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Report error Found 546 Enz. Inhib. hit(s) with Target = 'Cytochrome P450 2B6'
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50437753(CHEMBL2409564)
Affinity DataEC50: >1.00E+5nMAssay Description:Induction of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50088447(CHEBI:223316 | (+)-Artemisinin)
Affinity DataEC50:  600nMAssay Description:Induction of CYP2B6 in human hepatocytes after 72 hrs relative to vehicle-treated controlMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50249403(CHEMBL4091821)
Affinity DataEC50: >5.00E+4nMAssay Description:Induction of CYP2B6 in cryopreserved human hepatocytes measured after 48 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  4.10E+3nMAssay Description:Induction of CYP2B6 activity in human donor hepatocytes assessed as hydroxybupropion formation after 48 hrs by LC/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50003659(5H-dibenzo[b,f]azepine-5-carboxamide | TEGRETOL | ...)
Affinity DataEC50:  1.45E+5nMAssay Description:Induction of CYP2B6 activity in human donor hepatocytes assessed as hydroxybupropion formation after 48 hrs by LC/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50370232(BA-41166E | L-5103 | Rifadin | Rifampicin | RIFAMP...)
Affinity DataEC50:  1.30E+3nMAssay Description:Induction of CYP2B6 activity in human donor hepatocytes assessed as hydroxybupropion formation after 48 hrs by LC/MS methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50575174(Mavacamten)
Affinity DataEC50:  5.10E+3nMAssay Description:Induction of CYP2B6 in human hepatocytes assessed as mRNA expression incubated for 3 days by RT-RTPCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50577263(CHEMBL4850236)
Affinity DataEC50:  1.90E+3nMAssay Description:Induction of CYP2B6 in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM372346(US10245275, Example 2b | Method A: (R)-4-((1R,3aS,...)
Affinity DataEC50: >5.00E+3nMAssay Description:Induction of CYP2B6 in human hepatocyteMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50451549(CHEMBL4207737)
Affinity DataEC50: >5.00E+4nMAssay Description:Activation of CYP2B6 in human hepatocyte using bupropion as substrate preincubated for 5 days followed by substrate addition and measured after 1 hr ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50123453(CHEMBL3623290)
Affinity DataIC50: 50nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366395(CHEMBL4175869)
Affinity DataIC50: 60nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366411(CHEMBL4160749)
Affinity DataIC50: 62nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366399(CHEMBL4168669)
Affinity DataIC50: 73nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366379(CHEMBL4165249)
Affinity DataIC50: 87nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366426(CHEMBL4161819)
Affinity DataIC50: 93nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366435(CHEMBL4161400)
Affinity DataIC50: 120nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366394(CHEMBL4159065)
Affinity DataIC50: 180nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM85509(NSC_5472 | CAS_55142-85-3 | Ticlopidine)
Affinity DataIC50: 210nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate incubated for 5 to 45 mins in presence of NADPH by LC/MS analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366407(CHEMBL4169324)
Affinity DataIC50: 230nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366401(CHEMBL4169721)
Affinity DataIC50: 370nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM85509(NSC_5472 | CAS_55142-85-3 | Ticlopidine)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human CYP2B6 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50614709(CHEMBL5273615)
Affinity DataIC50: 780nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 790nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as 8-hydroxyefavirenz 14-hydroxylation after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366393(CHEMBL4176100)
Affinity DataIC50: 850nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50380508(CHEMBL2018923)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as bupropion 4-hydroxylation after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366403(CHEMBL4164142)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366334(CHEMBL4173133)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as efavirenz 8-hydroxylation after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using 8-hydroxyefavirenz as probe after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM520(ABT-538 | Norvir | CHEMBL163 | 1,3-thiazol-5-ylmet...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human CYP2B6 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50380510(CHEMBL2018925)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM668001(US20240124434, Compound S5-A)
Affinity DataIC50: 2.49E+3nMAssay Description:CYP inhibition by test compounds in human liver microsomes (HLM) for seven major CYP450 isoforms CYP1A2, CYP2C9, CYP2D6, CYP2B6, CYP2C8, CYP2C19 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50265079(CHEMBL496942 | 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLP...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of CYP2B6 (unknown origin) using bupropion substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50234041(US9765018, Example 116 | CHEMBL4060679)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50234040(US9765018, Example 114 | CHEMBL4060089)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50234039(US9765018, Example 115 | CHEMBL4082553)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366398(CHEMBL4164113)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50594408(CHEMBL5195440)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366406(CHEMBL4174365)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366414(CHEMBL4172017)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50380505(CHEMBL2018919)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50333117((2R,3S)-2,3-bis(2,4-difluorophenyl)-1-(1H-1,2,4-tr...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as probe after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM12351(US8609708, 4 | CHEMBL179669 | 3-(3-methylthiophen-...)
Affinity DataIC50: 3.90E+3nMpH: 7.5Assay Description:To gain insight into the selectivity of the synthetic compounds for inhibition of other CYPs, we examined the major CYPs present in human liver. Prio...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM12351(US8609708, 4 | CHEMBL179669 | 3-(3-methylthiophen-...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibitory concentration value against human cytochrome P-450 2B6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366404(CHEMBL4162449)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50432670(CHEMBL2347914)
Affinity DataIC50: 4.08E+3nMAssay Description:Inhibition of CYP2B1 (unknown origin)-mediated depentylation of resorufin pentyl ether after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50366400(CHEMBL4171984)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM668002(US20240124434, Compound S6-A)
Affinity DataIC50: 4.18E+3nMAssay Description:CYP inhibition by test compounds in human liver microsomes (HLM) for seven major CYP450 isoforms CYP1A2, CYP2C9, CYP2D6, CYP2B6, CYP2C8, CYP2C19 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

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