Compile Data Set for Download or QSAR
Found 227 Enz. Inhib. hit(s) with Target = 'Glutathione reductase, mitochondrial'
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50352164(CHEMBL1824793)
Affinity DataKi:  211nMAssay Description:Competitive inhibition of human erythrocyte Glutathione reductase using GSSG substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM94597((Z)-2-butenedioate;10-(1-methyl-4-piperidinylidene...)
Affinity DataKi:  800nM ΔG°:  -34.8kJ/mole IC50:  1.20E+4nMpH: 8.0 T: 2°CAssay Description:GR activity was determined by the method of Carlberg and Mannervik [Carlberg et al., FL:Academic Press, 72:248-254] with a Shimadzu Spectrophotometer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50352161(CHEMBL1824791)
Affinity DataKi:  4.16E+3nMAssay Description:Non-Competitive inhibition of human erythrocyte Glutathione reductase using GSSG substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50352163(CHEMBL1824792)
Affinity DataKi:  4.57E+3nMAssay Description:Competitive inhibition of human erythrocyte Glutathione reductase using GSSG substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50056998(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataKi:  6.10E+3nM ΔG°:  -29.8kJ/mole IC50:  2.90E+4nMpH: 8.0 T: 2°CAssay Description:GR activity was determined by the method of Carlberg and Mannervik [Carlberg et al., FL:Academic Press, 72:248-254] with a Shimadzu Spectrophotometer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50422689(640/359 | CEFUROXIME)
Affinity DataKi:  1.04E+4nM IC50:  1.88E+4nMpH: 8.0Assay Description:Enzymatic activity was measured by Beutler's method with a Shimadzu Spectrophotometer UV-(1208), at 25C. The assay system contained 100 mM Tris-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50316592((2R(S),7R(S))-7-Hydroxybicyclo[2.2.1]heptan-2-yl n...)
Affinity DataKi:  1.17E+4nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM24778(2-methyl-1,4-dihydronaphthalene-1,4-dione | 2-meth...)
Affinity DataKi:  1.21E+4nMAssay Description:Inhibitory concentration against human glutathione reductase (In presence of glutathione disulfide)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50293668((2S(R),7R(S))-7-Hydroxybicyclo[2.2.1]heptan-2-yl n...)
Affinity DataKi:  1.31E+4nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM24778(2-methyl-1,4-dihydronaphthalene-1,4-dione | 2-meth...)
Affinity DataKi:  1.61E+4nMAssay Description:Inhibitory concentration against human glutathione reductase (In presence of NADPH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50049707((6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxy...)
Affinity DataKi:  1.73E+4nM IC50:  2.13E+4nMpH: 8.0Assay Description:Enzymatic activity was measured by Beutler's method with a Shimadzu Spectrophotometer UV-(1208), at 25C. The assay system contained 100 mM Tris-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50293667((1R(S),2R(S),3S(R),4S(R))-2,3-Dihydroxycyclo-hexan...)
Affinity DataKi:  1.74E+4nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50336640((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Affinity DataKi:  1.74E+4nMAssay Description:Competitive inhibition of human erythrocyte Glutathione reductase using GSSG substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50293666((1S(R),3S(R),4S(R),6S(R))-4,6-Dihydroxycyclo-hexan...)
Affinity DataKi:  1.79E+4nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50293665((1R(S),2R(S),4R(S),5R(S))-2,5-Dihydroxycyclo-hexan...)
Affinity DataKi:  1.84E+4nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50293664(9(R(S))-Hydroxy-1,2,3,4-tetrahydro-1,4-methano-nap...)
Affinity DataKi:  1.88E+4nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50293663((1S(R),2S(R),5R(S),6R(S))-5-Bromo-9-oxabicyclo[4.2...)
Affinity DataKi:  2.15E+4nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50293661(CHEMBL556256 | trans-(1S(R),2S(R))-2-Hydroxycycloo...)
Affinity DataKi:  2.19E+4nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM237182(Ceftizoxime)
Affinity DataKi:  2.28E+4nM IC50:  3.97E+4nMpH: 8.0Assay Description:Enzymatic activity was measured by Beutler's method with a Shimadzu Spectrophotometer UV-(1208), at 25C. The assay system contained 100 mM Tris-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50293660(CHEMBL563619 | trans-(R(S))-2-Hydroxy-1-phenylethy...)
Affinity DataKi:  2.56E+4nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50390999(CEFOPERAZONE)
Affinity DataKi:  2.87E+4nM IC50:  4.84E+4nMpH: 8.0Assay Description:Enzymatic activity was measured by Beutler's method with a Shimadzu Spectrophotometer UV-(1208), at 25C. The assay system contained 100 mM Tris-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50293658(CHEMBL555721 | trans-(1S(R),6S(R))-6-Hydroxycycloh...)
Affinity DataKi:  3.51E+4nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataKi:  4.27E+4nMAssay Description:Competitive inhibition of human erythrocyte Glutathione reductase using GSSG substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50293659(CHEMBL562358 | trans-(1S(R),2S(R))-2-Hydroxycycloh...)
Affinity DataKi:  4.37E+4nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50293662(CHEMBL559615 | trans-(1S(R),8S(R),Z)-8-Hydroxycycl...)
Affinity DataKi:  4.43E+4nMAssay Description:Inhibition of human erythrocyte glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50352165(LYSINE)
Affinity DataKi:  5.46E+4nMAssay Description:Competitive inhibition of human erythrocyte Glutathione reductase using GSSG substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50170723(1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide...)
Affinity DataKi:  1.92E+5nMAssay Description:Inhibitory constant against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50352162(NITROBENZENE)
Affinity DataKi:  2.74E+5nMAssay Description:Competitive inhibition of human erythrocyte Glutathione reductase using GSSG substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM235694(Phenyramidol-HCl)
Affinity DataKi:  4.34E+5nM ΔG°:  -19.2kJ/mole IC50:  9.90E+5nMpH: 8.0 T: 2°CAssay Description:GR activity was determined by the method of Carlberg and Mannervik [Carlberg et al., FL:Academic Press, 72:248-254] with a Shimadzu Spectrophotometer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50091152(CHEMBL106108 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  2.00E+6nMAssay Description:Inhibitory activity against Human Erythrocyte glutathione reductase (GR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50091149((4-Chloro-benzyl)-[3-(2-chloro-phenothiazin-10-yl)...)
Affinity DataKi:  2.20E+6nMAssay Description:Inhibitory activity against Human Erythrocyte glutathione reductase (GR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50093207((E)-3-(3,4-Dihydroxy-phenyl)-N-[3-(4-{3-[(E)-3-(3,...)
Affinity DataKi: >1.00E+7nMAssay Description:The compound was evaluated for inhibition of human Glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM233150(Gadopentetic acid)
Affinity DataKi:  2.88E+7nM ΔG°:  -8.79kJ/mole IC50:  1.38E+8nMpH: 8.0 T: 2°CAssay Description:GR activity was determined by the method of Carlberg and Mannervik [Carlberg et al., FL:Academic Press, 72:248-254] with a Shimadzu Spectrophotometer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50176071(2-(2-Amino-ethylamino)-N-(7-{2-[N'-(5-nitro-furan-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50121447(5-Nitro-furan-2-carboxylic acid N'-(2-naphthalen-2...)
Affinity DataIC50:  4.10nMAssay Description:Inhibitory concentration against human glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50352164(CHEMBL1824793)
Affinity DataIC50:  344nMAssay Description:Inhibition of human erythrocyte Glutathione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50096035(6-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  750nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50096062(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50052000(10-(3-Trifluoromethyl-phenyl)-10H-benzo[g]pteridin...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 microM GSSGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50052014(3-Methyl-10-(3-trifluoromethyl-phenyl)-10H-benzo[g...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 microM GSSGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50051997(10-(4-Chloro-phenyl)-8-fluoro-3-methyl-10H-benzo[g...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 microM GSSGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50096035(6-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  1.30E+3nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50052004(3-Methyl-10-phenyl-10H-benzo[g]pteridine-2,4-dione...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 microM GSSGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50051998(3-Methyl-10-naphthalen-1-yl-10H-benzo[g]pteridine-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 microM GSSGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50052001(8-Azido-10-(4-chloro-phenyl)-3-methyl-10H-benzo[g]...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibitory activity against human glutathione reductase in presence of 100 microM GSSGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50096062(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  2.50E+3nMAssay Description:In vitro inhibition of Plasmodium falciparum Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  2.60E+3nMAssay Description:In vitro inhibition of human Glutathione ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathione reductase, mitochondrial(Homo sapiens (Human))
Batman University

Curated by ChEMBL
LigandPNGBDBM50096018(6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)H...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory concentration against human glutathione reductase in the the presence of 200 uM exogenous NADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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