Compile Data Set for Download or QSAR
Report error Found 181 Enz. Inhib. hit(s) with Target = 'NPC1-like intracellular cholesterol transporter 1'
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045524(CHEMBL3311502)
Affinity DataEC50:  86nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045525(CHEMBL3311372)
Affinity DataEC50:  150nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045527(CHEMBL3311373)
Affinity DataEC50:  290nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045529(CHEMBL3311374)
Affinity DataEC50:  360nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045530(CHEMBL3311500)
Affinity DataEC50:  360nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045531(CHEMBL3311498)
Affinity DataEC50:  370nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045532(CHEMBL3311379)
Affinity DataEC50:  560nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045533(CHEMBL3311378)
Affinity DataEC50:  840nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045534(CHEMBL3311371)
Affinity DataEC50:  880nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045535(CHEMBL3311377)
Affinity DataEC50:  1.00E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045536(CHEMBL3311369)
Affinity DataEC50:  1.40E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045537(CHEMBL3311218)
Affinity DataEC50:  1.50E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045538(CHEMBL1277915)
Affinity DataEC50:  1.70E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045539(CHEBI:28082 | 3Beta,5Alpha,6Beta-Trihydroxycholest...)
Affinity DataEC50:  1.70E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045540(CHEMBL3311217)
Affinity DataEC50:  1.70E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045541(CHEMBL2418972)
Affinity DataEC50:  1.70E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045542(CHEMBL3311376)
Affinity DataEC50:  1.80E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045543(CHEMBL3311219)
Affinity DataEC50:  1.90E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM20176((1S,2R,5S,10S,11S,14R,15S)-14-[(2S,3S)-3-hydroxy-6...)
Affinity DataEC50:  2.90E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM20186((4R)-4-[(1S,2R,5S,10S,11S,14R,15R)-5-hydroxy-2,15-...)
Affinity DataEC50:  3.10E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045544(5alpha-CHOLESTAN-3beta-OL-6-ONE)
Affinity DataEC50:  3.40E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045545(CHEBI:42989 | 7Beta-Hydroxycholesterol | CHEMBL497...)
Affinity DataEC50:  3.40E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045546(CHEMBL3311495)
Affinity DataEC50:  3.40E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045547(CHEMBL3311220)
Affinity DataEC50:  4.00E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045548(Cholestane-3b,4b,5a-triol | CHEMBL1824835)
Affinity DataEC50:  4.30E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045549(CHEMBL3311370)
Affinity DataEC50:  4.80E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045550(CHEMBL3311496)
Affinity DataEC50:  6.10E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045551(CHEMBL3311499)
Affinity DataEC50:  6.80E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045552(CHEBI:64294 | 7-OXOCHOLESTEROL)
Affinity DataEC50:  8.70E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045553(CHEMBL3311368)
Affinity DataEC50:  9.90E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50223368(Prasterone | 3beta-hydroxyandrost-5-en-17-one | CH...)
Affinity DataEC50: >1.00E+4nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50045554(CHEMBL3311501)
Affinity DataEC50: >1.00E+4nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM20182((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...)
Affinity DataEC50:  3.30E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50300992((2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-3-[(S)-3-(4-Fluoro-...)
Affinity DataIC50: 4nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50300992((2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-3-[(S)-3-(4-Fluoro-...)
Affinity DataIC50: 4nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50300992((2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-3-[(S)-3-(4-Fluoro-...)
Affinity DataIC50: 4nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50300992((2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-3-[(S)-3-(4-Fluoro-...)
Affinity DataIC50: 4nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50258479((2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorop...)
Affinity DataIC50: 7nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258479((2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorop...)
Affinity DataIC50: 16nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50258479((2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorop...)
Affinity DataIC50: 20nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50300992((2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-3-[(S)-3-(4-Fluoro-...)
Affinity DataIC50: 44nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNPC1-like intracellular cholesterol transporter 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50300993((2S,3S,4S,5R,6S)-6-{4-[(2S,3R)-3-[(3S)-3-(4-fluoro...)
Affinity DataIC50: 127nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50300993((2S,3S,4S,5R,6S)-6-{4-[(2S,3R)-3-[(3S)-3-(4-fluoro...)
Affinity DataIC50: 150nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50300993((2S,3S,4S,5R,6S)-6-{4-[(2S,3R)-3-[(3S)-3-(4-fluoro...)
Affinity DataIC50: 173nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50300993((2S,3S,4S,5R,6S)-6-{4-[(2S,3R)-3-[(3S)-3-(4-fluoro...)
Affinity DataIC50: 200nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50240720((2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-1-(4-Fluoro-phenyl)...)
Affinity DataIC50: 300nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50240720((2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-1-(4-Fluoro-phenyl)...)
Affinity DataIC50: 300nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50371521(EZETIMIBE)
Affinity DataIC50: 370nMAssay Description:Inhibition of NPC1L1 (unknown origin) assessed as inhibition of cholesterol cellular uptake by BCA colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetNPC1-like intracellular cholesterol transporter 1(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50258548((1-(1-naphthoyl)-5-phenylpiperidin-3-yl)(spiro[ind...)
Affinity DataIC50: 390nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNPC1-like intracellular cholesterol transporter 1(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50240720((2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-1-(4-Fluoro-phenyl)...)
Affinity DataIC50: 580nMAssay Description:Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoaz...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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