Compile Data Set for Download or QSAR
Found 20592 Enz. Inhib. hit(s) with Target = 'Mu-type opioid receptor'
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50111903((S)-1-[(S)-2-{2-[(S)-2-{(S)-2-[(S)-2-Amino-3-(4-hy...)
Affinity DataKi:  0.000540nMAssay Description:Binding affinity of the compound against Opioid receptor mu 1 using [3H]-DAMGO in rat brain synaptosomes was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50133817(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Affinity DataKi:  0.000950nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50292912(17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5r-epoxy...)
Affinity DataKi:  0.00130nMAssay Description:Displacement of [3H]-DAMGO from human HA-tagged mu-opioid receptor expressed in HEK293 cells after 90 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50402775(CHEMBL2208351)
Affinity DataKi:  0.00160nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50125999((R)-2-[(S)-2-Amino-3-(4-hydroxy-2,6-dimethyl-pheny...)
Affinity DataKi:  0.00205nMAssay Description:Ability of the compound to displace [3H]-DAMGO from mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  0.00240nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Wistar rat brain after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50366764(CHEMBL1790045 | MCL-117)
Affinity DataKi:  0.00300nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50366764(CHEMBL1790045 | MCL-117)
Affinity DataKi:  0.00320nMAssay Description:Binding affinity towards Opioid receptor mu 1 in guinea pig brain membranes using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50430798(CHEMBL2335120)
Affinity DataKi:  0.00372nMAssay Description:Displacement of [3H]DAMGO from FLAG-tagged mu-type opioid receptor (unknown origin) expressed in HEK293 cells after 60 mins by liquid scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50451302(CHEMBL2115245)
Affinity DataKi:  0.00480nMAssay Description:Binding affinity towards Opioid receptor mu 1 in guinea pig brain membranes using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50402777(CHEMBL2208347)
Affinity DataKi:  0.00490nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50033531(CHEMBL333410 | N-[1-(2-Hydroxy-2-phenyl-ethyl)-3-m...)
Affinity DataKi:  0.00500nMAssay Description:Inhibition against Opioid receptor mu 1 using [3H]- DAMGO radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50229232(CHEMBL610527)
Affinity DataKi:  0.00500nMAssay Description:Compound was evaluated for the binding affinity to Opioid receptor mu using [3H]DAMGO as radioligand in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50033532(CHEMBL435380 | N-[(3S,4R)-1-((R)-2-Hydroxy-2-pheny...)
Affinity DataKi:  0.00500nMAssay Description:Binding affinity towards Opioid receptor mu 1 using [3H]DAMGO as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50033536(CHEMBL121494 | N-[(3R,4R)-1-((R)-2-Hydroxy-2-pheny...)
Affinity DataKi:  0.00550nMAssay Description:Binding affinity towards Opioid receptor mu 1 using [3H]DAMGO as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50402777(CHEMBL2208347)
Affinity DataKi:  0.00560nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50402776(CHEMBL2208349)
Affinity DataKi:  0.00560nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50551316(CHEMBL4776706)
Affinity DataKi:  0.00630nMAssay Description:Displacement of [3H]DAMGO from MOR in Wistar rat brain membranes measured after 45 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50096716(CHEMBL100480 | Enkephalin derivative)
Affinity DataKi:  0.00680nMAssay Description:Binding affinity was determined towards Opioid receptor mu 1 in rat brain synaptosomes using [3H]-DAMGO as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50402772(CHEMBL2208350)
Affinity DataKi:  0.00710nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50008834(CHEMBL3236671)
Affinity DataKi:  0.00935nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50139013((S)-1-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyl]...)
Affinity DataKi:  0.00950nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in Wistar rat brain after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50430801(CHEMBL2334776)
Affinity DataKi:  0.00986nMAssay Description:Displacement of [3H]DAMGO from FLAG-tagged mu-type opioid receptor (unknown origin) expressed in HEK293 cells after 60 mins by liquid scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50474150(CHEMBL58362)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity to mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMu-type opioid receptor(GUINEA PIG)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50180190((1R,9R)-17-[(2S)-oxolan-2-ylmethyl]-17-azatetracyc...)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity towards Opioid receptor mu 1 by displacing the radioligand [3H]DAMGO from guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50180190((1R,9R)-17-[(2S)-oxolan-2-ylmethyl]-17-azatetracyc...)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50142700(CHEMBL326684)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity at mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Macaca mulatta)
Universit£t des Saarlandes

Curated by ChEMBL
LigandPNGBDBM50013847(CHEMBL312040 | Etonitazene | {2-[2-(4-Ethoxy-benzy...)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity to mu opioid receptor in rhesus monkey brain membrane in presence of Na+ ionsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50334988((S)-2-amino-N-((R)-1-(2-((S)-3-(4-fluorophenyl)-1-...)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptor expressed in mouse HN9.10 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50528967(CHEMBL4439415)
Affinity DataKi:  0.0109nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) expressed in HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50528965(CHEMBL4550234)
Affinity DataKi:  0.0109nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) expressed in HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50528960(CHEMBL4450250)
Affinity DataKi:  0.0109nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) expressed in HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50528966(CHEMBL4521879)
Affinity DataKi:  0.0109nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) expressed in HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50594821(CHEMBL5175179)
Affinity DataKi:  0.0110nMAssay Description:Displacement of [3H]DAMGO from MOP (unknown origin) stably expressed in HEK293 cells by liquid scintillation counter analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50133884(CHEMBL3634251)
Affinity DataKi:  0.0120nMAssay Description:Displacement of [3H]diprenorphine from rat mu-opioid receptor expressed in C6 cell membrane for 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50551315(CHEMBL4762529)
Affinity DataKi:  0.0125nMAssay Description:Displacement of [3H]DAMGO from MOR in Wistar rat brain membranes measured after 45 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50430802(CHEMBL2334775)
Affinity DataKi:  0.0128nMAssay Description:Displacement of [3H]DAMGO from FLAG-tagged mu-type opioid receptor (unknown origin) expressed in HEK293 cells after 60 mins by liquid scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50033535(CHEMBL331883 | N-[(3R,4S)-1-((R)-2-Hydroxy-2-pheny...)
Affinity DataKi:  0.0130nMAssay Description:Binding affinity against Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50031568(CHEMBL2369874 | [D-Asp2]Dyn A-(1-13)NH2)
Affinity DataKi:  0.0130nMAssay Description:Compound was evaluated for binding affinity against Opioid receptor mu 1 of rat forebrain using [3H]-DAMGO as the radioligand using competition bindi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50064515(3-[(3R,4R)-3,4-Dimethyl-1-((E)-3-o-tolyl-allyl)-pi...)
Affinity DataKi:  0.0130nMAssay Description:The compound was tested for antagonist activity by selective inhibition of [35S]-GTP-gammaS, binding to Opioid receptor mu 1 in Guinea pig caudate st...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50033535(CHEMBL331883 | N-[(3R,4S)-1-((R)-2-Hydroxy-2-pheny...)
Affinity DataKi:  0.0130nMAssay Description:Binding affinity towards Opioid receptor mu 1 using [3H]DAMGO as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50551313(CHEMBL4745764)
Affinity DataKi:  0.0136nMAssay Description:Displacement of [3H]DAMGO from MOR in Wistar rat brain membranes measured after 45 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50430803(CHEMBL2334774)
Affinity DataKi:  0.0137nMAssay Description:Displacement of [3H]DAMGO from FLAG-tagged mu-type opioid receptor (unknown origin) expressed in HEK293 cells after 60 mins by liquid scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50166065((S)-1-[(S)-2-Amino-3-(4-hydroxy-2,6-dimethyl-pheny...)
Affinity DataKi:  0.0140nMAssay Description:Inhibition of DAMGO (Tyr-[D-Ala]-Gly-[NMe-Phe]-Gly-ol) binding to rat brain mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50594822(CHEMBL5182849)
Affinity DataKi:  0.0140nMAssay Description:Displacement of [3H]DAMGO from MOP (unknown origin) stably expressed in HEK293 cells by liquid scintillation counter analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50254566(6,11-Dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,...)
Affinity DataKi:  0.0150nMAssay Description:Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50299217((5R,8S,11S,14S)-14-((S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  0.0160nMAssay Description:Binding affinity at mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50299217((5R,8S,11S,14S)-14-((S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  0.0160nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkermes, Plc

Curated by ChEMBL
LigandPNGBDBM50402773(CHEMBL2208358)
Affinity DataKi:  0.0180nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50002185(CHEMBL438741 | Tyr-Gly-Gly-Phe-Leu-Lys(Ac)-Arg-Ile...)
Affinity DataKi:  0.0180nMAssay Description:Inhibition of [3H]-DAMGO to opioid receptor mu of rat fore brain membranes was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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