Compile Data Set for Download or QSAR
Found 255 Enz. Inhib. hit(s) with Target = 'Dual specificity mitogen-activated protein kinase kinase 4'
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
Affinity DataIC50: 1nMAssay Description:Inhibition of Mitogen activated protein kinase kinase 4More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human MKK4 using JNK1 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
Affinity DataIC50: 9.90nMAssay Description:Inhibition of human MKK4 using JNK1 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50567689(CHEMBL4790247)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2n[nH]c3ncc(cc23)-c2ccc(cc2)S(=O)(=O)NC(C)=O)c1F
Show InChI InChI=1S/C24H21F2N5O6S2/c1-3-10-38(34,35)31-19-9-8-18(25)20(21(19)26)23(33)22-17-11-15(12-27-24(17)29-28-22)14-4-6-16(7-5-14)39(36,37)30-13(2)32/h4-9,11-12,31H,3,10H2,1-2H3,(H,30,32)(H,27,28,29)
Affinity DataIC50: 29nMAssay Description:Inhibition of MKK4 (unknown origin) by PanQinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(F)ccc12
Show InChI InChI=1S/C14H9FN2O2/c15-10-5-6-11-12(7-10)16-17-13(11)8-1-3-9(4-2-8)14(18)19/h1-7H,(H,16,17)(H,18,19)
Affinity DataIC50: 41nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(F)ccc12
Show InChI InChI=1S/C14H9FN2O2/c15-10-5-6-11-12(7-10)16-17-13(11)8-1-3-9(4-2-8)14(18)19/h1-7H,(H,16,17)(H,18,19)
Affinity DataIC50: 41nMAssay Description:Inhibition of MEK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558862(US11370770, Compound 6n)
Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C15H9F3N2O2/c16-15(17,18)10-5-6-12-11(7-10)13(20-19-12)8-1-3-9(4-2-8)14(21)22/h1-7H,(H,19,20)(H,21,22)
Affinity DataIC50: 60nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577661(CHEMBL4879048)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1n[nH]c2cc(F)ccc12
Show InChI InChI=1S/C13H10FN3O2S/c14-9-3-6-11-12(7-9)16-17-13(11)8-1-4-10(5-2-8)20(15,18)19/h1-7H,(H,16,17)(H2,15,18,19)
Affinity DataIC50: 61nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558880(US11370770, Compound 6ee)
Show SMILES Fc1ccc2c(n[nH]c2c1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C14H9FN2O2/c15-9-2-3-10-11(6-9)16-17-14(10)8-1-4-12-13(5-8)19-7-18-12/h1-6H,7H2,(H,16,17)
Affinity DataIC50: 63nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(F)ccc12
Show InChI InChI=1S/C14H9FN2O2/c15-10-5-6-11-12(7-10)16-17-13(11)8-1-3-9(4-2-8)14(18)19/h1-7H,(H,16,17)(H,18,19)
Affinity DataIC50: 66nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577689(CHEMBL4866649)
Show SMILES NC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2n[nH]c3cc(F)ccc23)cc1
Show InChI InChI=1S/C20H15FN4O3S/c21-14-6-9-17-18(11-14)23-24-19(17)13-2-1-3-16(10-13)29(27,28)25-15-7-4-12(5-8-15)20(22)26/h1-11,25H,(H2,22,26)(H,23,24)
Affinity DataIC50: 83nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50567688(CHEMBL4784779)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2n[nH]c3ncc(cc23)-c2ccc(cc2)S(N)(=O)=O)c1F
Show InChI InChI=1S/C22H19F2N5O5S2/c1-2-9-35(31,32)29-17-8-7-16(23)18(19(17)24)21(30)20-15-10-13(11-26-22(15)28-27-20)12-3-5-14(6-4-12)36(25,33)34/h3-8,10-11,29H,2,9H2,1H3,(H2,25,33,34)(H,26,27,28)
Affinity DataIC50: 89nMAssay Description:Inhibition of MKK4 (unknown origin) by PanQinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577657(CHEMBL4848865)
Show SMILES OC(=O)c1cccc(c1)-c1n[nH]c2cc(F)ccc12
Show InChI InChI=1S/C14H9FN2O2/c15-10-4-5-11-12(7-10)16-17-13(11)8-2-1-3-9(6-8)14(18)19/h1-7H,(H,16,17)(H,18,19)
Affinity DataIC50: 96nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50559798(CHEMBL4758063 | US11370770, Compound 6ff)
Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(F)ccc12
Show InChI InChI=1S/C14H9FN2O2/c15-10-5-6-11-12(7-10)16-17-13(11)8-1-3-9(4-2-8)14(18)19/h1-7H,(H,16,17)(H,18,19)
Affinity DataIC50: 100nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558875(US11370770, Compound 6z)
Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C15H9F3N2O2/c16-15(17,18)10-5-6-11-12(7-10)19-20-13(11)8-1-3-9(4-2-8)14(21)22/h1-7H,(H,19,20)(H,21,22)
Affinity DataIC50: 100nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558864(US11370770, Compound 6p)
Show SMILES Cc1ccc2[nH]nc(-c3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C15H12N2O2/c1-9-2-4-12-11(6-9)15(17-16-12)10-3-5-13-14(7-10)19-8-18-13/h2-7H,8H2,1H3,(H,16,17)
Affinity DataIC50: 110nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558878(US11370770, Compound 6cc)
Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C14H9ClN2O2/c15-10-5-6-11-12(7-10)16-17-13(11)8-1-3-9(4-2-8)14(18)19/h1-7H,(H,16,17)(H,18,19)
Affinity DataIC50: 120nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558862(US11370770, Compound 6n)
Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C15H9F3N2O2/c16-15(17,18)10-5-6-12-11(7-10)13(20-19-12)8-1-3-9(4-2-8)14(21)22/h1-7H,(H,19,20)(H,21,22)
Affinity DataIC50: 130nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50567686(CHEMBL4798975)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1cnc2[nH]nc(C(=O)c3c(F)ccc(NS(=O)(=O)Cc4ccccc4)c3F)c2c1
Show InChI InChI=1S/C26H19F2N5O5S2/c27-20-10-11-21(33-39(35,36)14-15-4-2-1-3-5-15)23(28)22(20)25(34)24-19-12-17(13-30-26(19)32-31-24)16-6-8-18(9-7-16)40(29,37)38/h1-13,33H,14H2,(H2,29,37,38)(H,30,31,32)
Affinity DataIC50: 146nMAssay Description:Inhibition of MKK4 (unknown origin) by PanQinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558867(US11370770, Compound 6s)
Show SMILES Cc1ccc2[nH]nc(-c3ccc(cc3)C(O)=O)c2c1
Show InChI InChI=1S/C15H12N2O2/c1-9-2-7-13-12(8-9)14(17-16-13)10-3-5-11(6-4-10)15(18)19/h2-8H,1H3,(H,16,17)(H,18,19)
Affinity DataIC50: 150nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558848(US11370770, Compound 6a)
Show SMILES OC(=O)c1cccc(c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C14H10N2O2/c17-14(18)10-5-3-4-9(8-10)13-11-6-1-2-7-12(11)15-16-13/h1-8H,(H,15,16)(H,17,18)
Affinity DataIC50: 180nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558867(US11370770, Compound 6s)
Show SMILES Cc1ccc2[nH]nc(-c3ccc(cc3)C(O)=O)c2c1
Show InChI InChI=1S/C15H12N2O2/c1-9-2-7-13-12(8-9)14(17-16-13)10-3-5-11(6-4-10)15(18)19/h2-8H,1H3,(H,16,17)(H,18,19)
Affinity DataIC50: 180nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50559799(CHEMBL4748767)
Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C14H10N2O2/c17-14(18)10-7-5-9(6-8-10)13-11-3-1-2-4-12(11)15-16-13/h1-8H,(H,15,16)(H,17,18)
Affinity DataIC50: 190nMAssay Description:Inhibition of MEK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558866(US11370770, Compound 6r)
Show SMILES Cc1ccc2[nH]nc(-c3ccc(cc3)C(N)=O)c2c1
Show InChI InChI=1S/C15H13N3O/c1-9-2-7-13-12(8-9)14(18-17-13)10-3-5-11(6-4-10)15(16)19/h2-8H,1H3,(H2,16,19)(H,17,18)
Affinity DataIC50: 200nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558865(US11370770, Compound 6q)
Show SMILES Cc1ccc2[nH]nc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C14H12N2O/c1-9-2-7-13-12(8-9)14(16-15-13)10-3-5-11(17)6-4-10/h2-8,17H,1H3,(H,15,16)
Affinity DataIC50: 210nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558867(US11370770, Compound 6s)
Show SMILES Cc1ccc2[nH]nc(-c3ccc(cc3)C(O)=O)c2c1
Show InChI InChI=1S/C15H12N2O2/c1-9-2-7-13-12(8-9)14(17-16-13)10-3-5-11(6-4-10)15(18)19/h2-8H,1H3,(H,16,17)(H,18,19)
Affinity DataIC50: 220nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558858(US11370770, Compound 6j)
Show SMILES Oc1ccc(cc1)-c1n[nH]c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C14H9F3N2O/c15-14(16,17)9-3-6-12-11(7-9)13(19-18-12)8-1-4-10(20)5-2-8/h1-7,20H,(H,18,19)
Affinity DataIC50: 240nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558858(US11370770, Compound 6j)
Show SMILES Oc1ccc(cc1)-c1n[nH]c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C14H9F3N2O/c15-14(16,17)9-3-6-12-11(7-9)13(19-18-12)8-1-4-10(20)5-2-8/h1-7,20H,(H,18,19)
Affinity DataIC50: 250nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558880(US11370770, Compound 6ee)
Show SMILES Fc1ccc2c(n[nH]c2c1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C14H9FN2O2/c15-9-2-3-10-11(6-9)16-17-14(10)8-1-4-12-13(5-8)19-7-18-12/h1-6H,7H2,(H,16,17)
Affinity DataIC50: 260nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577686(CHEMBL4865159)
Show SMILES CS(=O)(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2n[nH]c3cc(F)ccc23)cc1
Show InChI InChI=1S/C20H16FN3O4S2/c1-29(25,26)16-8-6-15(7-9-16)24-30(27,28)17-4-2-3-13(11-17)20-18-10-5-14(21)12-19(18)22-23-20/h2-12,24H,1H3,(H,22,23)
Affinity DataIC50: 290nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577671(CHEMBL4872723)
Show SMILES Fc1ccc2c(n[nH]c2c1)-c1cccc(c1)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C19H14FN3O2S/c20-14-9-10-17-18(12-14)21-22-19(17)13-5-4-8-16(11-13)26(24,25)23-15-6-2-1-3-7-15/h1-12,23H,(H,21,22)
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577647(CHEMBL4849172)
Show SMILES Fc1ccc2c(n[nH]c2c1)-c1ccccc1
Show InChI InChI=1S/C13H9FN2/c14-10-6-7-11-12(8-10)15-16-13(11)9-4-2-1-3-5-9/h1-8H,(H,15,16)
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558875(US11370770, Compound 6z)
Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C15H9F3N2O2/c16-15(17,18)10-5-6-11-12(7-10)19-20-13(11)8-1-3-9(4-2-8)14(21)22/h1-7H,(H,19,20)(H,21,22)
Affinity DataIC50: 360nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577673(CHEMBL4858450)
Show SMILES Fc1ccc2c(n[nH]c2c1)-c1cccc(c1)S(=O)(=O)NC1CC1
Show InChI InChI=1S/C16H14FN3O2S/c17-11-4-7-14-15(9-11)18-19-16(14)10-2-1-3-13(8-10)23(21,22)20-12-5-6-12/h1-4,7-9,12,20H,5-6H2,(H,18,19)
Affinity DataIC50: 380nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577682(CHEMBL4846360)
Show SMILES COc1ccc(NS(=O)(=O)c2cccc(c2)-c2n[nH]c3cc(F)ccc23)cc1
Show InChI InChI=1S/C20H16FN3O3S/c1-27-16-8-6-15(7-9-16)24-28(25,26)17-4-2-3-13(11-17)20-18-10-5-14(21)12-19(18)22-23-20/h2-12,24H,1H3,(H,22,23)
Affinity DataIC50: 390nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558863(US11370770, Compound 6o)
Show SMILES Cc1ccc2[nH]nc(-c3ccc(F)c(CO)c3)c2c1
Show InChI InChI=1S/C15H13FN2O/c1-9-2-5-14-12(6-9)15(18-17-14)10-3-4-13(16)11(7-10)8-19/h2-7,19H,8H2,1H3,(H,17,18)
Affinity DataIC50: 390nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Show SMILES Oc1ccc(cc1)-c1coc2cc(O)cc(O)c2c1=O
Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
Affinity DataIC50: 400nMAssay Description:Inhibition of recombinant human MEK4 (14 to 377 residues) after 5 mins by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558865(US11370770, Compound 6q)
Show SMILES Cc1ccc2[nH]nc(-c3ccc(O)cc3)c2c1
Show InChI InChI=1S/C14H12N2O/c1-9-2-7-13-12(8-9)14(16-15-13)10-3-5-11(17)6-4-10/h2-8,17H,1H3,(H,15,16)
Affinity DataIC50: 410nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558864(US11370770, Compound 6p)
Show SMILES Cc1ccc2[nH]nc(-c3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C15H12N2O2/c1-9-2-4-12-11(6-9)15(17-16-12)10-3-5-13-14(7-10)19-8-18-13/h2-7H,8H2,1H3,(H,16,17)
Affinity DataIC50: 410nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577680(CHEMBL4874017)
Show SMILES COc1ccccc1NS(=O)(=O)c1cccc(c1)-c1n[nH]c2cc(F)ccc12
Show InChI InChI=1S/C20H16FN3O3S/c1-27-19-8-3-2-7-17(19)24-28(25,26)15-6-4-5-13(11-15)20-16-10-9-14(21)12-18(16)22-23-20/h2-12,24H,1H3,(H,22,23)
Affinity DataIC50: 420nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558879(US11370770, Compound 6dd)
Show SMILES COC(=O)c1ccc(cc1)-c1n[nH]c2cc(F)ccc12
Show InChI InChI=1S/C15H11FN2O2/c1-20-15(19)10-4-2-9(3-5-10)14-12-7-6-11(16)8-13(12)17-18-14/h2-8H,1H3,(H,17,18)
Affinity DataIC50: 420nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577674(CHEMBL4871499)
Show SMILES Fc1ccc2c(n[nH]c2c1)-c1cccc(c1)S(=O)(=O)Nc1cccnc1
Show InChI InChI=1S/C18H13FN4O2S/c19-13-6-7-16-17(10-13)21-22-18(16)12-3-1-5-15(9-12)26(24,25)23-14-4-2-8-20-11-14/h1-11,23H,(H,21,22)
Affinity DataIC50: 450nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558848(US11370770, Compound 6a)
Show SMILES OC(=O)c1cccc(c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C14H10N2O2/c17-14(18)10-5-3-4-9(8-10)13-11-6-1-2-7-12(11)15-16-13/h1-8H,(H,15,16)(H,17,18)
Affinity DataIC50: 460nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558876(US11370770, Compound 6aa)
Show SMILES Clc1ccc2c(n[nH]c2c1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C14H9ClN2O2/c15-9-2-3-10-11(6-9)16-17-14(10)8-1-4-12-13(5-8)19-7-18-12/h1-6H,7H2,(H,16,17)
Affinity DataIC50: 460nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558862(US11370770, Compound 6n)
Show SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C15H9F3N2O2/c16-15(17,18)10-5-6-12-11(7-10)13(20-19-12)8-1-3-9(4-2-8)14(21)22/h1-7H,(H,19,20)(H,21,22)
Affinity DataIC50: 470nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577685(CHEMBL4854291)
Show SMILES Fc1ccc2c(n[nH]c2c1)-c1cccc(c1)S(=O)(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C20H13FN4O2S/c21-15-6-9-18-19(11-15)23-24-20(18)14-2-1-3-17(10-14)28(26,27)25-16-7-4-13(12-22)5-8-16/h1-11,25H,(H,23,24)
Affinity DataIC50: 470nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577659(CHEMBL4860404)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1n[nH]c2cc(F)ccc12
Show InChI InChI=1S/C14H12FN3O2S/c1-21(19,20)18-11-5-2-9(3-6-11)14-12-7-4-10(15)8-13(12)16-17-14/h2-8,18H,1H3,(H,16,17)
Affinity DataIC50: 480nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK4 expressed in Sf21 cells using p38 alpha as substrate pre-incubated for 30 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558866(US11370770, Compound 6r)
Show SMILES Cc1ccc2[nH]nc(-c3ccc(cc3)C(N)=O)c2c1
Show InChI InChI=1S/C15H13N3O/c1-9-2-7-13-12(8-9)14(18-17-13)10-3-5-11(6-4-10)15(16)19/h2-8H,1H3,(H2,16,19)(H,17,18)
Affinity DataIC50: 510nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558864(US11370770, Compound 6p)
Show SMILES Cc1ccc2[nH]nc(-c3ccc4OCOc4c3)c2c1
Show InChI InChI=1S/C15H12N2O2/c1-9-2-4-12-11(6-9)15(17-16-12)10-3-5-13-14(7-10)19-8-18-13/h2-7H,8H2,1H3,(H,16,17)
Affinity DataIC50: 560nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM558866(US11370770, Compound 6r)
Show SMILES Cc1ccc2[nH]nc(-c3ccc(cc3)C(N)=O)c2c1
Show InChI InChI=1S/C15H13N3O/c1-9-2-7-13-12(8-9)14(18-17-13)10-3-5-11(6-4-10)15(16)19/h2-8H,1H3,(H2,16,19)(H,17,18)
Affinity DataIC50: 560nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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