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Report error Found 6052 Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 6'
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50044610(CHEMBL3329438)
Affinity DataKi:  0.0400nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166333(US9067949, 190)
Affinity DataKi:  0.0500nM ΔG°:  -58.8kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50415991(CHEMBL1084794)
Affinity DataKi:  0.0501nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50477491(CHEMBL398034)
Affinity DataKi:  0.0631nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50415975(CHEMBL1085462)
Affinity DataKi:  0.0631nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50415981(CHEMBL1086326)
Affinity DataKi:  0.0794nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166213(US9067949, 70)
Affinity DataKi:  0.0830nM ΔG°:  -57.5kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM328391(6-chloro-3-(difluoromethyl)-1-((4-methoxy-3-(piper...)
Affinity DataKi:  0.0850nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50318625(CHEMBL1083654 | N-Methyl-(3-phenylsulfonyl)-7,8-di...)
Affinity DataKi:  0.0880nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50579331(CHEMBL4852099)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO-K1 cell membranes incubated for 1 hr by scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50415993(CHEMBL1086252)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50416007(CHEMBL1085120)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166328(US9067949, 185)
Affinity DataKi:  0.100nM ΔG°:  -57.1kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50416028(CHEMBL1085658)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50163035(5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic aci...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of [3H]-LSD binding to human 5-hydroxytryptamine 6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50416015(CHEMBL1086113)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50001524(CHEMBL24474)
Affinity DataKi:  0.110nMAssay Description:Binding constant towards serotonin receptor subtype 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]LSD as radioligandChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166358(US9067949, 215)
Affinity DataKi:  0.110nM ΔG°:  -56.8kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166331(US9067949, 188)
Affinity DataKi:  0.110nM ΔG°:  -56.8kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166303(US9067949, 160)
Affinity DataKi:  0.110nM ΔG°:  -56.8kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50318626(CHEMBL1082763 | N-Methyl-(3-phenylsulfonyl)-6,7,8,...)
Affinity DataKi:  0.112nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166197(US9067949, 54)
Affinity DataKi:  0.120nM ΔG°:  -56.6kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50416012(CHEMBL1084711)
Affinity DataKi:  0.126nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50415996(CHEMBL1085037)
Affinity DataKi:  0.126nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50416006(CHEMBL1083886)
Affinity DataKi:  0.126nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50001827(CHEMBL363792)
Affinity DataKi:  0.130nMAssay Description:Binding affinity for human 5-hydroxytryptamine 6 receptorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50001832(CHEMBL365569)
Affinity DataKi:  0.130nMAssay Description:Binding affinity for human 5-hydroxytryptamine 6 receptorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166310(US9067949, 167)
Affinity DataKi:  0.130nM ΔG°:  -56.4kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166244(US9067949, 101 | US9067949, 143)
Affinity DataKi:  0.130nM ΔG°:  -56.4kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166244(US9067949, 101 | US9067949, 143)
Affinity DataKi:  0.130nM ΔG°:  -56.4kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50358778(CHEMBL1922616)
Affinity DataKi:  0.140nMAssay Description:Inhibition of human recombinant 5-HT6 receptor expressed in human HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166225(US9067949, 81a | US9067949, 82a | US9067949, 82b)
Affinity DataKi:  0.150nM ΔG°:  -56.1kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50415987(CHEMBL1085617)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50415978(CHEMBL1086323)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50416000(CHEMBL1085585)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50416019(CHEMBL1084336)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50415972(CHEMBL1086079)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]LSD form human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50477488(CHEMBL394690)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50492797(CHEMBL2413990)
Affinity DataKi:  0.160nMAssay Description:Antagonist activity at recombinant human 5-HT6 receptor expressed in HEK293 cells assessed as 5-HT-induced intracellular cAMP production after 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166327(US9067949, 184)
Affinity DataKi:  0.160nM ΔG°:  -55.9kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166326(US9067949, 183)
Affinity DataKi:  0.160nM ΔG°:  -55.9kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166335(US9067949, 192)
Affinity DataKi:  0.170nM ΔG°:  -55.8kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166193(US9067949, 50)
Affinity DataKi:  0.170nM ΔG°:  -55.8kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50318633(3-benzenesulfonyl-8-piperazin-1-ylquinoline | CHEM...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 1 hr by scintillation spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50592784(CHEMBL5177311)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50417934(CHEMBL1668590 | US8829009, 1.1(7))
Affinity DataKi:  0.186nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP accumulation after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166311(US9067949, 168)
Affinity DataKi:  0.190nM ΔG°:  -55.5kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166306(US9067949, 163)
Affinity DataKi:  0.190nM ΔG°:  -55.5kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50291284(CHEMBL4170220)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to 5HT6R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM166309(US9067949, 166)
Affinity DataKi:  0.200nM ΔG°:  -55.4kJ/molepH: 7.5 T: 2°CAssay Description:For binding analysis vs. the human receptor, samples were incubated in 50 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 1 mM EDTA (4% DMSO final) with 10 nM [N-me...More data for this Ligand-Target Pair
In DepthDetails US Patent
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