Compile Data Set for Download or QSAR
Found 525 Enz. Inhib. hit(s) with Target = 'Arginase-1'
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561045(CHEMBL4758805)
Show SMILES NC(CCCCB(O)O)(CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C20H32BClN2O5/c22-17-6-4-16(5-7-17)20(27)10-14-24(15-11-20)13-3-9-19(23,18(25)26)8-1-2-12-21(28)29/h4-7,27-29H,1-3,8-15,23H2,(H,25,26)
Affinity DataKi: <10nMAssay Description:Inhibition of human Arg1 using L-arginine as substrate after 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561046(CHEMBL4790798)
Show SMILES NC(CCCCB(O)O)(CCCNCCc1ccccc1)C(O)=O
Show InChI InChI=1S/C17H29BN2O4/c19-17(16(21)22,10-4-5-12-18(23)24)11-6-13-20-14-9-15-7-2-1-3-8-15/h1-3,7-8,20,23-24H,4-6,9-14,19H2,(H,21,22)
Affinity DataKi: <10nMAssay Description:Inhibition of human Arg1 using L-arginine as substrate after 60 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50316603(2-(S)-amino-5-(2-aminoimidazol-1-yl)pentanoic acid...)
Show SMILES N[C@@H](CCCn1ccnc1N)C(O)=O
Show InChI InChI=1S/C8H14N4O2/c9-6(7(13)14)2-1-4-12-5-3-11-8(12)10/h3,5-6H,1-2,4,9H2,(H2,10,11)(H,13,14)/t6-/m0/s1
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assayMore data for this Ligand-Target Pair
TargetArginase-1(Bos taurus)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50375814(CHEMBL260628)
Show SMILES CN(CCC[C@H](N)C(O)=O)C(NO)N=O
Show InChI InChI=1S/C7H16N4O4/c1-11(7(9-14)10-15)4-2-3-5(8)6(12)13/h5,7,9,14H,2-4,8H2,1H3,(H,12,13)/t5-,7?/m0/s1
Affinity DataKi:  1.71E+4nMAssay Description:Inhibition of bovine liver arginaseMore data for this Ligand-Target Pair
TargetArginase-1(Bos taurus)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50230418(CHEMBL260629 | N(gamma)-hydroxy-L-arginine | N-OME...)
Show SMILES NC(NO)=NCCC[C@H]([NH3+])C([O-])=O
Show InChI InChI=1S/C6H14N4O3/c7-4(5(11)12)2-1-3-9-6(8)10-13/h4,13H,1-3,7H2,(H,11,12)(H3,8,9,10)/t4-/m0/s1
Affinity DataKi:  3.00E+4nMAssay Description:Inhibition of bovine liver arginaseMore data for this Ligand-Target Pair
TargetArginase-1(Bos taurus)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50553165(CHEMBL4754674)
Show SMILES Oc1ccc(CNc2ccc(O)c(O)c2)cc1O
Show InChI InChI=1S/C13H13NO4/c15-10-3-1-8(5-12(10)17)7-14-9-2-4-11(16)13(18)6-9/h1-6,14-18H,7H2
Affinity DataKi:  8.20E+4nMAssay Description:Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Cornish-Bowden plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Bos taurus)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50553165(CHEMBL4754674)
Show SMILES Oc1ccc(CNc2ccc(O)c(O)c2)cc1O
Show InChI InChI=1S/C13H13NO4/c15-10-3-1-8(5-12(10)17)7-14-9-2-4-11(16)13(18)6-9/h1-6,14-18H,7H2
Affinity DataKi:  8.20E+4nMAssay Description:Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Bos taurus)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50553165(CHEMBL4754674)
Show SMILES Oc1ccc(CNc2ccc(O)c(O)c2)cc1O
Show InChI InChI=1S/C13H13NO4/c15-10-3-1-8(5-12(10)17)7-14-9-2-4-11(16)13(18)6-9/h1-6,14-18H,7H2
Affinity DataKi:  8.20E+4nMAssay Description:Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Dixon plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Bos taurus)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50045936((E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol | (E)-...)
Show SMILES Oc1cc(O)cc(\C=C\c2ccc(O)c(O)c2)c1
Show InChI InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+
Affinity DataKi:  1.36E+5nMAssay Description:Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetArginase-1(Bos taurus)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50045936((E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol | (E)-...)
Show SMILES Oc1cc(O)cc(\C=C\c2ccc(O)c(O)c2)c1
Show InChI InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+
Affinity DataKi:  1.36E+5nMAssay Description:Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Cornish-Bowden plot analysisMore data for this Ligand-Target Pair
TargetArginase-1(Bos taurus)
Christian-Albrechts-University of Kiel

Curated by ChEMBL
LigandPNGBDBM50045936((E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol | (E)-...)
Show SMILES Oc1cc(O)cc(\C=C\c2ccc(O)c(O)c2)c1
Show InChI InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+
Affinity DataKi:  1.36E+5nMAssay Description:Mixed type inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by Dixon plot analysisMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50462601(CHEMBL4250607)
Show SMILES NC(=N)Nc1ccc(cc1)C(F)C(O)=O
Show InChI InChI=1S/C9H10FN3O2/c10-7(8(14)15)5-1-3-6(4-2-5)13-9(11)12/h1-4,7H,(H,14,15)(H4,11,12,13)
Affinity DataKi:  2.75E+5nMAssay Description:Irreversible inhibition of human arginase 1 using thioarginine as substrate measured up to 360 mins by UV micro plate methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50316607(2-amino-L-histidine | CHEMBL1099167 | L-2-aminohis...)
Show SMILES N[C@@H](Cc1cnc(N)[nH]1)C(O)=O
Show InChI InChI=1S/C6H10N4O2/c7-4(5(11)12)1-3-2-9-6(8)10-3/h2,4H,1,7H2,(H,11,12)(H3,8,9,10)/t4-/m0/s1
Affinity DataKi:  3.00E+5nMAssay Description:Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50462600(CHEMBL4238387)
Show SMILES CC(=O)OC(C(O)=O)c1ccc(NC(N)=N)cc1
Show InChI InChI=1S/C11H13N3O4/c1-6(15)18-9(10(16)17)7-2-4-8(5-3-7)14-11(12)13/h2-5,9H,1H3,(H,16,17)(H4,12,13,14)
Affinity DataKi:  3.82E+5nMAssay Description:Irreversible inhibition of human arginase 1 using thioarginine as substrate measured up to 360 mins by UV micro plate methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50316604((S)-2-amino-5-(imidazol-2-ylamino)pentanoic acid |...)
Show SMILES N[C@@H](CCCNc1ncc[nH]1)C(O)=O
Show InChI InChI=1S/C8H14N4O2/c9-6(7(13)14)2-1-3-10-8-11-4-5-12-8/h4-6H,1-3,9H2,(H,13,14)(H2,10,11,12)/t6-/m0/s1
Affinity DataKi:  5.00E+5nMAssay Description:Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50316606((2S)-2-amino-4-(2-amino-1H-imidazol-5-yl)butanoic ...)
Show SMILES N[C@@H](CCc1cnc(N)[nH]1)C(O)=O
Show InChI InChI=1S/C7H12N4O2/c8-5(6(12)13)2-1-4-3-10-7(9)11-4/h3,5H,1-2,8H2,(H,12,13)(H3,9,10,11)/t5-/m0/s1
Affinity DataKi:  3.00E+6nMAssay Description:Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50316608(1H-Imidazol-2-yl-ammonium | 1H-Imidazol-2-ylamine ...)
Show SMILES Nc1ncc[nH]1
Show InChI InChI=1S/C3H5N3/c4-3-5-1-2-6-3/h1-2H,(H3,4,5,6)
Affinity DataKi:  3.60E+6nMAssay Description:Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50316605(2-amino-5-(2-aminoimidazol-4-yl)pentanoic acid | C...)
Show SMILES NC(CCCc1cnc(N)[nH]1)C(O)=O
Show InChI InChI=1S/C8H14N4O2/c9-6(7(13)14)3-1-2-5-4-11-8(10)12-5/h4,6H,1-3,9H2,(H,13,14)(H3,10,11,12)
Affinity DataKi: >8.00E+7nMAssay Description:Inhibition of human recombinant full length arginase 1 expressed in Escherichia coli BL21(DE3) by fixed point assayMore data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561047(CHEMBL4764455)
Show SMILES NCCNS(=O)(=O)N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C10H23BN4O6S/c12-4-5-14-22(20,21)15-6-8(2-1-3-11(18)19)10(13,7-15)9(16)17/h8,14,18-19H,1-7,12-13H2,(H,16,17)/t8-,10-/m0/s1
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561040(CHEMBL4754637)
Show SMILES N[C@@H](C1CCCC1)C(=O)N[C@H]1CN[C@@H]([C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C15H28BN3O5/c17-12(9-4-1-2-5-9)14(20)19-11-8-18-13(15(21)22)10(11)6-3-7-16(23)24/h9-13,18,23-24H,1-8,17H2,(H,19,20)(H,21,22)/t10-,11+,12+,13+/m1/s1
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human Arg1 by TOGA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561042(CHEMBL4748950)
Show SMILES CC(C)(C)[C@H](N)C(=O)N[C@H]1CN[C@@H]([C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H28BN3O5/c1-14(2,3)11(16)12(19)18-9-7-17-10(13(20)21)8(9)5-4-6-15(22)23/h8-11,17,22-23H,4-7,16H2,1-3H3,(H,18,19)(H,20,21)/t8-,9+,10+,11-/m1/s1
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human Arg1 by TOGA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561052(CHEMBL4755855)
Show SMILES C[C@@H]1N(C[C@@H](CCB(O)O)C[C@]1(N)C(O)=O)C(=O)CN
Show InChI InChI=1S/C11H22BN3O5/c1-7-11(14,10(17)18)4-8(2-3-12(19)20)6-15(7)9(16)5-13/h7-8,19-20H,2-6,13-14H2,1H3,(H,17,18)/t7-,8-,11+/m0/s1
Affinity DataIC50: 1nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561042(CHEMBL4748950)
Show SMILES CC(C)(C)[C@H](N)C(=O)N[C@H]1CN[C@@H]([C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H28BN3O5/c1-14(2,3)11(16)12(19)18-9-7-17-10(13(20)21)8(9)5-4-6-15(22)23/h8-11,17,22-23H,4-7,16H2,1-3H3,(H,18,19)(H,20,21)/t8-,9+,10+,11-/m1/s1
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561053(CHEMBL4750602)
Show SMILES C[C@@H]1N(C[C@@H](CCB(O)O)C[C@]1(N)C(O)=O)C(=O)[C@@H](N)Cc1c[nH]cn1
Affinity DataIC50: 1nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561049(CHEMBL4793482)
Show SMILES N[C@@]1(C[C@H](CCB(O)O)CC[C@H]1CN1CCCCC1)C(O)=O
Show InChI InChI=1S/C15H29BN2O4/c17-15(14(19)20)10-12(6-7-16(21)22)4-5-13(15)11-18-8-2-1-3-9-18/h12-13,21-22H,1-11,17H2,(H,19,20)/t12-,13-,15+/m0/s1
Affinity DataIC50: 1nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561051(CHEMBL4749434)
Show SMILES C[C@H](N)C(=O)N1C[C@@H](CCB(O)O)C[C@@](N)([C@@H]1C)C(O)=O
Show InChI InChI=1S/C12H24BN3O5/c1-7(14)10(17)16-6-9(3-4-13(20)21)5-12(15,8(16)2)11(18)19/h7-9,20-21H,3-6,14-15H2,1-2H3,(H,18,19)/t7-,8-,9-,12+/m0/s1
Affinity DataIC50: 1nMAssay Description:Inhibition of human Arg1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50509011(CHEMBL4538713)
Show SMILES N[C@H](CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O)Cc1ccccc1
Show InChI InChI=1S/C17H28BN3O4/c19-15(9-13-5-2-1-3-6-13)11-21-10-14(7-4-8-18(24)25)17(20,12-21)16(22)23/h1-3,5-6,14-15,24-25H,4,7-12,19-20H2,(H,22,23)/t14-,15-,17-/m0/s1
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50579614(CHEMBL4871970)
Show SMILES OB(O)CCC[C@]12CCN[C@H]1CN[C@@H]2C(O)=O
Show InChI InChI=1S/C10H19BN2O4/c14-9(15)8-10(2-1-4-11(16)17)3-5-12-7(10)6-13-8/h7-8,12-13,16-17H,1-6H2,(H,14,15)/t7-,8+,10-/m0/s1
Affinity DataIC50: 1.60nMAssay Description:Inhibition of ARG1 (unknown origin) assessed as reduction in thio-ornithine production using thioarginine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561041(CHEMBL4791224)
Show SMILES CC(C)C[C@H](N)C(=O)N[C@H]1CN[C@@H]([C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H28BN3O5/c1-8(2)6-10(16)13(19)18-11-7-17-12(14(20)21)9(11)4-3-5-15(22)23/h8-12,17,22-23H,3-7,16H2,1-2H3,(H,18,19)(H,20,21)/t9-,10+,11+,12+/m1/s1
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human Arg1 by TOGA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50577469(CHEMBL4850213)
Show SMILES CC(C)[C@H](N)C(=O)N[C@H]1CN[C@@H]([C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C13H26BN3O5/c1-7(2)10(15)12(18)17-9-6-16-11(13(19)20)8(9)4-3-5-14(21)22/h7-11,16,21-22H,3-6,15H2,1-2H3,(H,17,18)(H,19,20)/t8-,9+,10+,11+/m1/s1
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50579610(CHEMBL4873520)
Show SMILES OB(O)CCC[C@H]1[C@H]2CN[C@@]1(CCN2)C(O)=O
Show InChI InChI=1S/C10H19BN2O4/c14-9(15)10-3-5-12-8(6-13-10)7(10)2-1-4-11(16)17/h7-8,12-13,16-17H,1-6H2,(H,14,15)/t7-,8+,10+/m0/s1
Affinity DataIC50: 2.20nMAssay Description:Inhibition of ARG1 (unknown origin) assessed as reduction in thio-ornithine production using thioarginine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50509016(CHEMBL4450972)
Show SMILES N[C@H](CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O)c1ccccc1
Show InChI InChI=1S/C16H26BN3O4/c18-14(12-5-2-1-3-6-12)10-20-9-13(7-4-8-17(23)24)16(19,11-20)15(21)22/h1-3,5-6,13-14,23-24H,4,7-11,18-19H2,(H,21,22)/t13-,14+,16-/m0/s1
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50509014(CHEMBL4557975)
Show SMILES N[C@]1(CN(C[C@H]2CCCCN2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H28BN3O4/c16-14(13(19)20)10-18(9-12-5-1-2-7-17-12)8-11(14)4-3-6-15(21)22/h11-12,17,21-22H,1-10,16H2,(H,19,20)/t11-,12+,14-/m0/s1
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561035(CHEMBL4763578)
Show SMILES N[C@H]1CN[C@@H]([C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H17BN2O4/c10-6-4-11-7(8(12)13)5(6)2-1-3-9(14)15/h5-7,11,14-15H,1-4,10H2,(H,12,13)/t5-,6+,7+/m1/s1
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM568474(US11420984, Example 24)
Show SMILES CN[C@H]1CN[C@@](CCCCB(O)O)(C1)C(O)=O
Show InChI InChI=1S/C10H20BN2O4/c1-12-8-6-10(9(14)15,13-7-8)4-2-3-5-11(16)17/h8,12,16-17H,2-7H2,1H3,(H,14,15)/t8-,10+/m1/s1
Affinity DataIC50: 3nMAssay Description:The inhibitory effects of Examples 1 to 30 on the activity of Human Arginase 1 and Arginase 2 activity were quantified by measuring the formation of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561039(CHEMBL4749355 | US11420984, Example 23)
Show SMILES CN[C@H]1CN[C@](CCCCB(O)O)(C1)C(O)=O
Show InChI InChI=1S/C10H21BN2O4/c1-12-8-6-10(9(14)15,13-7-8)4-2-3-5-11(16)17/h8,12-13,16-17H,2-7H2,1H3,(H,14,15)/t8-,10-/m1/s1
Affinity DataIC50: 3nMAssay Description:Inhibition of human Arg1 by TOGA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50579616(CHEMBL4845730)
Show SMILES COC(=O)[C@H]1NC[C@@H]2NCCC[C@]12CCCB(O)O
Show InChI InChI=1S/C12H23BN2O4/c1-19-11(16)10-12(4-2-6-13(17)18)5-3-7-14-9(12)8-15-10/h9-10,14-15,17-18H,2-8H2,1H3/t9-,10+,12-/m0/s1
Affinity DataIC50: 3.20nMAssay Description:Inhibition of ARG1 (unknown origin) assessed as reduction in thio-ornithine production using thioarginine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561035(CHEMBL4763578)
Show SMILES N[C@H]1CN[C@@H]([C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H17BN2O4/c10-6-4-11-7(8(12)13)5(6)2-1-3-9(14)15/h5-7,11,14-15H,1-4,10H2,(H,12,13)/t5-,6+,7+/m1/s1
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human Arg1 by TOGA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50579611(CHEMBL4871097)
Show SMILES OB(O)CCC[C@H]1[C@H]2C[C@@]1(CCN2)C(O)=O
Show InChI InChI=1S/C10H18BNO4/c13-9(14)10-3-5-12-8(6-10)7(10)2-1-4-11(15)16/h7-8,12,15-16H,1-6H2,(H,13,14)/t7-,8+,10+/m0/s1
Affinity DataIC50: 3.90nMAssay Description:Inhibition of ARG1 (unknown origin) assessed as reduction in thio-ornithine production using thioarginine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50538536(CHEMBL4639893)
Show SMILES N[C@H]1C[C@@H]2C[C@](N)([C@@H](CCCB(O)O)[C@@H]2C1)C(O)=O
Show InChI InChI=1S/C12H23BN2O4/c14-8-4-7-6-12(15,11(16)17)10(9(7)5-8)2-1-3-13(18)19/h7-10,18-19H,1-6,14-15H2,(H,16,17)/t7-,8+,9-,10+,12+/m1/s1
Affinity DataIC50: 4nMAssay Description:Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561036(CHEMBL4778978)
Show SMILES OB(O)CCC[C@@H]1[C@@H](O)CN[C@@H]1C(O)=O
Show InChI InChI=1S/C8H16BNO5/c11-6-4-10-7(8(12)13)5(6)2-1-3-9(14)15/h5-7,10-11,14-15H,1-4H2,(H,12,13)/t5-,6+,7+/m1/s1
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50579615(CHEMBL4865209)
Show SMILES OB(O)CCC[C@]12COC[C@H]1CN[C@@H]2C(O)=O
Show InChI InChI=1S/C10H18BNO5/c13-9(14)8-10(2-1-3-11(15)16)6-17-5-7(10)4-12-8/h7-8,12,15-16H,1-6H2,(H,13,14)/t7-,8-,10+/m1/s1
Affinity DataIC50: 5nMAssay Description:Inhibition of ARG1 (unknown origin) assessed as reduction in thio-ornithine production using thioarginine as substrate by fluorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50538548(CHEMBL4640681)
Show SMILES CN[C@H]1C[C@@H]2C[C@](N)([C@@H](CCCB(O)O)[C@@H]2[C@H]1F)C(O)=O
Show InChI InChI=1S/C13H24BFN2O4/c1-17-9-5-7-6-13(16,12(18)19)8(10(7)11(9)15)3-2-4-14(20)21/h7-11,17,20-21H,2-6,16H2,1H3,(H,18,19)/t7-,8+,9+,10-,11+,13+/m1/s1
Affinity DataIC50: 5nMAssay Description:Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50577476(CHEMBL4852406)
Show SMILES NC[C@@]1(CCCB(O)O)CCN[C@@H]1C(O)=O
Show InChI InChI=1S/C9H19BN2O4/c11-6-9(2-1-4-10(15)16)3-5-12-7(9)8(13)14/h7,12,15-16H,1-6,11H2,(H,13,14)/t7-,9-/m1/s1
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50577471(CHEMBL4864502)
Show SMILES CN[C@@H](C(C)C)C(=O)N[C@H]1CN[C@@H]([C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H28BN3O5/c1-8(2)11(16-3)13(19)18-10-7-17-12(14(20)21)9(10)5-4-6-15(22)23/h8-12,16-17,22-23H,4-7H2,1-3H3,(H,18,19)(H,20,21)/t9-,10+,11+,12+/m1/s1
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561036(CHEMBL4778978)
Show SMILES OB(O)CCC[C@@H]1[C@@H](O)CN[C@@H]1C(O)=O
Show InChI InChI=1S/C8H16BNO5/c11-6-4-10-7(8(12)13)5(6)2-1-3-9(14)15/h5-7,10-11,14-15H,1-4H2,(H,12,13)/t5-,6+,7+/m1/s1
Affinity DataIC50: 6nMAssay Description:Inhibition of human Arg1 by TOGA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50577477(CHEMBL4868283)
Show SMILES C[C@@H]1C[C@@H](CCCB(O)O)[C@H](N1)C(O)=O
Show InChI InChI=1S/C9H18BNO4/c1-6-5-7(3-2-4-10(14)15)8(11-6)9(12)13/h6-8,11,14-15H,2-5H2,1H3,(H,12,13)/t6-,7-,8+/m1/s1
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50538547(CHEMBL4648504)
Show SMILES CN[C@@H]1C[C@@H]2C[C@](N)([C@@H](CCCB(O)O)[C@@H]2[C@H]1F)C(O)=O
Show InChI InChI=1S/C13H24BFN2O4/c1-17-9-5-7-6-13(16,12(18)19)8(10(7)11(9)15)3-2-4-14(20)21/h7-11,17,20-21H,2-6,16H2,1H3,(H,18,19)/t7-,8+,9-,10-,11+,13+/m1/s1
Affinity DataIC50: 7nMAssay Description:Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50509010(CHEMBL4518246)
Show SMILES C[C@H](N)CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C11H24BN3O4/c1-8(13)5-15-6-9(3-2-4-12(18)19)11(14,7-15)10(16)17/h8-9,18-19H,2-7,13-14H2,1H3,(H,16,17)/t8-,9-,11-/m0/s1
Affinity DataIC50: 7.70nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetArginase-1(Homo sapiens (Human))
OncoArendi Therapeutics SA

Curated by ChEMBL
LigandPNGBDBM50561037(CHEMBL4762611)
Show SMILES NC[C@@]1(CCCB(O)O)CN[C@@H]1C(O)=O
Show InChI InChI=1S/C8H17BN2O4/c10-4-8(2-1-3-9(14)15)5-11-6(8)7(12)13/h6,11,14-15H,1-5,10H2,(H,12,13)/t6-,8+/m1/s1
Affinity DataIC50: 8nMAssay Description:Inhibition of human Arg1 by TOGA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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