Compile Data Set for Download or QSAR
Found 597 Enz. Inhib. hit(s) with Target = 'Discoidin domain-containing receptor 2'
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
Affinity DataIC50: 0.5nMAssay Description:Tet inducible human DDR1 over-expressing U2OS was pre-treated by media containing each of the compound for 1 hour and treated by changing the media t...More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50240780(CHEMBL4062877)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cc(N[C@@H](CO)c2ccccc2)cnc1-c1cc(F)ccc1O
Show InChI InChI=1S/C27H23FN4O2/c1-16-21-11-18(7-9-24(21)32-31-16)22-13-20(30-25(15-33)17-5-3-2-4-6-17)14-29-27(22)23-12-19(28)8-10-26(23)34/h2-14,25,30,33-34H,15H2,1H3,(H,31,32)/t25-/m0/s1
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant DDR2 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529769(CHEMBL4443643)
Show SMILES CC(C)c1cccc(NC(=O)c2ccc(C)c(c2)-c2ccc3cn[nH]c3c2)c1
Show InChI InChI=1S/C24H23N3O/c1-15(2)17-5-4-6-21(11-17)26-24(28)19-8-7-16(3)22(12-19)18-9-10-20-14-25-27-23(20)13-18/h4-15H,1-3H3,(H,25,27)(H,26,28)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human DDR2 using KKSRGDYMTMQIG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529769(CHEMBL4443643)
Show SMILES CC(C)c1cccc(NC(=O)c2ccc(C)c(c2)-c2ccc3cn[nH]c3c2)c1
Show InChI InChI=1S/C24H23N3O/c1-15(2)17-5-4-6-21(11-17)26-24(28)19-8-7-16(3)22(12-19)18-9-10-20-14-25-27-23(20)13-18/h4-15H,1-3H3,(H,25,27)(H,26,28)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of DDR2 (unknown origin) assessed as reduction in collagen-induced DDR2 activationMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529780(CHEMBL4448547)
Show SMILES Cc1ccc(cc1-c1ccc2cn[nH]c2c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H16F3N3O/c1-13-5-6-15(9-19(13)14-7-8-16-12-26-28-20(16)10-14)21(29)27-18-4-2-3-17(11-18)22(23,24)25/h2-12H,1H3,(H,26,28)(H,27,29)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529780(CHEMBL4448547)
Show SMILES Cc1ccc(cc1-c1ccc2cn[nH]c2c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H16F3N3O/c1-13-5-6-15(9-19(13)14-7-8-16-12-26-28-20(16)10-14)21(29)27-18-4-2-3-17(11-18)22(23,24)25/h2-12H,1H3,(H,26,28)(H,27,29)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50437147(CHEMBL2403875)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Nc3ncnc4ccccc34)c2)n(n1)-c1cccc(N)c1
Show InChI InChI=1S/C28H28N8O/c1-28(2,3)24-16-25(36(35-24)21-11-6-8-18(29)14-21)34-27(37)33-20-10-7-9-19(15-20)32-26-22-12-4-5-13-23(22)30-17-31-26/h4-17H,29H2,1-3H3,(H,30,31,32)(H2,33,34,37)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
Affinity DataIC50: 2nMAssay Description:Inhibition of DDR2 (unknown origin) after 1 hr by time resolved fluorescence methodMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529771(CHEMBL4535267)
Show SMILES CCn1cc(cn1)-c1n[nH]c2cc(ccc12)-c1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H22F3N5O/c1-3-35-15-19(14-31-35)25-22-10-9-17(12-24(22)33-34-25)23-11-18(8-7-16(23)2)26(36)32-21-6-4-5-20(13-21)27(28,29)30/h4-15H,3H2,1-2H3,(H,32,36)(H,33,34)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529766(CHEMBL4559322)
Show SMILES Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(CCN2CCOCC2)c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C31H29F3N6O2/c1-20-5-6-22(30(41)36-25-4-2-3-24(17-25)31(32,33)34)15-27(20)21-7-8-26-28(16-21)37-38-29(26)23-18-35-40(19-23)10-9-39-11-13-42-14-12-39/h2-8,15-19H,9-14H2,1H3,(H,36,41)(H,37,38)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529766(CHEMBL4559322)
Show SMILES Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(CCN2CCOCC2)c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C31H29F3N6O2/c1-20-5-6-22(30(41)36-25-4-2-3-24(17-25)31(32,33)34)15-27(20)21-7-8-26-28(16-21)37-38-29(26)23-18-35-40(19-23)10-9-39-11-13-42-14-12-39/h2-8,15-19H,9-14H2,1H3,(H,36,41)(H,37,38)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529771(CHEMBL4535267)
Show SMILES CCn1cc(cn1)-c1n[nH]c2cc(ccc12)-c1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H22F3N5O/c1-3-35-15-19(14-31-35)25-22-10-9-17(12-24(22)33-34-25)23-11-18(8-7-16(23)2)26(36)32-21-6-4-5-20(13-21)27(28,29)30/h4-15H,3H2,1-2H3,(H,32,36)(H,33,34)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50507707(CHEMBL4466555)
Show SMILES Cc1ccc(cc1NC(=O)C1(CC1)c1ncnc2[nH]cnc12)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H18ClF3N6O2/c1-12-2-3-13(21(35)33-14-4-5-16(25)15(9-14)24(26,27)28)8-17(12)34-22(36)23(6-7-23)19-18-20(31-10-29-18)32-11-30-19/h2-5,8-11H,6-7H2,1H3,(H,33,35)(H,34,36)(H,29,30,31,32)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human DDR2 using KKSRGDYMTMQIG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)
Show SMILES CN(C)Cc1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1
Show InChI InChI=1S/C29H29F3N4O3/c1-36(2)16-17-11-20(13-21(12-17)29(30,31)32)28(38)34-22-5-3-18-4-6-23(15-19(18)14-22)39-25-9-10-33-27-24(25)7-8-26(37)35-27/h4,6,9-13,15,22H,3,5,7-8,14,16H2,1-2H3,(H,34,38)(H,33,35,37)/t22-/m1/s1
Affinity DataIC50: 2.60nMAssay Description:Inhibition of DDR2More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529779(CHEMBL4525313)
Show SMILES Cc1ccc(cc1-c1ccc2cn[nH]c2c1)C(=O)Nc1cccc(c1)C(C)(C)C#N
Show InChI InChI=1S/C25H22N4O/c1-16-7-8-18(11-22(16)17-9-10-19-14-27-29-23(19)12-17)24(30)28-21-6-4-5-20(13-21)25(2,3)15-26/h4-14H,1-3H3,(H,27,29)(H,28,30)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529784(CHEMBL4460782)
Show SMILES CN(C)C(=O)Cn1cc(cn1)-c1n[nH]c2cc(ccc12)-c1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C29H25F3N6O2/c1-17-7-8-19(28(40)34-22-6-4-5-21(13-22)29(30,31)32)11-24(17)18-9-10-23-25(12-18)35-36-27(23)20-14-33-38(15-20)16-26(39)37(2)3/h4-15H,16H2,1-3H3,(H,34,40)(H,35,36)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529784(CHEMBL4460782)
Show SMILES CN(C)C(=O)Cn1cc(cn1)-c1n[nH]c2cc(ccc12)-c1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C29H25F3N6O2/c1-17-7-8-19(28(40)34-22-6-4-5-21(13-22)29(30,31)32)11-24(17)18-9-10-23-25(12-18)35-36-27(23)20-14-33-38(15-20)16-26(39)37(2)3/h4-15H,16H2,1-3H3,(H,34,40)(H,35,36)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529779(CHEMBL4525313)
Show SMILES Cc1ccc(cc1-c1ccc2cn[nH]c2c1)C(=O)Nc1cccc(c1)C(C)(C)C#N
Show InChI InChI=1S/C25H22N4O/c1-16-7-8-18(11-22(16)17-9-10-19-14-27-29-23(19)12-17)24(30)28-21-6-4-5-20(13-21)25(2,3)15-26/h4-14H,1-3H3,(H,27,29)(H,28,30)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529787(CHEMBL4572126)
Show SMILES Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(CCO)c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H22F3N5O2/c1-16-5-6-18(26(37)32-21-4-2-3-20(13-21)27(28,29)30)11-23(16)17-7-8-22-24(12-17)33-34-25(22)19-14-31-35(15-19)9-10-36/h2-8,11-15,36H,9-10H2,1H3,(H,32,37)(H,33,34)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529787(CHEMBL4572126)
Show SMILES Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(CCO)c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H22F3N5O2/c1-16-5-6-18(26(37)32-21-4-2-3-20(13-21)27(28,29)30)11-23(16)17-7-8-22-24(12-17)33-34-25(22)19-14-31-35(15-19)9-10-36/h2-8,11-15,36H,9-10H2,1H3,(H,32,37)(H,33,34)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50437152(CHEMBL2403816)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4ccccc34)cc2)n(n1)-c1cccc(N)c1
Show InChI InChI=1S/C28H28N8O/c1-28(2,3)24-16-25(36(35-24)21-8-6-7-18(29)15-21)34-27(37)33-20-13-11-19(12-14-20)32-26-22-9-4-5-10-23(22)30-17-31-26/h4-17H,29H2,1-3H3,(H,30,31,32)(H2,33,34,37)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50368552(CHEMBL4161036)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cnccn34)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C29H27F3N6O/c1-20-3-4-23(15-22(20)5-6-26-17-34-27-18-33-7-8-38(26)27)28(39)35-25-14-21(13-24(16-25)29(30,31)32)19-37-11-9-36(2)10-12-37/h3-4,7-8,13-18H,9-12,19H2,1-2H3,(H,35,39)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of DDR2 (unknown origin) incubated for 1 hr using fluorescein-poly-GAT substrate by TR-FRET based LANCE ULTRA kinase assayMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529770(CHEMBL4534119)
Show SMILES Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N5O/c1-16-5-6-18(27(37)33-21-4-2-3-20(13-21)28(29,30)31)11-24(16)17-7-10-23-25(12-17)34-35-26(23)19-14-32-36(15-19)22-8-9-22/h2-7,10-15,22H,8-9H2,1H3,(H,33,37)(H,34,35)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529770(CHEMBL4534119)
Show SMILES Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N5O/c1-16-5-6-18(27(37)33-21-4-2-3-20(13-21)28(29,30)31)11-24(16)17-7-10-23-25(12-17)34-35-26(23)19-14-32-36(15-19)22-8-9-22/h2-7,10-15,22H,8-9H2,1H3,(H,33,37)(H,34,35)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529762(CHEMBL4449358)
Show SMILES CCCn1cc(cn1)-c1n[nH]c2cc(ccc12)-c1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H24F3N5O/c1-3-11-36-16-20(15-32-36)26-23-10-9-18(13-25(23)34-35-26)24-12-19(8-7-17(24)2)27(37)33-22-6-4-5-21(14-22)28(29,30)31/h4-10,12-16H,3,11H2,1-2H3,(H,33,37)(H,34,35)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529762(CHEMBL4449358)
Show SMILES CCCn1cc(cn1)-c1n[nH]c2cc(ccc12)-c1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H24F3N5O/c1-3-11-36-16-20(15-32-36)26-23-10-9-18(13-25(23)34-35-26)24-12-19(8-7-17(24)2)27(37)33-22-6-4-5-21(14-22)28(29,30)31/h4-10,12-16H,3,11H2,1-2H3,(H,33,37)(H,34,35)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50112617(CHEMBL3608786)
Show SMILES Cc1ccc(CNC(=O)Nc2cccc(F)c2)cc1NC(=O)c1cnc2ccccn12
Show InChI InChI=1S/C23H20FN5O2/c1-15-8-9-16(13-26-23(31)27-18-6-4-5-17(24)12-18)11-19(15)28-22(30)20-14-25-21-7-2-3-10-29(20)21/h2-12,14H,13H2,1H3,(H,28,30)(H2,26,27,31)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of DDR2 (unknown origin) after 1 hr by time resolved fluorescence methodMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529788(CHEMBL4538678)
Show SMILES Cc1ccc(cc1-c1ccc2cn[nH]c2c1)C(=O)Nc1cc(CN2CCN(CCO)CC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H30F3N5O2/c1-19-2-3-22(14-26(19)21-4-5-23-17-33-35-27(23)15-21)28(39)34-25-13-20(12-24(16-25)29(30,31)32)18-37-8-6-36(7-9-37)10-11-38/h2-5,12-17,38H,6-11,18H2,1H3,(H,33,35)(H,34,39)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529788(CHEMBL4538678)
Show SMILES Cc1ccc(cc1-c1ccc2cn[nH]c2c1)C(=O)Nc1cc(CN2CCN(CCO)CC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H30F3N5O2/c1-19-2-3-22(14-26(19)21-4-5-23-17-33-35-27(23)15-21)28(39)34-25-13-20(12-24(16-25)29(30,31)32)18-37-8-6-36(7-9-37)10-11-38/h2-5,12-17,38H,6-11,18H2,1H3,(H,33,35)(H,34,39)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529786(CHEMBL4458216)
Show SMILES CC(O)Cn1cc(cn1)-c1n[nH]c2cc(ccc12)-c1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H24F3N5O2/c1-16-6-7-19(27(38)33-22-5-3-4-21(12-22)28(29,30)31)10-24(16)18-8-9-23-25(11-18)34-35-26(23)20-13-32-36(15-20)14-17(2)37/h3-13,15,17,37H,14H2,1-2H3,(H,33,38)(H,34,35)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529786(CHEMBL4458216)
Show SMILES CC(O)Cn1cc(cn1)-c1n[nH]c2cc(ccc12)-c1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H24F3N5O2/c1-16-6-7-19(27(38)33-22-5-3-4-21(12-22)28(29,30)31)10-24(16)18-8-9-23-25(11-18)34-35-26(23)20-13-32-36(15-20)14-17(2)37/h3-13,15,17,37H,14H2,1-2H3,(H,33,38)(H,34,35)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human DDR2 using KKSRGDYMTMQIG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529785(CHEMBL4437449)
Show SMILES CN1CCC(CC1)n1cc(cn1)-c1n[nH]c2cc(ccc12)-c1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C31H29F3N6O/c1-19-6-7-21(30(41)36-24-5-3-4-23(16-24)31(32,33)34)14-27(19)20-8-9-26-28(15-20)37-38-29(26)22-17-35-40(18-22)25-10-12-39(2)13-11-25/h3-9,14-18,25H,10-13H2,1-2H3,(H,36,41)(H,37,38)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529785(CHEMBL4437449)
Show SMILES CN1CCC(CC1)n1cc(cn1)-c1n[nH]c2cc(ccc12)-c1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C31H29F3N6O/c1-19-6-7-21(30(41)36-24-5-3-4-23(16-24)31(32,33)34)14-27(19)20-8-9-26-28(15-20)37-38-29(26)22-17-35-40(18-22)25-10-12-39(2)13-11-25/h3-9,14-18,25H,10-13H2,1-2H3,(H,36,41)(H,37,38)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529763(CHEMBL4521671)
Show SMILES CCN1CCN(Cc2cc(NC(=O)c3ccc(C)c(c3)-c3ccc4cn[nH]c4c3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C29H30F3N5O/c1-3-36-8-10-37(11-9-36)18-20-12-24(29(30,31)32)16-25(13-20)34-28(38)22-5-4-19(2)26(14-22)21-6-7-23-17-33-35-27(23)15-21/h4-7,12-17H,3,8-11,18H2,1-2H3,(H,33,35)(H,34,38)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529763(CHEMBL4521671)
Show SMILES CCN1CCN(Cc2cc(NC(=O)c3ccc(C)c(c3)-c3ccc4cn[nH]c4c3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C29H30F3N5O/c1-3-36-8-10-37(11-9-36)18-20-12-24(29(30,31)32)16-25(13-20)34-28(38)22-5-4-19(2)26(14-22)21-6-7-23-17-33-35-27(23)15-21/h4-7,12-17H,3,8-11,18H2,1-2H3,(H,33,35)(H,34,38)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529772(CHEMBL4524697)
Show SMILES Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(C)c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H20F3N5O/c1-15-6-7-17(25(35)31-20-5-3-4-19(12-20)26(27,28)29)10-22(15)16-8-9-21-23(11-16)32-33-24(21)18-13-30-34(2)14-18/h3-14H,1-2H3,(H,31,35)(H,32,33)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529772(CHEMBL4524697)
Show SMILES Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(C)c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H20F3N5O/c1-15-6-7-17(25(35)31-20-5-3-4-19(12-20)26(27,28)29)10-22(15)16-8-9-21-23(11-16)32-33-24(21)18-13-30-34(2)14-18/h3-14H,1-2H3,(H,31,35)(H,32,33)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50112628(CHEMBL3608789)
Show SMILES C[C@H](NC(=O)Nc1cccc(F)c1)c1ccc(C)c(NC(=O)c2cnc3ccccn23)c1
Show InChI InChI=1S/C24H22FN5O2/c1-15-9-10-17(16(2)27-24(32)28-19-7-5-6-18(25)13-19)12-20(15)29-23(31)21-14-26-22-8-3-4-11-30(21)22/h3-14,16H,1-2H3,(H,29,31)(H2,27,28,32)/t16-/m0/s1
Affinity DataIC50: 4.5nMAssay Description:Inhibition of DDR2 (unknown origin) after 1 hr by time resolved fluorescence methodMore data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50509519(CHEMBL4546339)
Show SMILES Cc1ccc(cc1NCc1cncc(c1)-c1ccn(C)n1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H22F3N5O/c1-16-6-7-18(24(34)31-21-5-3-4-20(12-21)25(26,27)28)11-23(16)30-14-17-10-19(15-29-13-17)22-8-9-33(2)32-22/h3-13,15,30H,14H2,1-2H3,(H,31,34)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of kinase tracer 178 binding to recombinant human His-tagged DDR2 expressed in baculovirus infected Sf9 cells incubated for 1 hr by TR-FRE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529777(CHEMBL4569749)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc(C)c(c3)-c3ccc4cn[nH]c4c3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C28H28F3N5O/c1-18-3-4-21(13-25(18)20-5-6-22-16-32-34-26(22)14-20)27(37)33-24-12-19(11-23(15-24)28(29,30)31)17-36-9-7-35(2)8-10-36/h3-6,11-16H,7-10,17H2,1-2H3,(H,32,34)(H,33,37)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50529777(CHEMBL4569749)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc(C)c(c3)-c3ccc4cn[nH]c4c3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C28H28F3N5O/c1-18-3-4-21(13-25(18)20-5-6-22-16-32-34-26(22)14-20)27(37)33-24-12-19(11-23(15-24)28(29,30)31)17-36-9-7-35(2)8-10-36/h3-6,11-16H,7-10,17H2,1-2H3,(H,32,34)(H,33,37)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of DDR2 (unknown origin) using poly (Glu, Tyr) 4:1 substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50509521(CHEMBL4439970)
Show SMILES Cc1ccc(cc1NCc1cncc(c1)C(N)=O)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H19F3N4O2/c1-13-5-6-15(21(31)29-18-4-2-3-17(9-18)22(23,24)25)8-19(13)28-11-14-7-16(20(26)30)12-27-10-14/h2-10,12,28H,11H2,1H3,(H2,26,30)(H,29,31)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of kinase tracer 178 binding to recombinant human His-tagged DDR2 expressed in baculovirus infected Sf9 cells incubated for 1 hr by TR-FRE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM185584(US9156852, 1 | USRE47451, Example 1)
Show SMILES Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H17ClN6OS/c1-12-2-7-16-15(8-9-26-22(16)29-14-5-3-13(24)4-6-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28)
Affinity DataIC50: 5nMAssay Description:As such, the compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profili...More data for this Ligand-Target Pair
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