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Report error Found 15032 Enz. Inhib. hit(s) with Target = 'Adenosine receptor A...
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50550812(CHEMBL4756283)
Affinity DataKi:  0.00380nMAssay Description:Displacement of [3H]MSX2 from human adenosine receptor A2A expressed in HEK293 cell membranes incubated for 30 mins by radioligand competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50493145(CHEMBL2419149)
Affinity DataKi:  0.00420nMAssay Description:Displacement of [3H]ZM241385 from human A2A receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50493145(CHEMBL2419149)
Affinity DataKi:  0.00420nMAssay Description:Displacement of [3H]MSX2 from human adenosine receptor A2A expressed in HEK293 cell membranes incubated for 30 mins by radioligand competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50493145(CHEMBL2419149)
Affinity DataKi:  0.00420nMAssay Description:Binding affinity to human adenosine A2A receptor expressed in HEK293T cells measured by radioligand binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50493144(CHEMBL2419144)
Affinity DataKi:  0.00470nMAssay Description:Displacement of [3H]ZM241385 from human A2A receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50315548(8-(2-Thioxo-7(3-m-iodophenyl)-2-(2-furyl)thiazolo[...)
Affinity DataKi:  0.00820nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50493151(CHEMBL2419139)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [3H]ZM241385 from human A2A receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50315541(8-(2-Thioxo-7(3-allyl)-2-(2-furyl)thiazole[4,3-e]1...)
Affinity DataKi:  0.0160nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50493157(CHEMBL2419146)
Affinity DataKi:  0.0270nMAssay Description:Displacement of [3H]ZM241385 from human A2A receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50493154(CHEMBL2419147)
Affinity DataKi:  0.0300nMAssay Description:Displacement of [3H]ZM241385 from human A2A receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50085666((2S,3S,4R,5R)-5-{6-(2,2-Diphenyl-ethylamino)-2-[2-...)
Affinity DataKi:  0.0300nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50315545(8-(2-Thioxo-7(3-m-chlorophenyl)-2-(2-furyl)thiazol...)
Affinity DataKi:  0.0380nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells after 60 mins by rapid filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50496138(CHEMBL3121727)
Affinity DataKi:  0.0420nMAssay Description:Displacement of [3H]-NECA from human recombinant adenosine A2A receptor expressed in CHO cell membranes after 3 hrs by microbeta counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50496133(CHEMBL3121725)
Affinity DataKi:  0.0450nMAssay Description:Displacement of [3H]-NECA from human recombinant adenosine A2A receptor expressed in CHO cell membranes after 3 hrs by microbeta counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50094037(2-Furan-2-yl-7-[3-(4-methoxy-phenyl)-propyl]-7H-py...)
Affinity DataKi:  0.0480nMAssay Description:Inhibitory activity against human adenosine A2A receptor expressed in HEK-293 cells by displacement of [3H]-SCH-58,261More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50094037(2-Furan-2-yl-7-[3-(4-methoxy-phenyl)-propyl]-7H-py...)
Affinity DataKi:  0.0480nMAssay Description:Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50094037(2-Furan-2-yl-7-[3-(4-methoxy-phenyl)-propyl]-7H-py...)
Affinity DataKi: >0.0480nMAssay Description:Binding affinity to human adenosine A2a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM618729(US20230293517, Example 4.7)
Affinity DataKi:  0.0500nMAssay Description:All FRET binding experiments were conducted at room temperature in white 384-well plates, in assay binding buffer containing 1×LabMed (Cisbio, France...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50085674((2S,3S,4R,5R)-5-[2-(4-Amino-cyclohexylamino)-6-(2,...)
Affinity DataKi:  0.0500nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457085(CHEMBL4203542)
Affinity DataKi:  0.0500nMAssay Description:Antagonist activity at rat A2A receptor assessed as reduction in CGS-21680-induced cAMP level pretreated for 15 mins followed by CGS-21680 addition m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM618748(US20230293517, Example 4.26)
Affinity DataKi:  0.0500nMAssay Description:All FRET binding experiments were conducted at room temperature in white 384-well plates, in assay binding buffer containing 1×LabMed (Cisbio, France...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50457098(CHEMBL4217582)
Affinity DataKi:  0.0600nMAssay Description:Antagonist activity at human A2A receptor expressed in HEK293 cell membranes assessed as reduction in CGS-21680-induced cAMP level pretreated for 15 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457098(CHEMBL4217582)
Affinity DataKi:  0.0600nMAssay Description:Antagonist activity at rat A2A receptor assessed as reduction in CGS-21680-induced cAMP level pretreated for 15 mins followed by CGS-21680 addition m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50493156(CHEMBL2419150)
Affinity DataKi:  0.0670nMAssay Description:Displacement of [3H]ZM241385 from human A2A receptor expressed in HEK293 cell membranes after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50457084(CHEMBL4217248)
Affinity DataKi:  0.0700nMAssay Description:Antagonist activity at human A2A receptor expressed in HEK293 cell membranes assessed as reduction in CGS-21680-induced cAMP level pretreated for 15 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50496134(CHEMBL3121726)
Affinity DataKi:  0.0720nMAssay Description:Displacement of [3H]-NECA from human recombinant adenosine A2A receptor expressed in CHO cell membranes after 3 hrs by microbeta counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50553403(CHEMBL4747929)
Affinity DataKi:  0.0780nMAssay Description:Inhibition of FRET-labelled CA200645 binding to human adenosine 2A receptor expressed in CHO cells incubated for 2 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM616065(US20230271964, Example 1-22)
Affinity DataKi:  0.0790nMAssay Description:Inhibition binding assays were performed using 0.2 µg of membranes prepared from HEK293 cells infected with BacMam human adenosine A2A receptor or 1....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM616103(US20230271964, Example 1-60 | US20230271964, Examp...)
Affinity DataKi:  0.0790nMAssay Description:Inhibition binding assays were performed using 0.2 µg of membranes prepared from HEK293 cells infected with BacMam human adenosine A2A receptor or 1....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50085671((2S,3S,4R,5R)-5-[6-(2,2-Diphenyl-ethylamino)-2-(2-...)
Affinity DataKi:  0.0800nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50600748(CHEMBL5176737)
Affinity DataKi:  0.0810nMAssay Description:Displacement of [3H]ZM241385 from human A2AAR expressed in HEK293 cells membrane assessed as inhibition constant preincubated for 5 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM618717(US20230293517, Example 3.8)
Affinity DataKi:  0.0900nMAssay Description:All FRET binding experiments were conducted at room temperature in white 384-well plates, in assay binding buffer containing 1×LabMed (Cisbio, France...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM618966(N-[5-[2,6-Bis(trideuteriomethyl)-4-pyridyl]-4-(3-c...)
Affinity DataKi:  0.0900nMAssay Description:All FRET binding experiments were conducted at room temperature in white 384-well plates, in assay binding buffer containing 1×LabMed (Cisbio, France...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM618952(US20230293517, Example 16.9)
Affinity DataKi:  0.100nMAssay Description:All FRET binding experiments were conducted at room temperature in white 384-well plates, in assay binding buffer containing 1×LabMed (Cisbio, France...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM618744(US20230293517, Example 4.22)
Affinity DataKi:  0.100nMAssay Description:All FRET binding experiments were conducted at room temperature in white 384-well plates, in assay binding buffer containing 1×LabMed (Cisbio, France...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM618749(US20230293517, Example 4.27)
Affinity DataKi:  0.100nMAssay Description:All FRET binding experiments were conducted at room temperature in white 384-well plates, in assay binding buffer containing 1×LabMed (Cisbio, France...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM616097(US20230271964, Example 1-54 | US20230271964, Examp...)
Affinity DataKi:  0.100nMAssay Description:Inhibition binding assays were performed using 0.2 µg of membranes prepared from HEK293 cells infected with BacMam human adenosine A2A receptor or 1....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM616108(US20230271964, Example 1-65)
Affinity DataKi:  0.100nMAssay Description:Inhibition binding assays were performed using 0.2 µg of membranes prepared from HEK293 cells infected with BacMam human adenosine A2A receptor or 1....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM616110(US20230271964, Example 1-67)
Affinity DataKi:  0.100nMAssay Description:Inhibition binding assays were performed using 0.2 µg of membranes prepared from HEK293 cells infected with BacMam human adenosine A2A receptor or 1....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50317007(2-amino-4-(furan-2-yl)-5H-indeno[1,2-d]pyrimidin-5...)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human recombinant adenosine receptor A2a by cAMP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50161342(2-Amino-4-phenyl-indeno[1,2-d]pyrimidin-5-one | 2-...)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50085668((2S,3S,4R,5R)-5-[6-Amino-2-((1R,2R)-2-hydroxy-cycl...)
Affinity DataKi:  0.100nMAssay Description:In vitro inhibition of human neutrophil activation via Adenosine A2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM21190(4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity towards human Adenosine A2a receptor expressed in HEK293 cells using 6 nM [3H]CGS-21680More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50394718(CHEMBL2165801)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human Adenosine receptor A2a assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50202775(8-(furan-2-yl)-3-(2-(4-(4-methoxyphenyl)piperazin-...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50202775(8-(furan-2-yl)-3-(2-(4-(4-methoxyphenyl)piperazin-...)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50317007(2-amino-4-(furan-2-yl)-5H-indeno[1,2-d]pyrimidin-5...)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM618723(4-Cyano-N-[4-(3-cyanophenyl)-5-(2,6-dimethyl-4-pyr...)
Affinity DataKi:  0.110nMAssay Description:All FRET binding experiments were conducted at room temperature in white 384-well plates, in assay binding buffer containing 1×LabMed (Cisbio, France...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50553401(CHEMBL4778265)
Affinity DataKi:  0.110nMAssay Description:Inhibition of FRET-labelled CA200645 binding to human adenosine 2A receptor expressed in CHO cells incubated for 2 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University of Bonn

Curated by ChEMBL
LigandPNGBDBM618777(US20230293517, Example 6.7)
Affinity DataKi:  0.110nMAssay Description:All FRET binding experiments were conducted at room temperature in white 384-well plates, in assay binding buffer containing 1×LabMed (Cisbio, France...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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