Compile Data Set for Download or QSAR
Found 1839 Enz. Inhib. hit(s) with Target = 'Phosphodiesterase'
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320710((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)-3-fluorop...)
Show SMILES CC(C)C(c1ccc(c(F)c1)C(F)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0250nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320811((R)- or (S)-1-(1-(4-(1,1-Difluoroethyl)-3- fluorop...)
Show SMILES CCC(c1ccc(c(F)c1)C(C)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0270nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320813((R)- or (S)-1-(1-(4-(1,1-Difluoroethyl)-3- fluorop...)
Show SMILES CC(C)C(c1ccc(c(F)c1)C(C)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0300nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320712((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)-2-fluorop...)
Show SMILES CC(C)C(c1ccc(cc1F)C(C)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0360nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320732((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)-2-...)
Show SMILES CC(C)C(c1ccc(cc1)C(C)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0400nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320801((R)- or (S)-l-(1-(4-(1,1- Difluoroethyl)phenyl)-2-...)
Show SMILES CC(C)C(c1ccc(cc1)C(C)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0430nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320728((R)- or (S)-1-(Cyclopropyl(2- fluoro-4- (trifluoro...)
Show SMILES CN(C)c1nc2n(nc(CO)c2c(=O)[nH]1)C(C1CC1)c1ccc(cc1F)C(F)(F)F
Affinity DataKi:  0.0500nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320809((R)- or (S)-1-(1-(4-(1,1-Difluoroethyl)-2- fluorop...)
Show SMILES CCC(c1ccc(cc1F)C(C)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0500nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320670((R)- or (S)-6-(Dimethylamino)-3- (hydroxymethyl)-1...)
Show SMILES CC(C)C(c1ccc(cc1)C(C)C)n1nc(CO)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0540nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320706((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)-3- fluoro...)
Show SMILES CCC(c1ccc(c(F)c1)C(F)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0550nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320770((R)- or (S)-6-(Dimethylamino)-3- (fluoromethyl)-1-...)
Show SMILES CC(C)C(c1ccc(cc1)C(C)C)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0580nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320797((R)- or (S)-1-(Cyclopropyl(2-fluoro-4- (trifluorom...)
Show SMILES CN(C)c1nc2n(nc(CF)c2c(=O)[nH]1)C(C1CC1)c1ccc(cc1F)C(F)(F)F
Affinity DataKi:  0.0580nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320726((R)- or (S)-6-(Dimethylamino)- 1-(1-(2-fluoro-4- (...)
Show SMILES CC(C)C(c1ccc(cc1F)C(F)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0590nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320817((R)- or (S)-6-(Dimethylamino)-1-(1-(3- fluoro-4-(t...)
Show SMILES CCC(c1ccc(c(F)c1)C(F)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0630nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320710((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)-3-fluorop...)
Show SMILES CC(C)C(c1ccc(c(F)c1)C(F)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0630nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320815((R)- or (S)-6-(Dimethylamino)-1-(1-(3- fluoro-4-(t...)
Show SMILES CC(C)C(c1ccc(c(F)c1)C(F)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0670nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320793((R)- or (S)-6-(Dimethylamino)-1-(1-(2- fluoro-4-(t...)
Show SMILES CCC(c1ccc(cc1F)C(F)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0680nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320789((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)eth...)
Show SMILES CC(c1ccc(cc1)C(C)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0700nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320756(US10174037, Example 162 | US10174037, Example 163)
Show SMILES CC(C)[C@@H](c1ccc(cc1)C(F)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0700nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320795((R)- or (S)-6-(Dimethylamino)-1-(1-(2- fluoro-4-(t...)
Show SMILES CC(C)C(c1ccc(cc1F)C(F)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0700nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320772((R)- or (S)-1-(Cyclopropyl(4- (trifluoromethyl)phe...)
Show SMILES CN(C)c1nc2n(nc(CF)c2c(=O)[nH]1)C(C1CC1)c1ccc(cc1)C(F)(F)F
Affinity DataKi:  0.0720nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320799((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)pro...)
Show SMILES CCC(c1ccc(cc1)C(C)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0720nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320807((R)- or (S)-1-(Cyclopropyl(4-(1,1- difluoroethyl)p...)
Show SMILES CN(C)c1nc2n(nc(CF)c2c(=O)[nH]1)C(C1CC1)c1ccc(cc1)C(C)(F)F
Affinity DataKi:  0.0750nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320656((R)- or (S)-6-Dimethylamino)-3- (hydroxymethyl)-1-...)
Show SMILES CC(C)C(c1ccc(cc1)C(F)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0760nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320776((R)- or (S)-1-(Cyclopropyl(3-fluoro-4- (trifluorom...)
Show SMILES CC(C)c1ccc(cc1)C(C1CC1)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0820nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320668((R)- or (S)-1-(Cyclopropyl(4- isopropylphenyl)meth...)
Show SMILES CC(C)c1ccc(cc1)C(C1CC1)n1nc(CO)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0840nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320766((R)- or (S)-6-(Dimethylamino)-3- (fluoromethyl)-1-...)
Show SMILES CCC(c1ccc(cc1)C(F)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.0960nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320734((R)- or (S)-1-(Cyclopropyl(4- (1,1- difluoroethyl)...)
Show SMILES CN(C)c1nc2n(nc(CO)c2c(=O)[nH]1)C(C1CC1)c1ccc(cc1)C(C)(F)F
Affinity DataKi:  0.0970nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM384842(N-[(1R)-1-(4-cyclopropyl-3- fluorophenyl)-2,2-dime...)
Show SMILES CN(C)c1nc(cc(=O)[nH]1)C(=O)N[C@@H](c1ccc(C2CC2)c(F)c1)C(C)(C)C
Affinity DataKi:  0.100nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM384821(2-(dimethylamino)-N-{(1R)-1-[2- fluoro-4-(trifluor...)
Show SMILES CN(C)c1nc(cc(=O)[nH]1)C(=O)N[C@@H](c1ccc(cc1F)C(F)(F)F)C(C)(C)C
Affinity DataKi:  0.110nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM384822(2-(dimethylamino)-N-{(1R)-2,2- dimethyl-1-[4-(pent...)
Show SMILES CN(C)c1nc(cc(=O)[nH]1)C(=O)N[C@@H](c1ccc(cc1)S(F)(F)F)C(C)(C)C
Affinity DataKi:  0.110nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320690((R)- or (S)-6-(Dimethylamino)-1-(1- (3-fluoro-4-(2...)
Show SMILES CCC(c1ccc(CC(F)(F)F)c(F)c1)n1nc(CO)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.110nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320774((R)- or (S)-1-(Cyclopropyl(3-fluoro-4- (trifluorom...)
Show SMILES CN(C)c1nc2n(nc(CF)c2c(=O)[nH]1)C(C1CC1)c1ccc(c(F)c1)C(F)(F)F
Affinity DataKi:  0.110nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM384789(US10285989, Example 2)
Show SMILES CC(NC(=O)c1cc(=O)[nH]c(n1)S(C)(=O)=O)c1ccc(cc1)C(F)(F)F
Affinity DataKi:  0.110nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM384860(N-{(1R)-1-[4-(1,1- difluoroethyl)phenyl]-2,2- dime...)
Show SMILES CN(C)c1nc(cc(=O)[nH]1)C(=O)N[C@@H](c1ccc(cc1)C(C)(F)F)C(C)(C)C
Affinity DataKi:  0.110nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM384819(N-[(1R)-1-(4-cyclopropylphenyl)-2,2- dimethylpropy...)
Show SMILES CN(C)c1nc(cc(=O)[nH]1)C(=O)N[C@@H](c1ccc(cc1)C1CC1)C(C)(C)C
Affinity DataKi:  0.120nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM384887(2-(dimethylamino)-N-[(1R)-2,2- dimethyl-1-{4- [(tr...)
Show SMILES CN(C)c1nc(cc(=O)[nH]1)C(=O)N[C@@H](c1ccc(SC(F)(F)F)cc1)C(C)(C)C
Affinity DataKi:  0.120nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320724((R)- or (S)-6-(Dimethylamino)- 1-(1-(2-fluoro-4- (...)
Show SMILES CCC(c1ccc(cc1F)C(F)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.120nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320700((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)-3-fluorop...)
Show SMILES CC(c1ccc(c(F)c1)C(C)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.120nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320744((R)- or (S)-1-(Cyclopropyl(3-fluoro- 4-(trifluorom...)
Show SMILES CN(C)c1nc2n(nc(CO)c2c(=O)[nH]1)C(C1CC1)c1ccc(c(F)c1)C(F)(F)F
Affinity DataKi:  0.120nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320706((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)-3- fluoro...)
Show SMILES CCC(c1ccc(c(F)c1)C(F)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.130nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM384949(N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethyl)phenyl...)
Show SMILES CC(C)(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)N1CC[C@H](F)C1)c1ccc(cc1)C(F)(F)F
Affinity DataKi:  0.140nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM384885(2-(dimethylamino)-N-{(1R)-1-[3-fluoro- 4-(trifluor...)
Show SMILES CN(C)c1nc(cc(=O)[nH]1)C(=O)N[C@@H](c1ccc(OC(F)(F)F)c(F)c1)C(C)(C)C
Affinity DataKi:  0.140nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320781((R)- or (S)-6-(Dimethylamino)-1-(1-(2- fluoro-4-(t...)
Show SMILES CC(c1ccc(cc1F)C(F)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.140nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320730((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)pro...)
Show SMILES CCC(c1ccc(cc1)C(C)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.140nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320803((R)- or (S)-1-(1-(4-(1,1-Difluoroethyl)-2- fluorop...)
Show SMILES CC(c1ccc(cc1F)C(C)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.140nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320670((R)- or (S)-6-(Dimethylamino)-3- (hydroxymethyl)-1...)
Show SMILES CC(C)C(c1ccc(cc1)C(C)C)n1nc(CO)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.140nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320704((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)-2- fluoro...)
Show SMILES CCC(c1ccc(cc1F)C(C)(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.140nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM320789((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)eth...)
Show SMILES CC(c1ccc(cc1)C(C)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C
Affinity DataKi:  0.140nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM384928(N-[(1R)-2- methyl-1-{4- [(trifluoromethyl) sulfany...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)N1CCCC1)c1ccc(SC(F)(F)F)cc1
Affinity DataKi:  0.150nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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