Compile Data Set for Download or QSAR
Report error Found 2042 Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 4'
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50436989(CHEMBL2402904)
Affinity DataEC50:  2.5nMAssay Description:Induction of 5-HT4 receptor-mediated contraction in guinea pig longitudinal muscle myenteric plexusMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50240618(CHEMBL76370 | (2E)-2-[(5-methoxy-1H-indol-3-yl)met...)
Affinity DataEC50:  13nMAssay Description:Induction of 5-HT4 receptor-mediated contraction in guinea pig longitudinal muscle myenteric plexusMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50388686(CHEMBL74656)
Affinity DataEC50:  100nMAssay Description:Induction of 5-HT4 receptor-mediated contraction in guinea pig longitudinal muscle myenteric plexusMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM29532((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,...)
Affinity DataEC50:  1.00E+4nMAssay Description:EC/IC50 was the effective concentration of agonist inhibiting the formation of A-beta fibrils to 50% of the control value. Three independent measurem...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM29528(ML10302 scaffold, 9{a;y})
Affinity DataAssay Description:EC/IC50 was the effective concentration of agonist inhibiting the formation of A-beta fibrils to 50% of the control value. Three independent measurem...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM29529(ML10302 scaffold, 14)
Affinity DataEC50:  9.00E+3nMAssay Description:EC/IC50 was the effective concentration of agonist inhibiting the formation of A-beta fibrils to 50% of the control value. Three independent measurem...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50155152(4-Amino-N-(1-aza-tricyclo[3.3.1.1*3,7*]dec-4-yl)-5...)
Affinity DataEC50:  538nMAssay Description:Compound was evaluated for the agonistic activity towards 5-hydroxytryptamine 4 receptor using the rat tunica muscularis mucosae (TMM) esophagus stri...More data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50449570(CHEMBL2448137)
Affinity DataEC50:  3.87E+3nMAssay Description:Compound was evaluated for the agonistic activity towards 5-hydroxytryptamine 4 receptor using the rat tunica muscularis mucosae (TMM) esophagus stri...More data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50181836(CHEMBL319673 | 4-amino-N-1-azatricyclo[3.3.1.0~3,7...)
Affinity DataEC50:  51nMAssay Description:Compound was evaluated for the agonistic activity towards 5-hydroxytryptamine 4 receptor using the rat tunica muscularis mucosae (TMM) esophagus stri...More data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50289989(4-Amino-N-(3-aza-tricyclo[3.3.1.0*3,7*]non-9-yl)-5...)
Affinity DataEC50:  382nMAssay Description:Agonist activity against serotonin 5-HT4 receptor in rat tunica muscularis mucosae assayMore data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50289990(4-Amino-N-(3-aza-tricyclo[3.3.1.0*3,7*]non-9-ylmet...)
Affinity DataEC50:  660nMAssay Description:Agonist activity against serotonin 5-HT4 receptor in rat tunica muscularis mucosae assayMore data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50282690(4-Amino-5-chloro-2-methoxy-benzoic acid 1-ethyl-pi...)
Affinity DataEC50:  44nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity as increased response to electrical stimulation in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50282689(4-Amino-5-chloro-2-methoxy-benzoic acid 1-methyl-p...)
Affinity DataEC50:  110nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity as increased response to electrical stimulation in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056399(4-Amino-5-chloro-2-methoxy-benzoic acid (R)-(1-aza...)
Affinity DataEC50:  110nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity as increased response to electrical stimulation in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50000492(ZACOPRIDE,R | 4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3...)
Affinity DataEC50:  260nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity as increased response to electrical stimulation in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataEC50: >1.00E+3nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity as increased response to electrical stimulation in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM29526(CHEMBL286136 | 2-Piperidinoethyl 4-amino-5-chloro-...)
Affinity DataEC50:  4nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity as increased response to electrical stimulation in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056421(4-Amino-5-chloro-2-methoxy-benzoic acid 8-methyl-8...)
Affinity DataEC50:  27nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity as increased response to electrical stimulation in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  5nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity as increased response to electrical stimulation in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50282688(4-Amino-5-chloro-2-methoxy-benzoic acid 1-ethyl-pi...)
Affinity DataEC50:  22nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity as increased response to electrical stimulation in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  17nMAssay Description:In vitro relaxation of carbachol pre-contracted rat oesophageal TMM.More data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50288594(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataEC50:  4.5nMAssay Description:In vitro relaxation of carbachol pre-contracted rat oesophageal TMM.More data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50288590(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataEC50:  11nMAssay Description:In vitro relaxation of carbachol pre-contracted rat oesophageal TMM.More data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50288591(2-(2,3-dihydrobenzo[b]furan-7-ylcarboxamido)-(2S)-...)
Affinity DataEC50: >1.00E+4nMAssay Description:In vitro relaxation of carbachol pre-contracted rat oesophageal TMM.More data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50288585(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataEC50:  7.40nMAssay Description:In vitro relaxation of carbachol pre-contracted rat oesophageal TMM.More data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50288596(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataEC50:  19nMAssay Description:In vitro relaxation of carbachol pre-contracted rat oesophageal TMM.More data for this Ligand-Target Pair
In DepthDetails Article

Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50058179((4-Amino-5-chloro-2-methoxy-phenyl)-carbamic acid ...)
Affinity DataEC50:  60nMAssay Description:concentration which gave a 50% increase in the response to electrical stimulation against 5-hydroxytryptamine 4 receptor in the guinea pig ileum. Act...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50058182((4-Amino-5-chloro-2-methoxy-phenyl)-carbamic acid ...)
Affinity DataEC50:  300nMAssay Description:concentration which gave a 50% increase in the response to electrical stimulation against 5-hydroxytryptamine 4 receptor in the guinea pig ileum. Act...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50058172((4-Amino-5-chloro-2-methoxy-phenyl)-carbamic acid ...)
Affinity DataEC50: >1.00E+3nMAssay Description:concentration which gave a 50% increase in the response to electrical stimulation against 5-hydroxytryptamine 4 receptor in the guinea pig ileum.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50058187((4-Amino-5-chloro-2-methoxy-phenyl)-carbamic acid ...)
Affinity DataEC50:  200nMAssay Description:concentration which gave a 50% increase in the response to electrical stimulation against 5-hydroxytryptamine 4 receptor in the guinea pig ileum. Act...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50058190((4-Amino-5-chloro-2-methoxy-phenyl)-carbamic acid ...)
Affinity DataEC50: >1.00E+3nMAssay Description:concentration which gave a 50% increase in the response to electrical stimulation against 5-hydroxytryptamine 4 receptor in the guinea pig ileum.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50058171((4-Amino-5-chloro-2-methoxy-phenyl)-carbamic acid ...)
Affinity DataEC50:  100nMAssay Description:concentration which gave a 50% increase in the response to electrical stimulation against 5-hydroxytryptamine 4 receptor in the guinea pig ileum.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056404(BIMU 8 | CHEMBL59834 | 3-Isopropyl-2-oxo-2,3-dihyd...)
Affinity DataEC50:  43nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50031475(4-Amino-N-(R)-1-aza-bicyclo[2.2.2]oct-3-yl-5-chlor...)
Affinity DataEC50:  166nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056399(4-Amino-5-chloro-2-methoxy-benzoic acid (R)-(1-aza...)
Affinity DataEC50:  110nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056396(4-Amino-5-chloro-2-methoxy-benzoic acid (S)-(1-aza...)
Affinity DataEC50:  153nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056407(4-Amino-5-chloro-2-methoxy-benzoic acid 2-dimethyl...)
Affinity DataEC50:  180nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM29526(CHEMBL286136 | 2-Piperidinoethyl 4-amino-5-chloro-...)
Affinity DataEC50:  4nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  5nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056406(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(3-methy...)
Affinity DataEC50:  15nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056412(4-Amino-5-chloro-2-methoxy-benzoic acid 2-pyrrolid...)
Affinity DataEC50:  40nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056419(ZACOPRIDE,R | 4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3...)
Affinity DataEC50:  77nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056414(4-Amino-5-chloro-2-methoxy-benzoic acid 2-morpholi...)
Affinity DataEC50:  113nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056413(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(3,6-dih...)
Affinity DataEC50:  29nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056410(4-Amino-5-chloro-2-methoxy-N-(2-piperidin-1-yl-eth...)
Affinity DataEC50: >1.00E+3nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056395(1-[2-(4-Amino-5-chloro-2-methoxy-benzoyloxy)-ethyl...)
Affinity DataEC50:  17nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056421(4-Amino-5-chloro-2-methoxy-benzoic acid 8-methyl-8...)
Affinity DataEC50:  27nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056418(4-Amino-5-chloro-2-methoxy-benzoic acid 2-azepan-1...)
Affinity DataEC50:  4.40nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056394(4-Amino-5-chloro-2-methoxy-N-methyl-N-(2-piperidin...)
Affinity DataEC50: >1.00E+3nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Theravance

Curated by ChEMBL
LigandPNGBDBM50056403(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(3-hydro...)
Affinity DataEC50:  4nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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