using [3H]GR-65630 as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50042718(1-(3,4-Dihydro-5-thia-2a-aza-acenaphthylen-1-yl)-3...)
Affinity DataKi:  0.190nMAssay Description:The binding affinity of the compound was measured on alpha2-adrenergic receptor using [3H]- clonidine as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50056419(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Affinity DataKi:  0.200nMAssay Description:Antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor in isolated rabbit vagus nerve (RVN)More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50288590(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity at 5-hydroxytryptamine 3 receptor in rat entorhinal cortex by [3H]BRL-43694 displacement.More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50056419(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50056419(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-BRL 43694 as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50014549(CHEMBL3261480 | US9045501, 4)
Affinity DataKi:  0.200nM ΔG°:  -55.4kJ/molepH: 7.5 T: 2°CAssay Description:The relative affinity of the various compounds for the human 5-HT3 receptor was measured in a radioligand binding assay, using a scintillation proxim...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50056419(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity at 5-hydroxytryptamine 3 receptor in rat entorhinal cortex by [3H]-BRL-43694 displacement.More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50000457(CHEMBL542904)
Affinity DataKi:  0.200nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50000450(CHEMBL542669)
Affinity DataKi:  0.200nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50000471(CHEMBL542900)
Affinity DataKi:  0.200nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50014549(CHEMBL3261480 | US9045501, 4)
Affinity DataKi:  0.200nMAssay Description:Displacement of [9-methyl-3H]BRL-43694 from human 5-HT3A receptor after overnight incubation by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50056419(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 receptor using [3H]BRL-43694 as radioligand in rat posterior cortexMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 3A(Mus musculus (house mouse))
Medical Research Council Centre

Curated by PDSP Ki Database
LigandPNGBDBM82473(CAS_124006 | GR 65630 | NSC_124006)
Affinity DataKi:  0.210nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50167015(3-Ethyl-2-(4-methyl-piperazin-1-yl)-quinoline-4-ca...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]granisetron from 5-hydroxytryptamine 3 receptor of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
University of Modena and Reggio Emilia

Curated by ChEMBL
LigandPNGBDBM50307826(1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]n...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]granisetron from human 5HT3A receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50368604(CHEMBL1907770)
Affinity DataKi:  0.230nMAssay Description:Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50042714(9-(2-Methyl-imidazol-1-ylmethyl)-4,5,8,9-tetrahydr...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50056419(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Affinity DataKi:  0.230nMAssay Description:Compound was evaluated in vivo for the antagonistic activity towards 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
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