Compile Data Set for Download or QSAR
Found 13484 Enz. Inhib. hit(s) with Target = 'Estrogen receptor'
TargetEstrogen receptor beta(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Affinity DataKi:  0.0140nMAssay Description:Antagonistic activity against estrogen receptor beta in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.0150nM ΔG°:  -61.8kJ/molepH: 7.5 T: 2°CAssay Description:The method employed was adapted from the scientific literature and described in detail by Osbourn et al. (1993, Biochemistry, 32, 6229-6236). Recombi...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.0150nM ΔG°:  -61.8kJ/molepH: 7.5 T: 2°CAssay Description:The method employed was adapted from the scientific literature and described in detail by Osboum et al. (1993, Biochemistry, 32, 6229-6236). Recombin...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.0150nMpH: 7.5Assay Description:The method employed was adapted from the scientific literature and described in detail by Osbourn et al. (1993, Biochemistry, 32, 6229-6236). Recombi...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire de Qu£bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0150nMAssay Description:Apparent binding affinity against estradiol-stimulated T-47D cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire de Qu£bec

Curated by ChEMBL
LigandPNGBDBM50471254(CHEMBL308234)
Affinity DataKi:  0.0160nMAssay Description:Apparent binding affinity against estradiol-stimulated T-47D cell proliferationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire de Qu£bec

Curated by ChEMBL
LigandPNGBDBM50471254(CHEMBL308234)
Affinity DataKi:  0.0230nMAssay Description:Stimulation of alkaline phosphatase activity in human endometrial Ishikawa cells with 1 nM E2 estradiolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM158504(US9034854, EE | US9040509, EE | US9561238, EE)
Affinity DataKi:  0.0250nM ΔG°:  -60.5kJ/molepH: 7.5 T: 2°CAssay Description:The method employed was adapted from the scientific literature and described in detail by Osboum et al. (1993, Biochemistry, 32, 6229-6236). Recombin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEstrogen receptor beta(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM158504(US9034854, EE | US9040509, EE | US9561238, EE)
Affinity DataKi:  0.0250nM ΔG°:  -60.5kJ/molepH: 7.5 T: 2°CAssay Description:The method employed was adapted from the scientific literature and described in detail by Osbourn et al. (1993, Biochemistry, 32, 6229-6236). Recombi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEstrogen receptor beta(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM158504(US9034854, EE | US9040509, EE | US9561238, EE)
Affinity DataKi:  0.0250nMpH: 7.5Assay Description:The method employed was adapted from the scientific literature and described in detail by Osbourn et al. (1993, Biochemistry, 32, 6229-6236). Recombi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire de Qu£bec

Curated by ChEMBL
LigandPNGBDBM50471256(CHEMBL291808)
Affinity DataKi:  0.0280nMAssay Description:Apparent binding affinity against estradiol-stimulated T-47D cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataKi:  0.0300nMAssay Description:Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Affinity DataKi:  0.0400nMAssay Description:Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire de Qu£bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0420nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire de Qu£bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0470nMAssay Description:Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50133069(3'-Ethylamino-[1,1';2',1'']terphenyl-4'-carbaldehy...)
Affinity DataKi:  0.0480nMAssay Description:Relative binding affinity for human estrogen receptor betacompared to [3H]-estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50104326(4-{3-(4-hydroxy-phenyl)-4-ethyl-5-[4-(2-piperidin-...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]-estradiol from Estrogen receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire de Qu£bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0690nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 2.5%DMFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50462974(CHEMBL4240100)
Affinity DataKi:  0.0700nMAssay Description:Antagonist activity at full length recombinant human ERalpha expressed in baculovirus expression system assessed as inhibition of estradiol-induced E...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire de Qu£bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0760nMAssay Description:Apparent inhibition constant for estrogen receptor in Human Breast cancer cytosol in 2.5%DMFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire de Qu£bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0900nMAssay Description:Apparent binding affinity against estradiol-stimulated ZR-75-1-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50212159(2-(4-isopropylphenyl)-3-(4-(2-(piperidin-1-yl)etho...)
Affinity DataKi:  0.0910nMAssay Description:Displacement of [3H]estradiol from human recombinant ERalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50076331(1-(hydroxymethyl)-12-(4-hydroxyphenyl)-1,12-dicarb...)
Affinity DataKi:  0.100nMAssay Description:In vitro inhibition of [6,7-3H]-17beta-estradiol binding to human estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire de Qu£bec

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.113nMAssay Description:Apparent inhibition constant for estrogen receptor in Human Breast cancer cytosol in 2.5%DMFMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire de Qu£bec

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.120nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanolMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire de Qu£bec

Curated by ChEMBL
LigandPNGBDBM20625(4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)
Affinity DataKi:  0.126nMAssay Description:Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol)More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire de Qu£bec

Curated by ChEMBL
LigandPNGBDBM20625(4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)
Affinity DataKi:  0.128nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanolMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50238727(CHEMBL4065838)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]estradiol from full-length human ERalpha receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire de Qu£bec

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.138nMAssay Description:Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol)More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50133070(CHEMBL335465 | [1,1';2',1'']Terphenyl-4'-carbaldeh...)
Affinity DataKi:  0.150nMAssay Description:Relative binding affinity for human estrogen receptor alpha compared to [3H]-estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.160nMAssay Description:Displacement of [2,4,6,7-3H]estradiol from human ERalpha expressed in HeLa cells after 18 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50212148(6-(3-fluorophenyl)-5-(4-(2-(piperidin-1-yl)ethoxy)...)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]estradiol from human recombinant ERbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Affinity DataKi:  0.160nMAssay Description:In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor betaMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM19968((2R,6S,7R)-7-(4-hydroxyphenyl)-8-oxatricyclo[7.4.0...)
Affinity DataKi:  0.170nM ΔG°:  -55.2kJ/molepH: 7.5 T: 2°CAssay Description:The binding affinities were determined by a competitive radiometric binding assay using [3H]estradiol as tracer. The Kd for 3H-estradiol was determin...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50212148(6-(3-fluorophenyl)-5-(4-(2-(piperidin-1-yl)ethoxy)...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]estradiol from human recombinant ERalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50238724(CHEMBL4060067)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]estradiol from full-length human ERalpha receptor by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire de Qu£bec

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.181nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 2.5%DMFMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50173652(2-(4-Hydroxy-phenyl)-1-[4-(2-piperidin-1-yl-ethoxy...)
Affinity DataKi:  0.190nMAssay Description:Antagonistic activity against estrogen receptor beta in presence of 0.1 nM estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM19968((2R,6S,7R)-7-(4-hydroxyphenyl)-8-oxatricyclo[7.4.0...)
Affinity DataKi:  0.190nM ΔG°:  -54.9kJ/molepH: 7.5 T: 2°CAssay Description:The binding affinities were determined by a competitive radiometric binding assay using [3H]estradiol as tracer. The Kd for 3H-estradiol was determin...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM19968((2R,6S,7R)-7-(4-hydroxyphenyl)-8-oxatricyclo[7.4.0...)
Affinity DataKi:  0.190nM ΔG°:  -54.9kJ/molepH: 7.5 T: 2°CAssay Description:The binding affinities were determined by a competitive radiometric binding assay using [3H]estradiol as tracer. The Kd for 3H-estradiol was determin...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM19968((2R,6S,7R)-7-(4-hydroxyphenyl)-8-oxatricyclo[7.4.0...)
Affinity DataKi:  0.190nM ΔG°:  -54.9kJ/mole EC50:  0.660nMpH: 7.5 T: 2°CAssay Description:The binding affinities were determined by a competitive radiometric binding assay using [3H]estradiol as tracer. The Kd for 3H-estradiol was determin...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50212157(6-(3,4-difluorophenyl)-5-(4-(2-(piperidin-1-yl)eth...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]estradiol from human recombinant ERalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM19964(6-(4-hydroxyphenyl)-5-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataKi:  0.200nM ΔG°:  -54.8kJ/mole EC50:  1.14nMpH: 7.5 T: 2°CAssay Description:The binding affinities were determined by a competitive radiometric binding assay using [3H]estradiol as tracer. The Kd for 3H-estradiol was determin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.210nM ΔG°:  -55.2kJ/molepH: 7.5 T: 2°CAssay Description:The method employed was adapted from the scientific literature and described in detail by Osbourn et al. (1993, Biochemistry, 32, 6229-6236). Recombi...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50212149(6-(3-hydroxyphenyl)-5-(4-(2-(piperidin-1-yl)ethoxy...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]estradiol from human recombinant ERalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.210nMpH: 7.5Assay Description:The method employed was adapted from the scientific literature and described in detail by Osbourn et al. (1993, Biochemistry, 32, 6229-6236). Recombi...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.210nM ΔG°:  -55.2kJ/molepH: 7.5 T: 2°CAssay Description:The method employed was adapted from the scientific literature and described in detail by Osboum et al. (1993, Biochemistry, 32, 6229-6236). Recombin...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataKi:  0.220nMAssay Description:Ability to displace [3H]-17-beta-estradiol from Estrogen receptor alpha by scintillation proximity assay.More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM158504(US9034854, EE | US9040509, EE | US9561238, EE)
Affinity DataKi:  0.230nM ΔG°:  -55.0kJ/molepH: 7.5 T: 2°CAssay Description:The method employed was adapted from the scientific literature and described in detail by Osbourn et al. (1993, Biochemistry, 32, 6229-6236). Recombi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM158504(US9034854, EE | US9040509, EE | US9561238, EE)
Affinity DataKi:  0.230nMpH: 7.5Assay Description:The method employed was adapted from the scientific literature and described in detail by Osbourn et al. (1993, Biochemistry, 32, 6229-6236). Recombi...More data for this Ligand-Target Pair
In DepthDetails US Patent
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