Compile Data Set for Download or QSAR
Found 4876 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2'
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM85212(CAS_5311260 | LY341495 | NSC_5311260)
Show SMILES NC(Cn1cnc2c1[nH]c(=O)[nH]c2=O)(C1CC1C(O)=O)C(O)=O
Show InChI InChI=1S/C12H13N5O6/c13-12(10(21)22,5-1-4(5)9(19)20)2-17-3-14-6-7(17)15-11(23)16-8(6)18/h3-5H,1-2,13H2,(H,19,20)(H,21,22)(H2,15,16,18,23)
Affinity DataKi:  0.0780nMMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50034503((1R,2R)-3-((S)-Amino-carboxy-methyl)-cyclopropane-...)
Show SMILES N[C@@H](C1[C@H]([C@@H]1C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO6/c8-4(7(13)14)1-2(5(9)10)3(1)6(11)12/h1-4H,8H2,(H,9,10)(H,11,12)(H,13,14)/t2-,3-,4+/m1/s1
Affinity DataKi:  0.368nMMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50004899((1R,2S)-2-((S)-Amino-carboxy-methyl)-cyclopropanec...)
Show SMILES N[C@@H]([C@H]1C[C@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3+,4-/m0/s1
Affinity DataKi:  0.378nMMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50257518(CHEMBL4063313)
Show SMILES O[C@@]1(CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F)C1CC1
Show InChI InChI=1S/C26H28ClF3N4O/c27-20-14-16(3-6-21(20)31-18-7-10-25(35,11-8-18)17-4-5-17)19-9-12-34-22(13-15-1-2-15)32-33-24(34)23(19)26(28,29)30/h3,6,9,12,14-15,17-18,31,35H,1-2,4-5,7-8,10-11,13H2/t18-,25+
Affinity DataKi:  0.891nMAssay Description:Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50209103(CHEMBL3885379)
Show SMILES FC(F)(F)c1c(OC[C@H]2C[C@@H]2c2ccc(Cl)cc2)ccn2c(CC3CC3)nnc12
Show InChI InChI=1S/C21H19ClF3N3O/c22-15-5-3-13(4-6-15)16-10-14(16)11-29-17-7-8-28-18(9-12-1-2-12)26-27-20(28)19(17)21(23,24)25/h3-8,12,14,16H,1-2,9-11H2/t14-,16-/m1/s1
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-JNJ-40068782 from human mGlu2 receptor expressed in HEK293 cell membranes coexpressing rat glutamate transporter measured after ...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151448((1R,2R,3R,5R,6R)-2-Amino-3-(3-carboxy-benzyloxy)-6...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc(c1)C(O)=O)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C16H16FNO7/c17-15(13(21)22)9-5-10(16(18,11(9)15)14(23)24)25-6-7-2-1-3-8(4-7)12(19)20/h1-4,9-11H,5-6,18H2,(H,19,20)(H,21,22)(H,23,24)/t9-,10-,11+,15-,16+/m1/s1
Affinity DataKi:  1.06nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151486((1R,2R,3R,5R,6R)-2-Amino-3-[(R)-1-(3,4-dichloro-ph...)
Show SMILES C[C@@H](O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H16Cl2FNO5/c1-6(7-2-3-9(17)10(18)4-7)25-11-5-8-12(15(8,19)13(21)22)16(11,20)14(23)24/h2-4,6,8,11-12H,5,20H2,1H3,(H,21,22)(H,23,24)/t6-,8-,11-,12+,15-,16+/m1/s1
Affinity DataKi:  1.45nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151439((1R,2R,3R,5R,6R)-2-Amino-3-[(R)-1-(3,4-dichloro-ph...)
Show SMILES CCC[C@@H](O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H20Cl2FNO5/c1-2-3-12(8-4-5-10(19)11(20)6-8)27-13-7-9-14(17(9,21)15(23)24)18(13,22)16(25)26/h4-6,9,12-14H,2-3,7,22H2,1H3,(H,23,24)(H,25,26)/t9-,12-,13-,14+,17-,18+/m1/s1
Affinity DataKi:  1.48nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50257556(CHEMBL4101354)
Show SMILES Cc1ccc(Oc2ccc(cc2Cl)-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)c(C)n1
Show InChI InChI=1S/C24H20ClF3N4O/c1-13-3-7-19(14(2)29-13)33-20-8-6-16(12-18(20)25)17-9-10-32-21(11-15-4-5-15)30-31-23(32)22(17)24(26,27)28/h3,6-10,12,15H,4-5,11H2,1-2H3
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151481((1R,2R,3R,5R,6R)-2-Amino-3-[(R)-1-(3,4-dichloro-ph...)
Show SMILES CC[C@@H](O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H18Cl2FNO5/c1-2-11(7-3-4-9(18)10(19)5-7)26-12-6-8-13(16(8,20)14(22)23)17(12,21)15(24)25/h3-5,8,11-13H,2,6,21H2,1H3,(H,22,23)(H,24,25)/t8-,11-,12-,13+,16-,17+/m1/s1
Affinity DataKi:  1.61nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151434((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-((S)-1-naphtha...)
Show SMILES C[C@H](O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H20FNO5/c1-10(12-7-6-11-4-2-3-5-13(11)8-12)27-15-9-14-16(19(14,21)17(23)24)20(15,22)18(25)26/h2-8,10,14-16H,9,22H2,1H3,(H,23,24)(H,25,26)/t10-,14+,15+,16-,19+,20-/m0/s1
Affinity DataKi:  1.79nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50257554(CHEMBL4075258)
Show SMILES Cc1ccc(Oc2ccc(cc2F)-c2ccn3c(CC4CC4)nnc3c2Cl)c(C)n1
Show InChI InChI=1S/C23H20ClFN4O/c1-13-3-7-19(14(2)26-13)30-20-8-6-16(12-18(20)25)17-9-10-29-21(11-15-4-5-15)27-28-23(29)22(17)24/h3,6-10,12,15H,4-5,11H2,1-2H3
Affinity DataKi:  1.90nMAssay Description:Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50257551(CHEMBL4077609)
Show SMILES O[C@H]1CC[C@@H](CC1)Oc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1S/C23H23ClF3N3O2/c24-18-12-14(3-8-19(18)32-16-6-4-15(31)5-7-16)17-9-10-30-20(11-13-1-2-13)28-29-22(30)21(17)23(25,26)27/h3,8-10,12-13,15-16,31H,1-2,4-7,11H2/t15-,16-
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50257525(CHEMBL4091370)
Show SMILES COc1ccc(CNc2ccc(cc2F)-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)cn1
Show InChI InChI=1S/C24H21F4N5O/c1-34-21-7-4-15(13-30-21)12-29-19-6-5-16(11-18(19)25)17-8-9-33-20(10-14-2-3-14)31-32-23(33)22(17)24(26,27)28/h4-9,11,13-14,29H,2-3,10,12H2,1H3
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151476((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-((R)-1-naphtha...)
Show SMILES C[C@@H](O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H20FNO5/c1-10(12-7-6-11-4-2-3-5-13(11)8-12)27-15-9-14-16(19(14,21)17(23)24)20(15,22)18(25)26/h2-8,10,14-16H,9,22H2,1H3,(H,23,24)(H,25,26)/t10-,14-,15-,16+,19-,20+/m1/s1
Affinity DataKi:  2.01nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151435((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)c(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14Cl2FNO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
Affinity DataKi:  2.20nMAssay Description:Binding affinity to mGLUR2More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50257548(CHEMBL4104081)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1S/C23H24ClF3N4O/c24-18-12-14(3-8-19(18)28-15-4-6-16(32)7-5-15)17-9-10-31-20(11-13-1-2-13)29-30-22(31)21(17)23(25,26)27/h3,8-10,12-13,15-16,28,32H,1-2,4-7,11H2/t15-,16-
Affinity DataKi:  2.20nMAssay Description:Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50257606(CHEMBL4073628)
Show SMILES FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)-c1ccc(NC2CC2)c(Cl)c1
Show InChI InChI=1S/C20H18ClF3N4/c21-15-10-12(3-6-16(15)25-13-4-5-13)14-7-8-28-17(9-11-1-2-11)26-27-19(28)18(14)20(22,23)24/h3,6-8,10-11,13,25H,1-2,4-5,9H2
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151453((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-difluoro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(F)c(F)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14F3NO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
Affinity DataKi:  2.27nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151435((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)c(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14Cl2FNO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
Affinity DataKi:  2.38nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151473((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(naphthalen-2-...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc3ccccc3c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C19H18FNO5/c20-18(16(22)23)13-8-14(19(21,15(13)18)17(24)25)26-9-10-5-6-11-3-1-2-4-12(11)7-10/h1-7,13-15H,8-9,21H2,(H,22,23)(H,24,25)/t13-,14-,15+,18-,19+/m1/s1
Affinity DataKi:  2.53nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151438((1R,2R,3R,5R,6R)-2-Amino-3-benzhydryloxy-6-fluoro-...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OC(c1ccccc1)c1ccccc1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H20FNO5/c22-20(18(24)25)14-11-15(21(23,17(14)20)19(26)27)28-16(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,14-17H,11,23H2,(H,24,25)(H,26,27)/t14-,15-,17+,20-,21+/m1/s1
Affinity DataKi:  2.58nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50257524(CHEMBL4080973)
Show SMILES Cc1ccc(Oc2ccc(cc2F)-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)c(C)n1
Show InChI InChI=1S/C24H20F4N4O/c1-13-3-7-19(14(2)29-13)33-20-8-6-16(12-18(20)25)17-9-10-32-21(11-15-4-5-15)30-31-23(32)22(17)24(26,27)28/h3,6-10,12,15H,4-5,11H2,1-2H3
Affinity DataKi:  2.60nMAssay Description:Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151478((1R,2R,3R,5R,6R)-2-Amino-3-[bis-(3,4-dichloro-phen...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OC(c1ccc(Cl)c(Cl)c1)c1ccc(Cl)c(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H16Cl4FNO5/c22-11-3-1-8(5-13(11)24)16(9-2-4-12(23)14(25)6-9)32-15-7-10-17(20(10,26)18(28)29)21(15,27)19(30)31/h1-6,10,15-17H,7,27H2,(H,28,29)(H,30,31)/t10-,15-,17+,20-,21+/m1/s1
Affinity DataKi:  2.61nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50089890(4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxyli...)
Show SMILES N[C@]1(COC2[C@@H](C12)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3?,4?,7+/m1/s1
Affinity DataKi:  2.70nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2).More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151475((1R,2R,3R,5R,6R)-2-Amino-3-(3-cyano-benzyloxy)-6-f...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc(c1)C#N)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C16H15FN2O5/c17-15(13(20)21)10-5-11(16(19,12(10)15)14(22)23)24-7-9-3-1-2-8(4-9)6-18/h1-4,10-12H,5,7,19H2,(H,20,21)(H,22,23)/t10-,11-,12+,15-,16+/m1/s1
Affinity DataKi:  2.94nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50257520(CHEMBL4074421)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C22H24Cl2N4O/c23-18-12-14(3-8-19(18)25-15-4-6-16(29)7-5-15)17-9-10-28-20(11-13-1-2-13)26-27-22(28)21(17)24/h3,8-10,12-13,15-16,25,29H,1-2,4-7,11H2/t15-,16-
Affinity DataKi:  3nMAssay Description:Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151482((1R,2R,3R,5R,6R)-2-Amino-3-[(S)-1-(3,4-dichloro-ph...)
Show SMILES CCC[C@H](O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H20Cl2FNO5/c1-2-3-12(8-4-5-10(19)11(20)6-8)27-13-7-9-14(17(9,21)15(23)24)18(13,22)16(25)26/h4-6,9,12-14H,2-3,7,22H2,1H3,(H,23,24)(H,25,26)/t9-,12+,13-,14+,17-,18+/m1/s1
Affinity DataKi:  3.05nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151445((1R,2R,3R,5R,6R)-2-Amino-3-[(S)-1-(3,4-dichloro-ph...)
Show SMILES CC[C@H](O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H18Cl2FNO5/c1-2-11(7-3-4-9(18)10(19)5-7)26-12-6-8-13(16(8,20)14(22)23)17(12,21)15(24)25/h3-5,8,11-13H,2,6,21H2,1H3,(H,22,23)(H,24,25)/t8-,11+,12-,13+,16-,17+/m1/s1
Affinity DataKi:  3.12nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
Affinity DataKi:  3.13nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151447((1R,2R,3R,5R,6R)-2-Amino-3-(4-chloro-benzyloxy)-6-...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)cc1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H15ClFNO5/c16-8-3-1-7(2-4-8)6-23-10-5-9-11(14(9,17)12(19)20)15(10,18)13(21)22/h1-4,9-11H,5-6,18H2,(H,19,20)(H,21,22)/t9-,10-,11+,14-,15+/m1/s1
Affinity DataKi:  3.17nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50257517(CHEMBL4093657)
Show SMILES COc1ccc(CNc2ccc(cc2)-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)cn1
Show InChI InChI=1S/C24H22F3N5O/c1-33-21-9-4-16(14-29-21)13-28-18-7-5-17(6-8-18)19-10-11-32-20(12-15-2-3-15)30-31-23(32)22(19)24(25,26)27/h4-11,14-15,28H,2-3,12-13H2,1H3
Affinity DataKi:  3.20nMAssay Description:Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151464((1R,2R,3R,5R,6R)-2-Amino-3-(3-chloro-benzyloxy)-6-...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H15ClFNO5/c16-8-3-1-2-7(4-8)6-23-10-5-9-11(14(9,17)12(19)20)15(10,18)13(21)22/h1-4,9-11H,5-6,18H2,(H,19,20)(H,21,22)/t9-,10-,11+,14-,15+/m1/s1
Affinity DataKi:  3.28nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50094843((+)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...)
Show SMILES N[C@]1(CC(=O)[C@@H]2[C@H]1[C@@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H8FNO5/c9-8(6(14)15)3-2(11)1-7(10,4(3)8)5(12)13/h3-4H,1,10H2,(H,12,13)(H,14,15)/t3-,4-,7+,8-/m1/s1
Affinity DataKi:  3.30nMAssay Description:Tested for binding affinity against Metabotropic glutamate receptor 2 in CHO cells using [3H]-7 as radioligandMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151469((1R,2R,3R,5R,6R)-2-Amino-3-(3-chloro-4-fluoro-benz...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(F)c(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14ClF2NO5/c16-8-3-6(1-2-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
Affinity DataKi:  3.57nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50257595(CHEMBL4087196)
Show SMILES Fc1cc(ccc1NC1CC1)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1S/C20H18F4N4/c21-15-10-12(3-6-16(15)25-13-4-5-13)14-7-8-28-17(9-11-1-2-11)26-27-19(28)18(14)20(22,23)24/h3,6-8,10-11,13,25H,1-2,4-5,9H2
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50257576(CHEMBL4072262)
Show SMILES Fc1cc(ccc1Oc1ccnc(c1)C1CC1)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1S/C25H20F4N4O/c26-19-12-16(5-6-21(19)34-17-7-9-30-20(13-17)15-3-4-15)18-8-10-33-22(11-14-1-2-14)31-32-24(33)23(18)25(27,28)29/h5-10,12-15H,1-4,11H2
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151443((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(3,4,5-trichlo...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cc(Cl)c(Cl)c(Cl)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H13Cl3FNO5/c16-7-1-5(2-8(17)10(7)18)4-25-9-3-6-11(14(6,19)12(21)22)15(9,20)13(23)24/h1-2,6,9,11H,3-4,20H2,(H,21,22)(H,23,24)/t6-,9-,11+,14-,15+/m1/s1
Affinity DataKi:  3.67nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50279772(2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cy...)
Show SMILES N[C@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20+/m0/s1
Affinity DataKi:  3.72nMAssay Description:Tested for binding affinity against Metabotropic glutamate receptor 2 in CHO cells using [3H]-7 as radioligandMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151480((1R,2R,3R,5R,6R)-2-Amino-3-[bis-(4-chloro-phenyl)-...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H18Cl2FNO5/c22-12-5-1-10(2-6-12)16(11-3-7-13(23)8-4-11)30-15-9-14-17(20(14,24)18(26)27)21(15,25)19(28)29/h1-8,14-17H,9,25H2,(H,26,27)(H,28,29)/t14-,15-,17+,20-,21+/m1/s1
Affinity DataKi:  3.75nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151488((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-pentafluorophe...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1c(F)c(F)c(F)c(F)c1F)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H11F6NO5/c16-6-3(7(17)9(19)10(20)8(6)18)2-27-5-1-4-11(14(4,21)12(23)24)15(5,22)13(25)26/h4-5,11H,1-2,22H2,(H,23,24)(H,25,26)/t4-,5-,11+,14-,15+/m1/s1
Affinity DataKi:  3.77nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151472((1R,2R,3R,5R,6R)-2-Amino-3-[bis-(4-fluoro-phenyl)-...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OC(c1ccc(F)cc1)c1ccc(F)cc1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H18F3NO5/c22-12-5-1-10(2-6-12)16(11-3-7-13(23)8-4-11)30-15-9-14-17(20(14,24)18(26)27)21(15,25)19(28)29/h1-8,14-17H,9,25H2,(H,26,27)(H,28,29)/t14-,15-,17+,20-,21+/m1/s1
Affinity DataKi:  3.79nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151451((1R,2R,3R,5R,6R)-2-Amino-3-(2,4-dichloro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)cc1Cl)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14Cl2FNO5/c16-7-2-1-6(9(17)3-7)5-24-10-4-8-11(14(8,18)12(20)21)15(10,19)13(22)23/h1-3,8,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t8-,10-,11+,14-,15+/m1/s1
Affinity DataKi:  3.89nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50089897(4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxyl...)
Show SMILES N[C@]1(CSC2[C@@H](C12)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO4S/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3?,4?,7+/m1/s1
Affinity DataKi:  3.90nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2).More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50257593(CHEMBL4067421)
Show SMILES CC(C)Nc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1S/C20H20ClF3N4/c1-11(2)25-16-6-5-13(10-15(16)21)14-7-8-28-17(9-12-3-4-12)26-27-19(28)18(14)20(22,23)24/h5-8,10-12,25H,3-4,9H2,1-2H3
Affinity DataKi:  3.90nMAssay Description:Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151449((1R,2R,3R,5R,6R)-2-Amino-3-(4-chloro-3-fluoro-benz...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)c(F)c1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14ClF2NO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
Affinity DataKi:  4.02nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151442((1R,2R,3R,5R,6R)-2-Amino-3-(biphenyl-2-ylmethoxy)-...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccccc1-c1ccccc1)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H20FNO5/c22-20(18(24)25)15-10-16(21(23,17(15)20)19(26)27)28-11-13-8-4-5-9-14(13)12-6-2-1-3-7-12/h1-9,15-17H,10-11,23H2,(H,24,25)(H,26,27)/t15-,16-,17+,20-,21+/m1/s1
Affinity DataKi:  4.07nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50503158(CHEMBL4589377)
Show SMILES FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)-c1ccc(CNC(=O)c2ccc(cc2)S(F)(=O)=O)cc1
Show InChI InChI=1S/C25H20F4N4O3S/c26-25(27,28)22-20(11-12-33-21(13-15-1-2-15)31-32-23(22)33)17-5-3-16(4-6-17)14-30-24(34)18-7-9-19(10-8-18)37(29,35)36/h3-12,15H,1-2,13-14H2,(H,30,34)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]JNJ-46281222 from human mGlu2 receptor expressed in CHOK1 cell membranes preincubated for 3 hrs followed by [3H]JNJ-46281222 addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151458((1R,2R,3R,5R,6R)-2-Amino-3-(2,3-difluoro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc(F)c1F)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14F3NO5/c16-8-3-1-2-6(10(8)17)5-24-9-4-7-11(14(7,18)12(20)21)15(9,19)13(22)23/h1-3,7,9,11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,9-,11+,14-,15+/m1/s1
Affinity DataKi:  4.25nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by PDSP Ki Database
LigandPNGBDBM50151470((1R,2R,3R,5R,6R)-2-Amino-3-(2,6-dichloro-benzyloxy...)
Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1c(Cl)cccc1Cl)[C@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H14Cl2FNO5/c16-8-2-1-3-9(17)6(8)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
Affinity DataKi:  4.30nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
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