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Report error Found 4476 Enz. Inhib. hit(s) with Target = 'Dihydroorotate dehydrogenase (quinone), mitochondrial'
LigandPNGBDBM50284844(2-Biphenyl-4-yl-3-methyl-quinoline-4-carboxylic ac...)
Affinity DataKi:  1.70nMAssay Description:Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver.More data for this Ligand-Target Pair
In DepthDetails
Article
LigandPNGBDBM29034(cyanohydroxybutenamide, 24)
Affinity DataKi:  2.70nM IC50:  22nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50526855(CHEMBL4580266 | US20240199535, Example 4)
Affinity DataKi:  3.70nMAssay Description:The in vitro inhibition of hDHODH was measured using an N-terminally truncated recombinant hDHODH enzyme as described in J. Med. Chem. 2006; 49:1239....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM50119488(CHEMBL143628 | X1-(4-Chloro-phenyl)-1H-pyrazole-3,...)
Affinity DataKi:  4nMAssay Description:Inhibition of dihydroorotate dehydrogenase (DHODase) of Helicobacter pyloriMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50119489(1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic a...)
Affinity DataKi:  4nMAssay Description:Inhibition of dihydroorotate dehydrogenase (DHODase) of Helicobacter pyloriMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50070857(CHEMBL50499 | Sodium; 6-fluoro-3-methyl-2-(4-pheny...)
Affinity DataKi:  4.5nMAssay Description:Immunosuppressive effect in an isolated enzyme assay using partially purified Dihydroorotate dehydrogenase from human liver for inhibition of the for...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50119481(1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic a...)
Affinity DataKi:  6nMAssay Description:Inhibition of dihydroorotate dehydrogenase (DHODase) of Helicobacter pyloriMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM29026(CHEMBL142996 | cyanocyclopropylpropenamide, 11)
Affinity DataKi:  7nM IC50:  53nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50119483(1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic a...)
Affinity DataKi:  8nMAssay Description:Inhibition of dihydroorotate dehydrogenase (DHODase) of Helicobacter pyloriMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50284826(CHEMBL288708 | Sodium; 2-biphenyl-4-yl-6-fluoro-3-...)
Affinity DataKi:  8nMAssay Description:Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver.More data for this Ligand-Target Pair
In DepthDetails
Article
LigandPNGBDBM50069968(CHEMBL104209 | Sodium; 9-fluoro-3-phenyl-5,6-dihyd...)
Affinity DataKi:  8.30nMAssay Description:Inhibition of human recombinant dihydroorotate dehydrogenase (DHODase)More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50284843(2-Biphenyl-4-yl-3-methyl-6-trifluoromethyl-quinoli...)
Affinity DataKi:  8.40nMAssay Description:Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver.More data for this Ligand-Target Pair
In DepthDetails
Article
LigandPNGBDBM50069950(CHEMBL321060 | Sodium; 9-fluoro-3-o-tolyl-5,6-dihy...)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant dihydroorotate dehydrogenase (DHODase)More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50284834(2-Biphenyl-4-yl-3,6-dimethyl-quinoline-4-carboxyli...)
Affinity DataKi:  10nMAssay Description:Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver.More data for this Ligand-Target Pair
In DepthDetails
Article
LigandPNGBDBM50284861(2-Biphenyl-4-yl-6-fluoro-quinoline-4-carboxylic ac...)
Affinity DataKi:  10nMAssay Description:Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver.More data for this Ligand-Target Pair
In DepthDetails
Article
LigandPNGBDBM29025(cyanohydroxybutenamide, 10)
Affinity DataKi:  11nM IC50:  90nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50284867(CHEMBL43639 | Sodium; 6-fluoro-2-(2'-fluoro-4'-hyd...)
Affinity DataKi:  11nMAssay Description:Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver.More data for this Ligand-Target Pair
In DepthDetails
Article
LigandPNGBDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...)
Affinity DataKi:  12nMAssay Description:Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver.More data for this Ligand-Target Pair
In DepthDetails
ArticleMMDB
PDB3D3D Structure (crystal)
LigandPNGBDBM50069959(Brequinar sodium | CHEMBL300058 | Sodium; 6-fluoro...)
Affinity DataKi:  12nMAssay Description:Inhibition of human recombinant dihydroorotate dehydrogenase (DHODase)More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50069959(Brequinar sodium | CHEMBL300058 | Sodium; 6-fluoro...)
Affinity DataKi:  12nMAssay Description:Immunosuppressive effect in an isolated enzyme assay using partially purified Dihydroorotate dehydrogenase from human liver for inhibition of the for...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50119485(1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic ...)
Affinity DataKi:  12nMAssay Description:Inhibition of dihydroorotate dehydrogenase (DHODase) of Helicobacter pyloriMore data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50284853(2-Biphenyl-4-yl-6-fluoro-3-methoxy-quinoline-4-car...)
Affinity DataKi:  13nMAssay Description:Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver.More data for this Ligand-Target Pair
In DepthDetails
Article
LigandPNGBDBM50069939(CHEMBL106467 | Sodium; 9-fluoro-3-p-tolyl-6H-thioc...)
Affinity DataKi:  13nMAssay Description:Inhibition of human recombinant dihydroorotate dehydrogenase (DHODase)More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50284858(2-Biphenyl-4-yl-6-fluoro-3-methylsulfanyl-quinolin...)
Affinity DataKi:  13nMAssay Description:Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver.More data for this Ligand-Target Pair
In DepthDetails
Article
LigandPNGBDBM29024(CHEMBL141732 | cyanocyclopropylpropenamide, 4)
Affinity DataKi:  14nM IC50:  117nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50070838(CHEMBL51082 | Sodium; 6-fluoro-3-methyl-2-(4-pheny...)
Affinity DataKi:  15nMAssay Description:Immunosuppressive effect in an isolated enzyme assay using partially purified Dihydroorotate dehydrogenase from human liver for inhibition of the for...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM29039(cyanohydroxybutenamide, 29)
Affinity DataKi:  16nM IC50:  130nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
LigandPNGBDBM29037(cyanohydroxybutenamide, 27)
Affinity DataKi:  16nM IC50:  130nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50284838(9-Fluoro-3-phenyl-5,6-dihydro-benzo[c]acridine-7-c...)
Affinity DataKi:  17nMAssay Description:Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver.More data for this Ligand-Target Pair
In DepthDetails
Article
LigandPNGBDBM50069951(CHEMBL104302 | Sodium; 9-fluoro-3-phenyl-6H-thioch...)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant dihydroorotate dehydrogenase (DHODase)More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM14699(1,3-diethyl 2-({8-thiatricyclo[7.4.0.0^{2,7}]tride...)
Affinity DataKi:  20nM ΔG°:  -43.9kJ/mole IC50:  160nMpH: 8.0 T: 25°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM14710(ChemBridge compound no. 2 | N-(4-Bromo-2-methylphe...)
Affinity DataKi:  20nM ΔG°:  -43.9kJ/mole IC50:  180nMpH: 8.0 T: 25°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50284862(2-Biphenyl-4-yl-6-chloro-3-methyl-quinoline-4-carb...)
Affinity DataKi:  20nMAssay Description:Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver.More data for this Ligand-Target Pair
In DepthDetails
Article
LigandPNGBDBM50069943(CHEMBL106515 | Sodium; 9-fluoro-3-(2-methoxy-pheny...)
Affinity DataKi:  20nMAssay Description:Inhibition of human recombinant dihydroorotate dehydrogenase (DHODase)More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM29028(cyanohydroxybutenamide, 18)
Affinity DataKi:  21nM IC50:  170nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50070832(CHEMBL49129 | Sodium; 2-(biphenyl-3-yloxy)-6-fluor...)
Affinity DataKi:  21nMAssay Description:Immunosuppressive effect in an isolated enzyme assay using partially purified Dihydroorotate dehydrogenase from human liver for inhibition of the for...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM29027(cyanohydroxybutenamide, 17)
Affinity DataKi:  22nM IC50:  180nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50070851(CHEMBL48531 | Sodium; 6-fluoro-2-(6-methoxy-4-phen...)
Affinity DataKi:  22nMAssay Description:Immunosuppressive effect in an isolated enzyme assay using partially purified Dihydroorotate dehydrogenase from human liver for inhibition of the for...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM29035(cyanohydroxybutenamide, 25)
Affinity DataKi:  23nM IC50:  190nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50070844(CHEMBL49089 | Sodium; 6-fluoro-3-methyl-2-[1-methy...)
Affinity DataKi:  23nMAssay Description:Immunosuppressive effect in an isolated enzyme assay using partially purified Dihydroorotate dehydrogenase from human liver for inhibition of the for...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50070841(CHEMBL49697 | Sodium; 6-fluoro-2-[4-(2-fluoro-phen...)
Affinity DataKi:  24nMAssay Description:Immunosuppressive effect in an isolated enzyme assay using partially purified Dihydroorotate dehydrogenase from human liver for inhibition of the for...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50070837(CHEMBL49913 | Sodium; 6-fluoro-3-methyl-2-[4-(3-tr...)
Affinity DataKi:  24nMAssay Description:Immunosuppressive effect in an isolated enzyme assay using partially purified Dihydroorotate dehydrogenase from human liver for inhibition of the for...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50284830(CHEMBL38421 | Sodium; 6-fluoro-3-methyl-2-(4'-meth...)
Affinity DataKi:  24nMAssay Description:Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver.More data for this Ligand-Target Pair
In DepthDetails
Article
LigandPNGBDBM29029(cyanohydroxybutenamide, 19)
Affinity DataKi:  25nM IC50:  200nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMedPDB3D3D Structure (crystal)
LigandPNGBDBM29036(cyanohydroxybutenamide, 26)
Affinity DataKi:  25nM IC50:  200nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50284846(2-Biphenyl-4-yl-5-chloro-3-methyl-quinoline-4-carb...)
Affinity DataKi:  25nMAssay Description:Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver.More data for this Ligand-Target Pair
In DepthDetails
Article
LigandPNGBDBM50069958(CHEMBL104146 | Sodium; 9-fluoro-3-o-tolyl-5H-6-thi...)
Affinity DataKi:  25nMAssay Description:Inhibition of human recombinant dihydroorotate dehydrogenase (DHODase)More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50070846(CHEMBL48244 | Sodium; 6-fluoro-3-methyl-2-(4-o-tol...)
Affinity DataKi:  25nMAssay Description:Immunosuppressive effect in an isolated enzyme assay using partially purified Dihydroorotate dehydrogenase from human liver for inhibition of the for...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50069948(CHEMBL107209 | Sodium; 9-fluoro-3-(3-methoxy-pheny...)
Affinity DataKi:  25nMAssay Description:Inhibition of human recombinant dihydroorotate dehydrogenase (DHODase)More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
LigandPNGBDBM50070839(CHEMBL48928 | Sodium; 6-fluoro-3-methyl-2-(5-pheny...)
Affinity DataKi:  26nMAssay Description:Immunosuppressive effect in an isolated enzyme assay using partially purified Dihydroorotate dehydrogenase from human liver for inhibition of the for...More data for this Ligand-Target Pair
In DepthDetails
ArticlePubMed
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