Compile Data Set for Download or QSAR
Report error Found 3538 Enz. Inhib. hit(s) with Target = 'Neuronal acetylcholine receptor subunit alpha-4/beta-2'
LigandPNGBDBM50437470(CHEMBL2409481)
Affinity DataEC50:  1.90E+4nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437471(CHEMBL2409489)
Affinity DataEC50:  1.20E+4nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437472(CHEMBL2409490)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437473(CHEMBL2409486)
Affinity DataEC50:  9.20E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437474(CHEMBL2409472)
Affinity DataEC50:  7.10E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437475(CHEMBL2409484)
Affinity DataEC50:  5.60E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437476(CHEMBL2409497)
Affinity DataEC50:  5.20E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437477(CHEMBL2409493)
Affinity DataEC50:  2.60E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437478(CHEMBL2409475)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437479(CHEMBL2409491)
Affinity DataEC50:  1.90E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437480(CHEMBL2409483)
Affinity DataEC50:  1.70E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437481(CHEMBL2409482)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437482(CHEMBL2409485)
Affinity DataEC50:  400nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437483(CHEMBL2409488)
Affinity DataEC50:  2.70E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50397890(CHEMBL2179529)
Affinity DataEC50:  4.90E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437484(CHEMBL2409495)
Affinity DataEC50:  9.90E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437485(CHEMBL3037928)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437486(CHEMBL2409476)
Affinity DataEC50:  2.40E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437487(CHEMBL2409478)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437488(CHEMBL2409494)
Affinity DataEC50:  1.30E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437489(CHEMBL2409477)
Affinity DataEC50:  930nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437490(CHEMBL3037929)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437491(CHEMBL2409487)
Affinity DataEC50:  430nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437492(CHEMBL2407115)
Affinity DataEC50:  1.90E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50397903(CHEMBL2179962)
Affinity DataEC50:  850nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437493(CHEMBL2409496)
Affinity DataEC50:  1.90E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437494(CHEMBL2409479)
Affinity DataEC50:  900nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50397904(CHEMBL2179961)
Affinity DataEC50:  470nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437495(CHEMBL2409480)
Affinity DataEC50:  190nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437496(CHEMBL3037927)
Affinity DataEC50:  18nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437499(CHEMBL2409492)
Affinity DataEC50:  1.00E+5nMAssay Description:Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437502(CHEMBL2409625)
Affinity DataEC50:  23nMAssay Description:Agonist activity at human alpha4beta2 nACHR expressed in human SHEP1 cells assessed as stimulation of 86Rb+ ion efflux after 5 mins by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437503(CHEMBL2409627)
Affinity DataEC50:  14nMAssay Description:Agonist activity at human alpha4beta2 nACHR expressed in human SHEP1 cells assessed as stimulation of 86Rb+ ion efflux after 5 mins by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50437504(CHEMBL2409631)
Affinity DataEC50:  6.20nMAssay Description:Agonist activity at human alpha4beta2 nACHR expressed in human SHEP1 cells assessed as stimulation of 86Rb+ ion efflux after 5 mins by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50382472(CHEMBL2024094)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human alpha4beta2 nACHR expressed in human SHEP1 cells assessed as stimulation of 86Rb+ ion efflux after 5 mins by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  290nMAssay Description:Agonist activity at human alpha4beta2 nACHR expressed in human SHEP1 cells assessed as stimulation of 86Rb+ ion efflux after 5 mins by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  2.40E+3nMAssay Description:The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β2 nAChR subtypes....More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM221048(US9303017, Varenicline | US9284322, varenicline)
Affinity DataEC50:  950nMAssay Description:The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β2 nAChR subtypes....More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)
Affinity DataEC50:  24nMAssay Description:The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β2 nAChR subtypes....More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50428085(CHEMBL2323566 | US9303017, (S)-15, YL-1-127)
Affinity DataEC50:  310nMAssay Description:The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β2 nAChR subtypes....More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50428079(CHEMBL2323569 | US9303017, 25, YL-1-199)
Affinity DataEC50:  160nMAssay Description:The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β2 nAChR subtypes....More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50428081(CHEMBL2323570 | US9303017, (S)-17)
Affinity DataEC50:  63nMAssay Description:The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β2 nAChR subtypes....More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50071366(7-Methoxy-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-h...)
Affinity DataEC50:  3.00E+3nMAssay Description:Compound was evaluated for agonist activity against activated human recombinant aNicotinic acetylcholine receptor alpha4-beta2 in Xenopus OocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataEC50:  1.80E+3nMAssay Description:The compound was tested on recombinant human alpha4-beta2 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50052593(Altinicline | 3-Ethynyl-5-((S)-1-methyl-pyrrolidin...)
Affinity DataEC50:  1.80E+3nMAssay Description:The compound was tested on recombinant human alpha4-beta2 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  2.10E+3nMAssay Description:The compound was tested on recombinant human alpha4-beta2 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50061562(CHEMBL335712 | Dihydro-Beta-erythroidine | (12R,13...)
Affinity DataEC50:  700nMAssay Description:Functional potency for Nicotinic acetylcholine receptor alpha4-beta2 (rat brain)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50035398(ABT-418 | (S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-...)
Affinity DataEC50:  1.00E+4nMAssay Description:Functional potency for Nicotinic acetylcholine receptor alpha4-beta2 (rat brain)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  4.00E+3nMAssay Description:Functional potency for Nicotinic acetylcholine receptor alpha4-beta2 (rat brain)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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