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Report error Found 546 Enz. Inhib. hit(s) with Target = 'Caspase-9'
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM10323((S)-1-Benzyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]s...)
Affinity DataKi:  120nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM10315((S)-5-{1-[2-(Anilinomethyl)pyrrolidinyl]sulfonyl}i...)
Affinity DataKi:  850nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Affinity DataKi:  1.10E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM10318((S)-5-{1-[2-(Phenoxymethyl)pyrrolidinyl]sulfonyl}i...)
Affinity DataKi:  1.20E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM10298(1-benzyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione |...)
Affinity DataKi:  5.00E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM10297(1-methyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione |...)
Affinity DataKi:  7.20E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM10309(5-(pyrrolidine-1-sulfonyl)-2,3-dihydro-1H-indole-2...)
Affinity DataKi:  1.20E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM10316((R)-5-{1-[2-(Anilinomethyl)pyrrolidinyl]sulfonyl}i...)
Affinity DataKi: >5.00E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM50140543(3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylam...)
Affinity DataIC50:  5nMAssay Description:Compound was evaluated for its inhibitory activity against the Caspase-9 enzymeMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM50223100(2-(2-((S)-2-(benzyloxycarbonyl)-3-methylbutanamido...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human caspase 9More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM50153668(3-[(S)-2-(2,4-Dichloro-benzyloxycarbonylamino)-3-m...)
Affinity DataIC50:  9nMAssay Description:Inhibition concentration required against caspase-9More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM34671(1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-...)
Affinity DataIC50:  25.6nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM50161452(5-Fluoro-3-((S)-3-methyl-2-phenylcarbamoyloxy-buty...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration against Caspase-9More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM572145(US11447497, Example 2)
Affinity DataIC50:  38nMAssay Description:Caspase-1 was diluted to 10 U/μl in assay buffer consisting of 50 mM HEPES, pH 7.4, 100 mM NaCl, 0.1% CHAPS, 1 mM EDTA, 10% glycerol and 10 mM D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM43224(1-ethyl-6-methyl-3-[(E)-2-phenylethenyl]pyrimido[5...)
Affinity DataIC50:  51.9nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM572147(US11447497, Example 4)
Affinity DataIC50:  107nMAssay Description:Caspase-1 was diluted to 10 U/μl in assay buffer consisting of 50 mM HEPES, pH 7.4, 100 mM NaCl, 0.1% CHAPS, 1 mM EDTA, 10% glycerol and 10 mM D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM572144(US11447497, Example 1)
Affinity DataIC50:  122nMAssay Description:Caspase-1 was diluted to 10 U/μl in assay buffer consisting of 50 mM HEPES, pH 7.4, 100 mM NaCl, 0.1% CHAPS, 1 mM EDTA, 10% glycerol and 10 mM D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM51771(1,6-dimethyl-3-(2-pyridinyl)pyrimido[5,4-e][1,2,4]...)
Affinity DataIC50:  145nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM50145622((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-ylamino)-ac...)
Affinity DataIC50:  160nMAssay Description:Binding affinity of the compound towards human Caspase-9More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM32061(1,8-bis(azanyl)-3,6-dipyrrolidin-1-yl-2,7-naphthyr...)
Affinity DataIC50:  209nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM50145661((S)-3-{(S)-4-Methyl-2-[(naphthalen-1-ylaminooxalyl...)
Affinity DataIC50:  230nMAssay Description:Binding affinity of the compound towards human Caspase-9More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM71274(6-(3-acetylphenyl)-3-anilino-2H-isoquinolin-1-one ...)
Affinity DataIC50:  289nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM50233673((+)-2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic ac...)
Affinity DataIC50:  300nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM160798(US10167313, Compound 65 | US9045524, 65)
Affinity DataIC50:  300nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM160798(US10167313, Compound 65 | US9045524, 65)
Affinity DataIC50:  300nMT: 37°CAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM83913(4-Chloro-3-nitro-benzoic acid N'-(3-1,2,3,4-te...)
Affinity DataIC50:  342nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM83973(CYANOCOBALAMIN | Cobalamin | MLS002153809 | RUVITE...)
Affinity DataIC50:  437nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM160792(US10167313, Compound 59 | US9045524, 59)
Affinity DataIC50:  500nMT: 37°CAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM160792(US10167313, Compound 59 | US9045524, 59)
Affinity DataIC50:  500nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM160781(US10167313, Compound 48 | US9045524, 48)
Affinity DataIC50:  500nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM41038((NE)-N-[3-(2-methylanilino)-4-oxo-1-naphthalenylid...)
Affinity DataIC50:  548nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM50099737(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Affinity DataIC50:  643nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM40313(3-phenyl-9,10-phenanthrenedione | 3-phenylphenanth...)
Affinity DataIC50:  685nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM41816((NE)-N-[3-(2,4-dimethylanilino)-4-keto-1-naphthyli...)
Affinity DataIC50:  689nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM83912(4-Nitro-benzoic acid N'-(3-1,2,3,4-tetrahydro-...)
Affinity DataIC50:  728nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM50240374(3-(4-biphenylylcarbonyl)propionic acid | 3-(4-phen...)
Affinity DataIC50:  760nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM50426562(CHEMBL2324339)
Affinity DataIC50:  800nMAssay Description:Inhibition of caspase-9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM85511(CAS_74103-07-4 | KETOROLAC | Ketorolac tris salt |...)
Affinity DataIC50:  850nMpH: 7.4Assay Description:Experiments were performed in a 384-well format (Greiner no. 781207) as per the conditions noted here. Caspase-1: 2.5 nM enzyme, 6.5 mM WEHD substrat...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM70782((NZ)-N-[4-keto-3-(p-toluidino)-1-naphthylidene]thi...)
Affinity DataIC50:  869nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM22857(1,2-Dione-Based Compound, 14 | 9,10-dihydrophenant...)
Affinity DataIC50:  903nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM71432((NE)-N-[3-(4-hydroxyanilino)-4-keto-1-naphthyliden...)
Affinity DataIC50:  937nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM50426566(CHEMBL2324341)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of caspase-9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM572146(US11447497, Example 3)
Affinity DataIC50:  1.00E+3nMAssay Description:Caspase-1 was diluted to 10 U/μl in assay buffer consisting of 50 mM HEPES, pH 7.4, 100 mM NaCl, 0.1% CHAPS, 1 mM EDTA, 10% glycerol and 10 mM D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM71268(6-bromanyl-3-[(2-methoxyphenyl)amino]-2H-isoquinol...)
Affinity DataIC50:  1.07E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM50426563(CHEMBL2323967)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of caspase-9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM65983(6-methyl-3-(4-pyridinyl)[1,2,4]triazolo[3,4-a]phth...)
Affinity DataIC50:  1.11E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM34768(6-N-[(4-methoxyphenyl)methylideneamino]-2-N,2-N,4-...)
Affinity DataIC50:  1.16E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM160781(US10167313, Compound 48 | US9045524, 48)
Affinity DataIC50:  1.20E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM160781(US10167313, Compound 48 | US9045524, 48)
Affinity DataIC50:  1.20E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCaspase-9(Human)
Glaxosmithkline

LigandPNGBDBM160781(US10167313, Compound 48 | US9045524, 48)
Affinity DataIC50:  1.20E+3nMT: 37°CAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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