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Report error Found 2820 Enz. Inhib. hit(s) with Target = 'Plasminogen'
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92482(CDE-008 | US9120744, CDE-008)
Affinity DataKd:  23nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92487(CDE-031 | US9120744, CDE-031)
Affinity DataKd:  31nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92483(CDE-034 | US9120744, CDE-034)
Affinity DataKd:  67nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92484(CDE-056 | US9120744, CDE-056)
Affinity DataKd:  51nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92485(CDE-066 | US9120744, CDE-066)
Affinity DataKd:  3.10nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92486(CDE-082 | US9120744, CDE-082)
Affinity DataKd:  5.30nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92482(CDE-008 | US9120744, CDE-008)
Affinity DataKd:  23nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92487(CDE-031 | US9120744, CDE-031)
Affinity DataKd:  31nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92483(CDE-034 | US9120744, CDE-034)
Affinity DataKd:  67nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92484(CDE-056 | US9120744, CDE-056)
Affinity DataKd:  51nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92485(CDE-066 | US9120744, CDE-066)
Affinity DataKd:  3.10nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM92486(CDE-082 | US9120744, CDE-082)
Affinity DataKd:  5.30nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2016
Entry Details
Go to US Patent

TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50003737(CHEMBL135724 | (Lactone4)N-[4-(4-Guanidino-phenyl)...)
Affinity DataKon:  0.0000130M-1s-1Assay Description:Compound was tested for the rate constant of deacylation against Urokinase-type plasminogen activatorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50046343(1-(4-Oxo-4-phenyl-butyryl)-pyrrolidine-2-carboxyli...)
Affinity DataEC50:  7.65E+3nMAssay Description:Inhibitory activity against human plasmin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50046345(2-{[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrol...)
Affinity DataEC50:  2.35E+3nMAssay Description:Inhibitory activity against human plasmin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50428067(CL-65336 | Trans Amcha | Cyklokapron | Lysteda | T...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to human plasma full length Glu-plasminogen K1 domain by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50428067(CL-65336 | Trans Amcha | Cyklokapron | Lysteda | T...)
Affinity DataKd:  2.20E+3nMAssay Description:Binding affinity to human plasma N-terminal truncated Lys-plasminogen K1 domain by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50428067(CL-65336 | Trans Amcha | Cyklokapron | Lysteda | T...)
Affinity DataKd:  3.60E+4nMAssay Description:Binding affinity to human plasma N-terminal truncated Lys-plasminogen by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50428067(CL-65336 | Trans Amcha | Cyklokapron | Lysteda | T...)
Affinity DataKd:  7.50E+5nMAssay Description:Binding affinity to human plasma full length Glu-plasminogen by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149275([{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol...)
Affinity DataKd:  480nMAssay Description:Binding affinity to towards NBD-labeled S119C Plasminogen activator inhibitor-1 mutant in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50149275([{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol...)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity of compound towards latent Plasminogen activator inhibitor-1 expressed as apparent KdMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen activator inhibitor 1(Human)
University of Michigan

LigandPNGBDBM50149275([{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol...)
Affinity DataKd:  1.50E+4nMAssay Description:Binding affinity to human immobilized PAI1 by surface plasmon resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50391540(CHEMBL2147469)
Affinity DataEC50:  4.90E+3nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50260045(CHEMBL4103815)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to human plasmin assessed as loss of intrinsic tryptophan fluorescence at 250 uM by spectrofluorometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50260047(CHEMBL4096754)
Affinity DataKd:  1.90E+3nMAssay Description:Binding affinity to human plasmin assessed as loss of intrinsic tryptophan fluorescence at 250 uM by spectrofluorometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50260048(CHEMBL4084933)
Affinity DataKd:  4.40E+3nMAssay Description:Binding affinity to human dansyl-EGR-chloromethylketone-plasmin complex assessed as loss of intrinsic tryptophan fluorescence by spectrofluorometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50260047(CHEMBL4096754)
Affinity DataKd:  5.40E+3nMAssay Description:Binding affinity to human dansyl-EGR-chloromethylketone-plasmin complex assessed as loss of intrinsic tryptophan fluorescence by spectrofluorometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50260048(CHEMBL4084933)
Affinity DataKd:  700nMAssay Description:Binding affinity to human plasmin assessed as loss of intrinsic tryptophan fluorescence at 250 uM by spectrofluorometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50260046(CHEMBL4060852)
Affinity DataKd:  3.60E+3nMAssay Description:Binding affinity to human plasmin assessed as loss of intrinsic tryptophan fluorescence at 250 uM by spectrofluorometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2020
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50428067(CL-65336 | Trans Amcha | Cyklokapron | Lysteda | T...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to plasminogen K1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50357211(177 J.D. | Amicar | Aminocaproic | AMINOCAPROIC AC...)
Affinity DataKd:  9.00E+3nMAssay Description:Binding affinity to human plasminogen K1 domain by ultrafiltration techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50120225(2-{[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl...)
Affinity DataIC50: 0.230nMAssay Description:Concentration required to inhibit Plasmin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50514073(CHEMBL4576519)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human plasmin preincubated for 15 mins followed by MeOSuc-Ala-Phe-Lys-AMC substrate addition and measured after 30 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50514062(CHEMBL4436082)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human plasmin preincubated for 15 mins followed by MeOSuc-Ala-Phe-Lys-AMC substrate addition and measured after 30 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50514076(CHEMBL4456691)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human plasmin preincubated for 15 mins followed by MeOSuc-Ala-Phe-Lys-AMC substrate addition and measured after 30 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50514063(CHEMBL4447001)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of human plasmin preincubated for 15 mins followed by MeOSuc-Ala-Phe-Lys-AMC substrate addition and measured after 30 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50514065(CHEMBL4570952)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human plasmin preincubated for 15 mins followed by MeOSuc-Ala-Phe-Lys-AMC substrate addition and measured after 30 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50514079(CHEMBL4449958)
Affinity DataIC50: 0.870nMAssay Description:Inhibition of human plasmin preincubated for 15 mins followed by MeOSuc-Ala-Phe-Lys-AMC substrate addition and measured after 30 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50514077(CHEMBL4475211)
Affinity DataIC50: 1nMAssay Description:Inhibition of human plasmin preincubated for 15 mins followed by MeOSuc-Ala-Phe-Lys-AMC substrate addition and measured after 30 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50514078(CHEMBL4582882)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human plasmin preincubated for 15 mins followed by MeOSuc-Ala-Phe-Lys-AMC substrate addition and measured after 30 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM652421(US20240059691, Example 1001 | 6-N-({6-[(1-methylpi...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM652422(US20240059691, Example 1002 | 5-N-({4-[(1-methylpi...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM652473(US20240059691, Example 1128 | 5-N-[(6-{5H,6H,8H-im...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM652497(US20240059691, Example 1197 | N-((6-(((1-methylpip...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM652632(US20240059691, Example 2212 | 5-N-[(2-fluoro-4-{2-...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM652645(US20240059691, Example 4259 | N6-((2-((1-methylpip...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM652648(US20240059691, Example 4262 | N-({2-[(1-methylpipe...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM652654(US20240059691, Example 4268 | 4-chloro-6-N-({2-[(1...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM652657(US20240059691, Example 4271 | 6-N-({2-[(1-methylpi...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetPlasminogen(Human)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM652689(US20240059691, Example 4308 | 4-fluoro-5-N-[(2-{5H...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

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