Compile Data Set for Download or QSAR
Report error Found 4557 Enz. Inhib. hit(s) with Target = 'Neuronal acetylcholine receptor subunit alpha-7'
LigandPNGBDBM50164613((S)-1'-azaspiro[oxazolidine-5,8'-bicyclo[2.2.2]oct...)
Affinity DataEC50:  2.10E+4nMAssay Description:Agonist activity at rat alpha7 nAchR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50164613((S)-1'-azaspiro[oxazolidine-5,8'-bicyclo[2.2.2]oct...)
Affinity DataEC50:  420nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in GH4 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50393243(CHEMBL2151437)
Affinity DataEC50:  340nMAssay Description:Agonist activity at human alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50393244(CHEMBL2151438)
Affinity DataEC50:  470nMAssay Description:Agonist activity at human alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50190795((R)-N-(quinuclidin-3-yl)-1H-indole-6-carboxamide |...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50190785(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzothioph...)
Affinity DataEC50:  48nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50190783(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataEC50:  86nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50190788(N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-...)
Affinity DataEC50:  43nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rhesus macaque)
Targacept

Curated by ChEMBL
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataEC50:  400nMAssay Description:Agonist activity at wild type monkey alpha7 nAChR by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataEC50:  800nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50393245(CHEMBL2151439)
Affinity DataEC50:  7.70E+3nMAssay Description:Agonist activity at human alpha7 nAChR expressed in QM7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50393246(CHEMBL2151440 | US9067931, 130 | US10214524, Examp...)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity at rat recombinant alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50393246(CHEMBL2151440 | US9067931, 130 | US10214524, Examp...)
Affinity DataEC50:  5.50E+3nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50393247(CHEMBL1258006)
Affinity DataEC50:  33nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50393248(CHEMBL1258005)
Affinity DataEC50:  50nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataEC50:  4.40E+3nMAssay Description:Partial agonist activity at human alpha7 nAChR expressed in Xenopus oocytes relative to acetylcholineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50296742(1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl car...)
Affinity DataEC50:  900nMAssay Description:Partial agonist activity at human alpha7 nAChR expressed in GH4C1 cells relative to acetylcholineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50248045((S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylca...)
Affinity DataKd:  200nMAssay Description:Displacement of [125I]alpha-bungarotoxin from human recombinant alpha7 nAchRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50248045((S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylca...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in human GH3 cells by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50248045((S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylca...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in human GH3 cells by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50248045((S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylca...)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as induction of inward currentMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50248045((S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylca...)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as induction of inward currentMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50393250(CHEMBL2151442)
Affinity DataEC50:  440nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50309873(4-(6-Chlorooxazolo[4,5-b]pyridin-2-yl)-1,4-diazabi...)
Affinity DataEC50:  160nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50309888(4-(6-Chloro-5-methyloxazolo[4,5-b]pyridin-2-yl)-1,...)
Affinity DataEC50:  160nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50393252(CHEMBL2151570)
Affinity DataEC50:  50nMAssay Description:Agonist activity at rat alpha7 nAchR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50393252(CHEMBL2151570)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50300803(5-(piperidin-1-yl)-N-(4-(pyridin-3-yl)phenyl)penta...)
Affinity DataEC50:  350nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50319671(1-(4-Piperidin-1-yl)butyl-3-(4-pyridin-3-ylphenyl)...)
Affinity DataEC50:  120nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50319679(1-(4-Piperidin-1-ylbutyl)-3-(4-pyridin-2-ylphenyl)...)
Affinity DataEC50:  130nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50060417(CHEMBL297784 | SB 206553 | SB-206553 | 5-Methyl-3,...)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at human alpha7 nAChR expressed in GH4C1 cells assessed as potentiation of nicotine-induced calcium signalMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50393251(CHEMBL2151569)
Affinity DataEC50:  320nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50278956(cis-2-(6-Phenyl-pyridazin-3-yl)-5-methyloctahydro-...)
Affinity DataEC50:  4.26E+3nMAssay Description:Agonist activity at alpha7 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50143314(CHEMBL298826 | (+)-Epibatidine | 2-(6-Chloro-pyrid...)
Affinity DataEC50:  28nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ul of 0.2 mg/ml an...More data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  740nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ul of 0.2 mg/ml an...More data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM91593(DMXB-A)
Affinity DataEC50:  2.40E+3nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ul of 0.2 mg/ml an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails

LigandPNGBDBM91594(Tropisetron)
Affinity DataEC50:  92nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ul of 0.2 mg/ml an...More data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50161764(CHEMBL177611 | (R)-4-chloro-N-(quinuclidin-3-yl)be...)
Affinity DataEC50:  40nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ul of 0.2 mg/ml an...More data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM50190786(CHEMBL214268 | PHA-543613 | N-[(3R)-1-azabicyclo[2...)
Affinity DataEC50:  4.20nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ul of 0.2 mg/ml an...More data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM91595(PHA568487)
Affinity DataEC50:  35nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ul of 0.2 mg/ml an...More data for this Ligand-Target Pair
In DepthDetails

LigandPNGBDBM91596(alpha7 agonists 1)
Affinity DataEC50:  3.70E+3nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 l of 0.2 mg/ml ant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM91707(alpha7 agonists 1')
Affinity DataEC50:  6.00E+3nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 l of 0.2 mg/ml ant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM91598(alpha7 agonists 2)
Affinity DataEC50:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 l of 0.2 mg/ml ant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM91599(2' | alpha7 agonists 2')
Affinity DataEC50:  4.20E+3nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 l of 0.2 mg/ml ant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM91600(alpha7 agonists 3)
Affinity DataEC50:  1.80E+3nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 l of 0.2 mg/ml ant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM91601(3' | alpha7 agonists 3')
Affinity DataEC50:  2.90E+3nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 l of 0.2 mg/ml ant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM91602(alpha7 agonists 4)
Affinity DataEC50:  300nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 l of 0.2 mg/ml ant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM91603(4' | alpha7 agonists 4')
Affinity DataEC50:  600nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 l of 0.2 mg/ml ant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM91604(alpha7 agonists 5)
Affinity DataEC50:  800nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 l of 0.2 mg/ml ant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM91605(5' | alpha7 agonists 5')
Affinity DataEC50:  2.00E+3nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 l of 0.2 mg/ml ant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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