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Report error Found 765 Enz. Inhib. hit(s) with Target = 'Chymase'
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520051(CHEMBL4592765)
Affinity DataKi:  0.220nMAssay Description:Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50098853(2-(2-{2-[5-Amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyr...)
Affinity DataKi:  1.12nMAssay Description:Inhibitory activity against canine skin chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50068901(3-[2,2-Difluoro-4-({(S)-1-[(S)-3-methyl-2-(3-pheny...)
Affinity DataKi:  1.30nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520048(CHEMBL4450993)
Affinity DataKi:  1.70nMAssay Description:Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520049(CHEMBL4560112)
Affinity DataKi:  1.80nMAssay Description:Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520060(CHEMBL4465306)
Affinity DataKi:  2.20nMAssay Description:Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50208224(2-(3-((1-(2-naphthoyl)piperidin-4-yl)(methyl)carba...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50139758((2-Naphthalen-2-yl-1-naphthalen-1-yl-2-oxo-ethyl)-...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of chymase in human mast cells using Suc-Ala-Ala-Pro-Phe-(p-nitroanilide) as substrate for 15 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50098874(4-{2-[5-Amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimid...)
Affinity DataKi:  2.62nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50068918((S)-4-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-p...)
Affinity DataKi:  3nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50068899(3-(4-{[(S)-1-((S)-2-Benzoylamino-3-methyl-butyryl)...)
Affinity DataKi:  3.10nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50098868(4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-a...)
Affinity DataKi:  3.56nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50098847(2-(2-{2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyri...)
Affinity DataKi:  3.68nMAssay Description:Inhibitory activity against canine skin chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50068919(3-(4-{[(S)-1-(2-tert-Butoxycarbonylamino-4-carboxy...)
Affinity DataKi:  3.90nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50374400(CHEMBL402185)
Affinity DataKi:  4.80nMAssay Description:Inhibition of human chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50098853(2-(2-{2-[5-Amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyr...)
Affinity DataKi:  4.85nMAssay Description:Inhibitory activity evaluated against chymase from human heart.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50098854(2-{2-[2-(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)...)
Affinity DataKi:  5.57nMAssay Description:Inhibitory activity evaluated against chymase from human heart.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50068911(3-(4-{[(S)-1-(2-tert-Butoxycarbonylamino-3-methyl-...)
Affinity DataKi:  5.60nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50374284(CHEMBL256270)
Affinity DataKi:  5.60nMAssay Description:Inhibition of human chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50068894(3-(4-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-met...)
Affinity DataKi:  5.60nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50098841(2-(2-{2-[5-Amino-2-(3-amino-phenyl)-6-oxo-6H-pyrim...)
Affinity DataKi:  5.60nMAssay Description:Inhibitory activity evaluated against chymase from human heart.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50068894(3-(4-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-met...)
Affinity DataKi:  5.60nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520063(CHEMBL4586444)
Affinity DataKi:  5.70nMAssay Description:Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50068917(5-(4-{[(S)-1-(2-tert-Butoxycarbonylamino-4-carboxy...)
Affinity DataKi:  6nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50068889(3-(4-{[(S)-1-((S)-2-Benzenesulfonylamino-3-methyl-...)
Affinity DataKi:  6.30nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50068896((4-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-methy...)
Affinity DataKi:  6.5nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520050(CHEMBL4457132)
Affinity DataKi:  6.60nMAssay Description:Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50068915(5-{(S)-2-[1-Benzyl-3-(3-carboxymethyl-phenylcarbam...)
Affinity DataKi:  6.70nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50068887(4-(4-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-met...)
Affinity DataKi:  6.80nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50068892(3-(4-{[(S)-1-((S)-2-Acetylamino-3-methyl-butyryl)-...)
Affinity DataKi:  7.10nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520064(CHEMBL4590739)
Affinity DataKi:  7.5nMAssay Description:Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymase(Rat)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50266989(CHEMBL4081142)
Affinity DataKi:  7.70nMAssay Description:Inhibition of rat mast cell chymase using Suc-AAPF-pNA as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50098892(4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-a...)
Affinity DataKi:  7.71nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50098879(4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-a...)
Affinity DataKi:  9.32nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50098880(3-{4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl...)
Affinity DataKi:  9.70nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520066(CHEMBL4442550)
Affinity DataKi:  10nMAssay Description:Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50098870(CHEMBL26182 | {4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-py...)
Affinity DataKi:  10.2nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50098878(4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-a...)
Affinity DataKi:  10.2nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520059(CHEMBL4561218)
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50208222((E)-2-(3-chloro-5-fluorostyrylamino)-1-(5-chlorobe...)
Affinity DataKi:  11nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50098875(4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-a...)
Affinity DataKi:  12nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50068905((4-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-methy...)
Affinity DataKi:  13nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50068903((4-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-methy...)
Affinity DataKi:  13nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM87059(CHEMBL247767 | Chymostatin)
Affinity DataKi:  13.1nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM87059(CHEMBL247767 | Chymostatin)
Affinity DataKi:  13.1nMAssay Description:inhibitory activity was evaluated against chymase from human heart.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50098882(4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-a...)
Affinity DataKi:  13.3nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50098877(4-{2-[5-Amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyrimi...)
Affinity DataKi:  13.8nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50068912(3-(4-{[(S)-1-(2-tert-Butoxycarbonylamino-4-carboxy...)
Affinity DataKi:  14nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50098849(2-(2-{2-[5-Amino-2-(3-fluoro-phenyl)-6-oxo-6H-pyri...)
Affinity DataKi:  14.3nMAssay Description:Inhibitory activity evaluated against chymase from human heart.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50098876(4-{2-[5-Amino-2-(3-fluoro-phenyl)-6-oxo-6H-pyrimid...)
Affinity DataKi:  15.7nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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