Report error Found 3300 Enz. Inhib. hit(s) with Target = 'Macrophage colony-stimulating factor 1 receptor'
Affinity DataKi: 8nMAssay Description:Binding affinity to CSF1R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 129nMAssay Description:Inhibition of human CSF1R using poly[Glu:Tyr] (4:1) as substrate after 120 mins in presence of [gamma-33P]-ATP by filtration methodMore data for this Ligand-Target Pair
Affinity DataKi: 166nMAssay Description:Inhibition of human FMS using KKKSPGEYVNIEFG as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counting based radiomet...More data for this Ligand-Target Pair
Affinity DataKi: 230nMAssay Description:Binding affinity to FMS (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.10E+3nMAssay Description:Inhibition of recombinant CSF1R after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMpH: 7.5 T: 22°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of FMS mediated phosphorylation using SYEGNSYTFIDPTQ as substrate after 80 mins by fluorescence polarizationMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMpH: 7.5 T: 22°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMpH: 7.5 T: 22°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMpH: 7.5 T: 22°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.410nMpH: 7.5Assay Description:An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.More data for this Ligand-Target Pair
Affinity DataIC50: 0.420nMpH: 7.5Assay Description:An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.More data for this Ligand-Target Pair
Affinity DataIC50: 0.420nMpH: 7.5 T: 25°CAssay Description:An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...More data for this Ligand-Target Pair
Affinity DataIC50: 0.420nMAssay Description:The operation method is briefly described as follows:The powders of the compound were dissolved in 100% DMSO to make a 10 mM stock solution. The init...More data for this Ligand-Target Pair
Affinity DataIC50: 0.430nMpH: 7.5Assay Description:An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor [555-568](Human)
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 0.440nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure
compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic
CS...More data for this Ligand-Target Pair
Affinity DataIC50: 0.440nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...More data for this Ligand-Target Pair
Affinity DataIC50: 0.470nMpH: 7.5Assay Description:An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.More data for this Ligand-Target Pair
Affinity DataIC50: 0.490nMpH: 7.5 T: 25°CAssay Description:An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMpH: 7.5 T: 22°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMpH: 7.5 T: 22°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMpH: 7.5 T: 22°CAssay Description:FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMpH: 7.5 T: 25°CAssay Description:An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity was determined against HSV-1 Ribonucleoside diphosphate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human FMS by fluorescence polarizationMore data for this Ligand-Target Pair
Affinity DataIC50: <0.5nMAssay Description:Inhibition of human CSF1R using poly[Glu:Tyr] (4:1) as substrate incubated for 2 hrs in presence of [33gammaP]ATP by P81 ion exchange chromatographic...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor [555-568](Human)
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 0.510nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure
compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic
CS...More data for this Ligand-Target Pair
Affinity DataIC50: 0.510nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...More data for this Ligand-Target Pair
Affinity DataIC50: 0.530nMAssay Description:Inhibition of wild-type human partial length CSF1R (I564 to S939 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.550nMAssay Description:CSF1R: The specific operation is as follows: Set the concentration gradient of the test compound and dilute the test compound to the working concentr...More data for this Ligand-Target Pair
Affinity DataIC50: 0.560nMpH: 7.5 T: 25°CAssay Description:An autophosphorylation, fluorescence polarization competition immunoassay was used to determine the potency for c-fms inhibition exhibited by selecte...More data for this Ligand-Target Pair
Affinity DataIC50: 0.570nMAssay Description:Inhibition of CSF1R (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor [555-568](Human)
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 0.600nMpH: 7.5Assay Description:A fluorescence polarization competition immunoassay was used to measure
compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic
CS...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarizationMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair
