Compile Data Set for Download or QSAR
Found 4045 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 2'
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM347461(US9790158, 12)
Affinity DataKi:  0.0400nMAssay Description:Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50492541(CHEMBL2408242)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50123957((E)-5-(3-Benzenesulfonylamino-phenyl)-pent-2-en-4-...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50492540(CHEMBL2408243)
Affinity DataKi:  0.120nMAssay Description:Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM348884(US9790158, 10)
Affinity DataKi:  0.130nMAssay Description:Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM347460(US9790158, 11)
Affinity DataKi:  0.220nMAssay Description:Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM347454(MO-OH-TM | US9790158, 5)
Affinity DataKi:  0.230nMAssay Description:Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM347451(MO-OH-NAP | US9790158, 2)
Affinity DataKi:  0.25nMAssay Description:Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM347330(MO-OH-PHE | US9790158, 1)
Affinity DataKi:  0.260nMAssay Description:Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM347453(MO-OH-DM | US9790158, 4)
Affinity DataKi:  0.420nMAssay Description:Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM347457(US9790158, 8)
Affinity DataKi:  0.510nMAssay Description:Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataKi:  0.760nMAssay Description:Inhibition of recombinant HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM347452(MO-OH-SM | US9790158, 3)
Affinity DataKi:  0.810nMAssay Description:Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataKi:  1.5nM ΔG°:  -50.4kJ/mole IC50:  13nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataKi:  1.5nMAssay Description:Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataKi:  1.90nMAssay Description:Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50105329(CHEMBL1213492)
Affinity DataKi:  3nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50463739(CHEMBL4237803)
Affinity DataKi:  3.10nMAssay Description:Inhibition of human recombinant HDAC2 using fluorogenic HDAC substrate after 15 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of full length recombinant human C-terminal GST-tagged HDAC2 expressed in baculovirus-infected insect cells using RHKK(Ac)AMC as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataKi:  6nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) assessed as inhibition constant (Ki) using (Ac-Leu-Gly-Lys(Ac)-AMC as substra...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  7nMAssay Description:Inhibition of human recombinant HDAC2 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50353233(CHEMBL1830536)
Affinity DataKi:  8.60nMAssay Description:Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50319209(6-[3-(4-Bromo-benzoyl)-ureido]-hexanoic acid hydro...)
Affinity DataKi:  12nMAssay Description:Inhibition of HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataKi:  13nMAssay Description:Inhibition of C-terminal GST-tagged recombinant human HDAC2 (1 to 488 residues) expressed in Baculovirus infected insect cells using Boc-Lys(Ac)-AMC ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM178095(BRD2492)
Affinity DataKi:  14nM ΔG°:  -44.8kJ/mole IC50:  19nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50353234(CHEMBL1830537)
Affinity DataKi:  14nMAssay Description:Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50330794(2-Hydroxy-4-isopropyl-cyclohepta-2,4,6-trienone | ...)
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant HDAC2 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50353231(CHEMBL1830422)
Affinity DataKi:  18nMAssay Description:Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50353230(CHEMBL1830420)
Affinity DataKi:  18nMAssay Description:Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM24622(3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoy...)
Affinity DataKi:  19nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50353227(CHEMBL3215861)
Affinity DataKi:  19nMAssay Description:Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM24622(3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoy...)
Affinity DataKi:  19nM ΔG°:  -43.6kJ/molepH: 7.4 T: 2°CAssay Description:HDAC activity was measured using a continuous trypsin-coupled assay. For inhibitor characterization, measurements were done using 96-well assay plat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM24622(3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoy...)
Affinity DataKi:  20nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50353232(CHEMBL1830424)
Affinity DataKi:  21nMAssay Description:Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataKi:  22nMAssay Description:Inhibition of human recombinant HDAC2 using fluorogenic HDAC substrate after 15 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  22nMAssay Description:Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi:  23nMAssay Description:Inhibition of human recombinant HDAC2 using fluorogenic HDAC substrate after 15 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50353229(CHEMBL1830397)
Affinity DataKi:  26nMAssay Description:Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataKi:  27nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataKi:  31nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) assessed as inhibition constant (Ki) using (Ac-Leu-Gly-Lys(Ac)-AMC as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataKi:  31nMAssay Description:Inhibition of human recombinant HDAC2 using fluorogenic HDAC substrate after 15 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50388925(CHEMBL2063396)
Affinity DataKi:  33nMAssay Description:Competitive inhibition of HDAC2 using Ac-Lys(Ac)-AMC as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50353228(CHEMBL1830396)
Affinity DataKi:  33nMAssay Description:Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM50248476(CHEMBL491316 | N-hydroxy-3-(2-phenethyl-1-(2-(pyrr...)
Affinity DataKi:  36nMAssay Description:Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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