Compile Data Set for Download or QSAR
Report error Found 1927 Enz. Inhib. hit(s) with Target = 'C-X-C chemokine receptor type 4'
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50196240(CHEMBL3896146)
Affinity DataEC50:  56nMAssay Description:Agonist activity at HA-tagged human CXCR4 receptor expressed in HEK293 cells co-transfected with Galphai1-91-RlucII, Gbeta1, and GFP10-G-gamma1 incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2018
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50196241(CHEMBL3902240)
Affinity DataEC50:  81nMAssay Description:Agonist activity at HA-tagged human CXCR4 receptor expressed in HEK293 cells co-transfected with Galphai1-91-RlucII, Gbeta1, and GFP10-G-gamma1 incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2018
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50196242(CHEMBL3940962)
Affinity DataEC50:  83nMAssay Description:Agonist activity at HA-tagged human CXCR4 receptor expressed in HEK293 cells co-transfected with Galphai1-91-RlucII, Gbeta1, and GFP10-G-gamma1 incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2018
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50196255(CHEMBL3955461)
Affinity DataEC50:  76nMAssay Description:Agonist activity at HA-tagged human CXCR4 receptor expressed in HEK293 cells co-transfected with Galphai1-91-RlucII, Gbeta1, and GFP10-G-gamma1 incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2018
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50196256(CHEMBL3970509)
Affinity DataEC50:  94nMAssay Description:Agonist activity at HA-tagged human CXCR4 receptor expressed in HEK293 cells co-transfected with Galphai1-91-RlucII, Gbeta1, and GFP10-G-gamma1 incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2018
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50196257(CHEMBL3903301)
Affinity DataEC50:  52nMAssay Description:Agonist activity at HA-tagged human CXCR4 receptor expressed in HEK293 cells co-transfected with Galphai1-91-RlucII, Gbeta1, and GFP10-G-gamma1 incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2018
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50196258(CHEMBL3924080)
Affinity DataEC50:  138nMAssay Description:Agonist activity at HA-tagged human CXCR4 receptor expressed in HEK293 cells co-transfected with Galphai1-91-RlucII, Gbeta1, and GFP10-G-gamma1 incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2018
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50096735(Compound T140 | CHEMBL2372983)
Affinity DataEC50:  3.30nMAssay Description:Effective concentration for 50% protection of HIV-induced cytopathogenicity in MT-4 cells on the MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50102046(Derivative of T140 peptide | CHEMBL2372989)
Affinity DataEC50:  2.70nMAssay Description:Effective concentration for 50% protection of HIV-induced cytopathogenicity in MT-4 cells on the MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50327302(CHEMBL1256583 | CHEMBL1256530)
Affinity DataEC50:  7.10nMAssay Description:Displacement of [125I]-SDF-1-alpha from CXCR4 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50166087(N-{3-[(2R,5S,8S,14R)-5-(3-Guanidino-propyl)-14-(4-...)
Affinity DataEC50:  520nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100599(CHEMBL3327366)
Affinity DataEC50:  5.80E+4nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100600(CHEMBL3327367)
Affinity DataEC50:  8.60E+4nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100601(CHEMBL3327368)
Affinity DataEC50:  4.40E+4nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100602(CHEMBL3327369)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100603(CHEMBL3327370)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100604(CHEMBL3327371)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100605(CHEMBL3327372)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100606(CHEMBL3327373)
Affinity DataEC50:  6.00E+4nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100607(CHEMBL3325468)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100608(CHEMBL3327374)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100609(CHEMBL3327375)
Affinity DataEC50:  8.00E+4nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100610(CHEMBL3327376)
Affinity DataEC50:  6.40E+4nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50166087(N-{3-[(2R,5S,8S,14R)-5-(3-Guanidino-propyl)-14-(4-...)
Affinity DataEC50:  525nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100599(CHEMBL3327366)
Affinity DataEC50:  5.75E+4nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100600(CHEMBL3327367)
Affinity DataEC50:  8.51E+4nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100601(CHEMBL3327368)
Affinity DataEC50:  4.37E+4nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100602(CHEMBL3327369)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100603(CHEMBL3327370)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100604(CHEMBL3327371)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100605(CHEMBL3327372)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100606(CHEMBL3327373)
Affinity DataEC50:  6.03E+4nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100607(CHEMBL3325468)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100608(CHEMBL3327374)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100609(CHEMBL3327375)
Affinity DataEC50:  7.94E+4nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50100610(CHEMBL3327376)
Affinity DataEC50:  6.31E+4nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of [3H]inositol-phosphates formation after 90 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50112266(CHEMBL3608763)
Affinity DataEC50:  7.00E+4nMAssay Description:Inhibition of CXCR4 assessed as reduction in fusion of human HeLa/67 as target cells expressing CD4, CCR5, and CXCR4) and Lai envelope-expressing eff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50112266(CHEMBL3608763)
Affinity DataEC50:  5.20E+4nMAssay Description:Inhibition of CXCR4 assessed as reduction in fusion of human ACTOne-X4 cells as target cells expressing only CXCR4) with effector cells expressing HI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50225415(WZ-811 | N,N'-di-2-pyridinyl-1,4-benzenedimethanam...)
Affinity DataEC50:  0.300nMAssay Description:Displacement of biotinylated TN14003 from CXCR4 in MDA-MB-231 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50155310(CHEMBL3779982)
Affinity DataEC50:  68nMAssay Description:Displacement of [125I]SDF-1 from human CXCR4 expressed in HEK293 cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50155311(CHEMBL3781301)
Affinity DataEC50:  1.90E+3nMAssay Description:Antagonist activity at CXCR4 expressed in human U373-MAGI cells assessed as inhibition of HIV1 gp120-induced cell-cell fusion between HIV1 NL4-3 enve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50327300(CHEMBL1256528)
Affinity DataEC50:  4.40nMAssay Description:Displacement of [125I]-SDF-1-alpha from CXCR4 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50327301(CHEMBL1256529)
Affinity DataEC50:  19nMAssay Description:Displacement of [125I]-SDF-1-alpha from CXCR4 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50327302(CHEMBL1256583 | CHEMBL1256530)
Affinity DataEC50:  7.10nMAssay Description:Displacement of [125I]-SDF-1-alpha from CXCR4 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50102031(Derivative of T140 peptide | CHEMBL2372986)
Affinity DataEC50:  68nMAssay Description:Effective concentration for 50% protection of HIV-induced cytopathogenicity in MT-4 cells on the MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50102034(Derivative of T140 peptide | CHEMBL2372995)
Affinity DataEC50:  6.80nMAssay Description:Effective concentration for 50% protection of HIV-induced cytopathogenicity in MT-4 cells on the MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50145605(Dideoxycytidine | CHEMBL853 | 4-amino-1-[(2R,5S)-5...)
Affinity DataEC50:  88nMAssay Description:Effective concentration for 50% protection of HIV-induced cytopathogenicity in MT-4 cells on the MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50102038(Derivative of T140 peptide | CHEMBL2372996)
Affinity DataEC50:  8.90nMAssay Description:Effective concentration for 50% protection of HIV-induced cytopathogenicity in MT-4 cells on the MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50102039(Derivative of T140 peptide | CHEMBL2372998)
Affinity DataEC50:  72nMAssay Description:Effective concentration for 50% protection of HIV-induced cytopathogenicity in MT-4 cells on the MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50102042(Derivative of T140 peptide | CHEMBL2373000)
Affinity DataEC50:  37nMAssay Description:Effective concentration for 50% protection of HIV-induced cytopathogenicity in MT-4 cells on the MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
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