Compile Data Set for Download or QSAR
Report error Found 110 Enz. Inhib. hit(s) with Target = 'N-lysine methyltransferase KMT5A'
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051117(CHEMBL3318285)
Affinity DataKd:  1.83E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli by ITC assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051117(CHEMBL3318285)
Affinity DataKd:  3.60E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50075100(CHEMBL3414625)
Affinity DataEC50: <1.00E+3nMAssay Description:Inhibition of SETD8 in HEK293T cells assessed as reduction in H4K20me level after 2 to 3 days by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50075099(TCMDC-124224 | CHEMBL580421)
Affinity DataEC50: <5.00E+3nMAssay Description:Inhibition of SETD8 in HEK293T cells assessed as reduction in H4K20me level after 2 to 3 days by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50106497(NSC-663284 | 6-Chloro-7-(2-morpholin-4-yl-ethylami...)
Affinity DataEC50: <5.00E+3nMAssay Description:Inhibition of SETD8 in HEK293T cells assessed as reduction in H4K20me level after 2 to 3 days by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50548178(CHEMBL4793474)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to recombinant SETD8 catalytic domain (unknown origin) (232 to 393 residues) expressed in Escherichia coli assessed as dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50106497(NSC-663284 | 6-Chloro-7-(2-morpholin-4-yl-ethylami...)
Affinity DataIC50: 210nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352) assessed as incorporation of [3H]-methyl group from [3H-Me]-SAM to biotinylated H4K20 p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50106497(NSC-663284 | 6-Chloro-7-(2-morpholin-4-yl-ethylami...)
Affinity DataIC50: 210nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352 residues) expressed in Escherichia coli Rosseta-2(DE3) cells using histone peptide subst...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50106497(NSC-663284 | 6-Chloro-7-(2-morpholin-4-yl-ethylami...)
Affinity DataIC50: 210nMAssay Description:Inhibition of SETD8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50201571(CHEMBL3934996)
Affinity DataIC50: 330nMAssay Description:Inhibition of human SETD8 (186 to 352 residues) using biotin-labeled H4K20 (1 to 24 residues) as substrate after 1 hr in presence of 3H-SAM by scinti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50086655(5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenz...)
Affinity DataIC50: 370nMAssay Description:Inhibition of SETD8 (unknown origin) using [3H]SAM and HeLa nucleosomes as substrates incubated for 1 hrMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50075100(CHEMBL3414625)
Affinity DataIC50: 500nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352) assessed as incorporation of [3H]-methyl group from [3H-Me]-SAM to biotinylated H4K20 p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50086655(5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenz...)
Affinity DataIC50: 500nMAssay Description:Inhibition of SETD8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50075100(CHEMBL3414625)
Affinity DataIC50: 500nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352 residues) expressed in Escherichia coli Rosseta-2(DE3) cells using histone peptide subst...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50075100(CHEMBL3414625)
Affinity DataIC50: 500nMAssay Description:Inhibition of SETD8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50075099(TCMDC-124224 | CHEMBL580421)
Affinity DataIC50: 700nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352) assessed as incorporation of [3H]-methyl group from [3H-Me]-SAM to biotinylated H4K20 p...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50075099(TCMDC-124224 | CHEMBL580421)
Affinity DataIC50: 700nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352 residues) expressed in Escherichia coli Rosseta-2(DE3) cells using histone peptide subst...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50075099(TCMDC-124224 | CHEMBL580421)
Affinity DataIC50: 700nMAssay Description:Inhibition of SETD8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50548177(CHEMBL4791952)
Affinity DataIC50: 804nMAssay Description:Inhibition of recombinant SETD8 catalytic domain (unknown origin) (232 to 393 residues) expressed in Escherichia coli assessed as reduction in incorp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50548178(CHEMBL4793474)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant SETD8 catalytic domain (unknown origin) (232 to 393 residues) expressed in Escherichia coli assessed as reduction in incorp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051116(CHEMBL3318284)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of SETD8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051116(CHEMBL3318284)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of SETD8 (unknown origin) using H4 (1 to 24) as substrate assessed as incorporation of [3H]-methyl group from [3H-Me]-SAM to peptide subst...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051116(CHEMBL3318284)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of SETD8 (unknown origin) using biotin-labeled H4 (1 to 24 residues) as substrate after 1 hr in presence of [3H]SAM by scintillation proxi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051116(CHEMBL3318284)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051116(CHEMBL3318284)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of SETD8 (unknown origin) using biotin-labeled histone H4 (1 to 24 residues) as substrate incubated for 1 hr in presence of [3H-Me]SAM by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051116(CHEMBL3318284)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of SETD8 (unknown origin) using biotinylated-H3 peptide as substrate measured after 1 hr in presence of [3H]-SAM by scintillation proximit...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50548177(CHEMBL4791952)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of recombinant SETD8 catalytic domain (unknown origin) (232 to 393 residues) expressed in Escherichia coli assessed as reduction in incorp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051117(CHEMBL3318285)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051121(CHEMBL3318289)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051122(CHEMBL3318290)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50498700(CHEMBL3621706)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50498722(CHEMBL3621701)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50498721(CHEMBL3621704)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051117(CHEMBL3318285)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of methyltransferase activity of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli assessed as decrease in methylation...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051133(CHEMBL3318301)
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50498730(CHEMBL3622290)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50353131(CHEMBL1829304)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SETD8 assessed as hydrolysis of S-adenosyl-L-homocysteine after 2 mins by SAHH-coupled fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50498718(CHEMBL3622293)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50498725(CHEMBL3622271)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051123(CHEMBL3318291)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50498731(CHEMBL3621703)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051127(CHEMBL3318295)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50498696(CHEMBL3622261)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of human SETD8 catalytic domain expressed in Escherichia coli assessed as reduction in transfer of tritiated methyl group from [3H]SAM to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051126(CHEMBL3318294)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051125(CHEMBL3318293)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051128(CHEMBL3318296)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051124(CHEMBL3318292)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051119(CHEMBL3318287)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051384(CHEMBL3318304)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetN-lysine methyltransferase KMT5A(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50051386(CHEMBL3318305)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of SETD8 (unknown origin) catalytic domain expressed in Escherichia coli using biotinylated H4 (1-24) peptide substrate after 1 hr by scin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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