Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 76 Enz. Inhib. hit(s) with Target = 'ATP-binding cassette sub-family C member 8/ATP-sensitive inward rectifier potassium channel 11'
LigandPNGBDBM50118351((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of human SUR1/Kir6.2 expressed in CHO cellsMore data for this Ligand-Target Pair
LigandPNGBDBM50190500(6-chloro-3-(1-methyl-1-phenylethyl)amino-4H-thieno...)
Affinity DataIC50:  81nMAssay Description:Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118349((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50:  120nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118348((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50:  180nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118360(CHEMBL336586 | tert-Butyl-(2-chloro-7,7-dioxo-4,7-...)
Affinity DataIC50:  230nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataIC50:  286nMAssay Description:Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataIC50:  320nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118343((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50:  340nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50023475(CHEMBL2111887)
Affinity DataIC50:  640nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118355((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50:  2.27E+3nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50099573(1N-[4-methoxy-3-methylamino(thioxo)methylsulfamoyl...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of human SUR1/Kir6.2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118351((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118349((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50:  1.46E+5nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataIC50:  1.65E+5nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118343((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50:  1.87E+5nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataIC50:  1.94E+5nMAssay Description:Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataIC50:  1.98E+5nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50023475(CHEMBL2111887)
Affinity DataIC50:  2.24E+5nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50190500(6-chloro-3-(1-methyl-1-phenylethyl)amino-4H-thieno...)
Affinity DataIC50:  3.60E+5nMAssay Description:Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118348((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50:  3.75E+5nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118360(CHEMBL336586 | tert-Butyl-(2-chloro-7,7-dioxo-4,7-...)
Affinity DataIC50:  3.93E+5nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50023475(CHEMBL2111887)
Affinity DataIC50:  4.87E+5nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118343((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50:  5.54E+5nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118355((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50:  5.84E+5nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at low ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataIC50:  6.85E+5nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataIC50:  6.96E+5nMAssay Description:Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataIC50:  7.40E+5nMAssay Description:Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataIC50:  7.50E+5nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118351((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50:  8.59E+5nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118348((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50:  8.99E+5nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118355((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50:  9.24E+5nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118349((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50:  9.43E+5nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118360(CHEMBL336586 | tert-Butyl-(2-chloro-7,7-dioxo-4,7-...)
Affinity DataIC50:  1.35E+6nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 without...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataEC50:  3.10E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as activation of K+ currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119269(CHEMBL102025 | Cyclobutyl-(7-fluoro-1,1-dioxo-1,4-...)
Affinity DataEC50:  356nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119273(CHEMBL101736 | N*3*-Cyclobutyl-1,1-dioxo-1,4-dihyd...)
Affinity DataEC50:  3.20E+4nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119271(CHEMBL319521 | Cyclobutyl-(7-methoxy-1,1-dioxo-1,4...)
Affinity DataEC50:  4.00E+3nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119270(CHEMBL319596 | Cyclobutyl-(1,1-dioxo-1,4-dihydro-1...)
Affinity DataEC50:  2.00E+3nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119274(CHEMBL100793 | Cyclobutyl-(7-nitro-1,1-dioxo-1,4-d...)
Affinity DataEC50:  530nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119273(CHEMBL101736 | N*3*-Cyclobutyl-1,1-dioxo-1,4-dihyd...)
Affinity DataEC50:  3.10E+4nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119271(CHEMBL319521 | Cyclobutyl-(7-methoxy-1,1-dioxo-1,4...)
Affinity DataEC50:  3.87E+3nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86248(CAS_364-98-7 | NSC_3019 | diazoxide)
Affinity DataEC50:  8.80E+3nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119270(CHEMBL319596 | Cyclobutyl-(1,1-dioxo-1,4-dihydro-1...)
Affinity DataEC50:  1.96E+3nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119272((7-Chloro-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1...)
Affinity DataEC50:  196nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119272((7-Chloro-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1...)
Affinity DataEC50:  200nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50119269(CHEMBL102025 | Cyclobutyl-(7-fluoro-1,1-dioxo-1,4-...)
Affinity DataEC50:  400nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50210318(6-chloro-4-hydroxy-2-oxo-N-1,3-thiazol-2-yl-2H-chr...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50210319(4-amino-6-methoxy-2-(trifluoromethyl)quinoline-3-c...)
Affinity DataEC50:  1.50E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50210320(CHEMBL226918 | [(2Z)-4-(4-fluorophenyl)-2-[(4-fluo...)
Affinity DataEC50:  2.10E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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