Compile Data Set for Download or QSAR
Found 110 Enz. Inhib. hit(s) with Target = 'Amiloride-sensitive amine oxidase [copper-containing]'
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50000999(CHEBI:81724 | DIMINAZENE)
Show SMILES NC(=N)c1ccc(N\N=N\c2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C14H15N7/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18/h1-8H,(H3,15,16)(H3,17,18)(H,19,20)
Affinity DataKi:  13nMAssay Description:Mixed type inhibition of recombinant human DAO expressed in drosophila S2 cellsMore data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50207159(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
Show SMILES NNC(N)=N
Show InChI InChI=1S/CH6N4/c2-1(3)5-4/h4H2,(H4,2,3,5)
Affinity DataKi:  140nMAssay Description:Tested for ability of the compound to competitively inhibit hog kidney diamine oxidase (DAO) in a spectrometric assayMore data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50281515((E)-3-(1H-Imidazol-4-yl)-allylamine | CHEMBL119195...)
Show SMILES NCC=Cc1cnc[nH]1
Show InChI InChI=1S/C6H9N3/c7-3-1-2-6-4-8-5-9-6/h1-2,4-5H,3,7H2,(H,8,9)
Affinity DataKi:  170nMAssay Description:Tested for ability of the compound to competitively inhibit hog kidney diamine oxidase (DAO) in a spectrometric assayMore data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50281515((E)-3-(1H-Imidazol-4-yl)-allylamine | CHEMBL119195...)
Show SMILES NCC=Cc1cnc[nH]1
Show InChI InChI=1S/C6H9N3/c7-3-1-2-6-4-8-5-9-6/h1-2,4-5H,3,7H2,(H,8,9)
Affinity DataKi:  200nMAssay Description:Tested for ability of the compound to competitively inhibit hog kidney diamine oxidase (DAO) in a spectrometric assayMore data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM45440(4-[5-(4-amidinophenoxy)pentoxy]benzamidine;2-hydro...)
Show SMILES NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
Affinity DataKi:  290nMAssay Description:Mixed type inhibition of recombinant human DAO expressed in drosophila S2 cellsMore data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50281517(3-(1H-Imidazol-4-yl)-prop-2-ynylamine | CHEMBL1165...)
Show SMILES NCC#Cc1cnc[nH]1
Show InChI InChI=1S/C6H7N3/c7-3-1-2-6-4-8-5-9-6/h4-5H,3,7H2,(H,8,9)
Affinity DataKi:  1.70E+3nMAssay Description:Tested for ability of the compound to competitively inhibit hog kidney diamine oxidase (DAO) in a spectrometric assayMore data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50020274(2,2-Difluoro-hex-5-yne-1,4-diamonium; dichloride |...)
Show SMILES [NH3+]CC(F)(F)CC([NH3+])C#C
Show InChI InChI=1S/C6H10F2N2/c1-2-5(10)3-6(7,8)4-9/h1,5H,3-4,9-10H2/p+2
Affinity DataKi:  2.70E+3nMAssay Description:In vitro inhibition against hog kidney diamine oxidaseMore data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50121458(1-[3-(2-Hydroxy-phenyl)-5-o-tolyl-4,5-dihydro-pyra...)
Show SMILES CC(=O)N1N=C(CC1c1ccccc1C)c1ccccc1O
Show InChI InChI=1S/C18H18N2O2/c1-12-7-3-4-8-14(12)17-11-16(19-20(17)13(2)21)15-9-5-6-10-18(15)22/h3-10,17,22H,11H2,1-2H3
Affinity DataKi:  5.50E+3nMAssay Description:Inhibitory activity of the compound against Swine kidney diamine oxidase (SKDAO)More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50281518(2-(1H-Imidazol-4-yl)-allylamine | CHEMBL116538)
Show SMILES NCC(=C)c1cnc[nH]1
Show InChI InChI=1S/C6H9N3/c1-5(2-7)6-3-8-4-9-6/h3-4H,1-2,7H2,(H,8,9)
Affinity DataKi:  7.10E+3nMAssay Description:Tested for ability of the compound to competitively inhibit hog kidney diamine oxidase (DAO) in a spectrometric assayMore data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50121455(1-[3-(2-Hydroxy-phenyl)-5-m-tolyl-4,5-dihydro-pyra...)
Show SMILES CC(=O)N1N=C(CC1c1cccc(C)c1)c1ccccc1O
Show InChI InChI=1S/C18H18N2O2/c1-12-6-5-7-14(10-12)17-11-16(19-20(17)13(2)21)15-8-3-4-9-18(15)22/h3-10,17,22H,11H2,1-2H3
Affinity DataKi:  8.00E+3nMAssay Description:Inhibitory activity of the compound against Swine kidney diamine oxidase (SKDAO)More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50121457(1-[3-(2,4-Dihydroxy-phenyl)-5-m-tolyl-4,5-dihydro-...)
Show SMILES CC(=O)N1N=C(CC1c1cccc(C)c1)c1ccc(O)cc1O
Show InChI InChI=1S/C18H18N2O3/c1-11-4-3-5-13(8-11)17-10-16(19-20(17)12(2)21)15-7-6-14(22)9-18(15)23/h3-9,17,22-23H,10H2,1-2H3
Affinity DataKi:  2.50E+4nMAssay Description:Inhibitory activity of the compound against Swine kidney diamine oxidase (SKDAO)More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50121456(1-[3-(2,4-Dihydroxy-phenyl)-5-o-tolyl-4,5-dihydro-...)
Show SMILES CC(=O)N1N=C(CC1c1ccccc1C)c1ccc(O)cc1O
Show InChI InChI=1S/C18H18N2O3/c1-11-5-3-4-6-14(11)17-10-16(19-20(17)12(2)21)15-8-7-13(22)9-18(15)23/h3-9,17,22-23H,10H2,1-2H3
Affinity DataKi:  1.00E+5nMAssay Description:Inhibitory activity of the compound against Swine kidney diamine oxidase (SKDAO)More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50161146(4-(aminomethyl)-5-(dimethyl-lambda~5~-azanyl)-N-me...)
Show SMILES CNc1cncc(N(C)C)c1CN
Show InChI InChI=1S/C9H16N4/c1-11-8-5-12-6-9(13(2)3)7(8)4-10/h5-6,11H,4,10H2,1-3H3
Affinity DataIC50: 61nMAssay Description:Inhibition of putrescine binding to against Diamine oxidase of porcine kidneyMore data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM220869(US9302986, 2)
Show SMILES NC\C(COc1ccc(cc1)C(N)=O)=C\F
Show InChI InChI=1S/C11H13FN2O2/c12-5-8(6-13)7-16-10-3-1-9(2-4-10)11(14)15/h1-5H,6-7,13H2,(H2,14,15)/b8-5-
Affinity DataIC50: 100nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM220884(US9302986, 18)
Show SMILES CN(C)C(=O)c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C13H17FN2O2/c1-16(2)13(17)11-3-5-12(6-4-11)18-9-10(7-14)8-15/h3-7H,8-9,15H2,1-2H3/b10-7-
Affinity DataIC50: 100nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50161153(4-(aminomethyl)-N-methyl-5-(methyl-lambda~5~-azany...)
Show SMILES CNc1cncc(NC)c1CN
Show InChI InChI=1S/C8H14N4/c1-10-7-4-12-5-8(11-2)6(7)3-9/h4-5,10-11H,3,9H2,1-2H3
Affinity DataIC50: 120nMAssay Description:Inhibition of putrescine binding to against Diamine oxidase of porcine kidneyMore data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50161135(4-(aminomethyl)-N-methylpyridin-3-amine dihydrochl...)
Show SMILES CNc1cnccc1CN
Show InChI InChI=1S/C7H11N3/c1-9-7-5-10-3-2-6(7)4-8/h2-3,5,9H,4,8H2,1H3
Affinity DataIC50: 160nMAssay Description:Inhibition of putrescine binding to against Diamine oxidase of porcine kidneyMore data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50161138(4-(aminomethyl)pyridin-3-amine dihydrochloride | C...)
Show SMILES NCc1ccncc1N
Show InChI InChI=1S/C6H9N3/c7-3-5-1-2-9-4-6(5)8/h1-2,4H,3,7-8H2
Affinity DataIC50: 300nMAssay Description:Inhibition of putrescine binding to against Diamine oxidase of porcine kidneyMore data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50161132(4-(aminomethyl)-N-ethylpyridin-3-amine dihydrochlo...)
Show SMILES CCNc1cnccc1CN
Show InChI InChI=1S/C8H13N3/c1-2-11-8-6-10-4-3-7(8)5-9/h3-4,6,11H,2,5,9H2,1H3
Affinity DataIC50: 500nMAssay Description:Inhibition of putrescine binding to against Diamine oxidase of porcine kidneyMore data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Rattus norvegicus)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50046207(6-((E)-{[(E)-[(2E)-2-({6-[(E)-amino(imino)methyl]p...)
Show SMILES NC(=N)c1cccc(C=NNC(=N)NN=Cc2cccc(n2)C(N)=N)n1
Show InChI InChI=1S/C15H17N11/c16-13(17)11-5-1-3-9(23-11)7-21-25-15(20)26-22-8-10-4-2-6-12(24-10)14(18)19/h1-8H,(H3,16,17)(H3,18,19)(H3,20,25,26)
Affinity DataIC50: 760nMAssay Description:In vitro inhibition of Diamine oxidase (DAO) from rat small intestine.More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Rattus norvegicus)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50046196(3-((E)-{[(Z)-((2E)-2-{3-[(E)-amino(imino)methyl]be...)
Show SMILES NC(NN=Cc1cccc(c1)C(N)=N)=NN=Cc1cccc(c1)C(N)=N
Show InChI InChI=1S/C17H19N9/c18-15(19)13-5-1-3-11(7-13)9-23-25-17(22)26-24-10-12-4-2-6-14(8-12)16(20)21/h1-10H,(H3,18,19)(H3,20,21)(H3,22,25,26)
Affinity DataIC50: 830nMAssay Description:In vitro inhibition of Diamine oxidase (DAO) from rat small intestine.More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Rattus norvegicus)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50046210(6-((E)-{[(E)-amino(imino)methyl]hydrazono}methyl)p...)
Show SMILES NC(=N)NN=Cc1cccc(n1)C(N)=N
Show InChI InChI=1S/C8H11N7/c9-7(10)6-3-1-2-5(14-6)4-13-15-8(11)12/h1-4H,(H3,9,10)(H4,11,12,15)
Affinity DataIC50: 870nMAssay Description:In vitro inhibition of Diamine oxidase (DAO) from rat small intestine.More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Rattus norvegicus)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50046203(3-((E)-{[(E)-amino(hydrazono)methyl]hydrazono}meth...)
Show SMILES NC(=N)c1cccc(CNN=C(N)N=N)c1
Show InChI InChI=1S/C9H13N7/c10-8(11)7-3-1-2-6(4-7)5-14-16-9(12)15-13/h1-4,13-14H,5H2,(H3,10,11)(H2,12,16)
Affinity DataIC50: 870nMAssay Description:In vitro inhibition of Diamine oxidase (DAO) from rat small intestine.More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM220860(US9302986, 1)
Show SMILES CC(C)(C)NC(=O)c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C15H21FN2O2/c1-15(2,3)18-14(19)12-4-6-13(7-5-12)20-10-11(8-16)9-17/h4-8H,9-10,17H2,1-3H3,(H,18,19)/b11-8-
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM220870(US9302986, 3)
Show SMILES NC\C(COc1ccc(cc1)C(N)=O)=C/F
Show InChI InChI=1S/C11H13FN2O2/c12-5-8(6-13)7-16-10-3-1-9(2-4-10)11(14)15/h1-5H,6-7,13H2,(H2,14,15)/b8-5+
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM220861(US9302986, 4)
Show SMILES CN(C)C(=O)c1ccc(OC\C(CN)=C/F)c(F)c1
Show InChI InChI=1S/C13H16F2N2O2/c1-17(2)13(18)10-3-4-12(11(15)5-10)19-8-9(6-14)7-16/h3-6H,7-8,16H2,1-2H3/b9-6-
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM220862(US9302986, 6)
Show SMILES CN(C)C(=O)c1ccc(OC\C(CN)=C/F)c(Cl)c1
Show InChI InChI=1S/C13H16ClFN2O2/c1-17(2)13(18)10-3-4-12(11(14)5-10)19-8-9(6-15)7-16/h3-6H,7-8,16H2,1-2H3/b9-6-
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM220873(US9302986, 7)
Show SMILES COc1cc(ccc1OCC(CN)=CF)C(=O)N(C)C
Show InChI InChI=1S/C14H19FN2O3/c1-17(2)14(18)11-4-5-12(13(6-11)19-3)20-9-10(7-15)8-16/h4-7H,8-9,16H2,1-3H3/b10-7+
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM220885(US9302986, 9)
Show SMILES NC\C(COc1ccc(cc1)S(N)(=O)=O)=C\F
Show InChI InChI=1S/C10H13FN2O3S/c11-5-8(6-12)7-16-9-1-3-10(4-2-9)17(13,14)15/h1-5H,6-7,12H2,(H2,13,14,15)/b8-5-
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM220883(US9302986, 10)
Show SMILES CN(C)S(=O)(=O)c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C12H17FN2O3S/c1-15(2)19(16,17)12-5-3-11(4-6-12)18-9-10(7-13)8-14/h3-7H,8-9,14H2,1-2H3/b10-7-
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM220871(US9302986, 13)
Show SMILES CN(C)C(=O)c1ccc(OC\C(CN)=C\F)cc1
Show InChI InChI=1S/C13H17FN2O2/c1-16(2)13(17)11-3-5-12(6-4-11)18-9-10(7-14)8-15/h3-7H,8-9,15H2,1-2H3/b10-7+
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM220863(US9302986, 20)
Show SMILES CN(C)C(=O)c1ccc(OC\C(CN)=C/F)c(Br)c1
Show InChI InChI=1S/C13H16BrFN2O2/c1-17(2)13(18)10-3-4-12(11(14)5-10)19-8-9(6-15)7-16/h3-6H,7-8,16H2,1-2H3/b9-6-
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM220868(US9302986, 25)
Show SMILES CNC(=O)c1ccc(OC\C(CN)=C\F)cc1
Show InChI InChI=1S/C12H15FN2O2/c1-15-12(16)10-2-4-11(5-3-10)17-8-9(6-13)7-14/h2-6H,7-8,14H2,1H3,(H,15,16)/b9-6+
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM220872(US9302986, 26)
Show SMILES CN(C)C(=O)c1ccc(OC\C(CN)=C/F)cc1C
Show InChI InChI=1S/C14H19FN2O2/c1-10-6-12(19-9-11(7-15)8-16)4-5-13(10)14(18)17(2)3/h4-7H,8-9,16H2,1-3H3/b11-7-
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM220878(US9302986, 29)
Show SMILES CNS(=O)(=O)c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C11H15FN2O3S/c1-14-18(15,16)11-4-2-10(3-5-11)17-8-9(6-12)7-13/h2-6,14H,7-8,13H2,1H3/b9-6-
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM220880(US9302986, 31)
Show SMILES CCNS(=O)(=O)c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C12H17FN2O3S/c1-2-15-19(16,17)12-5-3-11(4-6-12)18-9-10(7-13)8-14/h3-7,15H,2,8-9,14H2,1H3/b10-7-
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM220882(US9302986, 33)
Show SMILES CC(C)NS(=O)(=O)c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C13H19FN2O3S/c1-10(2)16-20(17,18)13-5-3-12(4-6-13)19-9-11(7-14)8-15/h3-7,10,16H,8-9,15H2,1-2H3/b11-7-
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50161149(4-(aminomethyl)-N-isopropyl-5-[isopropyl(methyl)-l...)
Show SMILES CC(C)Nc1cncc(N(C)C(C)C)c1CN
Show InChI InChI=1S/C13H24N4/c1-9(2)16-12-7-15-8-13(11(12)6-14)17(5)10(3)4/h7-10,16H,6,14H2,1-5H3
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of putrescine binding to against Diamine oxidase of porcine kidneyMore data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Rattus norvegicus)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50046201((2E)-2-((2E)-2-{[(E)-amino(imino)methyl]hydrazono}...)
Show SMILES CC(C=NNC(N)=N)=NN=C(N)N
Show InChI InChI=1S/C5H12N8/c1-3(11-13-5(8)9)2-10-12-4(6)7/h2H,1H3,(H4,6,7,12)(H4,8,9,13)
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro inhibition of Diamine oxidase (DAO) from rat small intestine.More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Rattus norvegicus)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50046192(6-((E)-{[(E)-amino(hydrazono)methyl]hydrazono}meth...)
Show SMILES NC(=N)c1cccc(CNN=C(N)N=N)n1
Show InChI InChI=1S/C8H12N8/c9-7(10)6-3-1-2-5(14-6)4-13-16-8(11)15-12/h1-3,12-13H,4H2,(H3,9,10)(H2,11,16)
Affinity DataIC50: 1.66E+3nMAssay Description:In vitro inhibition of Diamine oxidase (DAO) from rat small intestine.More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50161134(4-(aminomethyl)-N-ethyl-5-[ethyl(methyl)-lambda~5~...)
Show SMILES CCNc1cncc(N(C)CC)c1CN
Show InChI InChI=1S/C11H20N4/c1-4-14-10-7-13-8-11(9(10)6-12)15(3)5-2/h7-8,14H,4-6,12H2,1-3H3
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of putrescine binding to against Diamine oxidase of porcine kidneyMore data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Rattus norvegicus)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50046200((2E)-2-(1-{3-[(E)-amino(imino)methyl]phenyl}ethyli...)
Show SMILES CC(=NN=C(N)N)c1cccc(c1)C(N)=N
Show InChI InChI=1S/C10H14N6/c1-6(15-16-10(13)14)7-3-2-4-8(5-7)9(11)12/h2-5H,1H3,(H3,11,12)(H4,13,14,16)
Affinity DataIC50: 2.70E+3nMAssay Description:In vitro inhibition of Diamine oxidase (DAO) from rat small intestine.More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Rattus norvegicus)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50046191((2E)-2-{3-[(E)-amino(imino)methyl]benzylidene}-N'-...)
Show SMILES CCCCN=C(N)NN=Cc1cccc(c1)C(N)=N
Show InChI InChI=1S/C13H20N6/c1-2-3-7-17-13(16)19-18-9-10-5-4-6-11(8-10)12(14)15/h4-6,8-9H,2-3,7H2,1H3,(H3,14,15)(H3,16,17,19)
Affinity DataIC50: 2.80E+3nMAssay Description:In vitro inhibition of Diamine oxidase (DAO) from rat small intestine.More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Rattus norvegicus)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50046195(4-((E)-{[(E)-amino(imino)methyl]hydrazono}methyl)p...)
Show SMILES NC(=N)NN=Cc1ccnc(c1)C(N)=N
Show InChI InChI=1S/C8H11N7/c9-7(10)6-3-5(1-2-13-6)4-14-15-8(11)12/h1-4H,(H3,9,10)(H4,11,12,15)
Affinity DataIC50: 3.20E+3nMAssay Description:In vitro inhibition of Diamine oxidase (DAO) from rat small intestine.More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Rattus norvegicus)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50046211(2-((E)-{[(E)-amino(imino)methyl]hydrazono}methyl)p...)
Show SMILES NC(=N)NN=Cc1nccc(n1)C(N)=N
Show InChI InChI=1S/C7H10N8/c8-6(9)4-1-2-12-5(14-4)3-13-15-7(10)11/h1-3H,(H3,8,9)(H4,10,11,15)
Affinity DataIC50: 3.40E+3nMAssay Description:In vitro inhibition of Diamine oxidase (DAO) from rat small intestine.More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Rattus norvegicus)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50046199((2E)-2-{3-[(E)-amino(butylimino)methyl]benzylidene...)
Show SMILES CCCCN=C(N)c1cccc(C=NNC(N)=N)c1
Show InChI InChI=1S/C13H20N6/c1-2-3-7-17-12(14)11-6-4-5-10(8-11)9-18-19-13(15)16/h4-6,8-9H,2-3,7H2,1H3,(H2,14,17)(H4,15,16,19)
Affinity DataIC50: 5.00E+3nMAssay Description:In vitro inhibition of Diamine oxidase (DAO) from rat small intestine.More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Homo sapiens (Human))
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50161147(4-(aminomethyl)-N-cyclopropylpyridin-3-amine dihyd...)
Show SMILES NCc1ccncc1NC1CC1
Show InChI InChI=1S/C9H13N3/c10-5-7-3-4-11-6-9(7)12-8-1-2-8/h3-4,6,8,12H,1-2,5,10H2
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of putrescine binding to against Diamine oxidase of porcine kidneyMore data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Rattus norvegicus)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50046189((2E)-2-{3-[(Z)-amino(imino)methyl]benzylidene}hydr...)
Show SMILES NC(=N)NN=Cc1cccc(c1)C(N)=N
Show InChI InChI=1S/C9H12N6/c10-8(11)7-3-1-2-6(4-7)5-14-15-9(12)13/h1-5H,(H3,10,11)(H4,12,13,15)
Affinity DataIC50: 5.60E+3nMAssay Description:In vitro inhibition of Diamine oxidase (DAO) from rat small intestine.More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Rattus norvegicus)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50046202(6-((E)-{[(E)-amino(hydroxyimino)methyl]hydrazono}m...)
Show SMILES NC(NO)=NN=Cc1cccc(n1)C(N)=N
Show InChI InChI=1S/C8H11N7O/c9-7(10)6-3-1-2-5(13-6)4-12-14-8(11)15-16/h1-4,16H,(H3,9,10)(H3,11,14,15)
Affinity DataIC50: 7.50E+3nMAssay Description:In vitro inhibition of Diamine oxidase (DAO) from rat small intestine.More data for this Ligand-Target Pair
TargetAmiloride-sensitive amine oxidase [copper-containing](Rattus norvegicus)
Ciba-Geigy AG

Curated by ChEMBL
LigandPNGBDBM50046194(4-((E)-{[(E)-amino(imino)methyl]hydrazono}methyl)p...)
Show SMILES NC(=N)NN=Cc1ccnc(n1)C(N)=N
Show InChI InChI=1S/C7H10N8/c8-5(9)6-12-2-1-4(14-6)3-13-15-7(10)11/h1-3H,(H3,8,9)(H4,10,11,15)
Affinity DataIC50: 8.05E+3nMAssay Description:In vitro inhibition of Diamine oxidase (DAO) from rat small intestine.More data for this Ligand-Target Pair
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