Compile Data Set for Download or QSAR
Found 7101 Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2'
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50605126(CHEMBL5187340)
Affinity DataKi:  0.00200nMAssay Description:Displacement of 5-FAM labeled PDI peptide from MDM2 (1 to 118 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as inhibit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50513202(CHEMBL4463050)
Affinity DataKi:  0.0450nMAssay Description:Inhibition of p53 protein binding to MDM2 in human SJSA1 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50069799(CHEMBL3407579 | US9187441, 7M)
Affinity DataKi:  0.130nM ΔG°:  -55.5kJ/moleT: 2°CAssay Description:Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM192221(US9187441, 7K)
Affinity DataKi:  0.150nM ΔG°:  -55.1kJ/moleT: 2°CAssay Description:Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50041086(CHEMBL3355430)
Affinity DataKi:  0.160nMAssay Description:Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM192225(US9187441, 7P)
Affinity DataKi:  0.170nM ΔG°:  -54.8kJ/moleT: 2°CAssay Description:Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM192217(US9187441, 7G)
Affinity DataKi:  0.200nM ΔG°:  -54.4kJ/moleT: 2°CAssay Description:Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM129823(US8815926, 102)
Affinity DataKi:  0.210nMAssay Description:Inhibition of MDM2 (unknown origin)More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM192155(US9187441, 7E)
Affinity DataKi:  0.25nM ΔG°:  -53.9kJ/moleT: 2°CAssay Description:Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM192161(US9187441, 7I)
Affinity DataKi:  0.300nM ΔG°:  -53.4kJ/moleT: 2°CAssay Description:Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM192204(US9187441, 6M)
Affinity DataKi:  0.400nM ΔG°:  -52.7kJ/moleT: 2°CAssay Description:Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50513204(CHEMBL4537250)
Affinity DataKi:  0.440nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50513204(CHEMBL4537250)
Affinity DataKi:  0.440nMAssay Description:Inhibition of wild type p53 protein binding to MDM2 in human HCT116 cells by immunoblot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50436682(CHEMBL2396674)
Affinity DataKi:  0.440nMAssay Description:Binding affinity to recombinant human His-tagged MDM2 (1 to 118 amino acids) using p53-based PMDM6-F as probe after 15 mins by competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM192213(US9187441, 7B)
Affinity DataKi:  0.450nM ΔG°:  -52.5kJ/moleT: 2°CAssay Description:Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50605132(CHEMBL5171665)
Affinity DataKi:  0.5nMAssay Description:Displacement of 5-FAM labeled PDI peptide from MDM2 (1 to 118 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as inhibit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM192196(US9187441, 6E)
Affinity DataKi:  0.5nM ΔG°:  -52.2kJ/moleT: 2°CAssay Description:Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50513202(CHEMBL4463050)
Affinity DataKi:  0.600nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50300114((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50436688(CHEMBL2398473)
Affinity DataKi:  0.610nMAssay Description:Binding affinity to recombinant human His-tagged MDM2 (1 to 118 amino acids) using p53-based PMDM6-F as probe after 15 mins by competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50436681(CHEMBL2398479)
Affinity DataKi:  0.620nMAssay Description:Binding affinity to recombinant human His-tagged MDM2 (1 to 118 amino acids) using p53-based PMDM6-F as probe after 15 mins by competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50436685(CHEMBL2398476)
Affinity DataKi:  0.620nMAssay Description:Binding affinity to recombinant human His-tagged MDM2 (1 to 118 amino acids) using p53-based PMDM6-F as probe after 15 mins by competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM192228(US9187441, 7S)
Affinity DataKi:  0.700nM ΔG°:  -51.4kJ/moleT: 2°CAssay Description:Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50300115((2'R,3S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophe...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50605125(CHEMBL5197279)
Affinity DataKi:  0.800nMAssay Description:Displacement of 5-FAM labeled PDI peptide from MDM2 (1 to 118 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as inhibit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM192151(US9187441, 7C)
Affinity DataKi:  0.810nM ΔG°:  -51.0kJ/moleT: 2°CAssay Description:Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50436689(CHEMBL2398472)
Affinity DataKi:  0.860nMAssay Description:Binding affinity to recombinant human His-tagged MDM2 (1 to 118 amino acids) using p53-based PMDM6-F as probe after 15 mins by competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50433561(CHEMBL2381408)
Affinity DataKi:  0.880nMAssay Description:Binding affinity to MDM2 (unknown origin)More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50433561(CHEMBL2381408)
Affinity DataKi:  0.880nMAssay Description:Inhibition of FAM tagged p53-based peptide binding to recombinant human His-tagged MDM2 protein (residues 1 to 118 residues) incubated for 15 mins by...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50433561(CHEMBL2381408)
Affinity DataKi:  0.880nMAssay Description:Binding affinity to MDM2 (unknown origin)More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50433561(CHEMBL2381408)
Affinity DataKi:  0.880nMAssay Description:Binding affinity to recombinant human His6-tagged HDM2 (1 to 118 residues) assessed as reduction in PMDM6-F binding incubated for 15 to 30 mins by fl...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50433561(CHEMBL2381408)
Affinity DataKi:  0.880nMAssay Description:Inhibition of MDM2 (unknown origin)More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50433561(CHEMBL2381408)
Affinity DataKi:  0.880nMAssay Description:Inhibition of FAM-tagged p53-based fluorescent probe binding to human His-tagged MDM2 (1 to 118 residues) after 15 mins by fluorescence polarization ...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50433561(CHEMBL2381408)
Affinity DataKi:  0.880nMAssay Description:Inhibition of PMDM6-F binding to recombinant human His-tagged MDM2 (1 to 118 residues) after 15 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50513209(CHEMBL4440151)
Affinity DataKi:  0.880nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50542271(CHEMBL4639742)
Affinity DataKi:  0.900nMAssay Description:Inhibition of MDM2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50436686(CHEMBL2398475)
Affinity DataKi:  0.940nMAssay Description:Binding affinity to recombinant human His-tagged MDM2 (1 to 118 amino acids) using p53-based PMDM6-F as probe after 15 mins by competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50436683(CHEMBL2398478)
Affinity DataKi:  0.970nMAssay Description:Binding affinity to recombinant human His-tagged MDM2 (1 to 118 amino acids) using p53-based PMDM6-F as probe after 15 mins by competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM112737(US8629141, 4)
Affinity DataKi:  1nM IC50:  15.6nMAssay Description:The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM112757(US8629141, 27)
Affinity DataKi: <1nMAssay Description:Inhibition of FAM-tagged p53-based PMDM6-F peptide binding to human recombinant His-tagged MDM2 (1 to 118 residues) after 30 mins by fluorescence pol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50237764(CHEMBL4060006)
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha-5-beta-3-gamma-2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50237744(CHEMBL4072857)
Affinity DataKi: <1nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha-5-beta-3-gamma-2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50237766(CHEMBL4085815)
Affinity DataKi: <1nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50237745(CHEMBL4064790)
Affinity DataKi: <1nMAssay Description:Inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha-5-beta-3-gamma-2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50237763(CHEMBL4084366)
Affinity DataKi: <1nMAssay Description:Inhibition of FAM-tagged p53-based PMDM6-F peptide binding to human recombinant His-tagged MDM2 (1 to 118 residues) after 30 mins by fluorescence pol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM112773(US8629141, 43)
Affinity DataKi: <1nMAssay Description:Inhibition of FAM-tagged p53-based PMDM6-F peptide binding to human recombinant His-tagged MDM2 (1 to 118 residues) after 30 mins by fluorescence pol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50236827(CHEMBL4066694)
Affinity DataKi: <1nMAssay Description:Inhibition of FAM-tagged p53-based PMDM6-F peptide binding to human recombinant His-tagged MDM2 (1 to 118 residues) after 30 mins by fluorescence pol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM112761(US8629141, 31)
Affinity DataKi: <1nMAssay Description:Inhibition of FAM-tagged p53-based PMDM6-F peptide binding to human recombinant His-tagged MDM2 (1 to 118 residues) after 30 mins by fluorescence pol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50237739(CHEMBL4091801)
Affinity DataKi: <1nMAssay Description:Inhibition of FAM-tagged p53-based PMDM6-F peptide binding to human recombinant His-tagged MDM2 (1 to 118 residues) after 30 mins by fluorescence pol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM112759(US8629141, 29)
Affinity DataKi: <1nMAssay Description:Inhibition of FAM-tagged p53-based PMDM6-F peptide binding to human recombinant His-tagged MDM2 (1 to 118 residues) after 30 mins by fluorescence pol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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