Compile Data Set for Download or QSAR
Found 49 Enz. Inhib. hit(s) with Target = 'Acid-sensing ion channel 1'
TargetAcid-sensing ion channel 1(Homo sapiens (Human))
Bogomoletz Institute of Physiology of NAS Ukraine

Curated by ChEMBL
LigandPNGBDBM50096642(CHEMBL3577296)
Show SMILES CCN(CC)CCN(Cc1ccc(Cl)cc1)c1ccc2cc(C(N)=N)c(=O)oc2c1
Show InChI InChI=1S/C23H27ClN4O2/c1-3-27(4-2)11-12-28(15-16-5-8-18(24)9-6-16)19-10-7-17-13-20(22(25)26)23(29)30-21(17)14-19/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H3,25,26)
Affinity DataIC50: 27nMpH: 6.7Assay Description:Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 6.7 by standard whole cell patch clamp...More data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Homo sapiens (Human))
Bogomoletz Institute of Physiology of NAS Ukraine

Curated by ChEMBL
LigandPNGBDBM50348098(CHEMBL1800430)
Show SMILES NCc1sc2cc(ccc2c1Cl)C#Cc1ccc2CCNCc2c1
Show InChI InChI=1S/C20H17ClN2S/c21-20-17-6-4-14(10-18(17)24-19(20)11-22)2-1-13-3-5-15-7-8-23-12-16(15)9-13/h3-6,9-10,23H,7-8,11-12,22H2
Affinity DataIC50: 224nMAssay Description:Inhibition of ASIC1aMore data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50157090(6-(2-(1-isopropyl-2-methyl-1,2,3,4-tetrahydroisoqu...)
Show SMILES CC(C)C1N(C)CCc2ccc(cc12)C1CC1c1ccc2cc(ccc2c1)C(N)=N
Show InChI InChI=1S/C27H31N3/c1-16(2)26-25-14-21(7-4-17(25)10-11-30(26)3)24-15-23(24)20-8-5-19-13-22(27(28)29)9-6-18(19)12-20/h4-9,12-14,16,23-24,26H,10-11,15H2,1-3H3,(H3,28,29)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of ASIC1a in rat dorsal root ganglion neurons assessed as reduction in peak current preincubated for 120 secs followed by acid medium stim...More data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Homo sapiens (Human))
Bogomoletz Institute of Physiology of NAS Ukraine

Curated by ChEMBL
LigandPNGBDBM50096642(CHEMBL3577296)
Show SMILES CCN(CC)CCN(Cc1ccc(Cl)cc1)c1ccc2cc(C(N)=N)c(=O)oc2c1
Show InChI InChI=1S/C23H27ClN4O2/c1-3-27(4-2)11-12-28(15-16-5-8-18(24)9-6-16)19-10-7-17-13-20(22(25)26)23(29)30-21(17)14-19/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H3,25,26)
Affinity DataIC50: 7.34E+3nMpH: 5.0Assay Description:Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 5.0 by standard whole cell patch clamp...More data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510034(CHEMBL4593063)
Show SMILES Cc1nn(c(C)c1-c1cccc(F)c1)-c1ccc(CN)cc1
Show InChI InChI=1S/C18H18FN3/c1-12-18(15-4-3-5-16(19)10-15)13(2)22(21-12)17-8-6-14(11-20)7-9-17/h3-10H,11,20H2,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510055(CHEMBL4440787)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C18H14FN3/c1-12-18(15-5-7-16(19)8-6-15)13(2)22(21-12)17-9-3-14(11-20)4-10-17/h3-10H,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510050(CHEMBL4463485)
Show SMILES Cc1nn(c(C)c1-c1cccc(F)c1)-c1ccc2NCCc2c1
Show InChI InChI=1S/C19H18FN3/c1-12-19(15-4-3-5-16(20)10-15)13(2)23(22-12)17-6-7-18-14(11-17)8-9-21-18/h3-7,10-11,21H,8-9H2,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510056(CHEMBL4450681)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc(CCN)cc1
Show InChI InChI=1S/C19H20FN3/c1-13-19(16-5-7-17(20)8-6-16)14(2)23(22-13)18-9-3-15(4-10-18)11-12-21/h3-10H,11-12,21H2,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510052(CHEMBL4446500)
Show SMILES Cc1nn(c(C)c1-c1ccc(C)c(F)c1)-c1ccc(CN)cc1
Show InChI InChI=1S/C19H20FN3/c1-12-4-7-16(10-18(12)20)19-13(2)22-23(14(19)3)17-8-5-15(11-21)6-9-17/h4-10H,11,21H2,1-3H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510049(CHEMBL4590631)
Show SMILES Cc1nn(c(C)c1-c1ccc(C)cc1)-c1ccc(CN)cc1
Show InChI InChI=1S/C19H21N3/c1-13-4-8-17(9-5-13)19-14(2)21-22(15(19)3)18-10-6-16(12-20)7-11-18/h4-11H,12,20H2,1-3H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510051(CHEMBL4527919)
Show SMILES CN1Cc2ncnc(c2C1)-n1nc(C)c(c1C)-c1cccc(F)c1
Show InChI InChI=1S/C18H18FN5/c1-11-17(13-5-4-6-14(19)7-13)12(2)24(22-11)18-15-8-23(3)9-16(15)20-10-21-18/h4-7,10H,8-9H2,1-3H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510053(CHEMBL4591499)
Show SMILES Cc1nn(c(C)c1-c1ccc(C)nc1)-c1ccc(CN)cc1
Show InChI InChI=1S/C18H20N4/c1-12-4-7-16(11-20-12)18-13(2)21-22(14(18)3)17-8-5-15(10-19)6-9-17/h4-9,11H,10,19H2,1-3H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510054(CHEMBL4445209)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc(CN)cn1
Show InChI InChI=1S/C17H17FN4/c1-11-17(14-4-6-15(18)7-5-14)12(2)22(21-11)16-8-3-13(9-19)10-20-16/h3-8,10H,9,19H2,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510036(CHEMBL4555958)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1cccc(CN)c1
Show InChI InChI=1S/C18H18FN3/c1-12-18(15-6-8-16(19)9-7-15)13(2)22(21-12)17-5-3-4-14(10-17)11-20/h3-10H,11,20H2,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510037(CHEMBL4463769)
Show SMILES Cc1nn(c(C)c1-c1cccc(F)c1)-c1ncnc2CNCc12
Show InChI InChI=1S/C17H16FN5/c1-10-16(12-4-3-5-13(18)6-12)11(2)23(22-10)17-14-7-19-8-15(14)20-9-21-17/h3-6,9,19H,7-8H2,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510048(CHEMBL4442568)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ncnc2CNCc12
Show InChI InChI=1S/C17H16FN5/c1-10-16(12-3-5-13(18)6-4-12)11(2)23(22-10)17-14-7-19-8-15(14)20-9-21-17/h3-6,9,19H,7-8H2,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510047(CHEMBL4517411)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc(CN)nc1
Show InChI InChI=1S/C17H17FN4/c1-11-17(13-3-5-14(18)6-4-13)12(2)22(21-11)16-8-7-15(9-19)20-10-16/h3-8,10H,9,19H2,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510046(CHEMBL4440380)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc2CCNc2c1
Show InChI InChI=1S/C19H18FN3/c1-12-19(15-3-6-16(20)7-4-15)13(2)23(22-12)17-8-5-14-9-10-21-18(14)11-17/h3-8,11,21H,9-10H2,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510045(CHEMBL4587871)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc2CNCc2c1
Show InChI InChI=1S/C19H18FN3/c1-12-19(14-3-6-17(20)7-4-14)13(2)23(22-12)18-8-5-15-10-21-11-16(15)9-18/h3-9,21H,10-11H2,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510044(CHEMBL4462808)
Show SMILES CC(N)c1ccc(cc1)-n1nc(C)c(c1C)-c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN3/c1-12(21)15-6-10-18(11-7-15)23-14(3)19(13(2)22-23)16-4-8-17(20)9-5-16/h4-12H,21H2,1-3H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510043(CHEMBL4524195)
Show SMILES Cc1nn(Cc2ccc(CN)cc2)c(C)c1-c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN3/c1-13-19(17-7-9-18(20)10-8-17)14(2)23(22-13)12-16-5-3-15(11-21)4-6-16/h3-10H,11-12,21H2,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510042(CHEMBL4593172)
Show SMILES NCc1ccc(cc1)-n1cc(cn1)-c1ccc(F)cc1
Show InChI InChI=1S/C16H14FN3/c17-15-5-3-13(4-6-15)14-10-19-20(11-14)16-7-1-12(9-18)2-8-16/h1-8,10-11H,9,18H2
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510041(CHEMBL4476781)
Show SMILES Cc1nn(c(C)c1-c1ccc(CN)cc1)-c1ccc(CN)cc1
Show InChI InChI=1S/C19H22N4/c1-13-19(17-7-3-15(11-20)4-8-17)14(2)23(22-13)18-9-5-16(12-21)6-10-18/h3-10H,11-12,20-21H2,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510040(CHEMBL4469611)
Show SMILES Cc1nn(c(C)c1-c1ccc(cc1)C(F)(F)F)-c1ccc(CN)cc1
Show InChI InChI=1S/C19H18F3N3/c1-12-18(15-5-7-16(8-6-15)19(20,21)22)13(2)25(24-12)17-9-3-14(11-23)4-10-17/h3-10H,11,23H2,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1/2(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510034(CHEMBL4593063)
Show SMILES Cc1nn(c(C)c1-c1cccc(F)c1)-c1ccc(CN)cc1
Show InChI InChI=1S/C18H18FN3/c1-12-18(15-4-3-5-16(19)10-15)13(2)22(21-12)17-8-6-14(11-20)7-9-17/h3-10H,11,20H2,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.25-stimulated mouse ASIC1a/2a heterodimer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510057(CHEMBL4538655)
Show SMILES COc1ccc(cc1)-c1c(C)nn(c1C)-c1ccc(CN)cc1
Show InChI InChI=1S/C19H21N3O/c1-13-19(16-6-10-18(23-3)11-7-16)14(2)22(21-13)17-8-4-15(12-20)5-9-17/h4-11H,12,20H2,1-3H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510035(CHEMBL4528810)
Show SMILES Cc1nn(c(C)c1-c1cccc(F)c1)-c1ccc2CNCc2c1
Show InChI InChI=1S/C19H18FN3/c1-12-19(14-4-3-5-17(20)8-14)13(2)23(22-12)18-7-6-15-10-21-11-16(15)9-18/h3-9,21H,10-11H2,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510038(CHEMBL4518161)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc(CN)cc1
Show InChI InChI=1S/C18H18FN3/c1-12-18(15-5-7-16(19)8-6-15)13(2)22(21-12)17-9-3-14(11-20)4-10-17/h3-10H,11,20H2,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50510039(CHEMBL4456021)
Show SMILES Cc1nn(c(C)c1-c1ccc(Cl)cc1)-c1ccc(CN)cc1
Show InChI InChI=1S/C18H18ClN3/c1-12-18(15-5-7-16(19)8-6-15)13(2)22(21-12)17-9-3-14(11-20)4-10-17/h3-10H,11,20H2,1-2H3
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM16173(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)
Show SMILES NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
Show InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
Affinity DataIC50: 3.02E+4nMAssay Description:Inhibition of ASIC1 in Sprague-Dawley rat articular chondrocytes assessed as decrease in acid-induced intracellular calcium level by Fluo-3AM dye bas...More data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Mus musculus)
Promidis

Curated by ChEMBL
LigandPNGBDBM50000999(CHEBI:81724 | DIMINAZENE)
Show SMILES NC(=N)c1ccc(N\N=N\c2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C14H15N7/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18/h1-8H,(H3,15,16)(H3,17,18)(H,19,20)
Affinity DataIC50: 5.69E+4nMAssay Description:Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assayMore data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.9 by two electrode voltage clampMore data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.9 by two electrode voltage clampMore data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50074922((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)
Show SMILES CC(C(O)=O)c1ccc(c(F)c1)-c1ccccc1
Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
Affinity DataIC50: 1.70E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50250133(Butibufen)
Show SMILES CCC(C(O)=O)c1ccc(CC(C)C)cc1
Show InChI InChI=1S/C14H20O2/c1-4-13(14(15)16)12-7-5-11(6-8-12)9-10(2)3/h5-8,10,13H,4,9H2,1-3H3,(H,15,16)
Affinity DataIC50: 1.82E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50169044((-)-ibuprofen | (2R)-2-(4-isobutylphenyl)propanoic...)
Show SMILES CC(C)Cc1ccc(cc1)[C@@H](C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m1/s1
Affinity DataIC50: 2.88E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
Affinity DataIC50: 2.95E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.4 by two electrode voltage clampMore data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
Affinity DataIC50: 2.95E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.4 by two electrode voltage clampMore data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
Affinity DataIC50: 2.95E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50169047((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
Show SMILES CC(C)Cc1ccc(cc1)[C@H](C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1
Affinity DataIC50: 3.47E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50250130(CHEMBL4083814)
Show SMILES CC(C)Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C11H14O2/c1-8(2)7-9-3-5-10(6-4-9)11(12)13/h3-6,8H,7H2,1-2H3,(H,12,13)
Affinity DataIC50: 4.17E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
Affinity DataIC50: 5.13E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.7 by two electrode voltage clampMore data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50009859((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
Affinity DataIC50: 5.13E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.7 by two electrode voltage clampMore data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50250132(CHEMBL4080879)
Show SMILES CC(C)Cc1ccc(cc1)C(F)C(O)=O
Show InChI InChI=1S/C12H15FO2/c1-8(2)7-9-3-5-10(6-4-9)11(13)12(14)15/h3-6,8,11H,7H2,1-2H3,(H,14,15)
Affinity DataIC50: 9.55E+5nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50295285((4-Isobutyl-phenyl)-acetic acid | 2-(4-isobutylphe...)
Show SMILES CC(C)Cc1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C12H16O2/c1-9(2)7-10-3-5-11(6-4-10)8-12(13)14/h3-6,9H,7-8H2,1-2H3,(H,13,14)
Affinity DataIC50: 1.02E+6nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Rattus norvegicus)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50250131(CHEMBL190275)
Show SMILES CC(C(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C10H12O2/c1-7-3-5-9(6-4-7)8(2)10(11)12/h3-6,8H,1-2H3,(H,11,12)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clampMore data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Homo sapiens (Human))
Bogomoletz Institute of Physiology of NAS Ukraine

Curated by ChEMBL
LigandPNGBDBM50096642(CHEMBL3577296)
Show SMILES CCN(CC)CCN(Cc1ccc(Cl)cc1)c1ccc2cc(C(N)=N)c(=O)oc2c1
Show InChI InChI=1S/C23H27ClN4O2/c1-3-27(4-2)11-12-28(15-16-5-8-18(24)9-6-16)19-10-7-17-13-20(22(25)26)23(29)30-21(17)14-19/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H3,25,26)
Affinity DataEC50:  6.20nMAssay Description:Orthosteric non-competitive inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current assessed as EC50...More data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Homo sapiens (Human))
Bogomoletz Institute of Physiology of NAS Ukraine

Curated by ChEMBL
LigandPNGBDBM50096642(CHEMBL3577296)
Show SMILES CCN(CC)CCN(Cc1ccc(Cl)cc1)c1ccc2cc(C(N)=N)c(=O)oc2c1
Show InChI InChI=1S/C23H27ClN4O2/c1-3-27(4-2)11-12-28(15-16-5-8-18(24)9-6-16)19-10-7-17-13-20(22(25)26)23(29)30-21(17)14-19/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H3,25,26)
Affinity DataEC50:  6.40nMAssay Description:Orthosteric non-competitive inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current assessed as EC50...More data for this Ligand-Target Pair
TargetAcid-sensing ion channel 1(Homo sapiens (Human))
Bogomoletz Institute of Physiology of NAS Ukraine

Curated by ChEMBL
LigandPNGBDBM50096642(CHEMBL3577296)
Show SMILES CCN(CC)CCN(Cc1ccc(Cl)cc1)c1ccc2cc(C(N)=N)c(=O)oc2c1
Show InChI InChI=1S/C23H27ClN4O2/c1-3-27(4-2)11-12-28(15-16-5-8-18(24)9-6-16)19-10-7-17-13-20(22(25)26)23(29)30-21(17)14-19/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H3,25,26)
Affinity DataEC50:  6.5nMAssay Description:Orthosteric non-competitive inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current assessed as EC50...More data for this Ligand-Target Pair