Report error Found 277 Enz. Inhib. hit(s) with Target = 'Insulin-degrading enzyme'
Affinity DataKi: 1.40nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Inhibition of human recombinant IDE expressed in CHO cells in presence of [125I]-insulin by HTRF assayMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
Affinity DataKi: 23nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: 38nMAssay Description:Inhibition of human recombinant IDE-mediated insulin degradationMore data for this Ligand-Target Pair
Affinity DataKi: 44nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: 50nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: 70nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
Affinity DataKi: 73nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: 78nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: 85nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: 87nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: 103nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: 107nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
Affinity DataKi: 171nMAssay Description:Inhibition of human recombinant IDE-mediated insulin degradationMore data for this Ligand-Target Pair
Affinity DataKi: 228nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
Affinity DataKi: 246nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
Affinity DataKi: 275nMAssay Description:Inhibition of human recombinant IDE-mediated insulin degradationMore data for this Ligand-Target Pair
Affinity DataKi: 365nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
Affinity DataKi: 410nMAssay Description:Inhibition of human recombinant IDE-mediated insulin degradationMore data for this Ligand-Target Pair
Affinity DataKi: 498nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: 833nMAssay Description:Inhibition of human recombinant IDE-mediated insulin degradationMore data for this Ligand-Target Pair
Affinity DataKi: 927nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
Affinity DataKi: 1.15E+3nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: 1.28E+3nMAssay Description:Inhibition of human recombinant IDE-mediated insulin degradationMore data for this Ligand-Target Pair
Affinity DataKi: 1.89E+3nMAssay Description:Inhibition of human recombinant IDE-mediated insulin degradationMore data for this Ligand-Target Pair
Affinity DataKi: 3.26E+3nMAssay Description:Inhibition of human recombinant IDE-mediated insulin degradationMore data for this Ligand-Target Pair
Affinity DataKi: 5.28E+3nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: 7.02E+3nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: 7.75E+3nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: 1.80E+4nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: >3.30E+4nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: >3.30E+4nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: >3.30E+4nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataKi: >3.30E+4nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant IDE exosite (unknown origin) expressed in Escherichia coli using insulin as substrate incubated for 4 hrs by AlphaLisa assa...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using insulin as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of mouse His-tagged IDE (42 to 1019 residues) using fluorophore/quencher-tagged RPPGFSAFK(Dnp)-OH peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using ATTO 655- Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of mouse His-tagged IDE (42 to 1019 residues) using fluorophore/quencher-tagged RPPGFSAFK(Dnp)-OH peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of N-terminal His6-tagged mouse recombinant IDE Escherichia coli BL21 (DE3) cells using fluorogenic peptide Mca-RPPGFSAFK(Dnp)-OH as subst...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of IDE (unknown origin) assessed as cleavage of Mca-RPPGFSAFK(Dnp)-OH by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of IDE (unknown origin) assessed as cleavage of Mca-RPPGFSAFK(Dnp)-OH by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using insulin as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of human recombinant IDE pre-incubated for 10 mins before Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp substrate addition and measured after 30...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of human IDE using insulin as substrate preincubated for 10 mis followed by substrate addition and measured after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of mouse His-tagged IDE (42 to 1019 residues) using fluorophore/quencher-tagged RPPGFSAFK(Dnp)-OH peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
