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Report error Found 167 Enz. Inhib. hit(s) with Target = 'DNA polymerase alpha catalytic subunit'
LigandPNGBDBM50225280(CHEMBL3144215)
Affinity DataKi:  1nMAssay Description:Compound was tested for its inhibitory activity against HeLa DNA polymerase alpha, Ki values were obtained in the absence of dGTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50293303(CHEMBL498103 | gallic acid 5,6-dihydroxy-3-carboxy...)
Affinity DataKi:  830nMAssay Description:Inhibition of DNA polymerase alpha from human KB3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50025592((4-Butyl-phenyl)-(6-methylsulfanyl-9H-purin-2-yl)-...)
Affinity DataKi:  1.00E+3nMAssay Description:Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50025600((4-Butyl-phenyl)-(6-methoxy-9H-purin-2-yl)-amine |...)
Affinity DataKi:  1.40E+3nMAssay Description:Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50025598((4-Butyl-phenyl)-(6-chloro-9H-purin-2-yl)-amine | ...)
Affinity DataKi:  2.60E+3nMAssay Description:Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153106(CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...)
Affinity DataKi:  3.75E+3nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50025597((4-Butyl-phenyl)-(9H-purin-2-yl)-amine | CHEMBL278...)
Affinity DataKi:  5.00E+3nMAssay Description:Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50013074(2-(4-Butyl-phenylamino)-1,9-dihydro-purin-6-one | ...)
Affinity DataKi:  7.50E+3nMAssay Description:Compound was tested for its inhibitory activity against HeLa DNA polymerase alpha, Ki values were obtained in the absence of dGTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153111(CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...)
Affinity DataKi:  7.84E+3nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153113(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)
Affinity DataKi:  1.12E+4nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50013074(2-(4-Butyl-phenylamino)-1,9-dihydro-purin-6-one | ...)
Affinity DataKi:  1.20E+4nMAssay Description:Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153111(CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...)
Affinity DataKi:  1.38E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50025593(CHEMBL16122 | N*2*-(4-Butyl-phenyl)-9H-purine-2,6-...)
Affinity DataKi:  1.44E+4nMAssay Description:Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153106(CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...)
Affinity DataKi:  1.85E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50405103(CHEMBL2115349)
Affinity DataKi:  2.20E+4nMAssay Description:Compound was tested for its inhibitory activity against HeLa DNA polymerase alpha, Ki values were obtained in the absence of dGTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153113(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)
Affinity DataKi:  2.79E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50025595(2-(4-Butyl-phenylamino)-1,9-dihydro-purine-6-thion...)
Affinity DataKi:  3.60E+4nMAssay Description:Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50405103(CHEMBL2115349)
Affinity DataKi:  3.70E+4nMAssay Description:Compound was tested for its inhibitory activity against HeLa DNA polymerase alpha, Ki values were obtained in the absence of dGTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50405103(CHEMBL2115349)
Affinity DataKi:  3.70E+4nMAssay Description:Compound was tested for its inhibitory activity against HeLa DNA polymerase alpha, Ki values were obtained in the absence of dGTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50013075(2-(Indan-5-ylamino)-1,9-dihydro-purin-6-one | CHEM...)
Affinity DataKi:  4.40E+4nMAssay Description:Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118823(2,2-Dimethyl-propionic acid [5-(7-amino-[1,2,3]tri...)
Affinity DataKi:  1.56E+5nMAssay Description:Ability to inhibit the incorporation of dATP into DNA by DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50118822(2,2-Dimethyl-propionic acid [5-(6-amino-8-bromo-pu...)
Affinity DataKi:  5.48E+5nMAssay Description:Ability to inhibit the incorporation of dATP into DNA by DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50013093(2-(3-Ethyl-4-methyl-phenylamino)-1,9-dihydro-purin...)
Affinity DataKi:  1.76E+6nMAssay Description:Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50408427(CHEMBL483492)
Affinity DataIC50:  15nMAssay Description:Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50408426(CHEMBL2092833)
Affinity DataIC50:  480nMAssay Description:Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50443277(CHEMBL5281189)
Affinity DataIC50:  680nMAssay Description:Inhibition of DNA polymerase alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50205415(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50205415(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184755((3aS,4S,7R,7aR)-1,6-dihexadecyl-2,7-bis(methoxycar...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184758((3aS,4S,7R,7aR)-1,6-didodecyl-2,7-bis(methoxycarbo...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184757((3aR,4R,7S,7aS)-7-ethyl 2,4-dimethyl 3,5-dihexadec...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human DNA polymerase alpha using 5' end radiolabeled 24nt DNA/48nt DNA as primer/template after 5 mins by PAGE analysisMore data for this Ligand-Target Pair
LigandPNGBDBM50335554(({[({[2-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)e...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human DNA polymerase alpha by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)
Affinity DataIC50:  2.60E+3nMpH: 7.5Assay Description:Inhibition of human alpha DNA polymerase (95 uL) activity in a solution containg 6.4 mM HEPES (pH 7.5) upon incubation for 12 minutes at 26 degrees C...More data for this Ligand-Target Pair
LigandPNGBDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human DNA polymerase alphaMore data for this Ligand-Target Pair
LigandPNGBDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)
Affinity DataIC50:  3.00E+3nMAssay Description:Compound was evaluated for the inhibitory activity against Human alpha polymeraseMore data for this Ligand-Target Pair
LigandPNGBDBM23926((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human DNA polymerase-alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184752((3aS,4S,7R,7aR)-1,6-dihexadecyl-2,7-bis(isopropoxy...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184756((3aR,4S,7S,7aS)-7-ethyl 2,4-dimethyl 3,5-dihexadec...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184754((E)-methyl-3,6-dioxo-4-docosenoate | CHEMBL425779)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human DNA polymerase alpha using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP...More data for this Ligand-Target Pair
LigandPNGBDBM50143526(CHEMBL366792 | Untenone A)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human DNA polymerase alpha using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP...More data for this Ligand-Target Pair
LigandPNGBDBM50313783(CHEMBL1092799 | N-(4-chlorobenzyl)-1-methyl-9-(mor...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human recombinant DNA polymerase alpha expressed in baculovirus infected SF9 cells after 12 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50313784((R)-9-(((2-(benzofuran-2-yl)-2-hydroxyethyl)(methy...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human recombinant DNA polymerase alpha expressed in baculovirus infected SF9 cells after 12 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184761((3aR,4R,7S,7aS)-dimethyl 3,5-dihexadecyl-1-oxo-7-(...)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184750((2R,3S,4R)-4-hydroxy-5-[2-oxo-nonadec-ylidene]-1-p...)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153113(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibitory concentration against human DNA polymerase alpha incubated with 0.05 unitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184748((2S,3S,4R)-methyl 2-ethyl-4-hydroxy-5-(2-oxononade...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50181922(2-(4-(bis(3-fluorophenyl)methoxy)phenyl)-1-cyclohe...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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