Compile Data Set for Download or QSAR
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Report error Found 7488 Enz. Inhib. hit(s) with Target = 'Integrase'
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50559797(CHEMBL4786078)
Affinity DataKi:  8nMAssay Description:Binding affinity to wild type HIV1 integrase G140S/Q148H mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50559796(CHEMBL4779601)
Affinity DataKi:  17nMAssay Description:Binding affinity to wild type HIV1 integrase G140S/Q148H mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527158(CHEMBL4476366)
Affinity DataKi:  40nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527145(CHEMBL4460705)
Affinity DataKi:  60nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527154(CHEMBL4454255)
Affinity DataKi:  90nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetIntegrase(Human immunodeficiency virus type 1)
University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50595032(CHEMBL5178418)
Affinity DataKi:  130nMAssay Description:Binding affinity to influenza A/Beijing/262/95 H1N1 neuraminidase expressed in baculovirus expression system using sialyl-lactose as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527152(CHEMBL4573064)
Affinity DataKi:  170nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527152(CHEMBL4573064)
Affinity DataKi:  170nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetIntegrase(Human immunodeficiency virus type 1)
University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50595031(CHEMBL5199902)
Affinity DataKi:  280nMAssay Description:Binding affinity to influenza A/Beijing/262/95 H1N1 neuraminidase expressed in baculovirus expression system using sialyl-lactose as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527149(CHEMBL4565963)
Affinity DataKi:  310nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527146(CHEMBL4538853)
Affinity DataKi:  430nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527148(CHEMBL4461955)
Affinity DataKi:  680nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50495689(CHEMBL3116306)
Affinity DataKi:  1.00E+3nMAssay Description:Non-competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-recipro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50495689(CHEMBL3116306)
Affinity DataKi:  2.00E+3nMAssay Description:Non-competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-recipro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527153(CHEMBL4469948)
Affinity DataKi:  2.00E+3nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50300129(CHEMBL572528 | CIBACRON BLUE | Cibacron Blue 3Ga)
Affinity DataKi:  2.90E+3nMAssay Description:Binding affinity to influenza A/Beijing/262/95 H1N1 neuraminidase expressed in baculovirus expression system using sialyl-lactose as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527150(CHEMBL4541973)
Affinity DataKi:  3.40E+3nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527157(CHEMBL4452801)
Affinity DataKi:  3.70E+3nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataKi:  4.40E+3nMAssay Description:Non-competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-recipro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527160(CHEMBL4475105)
Affinity DataKi:  4.40E+3nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527144(CHEMBL4587557)
Affinity DataKi:  1.53E+4nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50240448(2-(3,4-dichlorophenyl)-1-hydroxyethane-1,1-diyldip...)
Affinity DataKi:  3.80E+4nMAssay Description:Competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-reciprocal ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527151(CHEMBL4440179)
Affinity DataKi: >4.00E+4nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527156(CHEMBL4551451)
Affinity DataKi: >4.00E+4nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527147(CHEMBL4592796)
Affinity DataKi: >4.00E+4nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527155(CHEMBL4439901)
Affinity DataKi: >5.30E+4nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50527159(CHEMBL4560817)
Affinity DataKi:  6.70E+4nMAssay Description:Allosteric inhibition of [3H]-2-tert-butoxy-2-[2-methyl-4-(p-tolyl)-3-quinolyl]acetic acid binding to HIV1 integrase measured after 1 hr under dark c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50021581(CHEMBL414850 | L-870810)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of HIV1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Newcastle

Curated by ChEMBL
LigandPNGBDBM23402(5-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(4-fluoropheny...)
Affinity DataIC50:  0.5nMAssay Description:In vitro concentration required to inhibit the overall HIV-1 integrase strand transferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50021581(CHEMBL414850 | L-870810)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of HIV1 integrase using labelled oligonucleotide substrate by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50062551(CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of HIV integrase strand transfer activityMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50170870(CHEMBL3805182)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of pseudotype HIV1 integrase strand transfer activity assessed as reduction in viral replication in HIV1 infected human CIP4 cells after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50062551(CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572)
Affinity DataIC50:  0.680nMAssay Description:Inhibition of HIV-1 integrase Q148K mutantMore data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50170867(CHEMBL3806067)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of pseudotype HIV1 integrase strand transfer activity assessed as reduction in viral replication in HIV1 infected human CIP4 cells after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50170867(CHEMBL3806067)
Affinity DataIC50:  1nMAssay Description:Inhibition of pseudotype HIV1 integrase strand transfer activity assessed as reduction in viral replication in in HIV1 infected human CIP4 cells afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50484379(CHEMBL1917873)
Affinity DataIC50:  1nMAssay Description:Inhibition of HIV1 integrase strand transfer by biochemical assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of HIV1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50176113((Z)-4-[1-(4-Fluoro-benzyl)-1H-indol-3-yl]-2-hydrox...)
Affinity DataIC50:  2nMAssay Description:In vitro concentration required to inhibit the overall HIV-1 integrase strand transferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50489299(CHEMBL2316125)
Affinity DataIC50:  2nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataIC50:  2nMAssay Description:Inhibition of HIV1 integrase by overall integration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50480704(CHEMBL556894)
Affinity DataIC50:  2nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity treated after enzyme assembly and washingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50480698(CHEMBL549422)
Affinity DataIC50:  2nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity treated after enzyme assembly and washingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273914(CHEMBL4126686)
Affinity DataIC50:  2nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Newcastle

Curated by ChEMBL
LigandPNGBDBM294624((S)-2-(tert-butoxy)-2-((M)-2-(3,3-dimethylbutanoyl...)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetIntegrase(Human immunodeficiency virus type 1)
University of Newcastle

Curated by ChEMBL
LigandPNGBDBM294623(US10112899, Example 103)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetIntegrase(Human immunodeficiency virus type 1)
University of Newcastle

Curated by ChEMBL
LigandPNGBDBM294622((S)-2-(tert-butoxy)-2-((R)-2-(3,3-difluoropiperidi...)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50273951(CHEMBL4126165)
Affinity DataIC50:  2nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM25351(N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydr...)
Affinity DataIC50:  2nMAssay Description:Inhibition of HIV integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Newcastle

Curated by ChEMBL
LigandPNGBDBM294657((S)-2-(tert-butoxy)-2-((R)-2-(5-fluoro-2-methylben...)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetIntegrase(Human immunodeficiency virus type 1)
University of Newcastle

Curated by ChEMBL
LigandPNGBDBM294658(US10112899, Example 137)
Affinity DataIC50:  2nMAssay Description:Antiviral HIV activity and cytotoxicity values for compounds of the invention from Table 1 were measured in parallel in the HTLV-1 transformed cell l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

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