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Report error Found 1077 Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EHMT2'
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataKd:  130nMAssay Description:Binding affinity to G9a by isothermal titration colorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50300041(7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl...)
Affinity DataKd:  23nMAssay Description:Binding affinity to G9a by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50300041(7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl...)
Affinity DataKd:  23nMAssay Description:Binding affinity to G9a by isothermal titration colorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50396024(CHEMBL1232453)
Affinity DataKd:  164nMAssay Description:Binding affinity to human recombinant G9a catalytic domain amino acid 913 to 1193 expressed in Escherichia coli BL21 (DE3) by isothermal titration ca...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM225263(Brd4470)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Mouse)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50202440(CHEMBL3933828)
Affinity DataKd:  1.81E+4nMAssay Description:Inhibition of His-sumo-tagged BALB/c mouse thymus histone methyltransferase G9a (969 to 1263 residues) catalytic domain expressed in Escherichia coli...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50268886(CHEMBL4072211)
Affinity DataKd:  510nMAssay Description:Binding affinity to human G9a in presence of SAM by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50268879(CHEMBL4094717)
Affinity DataKd:  1.07E+3nMAssay Description:Binding affinity to human G9a in presence of SAM by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50282113(CHEMBL4168535)
Affinity DataKd:  1.40E+4nMAssay Description:Binding affinity to G9a (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50282160(CHEMBL4176399)
Affinity DataKd:  6.00E+3nMAssay Description:Binding affinity to G9a (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50300032(6,7-Dimethoxy-N-(1-methylpiperidin-4-yl)-2-morphol...)
Affinity DataKd:  445nMAssay Description:Binding affinity to recombinant G9a catalytic SET domain (913 to 1193 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) codon plus ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50501525(CHEMBL4086403)
Affinity DataKd:  610nMAssay Description:Binding affinity to recombinant G9a catalytic SET domain (913 to 1193 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) codon plus ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50504581(CHEMBL4554522)
Affinity DataEC50:  1.42E+5nMAssay Description:Inhibition of human G9a using core histone H3 (1 to 21 residues) as substrate incubated for 1 hr in presence of [3H]-SAM by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50506774(CHEMBL4470149)
Affinity DataEC50:  5.09E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-fused G9a (786 to 1210 residues) expressed in Escherichia coli using biotinylated H3 (1 to 21 residues...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50506782(CHEMBL4461581)
Affinity DataEC50:  3.18E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-fused G9a (786 to 1210 residues) expressed in Escherichia coli using biotinylated H3 (1 to 21 residues...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50506785(CHEMBL4537137)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal GST-fused G9a (786 to 1210 residues) expressed in Escherichia coli using biotinylated H3 (1 to 21 residues...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50506787(CHEMBL4558658)
Affinity DataEC50:  1.37E+5nMAssay Description:Inhibition of recombinant human N-terminal GST-fused G9a (786 to 1210 residues) expressed in Escherichia coli using biotinylated H3 (1 to 21 residues...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50506784(CHEMBL4527662)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal GST-fused G9a (786 to 1210 residues) expressed in Escherichia coli using biotinylated H3 (1 to 21 residues...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataKd:  1.42E+3nMAssay Description:Binding affinity to human His-tagged G9a expressed in Escherichia coli Rosetta (DE3) after 30 mins by MST binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50526221(CHEMBL4454542)
Affinity DataKd:  1.13E+3nMAssay Description:Binding affinity to human His-tagged G9a expressed in Escherichia coli Rosetta (DE3) after 30 mins by MST binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50595368(CHEMBL5191615)
Affinity DataKd:  790nMAssay Description:Binding affinity to human G9a (913 to 1193 residues) assessed as dissociation constant by isothermal titration calorimetry methodMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50595369(CHEMBL5170450)
Affinity DataKd:  44nMAssay Description:Binding affinity to human G9a (913 to 1193 residues) assessed as dissociation constant by isothermal titration calorimetry methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataKd:  230nMAssay Description:Binding affinity to human G9a (913 to 1193 residues) assessed as dissociation constant by isothermal titration calorimetry methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50595370(CHEMBL5189737)
Affinity DataKd:  48nMAssay Description:Binding affinity to human G9a (913 to 1193 residues) assessed as dissociation constant measured after 1 hr by isothermal titration calorimetry methodMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50622552(CHEMBL5437232)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of G9a (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50622549(CHEMBL5403007)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of G9a (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50281305(CHEMBL4162206)
Affinity DataIC50: 0.5nMAssay Description:Non-competitive inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of 2 to 640 uM SAM by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50281300(CHEMBL4170225)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of G9a (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50622551(CHEMBL5424749)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of G9a (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50622550(CHEMBL5405913)
Affinity DataIC50: 0.530nMAssay Description:Inhibition of G9a (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50281305(CHEMBL4162206)
Affinity DataIC50: 0.700nMAssay Description:Competitive inhibition of human G9a using 40 to 2560 nM biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50281305(CHEMBL4162206)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50622548(CHEMBL5416767)
Affinity DataIC50: 0.710nMAssay Description:Inhibition of G9a (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50446378(CHEMBL3109639)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of G9a (unknown origin) using biotinylated-histone H3(1-21) peptide as substrate after 3 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50446386(CHEMBL3109631)
Affinity DataIC50: 1nMAssay Description:Inhibition of G9a (unknown origin) using biotinylated-histone H3(1-21) peptide as substrate after 3 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50592391(CHEMBL5187766)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50622553(CHEMBL5435285)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of G9a (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50634384(CHEMBL5396581)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant G9a (785 to 1210 residues) expressed in baculovirus-infected Sf9 cells using biotinylated histo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50353121(CHEMBL1829295)
Affinity DataIC50: 2nMAssay Description:Inhibition of G9a assessed as hydrolysis of S-adenosyl-L-homocysteine after 2 mins by SAHH-coupled fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50281311(CHEMBL4159604)
Affinity DataIC50: 2nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50281304(CHEMBL4160008)
Affinity DataIC50: 2nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50281304(CHEMBL4160008)
Affinity DataIC50: 2nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50634383(CHEMBL5414343)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant G9a (785 to 1210 residues) expressed in baculovirus-infected Sf9 cells using biotinylated histo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50592384(CHEMBL5195846)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of G9a (unknown origin) using [histone H3 1 to 25 residues] and SAM substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of G9a (unknown origin) incorporation of tritium-labeled methyl group to biotinylated peptide substrates by Scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50442103(CHEMBL2441082)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of G9a (unknown origin) using H3(1-20)-cys as substrate by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
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