Compile Data Set for Download or QSAR
Found 884 Enz. Inhib. hit(s) with Target = 'Arginase'
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
Affinity DataKi:  8.5nMAssay Description:Binding affinity to human arginase 2More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
Affinity DataKi:  8.5nMAssay Description:Inhibition of human Arg2 at pH 7.5More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561045(CHEMBL4758805)
Show SMILES NC(CCCCB(O)O)(CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C20H32BClN2O5/c22-17-6-4-16(5-7-17)20(27)10-14-24(15-11-20)13-3-9-19(23,18(25)26)8-1-2-12-21(28)29/h4-7,27-29H,1-3,8-15,23H2,(H,25,26)
Affinity DataKi: <10nMAssay Description:Inhibition of human Arg1 using L-arginine as substrate after 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561046(CHEMBL4790798)
Show SMILES NC(CCCCB(O)O)(CCCNCCc1ccccc1)C(O)=O
Show InChI InChI=1S/C17H29BN2O4/c19-17(16(21)22,10-4-5-12-18(23)24)11-6-13-20-14-9-15-7-2-1-3-8-15/h1-3,7-8,20,23-24H,4-6,9-14,19H2,(H,21,22)
Affinity DataKi: <10nMAssay Description:Inhibition of human Arg1 using L-arginine as substrate after 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails PubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50561045(CHEMBL4758805)
Show SMILES NC(CCCCB(O)O)(CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C20H32BClN2O5/c22-17-6-4-16(5-7-17)20(27)10-14-24(15-11-20)13-3-9-19(23,18(25)26)8-1-2-12-21(28)29/h4-7,27-29H,1-3,8-15,23H2,(H,25,26)
Affinity DataKi: <10nMAssay Description:Inhibition of human Arg2 using L-arginine as substrate after 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails PubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50561046(CHEMBL4790798)
Show SMILES NC(CCCCB(O)O)(CCCNCCc1ccccc1)C(O)=O
Show InChI InChI=1S/C17H29BN2O4/c19-17(16(21)22,10-4-5-12-18(23)24)11-6-13-20-14-9-15-7-2-1-3-8-15/h1-3,7-8,20,23-24H,4-6,9-14,19H2,(H,21,22)
Affinity DataKi: <10nMAssay Description:Inhibition of human Arg2 using L-arginine as substrate after 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails PubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50561034(CHEMBL4244287)
Show SMILES N[C@@H](CSCCB(O)O)C(O)=O
Show InChI InChI=1S/C5H12BNO4S/c7-4(5(8)9)3-12-2-1-6(10)11/h4,10-11H,1-3,7H2,(H,8,9)/t4-/m0/s1
Affinity DataKi:  30nMAssay Description:Inhibition of human Arg2 at pH 7.5More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50008099(CHEMBL1234777)
Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O
Show InChI InChI=1S/C5H12N4O3/c6-3(4(10)11)1-2-8-5(7)9-12/h3,12H,1-2,6H2,(H,10,11)(H3,7,8,9)/t3-/m0/s1
Affinity DataKi:  51nMAssay Description:Inhibition of arginase 2 (unknown origin)More data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50008099(CHEMBL1234777)
Show SMILES N[C@@H](CCNC(=N)NO)C(O)=O
Show InChI InChI=1S/C5H12N4O3/c6-3(4(10)11)1-2-8-5(7)9-12/h3,12H,1-2,6H2,(H,10,11)(H3,7,8,9)/t3-/m0/s1
Affinity DataKi:  51nMAssay Description:Inhibition of human Arg2 at pH 7.5More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetArginase(Leishmania amazonensis)
Universidade Federal de S£o Carlos

Curated by ChEMBL
LigandPNGBDBM23417(α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...)
Show SMILES O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1
Affinity DataKi:  200nMAssay Description:Noncompetitive inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substr...More data for this Ligand-Target Pair
TargetArginase(Leishmania amazonensis)
Universidade Federal de S£o Carlos

Curated by ChEMBL
LigandPNGBDBM23416(α-CA inhibitor, 3 | (+)-Catechin | (2R,3S)-2-...)
Show SMILES O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15+/m0/s1
Affinity DataKi:  600nMAssay Description:Noncompetitive inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substr...More data for this Ligand-Target Pair
TargetArginase(Leishmania amazonensis)
Universidade Federal de S£o Carlos

Curated by ChEMBL
LigandPNGBDBM50241867(((2R,3R,4R,5R,6R)-6-(3,4-dihydroxyphenethoxy)-5-hy...)
Show SMILES C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](OCCc3ccc(O)c(O)c3)O[C@H](CO)[C@H]2OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C29H36O15/c1-13-22(36)23(37)24(38)29(41-13)44-27-25(39)28(40-9-8-15-3-6-17(32)19(34)11-15)42-20(12-30)26(27)43-21(35)7-4-14-2-5-16(31)18(33)10-14/h2-7,10-11,13,20,22-34,36-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27+,28+,29-/m0/s1
Affinity DataKi:  700nMAssay Description:Competitive inhibition of Leishmania amazonensis arginase assessed as inhibition constant for enzyme-inhibitor complex using L-arginine as substrate ...More data for this Ligand-Target Pair
TargetArginase(Leishmania amazonensis)
Universidade Federal de S£o Carlos

Curated by ChEMBL
LigandPNGBDBM50446567(CHEMBL3109443)
Show SMILES CC(=O)O[C@H]1[C@@H](Oc2cc(OC(C)=O)cc(OC(C)=O)c2C1=O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C21H18O10/c1-9(22)28-13-7-16(29-10(2)23)18-17(8-13)31-20(21(19(18)27)30-11(3)24)12-4-5-14(25)15(26)6-12/h4-8,20-21,25-26H,1-3H3/t20-,21+/m0/s1
Affinity DataKi:  900nMAssay Description:Noncompetitive inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substr...More data for this Ligand-Target Pair
TargetArginase(Leishmania amazonensis)
Universidade Federal de S£o Carlos

Curated by ChEMBL
LigandPNGBDBM15236(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
Affinity DataKi:  1.20E+3nMAssay Description:Noncompetitive inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substr...More data for this Ligand-Target Pair
TargetArginase(Leishmania amazonensis)
Universidade Federal de S£o Carlos

Curated by ChEMBL
LigandPNGBDBM50521944(CHEMBL4204512)
Show SMILES CC(=O)Nc1ccc(C)cc1C(F)(F)C(=O)NNc1ccccc1
Show InChI InChI=1S/C17H17F2N3O2/c1-11-8-9-15(20-12(2)23)14(10-11)17(18,19)16(24)22-21-13-6-4-3-5-7-13/h3-10,21H,1-2H3,(H,20,23)(H,22,24)
Affinity DataKi:  1.30E+3nMAssay Description:Competitive inhibition of recombinant Leishmania amazonensis arginase expressed in Escherichia coli assessed as reduction in urea production by measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50230418(CHEMBL260629 | N(gamma)-hydroxy-L-arginine | N-OME...)
Show SMILES NC(NO)=NCCC[C@H]([NH3+])C([O-])=O
Show InChI InChI=1S/C6H14N4O3/c7-4(5(11)12)2-1-3-9-6(8)10-13/h4,13H,1-3,7H2,(H,11,12)(H3,8,9,10)/t4-/m0/s1
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of human Arg2 at pH 7.5More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetArginase(Schistosoma mansoni (flatworms))
University of Pennsylvania

LigandPNGBDBM130378(2(S)-amino-6-boronohexanoic acid (ABH))
Show SMILES N[C@@H](CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
Affinity DataKi:  1.80E+3nMpH: 8.5Assay Description:Briefly, 0.5-50 mM L-arginine (pH 8.5) was added to a solution of 50 mM 4-(2-hydroxyethyl)piperazine-1-propanesulfonic acid (EPPS) (pH 8.5) and 100 &...More data for this Ligand-Target Pair
TargetArginase(Schistosoma mansoni (flatworms))
University of Pennsylvania

LigandPNGBDBM130379(N-hydroxy-L-arginine (NOHA))
Show SMILES NC(=N)NCCC[C@H](NO)C(O)=O
Show InChI InChI=1S/C6H14N4O3/c7-6(8)9-3-1-2-4(10-13)5(11)12/h4,10,13H,1-3H2,(H,11,12)(H4,7,8,9)/t4-/m0/s1
Affinity DataKi:  3.70E+3nMpH: 8.5Assay Description:Briefly, 0.5-50 mM L-arginine (pH 8.5) was added to a solution of 50 mM 4-(2-hydroxyethyl)piperazine-1-propanesulfonic acid (EPPS) (pH 8.5) and 100 &...More data for this Ligand-Target Pair
TargetArginase(Leishmania amazonensis)
Universidade Federal de S£o Carlos

Curated by ChEMBL
LigandPNGBDBM50446568(CHEMBL3109439)
Show SMILES C[C@H]1O[C@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2cc(O)c(O)c(O)c2)[C@@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H20O12/c1-6-14(26)17(29)18(30)21(31-6)33-20-16(28)13-9(23)4-8(22)5-12(13)32-19(20)7-2-10(24)15(27)11(25)3-7/h2-6,14,17-18,21-22,24-30H,1H3/t6-,14-,17+,18+,21-/m1/s1
Affinity DataKi:  3.80E+3nMAssay Description:Noncompetitive inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substr...More data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50316603(2-(S)-amino-5-(2-aminoimidazol-1-yl)pentanoic acid...)
Show SMILES N[C@@H](CCCn1ccnc1N)C(O)=O
Show InChI InChI=1S/C8H14N4O2/c9-6(7(13)14)2-1-4-12-5-3-11-8(12)10/h3,5-6H,1-2,4,9H2,(H2,10,11)(H,13,14)/t6-/m0/s1
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assayMore data for this Ligand-Target Pair
TargetArginase(Leishmania amazonensis)
Universidade Federal de S£o Carlos

Curated by ChEMBL
LigandPNGBDBM50521942(CHEMBL4216180)
Show SMILES CC(=O)Nc1ccccc1C(F)(F)C(=O)NNc1ccccc1
Show InChI InChI=1S/C16H15F2N3O2/c1-11(22)19-14-10-6-5-9-13(14)16(17,18)15(23)21-20-12-7-3-2-4-8-12/h2-10,20H,1H3,(H,19,22)(H,21,23)
Affinity DataKi:  5.10E+3nMAssay Description:Competitive inhibition of recombinant Leishmania amazonensis arginase expressed in Escherichia coli assessed as reduction in urea production by measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase(Leishmania amazonensis)
Universidade Federal de S£o Carlos

Curated by ChEMBL
LigandPNGBDBM84978(Quercitrin | cid_5280459)
Show SMILES C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C21H20O11/c1-7-15(26)17(28)18(29)21(30-7)32-20-16(27)14-12(25)5-9(22)6-13(14)31-19(20)8-2-3-10(23)11(24)4-8/h2-7,15,17-18,21-24,26-29H,1H3/t7-,15-,17+,18+,21-/m0/s1
Affinity DataKi:  7.90E+3nMAssay Description:Noncompetitive inhibition of Leishmania amazonensis recombinant arginase expressed in Escherichia coli Rosetta (DE3) pLysS using L-arginine as substr...More data for this Ligand-Target Pair
TargetArginase(Plasmodium falciparum)
Drexel University

Curated by ChEMBL
LigandPNGBDBM50350311(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of Plasmodium falciparum arginase using L-arginine as substrate by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase(Leishmania amazonensis)
Universidade Federal de S£o Carlos

Curated by ChEMBL
LigandPNGBDBM50510706(CHEMBL4515068)
Show SMILES Cc1cc(NNC(N)=S)n2nc(nc2n1)C(F)(F)F
Show InChI InChI=1S/C8H8F3N7S/c1-3-2-4(15-16-6(12)19)18-7(13-3)14-5(17-18)8(9,10)11/h2,15H,1H3,(H3,12,16,19)
Affinity DataKi:  1.70E+4nMAssay Description:Non-competitive inhibition of Leishmania amazonensis arginase using L-arginine as substrate incubated for 15 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Bos taurus)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50375814(CHEMBL260628)
Show SMILES CN(CCC[C@H](N)C(O)=O)C(NO)N=O
Show InChI InChI=1S/C7H16N4O4/c1-11(7(9-14)10-15)4-2-3-5(8)6(12)13/h5,7,9,14H,2-4,8H2,1H3,(H,12,13)/t5-,7?/m0/s1
Affinity DataKi:  1.71E+4nMAssay Description:Inhibition of bovine liver arginaseMore data for this Ligand-Target Pair
TargetArginase(Leishmania amazonensis)
Universidade Federal de S£o Carlos

Curated by ChEMBL
LigandPNGBDBM50521943(CHEMBL4574177)
Show SMILES CC(=O)Nc1ccccc1C(F)(F)C(=O)NNc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H14F5N3O2/c1-10(26)23-14-5-3-2-4-13(14)16(18,19)15(27)25-24-12-8-6-11(7-9-12)17(20,21)22/h2-9,24H,1H3,(H,23,26)(H,25,27)
Affinity DataKi:  2.60E+4nMAssay Description:Competitive inhibition of recombinant Leishmania amazonensis arginase expressed in Escherichia coli assessed as reduction in urea production by measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Bos taurus)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50230418(CHEMBL260629 | N(gamma)-hydroxy-L-arginine | N-OME...)
Show SMILES NC(NO)=NCCC[C@H]([NH3+])C([O-])=O
Show InChI InChI=1S/C6H14N4O3/c7-4(5(11)12)2-1-3-9-6(8)10-13/h4,13H,1-3,7H2,(H,11,12)(H3,8,9,10)/t4-/m0/s1
Affinity DataKi:  3.00E+4nMAssay Description:Inhibition of bovine liver arginaseMore data for this Ligand-Target Pair
TargetArginase(Leishmania amazonensis)
Universidade Federal de S£o Carlos

Curated by ChEMBL
LigandPNGBDBM50521947(CHEMBL4530523)
Show SMILES CC(=O)Nc1ccccc1C(F)(F)C(=O)NCc1ccccc1
Show InChI InChI=1S/C17H16F2N2O2/c1-12(22)21-15-10-6-5-9-14(15)17(18,19)16(23)20-11-13-7-3-2-4-8-13/h2-10H,11H2,1H3,(H,20,23)(H,21,22)
Affinity DataKi:  3.20E+4nMAssay Description:Competitive inhibition of recombinant Leishmania amazonensis arginase expressed in Escherichia coli assessed as reduction in urea production by measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Bos taurus)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50553165(CHEMBL4754674)
Show SMILES Oc1ccc(CNc2ccc(O)c(O)c2)cc1O
Show InChI InChI=1S/C13H13NO4/c15-10-3-1-8(5-12(10)17)7-14-9-2-4-11(16)13(18)6-9/h1-6,14-18H,7H2
Affinity DataKi:  8.20E+4nMAssay Description:Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Dixon plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Bos taurus)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50553165(CHEMBL4754674)
Show SMILES Oc1ccc(CNc2ccc(O)c(O)c2)cc1O
Show InChI InChI=1S/C13H13NO4/c15-10-3-1-8(5-12(10)17)7-14-9-2-4-11(16)13(18)6-9/h1-6,14-18H,7H2
Affinity DataKi:  8.20E+4nMAssay Description:Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Cornish-Bowden plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Bos taurus)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50553165(CHEMBL4754674)
Show SMILES Oc1ccc(CNc2ccc(O)c(O)c2)cc1O
Show InChI InChI=1S/C13H13NO4/c15-10-3-1-8(5-12(10)17)7-14-9-2-4-11(16)13(18)6-9/h1-6,14-18H,7H2
Affinity DataKi:  8.20E+4nMAssay Description:Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Bos taurus)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50045936((E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol | (E)-...)
Show SMILES Oc1cc(O)cc(\C=C\c2ccc(O)c(O)c2)c1
Show InChI InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+
Affinity DataKi:  1.36E+5nMAssay Description:Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Dixon plot analysisMore data for this Ligand-Target Pair
TargetArginase-1(Bos taurus)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50045936((E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol | (E)-...)
Show SMILES Oc1cc(O)cc(\C=C\c2ccc(O)c(O)c2)c1
Show InChI InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+
Affinity DataKi:  1.36E+5nMAssay Description:Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetArginase-1(Bos taurus)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50045936((E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol | (E)-...)
Show SMILES Oc1cc(O)cc(\C=C\c2ccc(O)c(O)c2)c1
Show InChI InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+
Affinity DataKi:  1.36E+5nMAssay Description:Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Cornish-Bowden plot analysisMore data for this Ligand-Target Pair
TargetArginase(Plasmodium falciparum)
Drexel University

Curated by ChEMBL
LigandPNGBDBM50350309(CHEMBL1812662)
Show SMILES CC([NH3+])(CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C7H16BNO4/c1-7(9,6(10)11)4-2-3-5-8(12)13/h12-13H,2-5,9H2,1H3,(H,10,11)
Affinity DataKi:  2.60E+5nMAssay Description:Inhibition of Plasmodium falciparum arginase using L-arginine as substrate by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50462601(CHEMBL4250607)
Show SMILES NC(=N)Nc1ccc(cc1)C(F)C(O)=O
Show InChI InChI=1S/C9H10FN3O2/c10-7(8(14)15)5-1-3-6(4-2-5)13-9(11)12/h1-4,7H,(H,14,15)(H4,11,12,13)
Affinity DataKi:  2.75E+5nMAssay Description:Irreversible inhibition of human arginase 1 using thioarginine as substrate measured up to 360 mins by UV micro plate methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50316607(2-amino-L-histidine | CHEMBL1099167 | L-2-aminohis...)
Show SMILES N[C@@H](Cc1cnc(N)[nH]1)C(O)=O
Show InChI InChI=1S/C6H10N4O2/c7-4(5(11)12)1-3-2-9-6(8)10-3/h2,4H,1,7H2,(H,11,12)(H3,8,9,10)/t4-/m0/s1
Affinity DataKi:  3.00E+5nMAssay Description:Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assayMore data for this Ligand-Target Pair
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50462601(CHEMBL4250607)
Show SMILES NC(=N)Nc1ccc(cc1)C(F)C(O)=O
Show InChI InChI=1S/C9H10FN3O2/c10-7(8(14)15)5-1-3-6(4-2-5)13-9(11)12/h1-4,7H,(H,14,15)(H4,11,12,13)
Affinity DataKi:  3.22E+5nMAssay Description:Irreversible inhibition of human arginase 2 using thioarginine as substrate measured up to 360 mins by UV micro plate methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50462600(CHEMBL4238387)
Show SMILES CC(=O)OC(C(O)=O)c1ccc(NC(N)=N)cc1
Show InChI InChI=1S/C11H13N3O4/c1-6(15)18-9(10(16)17)7-2-4-8(5-3-7)14-11(12)13/h2-5,9H,1H3,(H,16,17)(H4,12,13,14)
Affinity DataKi:  3.82E+5nMAssay Description:Irreversible inhibition of human arginase 1 using thioarginine as substrate measured up to 360 mins by UV micro plate methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50462600(CHEMBL4238387)
Show SMILES CC(=O)OC(C(O)=O)c1ccc(NC(N)=N)cc1
Show InChI InChI=1S/C11H13N3O4/c1-6(15)18-9(10(16)17)7-2-4-8(5-3-7)14-11(12)13/h2-5,9H,1H3,(H,16,17)(H4,12,13,14)
Affinity DataKi:  4.37E+5nMAssay Description:Irreversible inhibition of human arginase 2 using thioarginine as substrate measured up to 360 mins by UV micro plate methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50316604((S)-2-amino-5-(imidazol-2-ylamino)pentanoic acid |...)
Show SMILES N[C@@H](CCCNc1ncc[nH]1)C(O)=O
Show InChI InChI=1S/C8H14N4O2/c9-6(7(13)14)2-1-3-10-8-11-4-5-12-8/h4-6H,1-3,9H2,(H,13,14)(H2,10,11,12)/t6-/m0/s1
Affinity DataKi:  5.00E+5nMAssay Description:Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assayMore data for this Ligand-Target Pair
TargetArginase(Plasmodium falciparum)
Drexel University

Curated by ChEMBL
LigandPNGBDBM50350310(CHEMBL1812663)
Show SMILES [NH3+]C(CCCCB(O)O)(C(F)F)C([O-])=O
Show InChI InChI=1S/C7H14BF2NO4/c9-5(10)7(11,6(12)13)3-1-2-4-8(14)15/h5,14-15H,1-4,11H2,(H,12,13)
Affinity DataKi:  2.00E+6nMAssay Description:Inhibition of Plasmodium falciparum arginase using L-arginine as substrate by colorimetric assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50316606((2S)-2-amino-4-(2-amino-1H-imidazol-5-yl)butanoic ...)
Show SMILES N[C@@H](CCc1cnc(N)[nH]1)C(O)=O
Show InChI InChI=1S/C7H12N4O2/c8-5(6(12)13)2-1-4-3-10-7(9)11-4/h3,5H,1-2,8H2,(H,12,13)(H3,9,10,11)/t5-/m0/s1
Affinity DataKi:  3.00E+6nMAssay Description:Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50316608(1H-Imidazol-2-yl-ammonium | 1H-Imidazol-2-ylamine ...)
Show SMILES Nc1ncc[nH]1
Show InChI InChI=1S/C3H5N3/c4-3-5-1-2-6-3/h1-2H,(H3,4,5,6)
Affinity DataKi:  3.60E+6nMAssay Description:Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50316605(2-amino-5-(2-aminoimidazol-4-yl)pentanoic acid | C...)
Show SMILES NC(CCCc1cnc(N)[nH]1)C(O)=O
Show InChI InChI=1S/C8H14N4O2/c9-6(7(13)14)3-1-2-5-4-11-8(10)12-5/h4,6H,1-3,9H2,(H,13,14)(H3,10,11,12)
Affinity DataKi: >8.00E+7nMAssay Description:Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561047(CHEMBL4764455)
Show SMILES NCCNS(=O)(=O)N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C10H23BN4O6S/c12-4-5-14-22(20,21)15-6-8(2-1-3-11(18)19)10(13,7-15)9(16)17/h8,14,18-19H,1-7,12-13H2,(H,16,17)/t8-,10-/m0/s1
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50561047(CHEMBL4764455)
Show SMILES NCCNS(=O)(=O)N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C10H23BN4O6S/c12-4-5-14-22(20,21)15-6-8(2-1-3-11(18)19)10(13,7-15)9(16)17/h8,14,18-19H,1-7,12-13H2,(H,16,17)/t8-,10-/m0/s1
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human Arg2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561040(CHEMBL4754637)
Show SMILES N[C@@H](C1CCCC1)C(=O)N[C@H]1CN[C@@H]([C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C15H28BN3O5/c17-12(9-4-1-2-5-9)14(20)19-11-8-18-13(15(21)22)10(11)6-3-7-16(23)24/h9-13,18,23-24H,1-8,17H2,(H,19,20)(H,21,22)/t10-,11+,12+,13+/m1/s1
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human Arg1 by TOGA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561042(CHEMBL4748950)
Show SMILES CC(C)(C)[C@H](N)C(=O)N[C@H]1CN[C@@H]([C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H28BN3O5/c1-14(2,3)11(16)12(19)18-9-7-17-10(13(20)21)8(9)5-4-6-15(22)23/h8-11,17,22-23H,4-7,16H2,1-3H3,(H,18,19)(H,20,21)/t8-,9+,10+,11-/m1/s1
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human Arg1 by TOGA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561042(CHEMBL4748950)
Show SMILES CC(C)(C)[C@H](N)C(=O)N[C@H]1CN[C@@H]([C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H28BN3O5/c1-14(2,3)11(16)12(19)18-9-7-17-10(13(20)21)8(9)5-4-6-15(22)23/h8-11,17,22-23H,4-7,16H2,1-3H3,(H,18,19)(H,20,21)/t8-,9+,10+,11-/m1/s1
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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