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Report error Found 181 Enz. Inhib. hit(s) with Target = 'Chymotrypsinogen B'
TargetChymotrypsinogen B2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520048(CHEMBL4450993)
Affinity DataKi:  0.420nMAssay Description:Inhibition of human chymotrypsin using Suc-AAPF-MCA as substrate at pH 8 and 298 K measured every 60 secs for 600 secsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520063(CHEMBL4586444)
Affinity DataKi:  0.880nMAssay Description:Inhibition of human chymotrypsin using Suc-AAPF-MCA as substrate at pH 8 and 298 K measured every 60 secs for 600 secsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520058(CHEMBL4469390)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human chymotrypsin using Suc-AAPF-MCA as substrate at pH 8 and 298 K measured every 60 secs for 600 secsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50024092(6-Iodomethylene-4-phenyl-tetrahydro-pyran-2-one | ...)
Affinity DataKi:  5.30nMAssay Description:Binding constant of the compound alpha-chymotrypsin was determined by competitive inhibition assay with BTEE as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520064(CHEMBL4590739)
Affinity DataKi:  11nMAssay Description:Inhibition of human chymotrypsin using Suc-AAPF-MCA as substrate at pH 8 and 298 K measured every 60 secs for 600 secsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50014743(CHEMBL132171 | N-(1-{2-[2-(1-Benzyl-3,3,3-trifluor...)
Affinity DataKi:  17nMAssay Description:Binding affinity against alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50541586(CHEMBL4638245)
Affinity DataKi:  20nMAssay Description:Inhibition of human chymotrypsin by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM247411(US10336754, Example 353 | US11053247, Example 353 ...)
Affinity DataKi:  35nMAssay Description:Binding affinity to human chymotrypsin assessed as inhibition constant using 3-Carbomethoxypropionyl-L-arginyl-Lprolyl-L-tyrosine p-Nitroaniline as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50014731(3-[(1-{2-[2-(3-Methoxycarbonyl-propionylamino)-pro...)
Affinity DataKi:  79nMAssay Description:Binding affinity against alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520051(CHEMBL4592765)
Affinity DataKi:  150nMAssay Description:Inhibition of human chymotrypsin using Suc-AAPF-MCA as substrate at pH 8 and 298 K measured every 60 secs for 600 secsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50025866(CHEMBL60695 | N-[1R-(2-phenyl ethyl)]benzamide dif...)
Affinity DataKi:  270nMAssay Description:Competetive inhibition of alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50025877(CHEMBL58683 | N-[1R-(2-phenyl ethyl)]propanamide d...)
Affinity DataKi:  290nMAssay Description:Competetive inhibition of alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Affinity DataKi:  320nMAssay Description:Inhibitory activity against human ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50025875(2-Amino-N-[1R-(2-phenyl ethyl)]propanamide boronic...)
Affinity DataKi:  320nMAssay Description:Competetive inhibition of alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520049(CHEMBL4560112)
Affinity DataKi:  330nMAssay Description:Inhibition of human chymotrypsin using Suc-AAPF-MCA as substrate at pH 8 and 298 K measured every 60 secs for 600 secsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50025872(CHEMBL293513 | N-[1R-(2-phenyl ethyl)]benzamide bo...)
Affinity DataKi:  360nMAssay Description:Competetive inhibition of alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM521743(US11149067, Compound Ahp2)
Affinity DataKi:  370nMAssay Description:In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetChymotrypsinogen B2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50502655(CHEMBL4560512)
Affinity DataKi:  463nMAssay Description:Inhibition of human chymotrypsin using Suc-AAPF-MCA as substrate by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50025870(CHEMBL57262 | N-(2-phenyl ethyl)benzamide difluoro...)
Affinity DataKi:  650nMAssay Description:Competetive inhibition of alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50025860(CHEMBL292664 | N-(2-phenyl ethyl)benzamide boronic...)
Affinity DataKi:  650nMAssay Description:Competetive inhibition of alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520061(CHEMBL4556207)
Affinity DataKi:  920nMAssay Description:Inhibition of human chymotrypsin using Suc-AAPF-MCA as substrate at pH 8 and 298 K measured every 60 secs for 600 secsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50025868(2-Amino-N-(2-phenyl ethyl)propanamide difluorobora...)
Affinity DataKi:  1.40E+3nMAssay Description:Competetive inhibition of alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520060(CHEMBL4465306)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of human chymotrypsin using Suc-AAPF-MCA as substrate at pH 8 and 298 K measured every 60 secs for 600 secsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50025865(CHEMBL292593 | N-[1R-(2-phenyl ethyl)]acetamide di...)
Affinity DataKi:  1.70E+3nMAssay Description:Competetive inhibition of alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50025874(2-Amino-N-benzylpropanamide difluoroborane | CHEMB...)
Affinity DataKi:  2.00E+3nMAssay Description:Competetive inhibition of alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM521750(US11149067, Compound Ahp9)
Affinity DataKi:  2.10E+3nMAssay Description:In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50025862(CHEMBL58706 | N-[1R-(2-phenyl ethyl)]acetamide bor...)
Affinity DataKi:  2.10E+3nMAssay Description:Competetive inhibition of alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50284625((3R,4S)-3-Benzyl-4-bromomethyl-oxetan-2-one | CHEM...)
Affinity DataKi:  2.55E+3nMAssay Description:Inhibition of Alpha-chymotrypsin was determined by competitive substrate assay methodMore data for this Ligand-Target Pair
In DepthDetails Article
TargetChymotrypsinogen B2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50520050(CHEMBL4457132)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of human chymotrypsin using Suc-AAPF-MCA as substrate at pH 8 and 298 K measured every 60 secs for 600 secsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50133629(2,3-Dioxo-2,3-dihydro-indole-1-carboxylic acid ben...)
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition constant against alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50025861(CHEMBL56829 | N-benzylbenzamide difluoroborane)
Affinity DataKi:  5.00E+3nMAssay Description:Competetive inhibition of alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50025863(2-Amino-N-[(1R)-benzyl]propanamide difluoroborane ...)
Affinity DataKi:  6.50E+3nMAssay Description:Competetive inhibition of alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50025859(CHEMBL61146 | N-(2-phenyl ethyl)acetamide boronic ...)
Affinity DataKi:  6.50E+3nMAssay Description:Competetive inhibition of alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50025871(CHEMBL430767 | N-(2-phenyl ethyl)acetamide difluor...)
Affinity DataKi:  7.40E+3nMAssay Description:Competetive inhibition of alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi:  9.42E+3nMAssay Description:Binding affinity to chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50504368(CHEMBL4435573)
Affinity DataKi:  1.24E+4nMAssay Description:Inhibition of human chymotrypsin using S-2586 as substrate incubated for 15 mins followed by substrate addition and measured after 1 hr by chromogeni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50504369(CHEMBL4439549)
Affinity DataKi:  1.63E+4nMAssay Description:Inhibition of human chymotrypsin using S-2586 as substrate incubated for 15 mins followed by substrate addition and measured after 1 hr by chromogeni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM12657(1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2-(methylsul...)
Affinity DataKi: >1.70E+4nMAssay Description:Tested in vitro for inhibition of human ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM12657(1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2-(methylsul...)
Affinity DataKi: >1.70E+4nMAssay Description:In vitro activity against human Chymotrypsinogen B1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50126635(3-[3-({[(Z)-amino(imino)methyl]amino}oxy)ethoxy]-5...)
Affinity DataKi: >2.20E+4nMAssay Description:In vitro inhibitory activity of the compound was tested against serine protease ChymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50287589((S)-3-Acetylamino-2,2-difluoro-4-phenyl-butyric ac...)
Affinity DataKi:  3.40E+4nMpH: 7.8Assay Description:Reversible inhibitory activity of the compound toward alpha-chymotrypsin (5 nM concentration) at a pH of 7.8 by progress curve method.More data for this Ligand-Target Pair
In DepthDetails Article
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50152753((S)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[(pyrazi...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity towards human ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity towards human ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM521748(US11149067, Compound Ahp7)
Affinity DataKi: >5.00E+4nMAssay Description:In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM521749(US11149067, Compound Ahp8)
Affinity DataKi: >5.00E+4nMAssay Description:In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM521746(US11149067, Compound Ahp5)
Affinity DataKi: >5.00E+4nMAssay Description:In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM521745(US11149067, Compound Ahp4)
Affinity DataKi: >5.00E+4nMAssay Description:In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM521744(US11149067, Compound Ahp3)
Affinity DataKi: >5.00E+4nMAssay Description:In general, proteolytic activity was tested by monitoring the cleavage of the specific chromogenic substrate at 405 nm wavelength for 60 or 120 minut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50152754(2-((S)-2-{(S)-2-Cyclohexyl-2-[(pyrazine-2-carbonyl...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity towards human ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50152751(2-((S)-2-{(S)-2-Cyclohexyl-2-[((R)-pyrazine-2-carb...)
Affinity DataKi: >5.00E+4nMAssay Description:Binding affinity towards human ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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