Compile Data Set for Download or QSAR
Report error Found 18634 Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily H member 2'
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM65906(VU0404032-1 | 5-chloranyl-2-[(5-chloranyl-1,3-benz...)
Affinity DataEC50:  1.07E+5nMAssay Description:Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Mode of action, Concentration-Response Relationship Observed Source (MLPCN Center Name)...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM689269(US20240254124, Compound 1 | Synthesis of N-(2-fluo...)
Affinity DataKd: >1.00E+5nMAssay Description:Compounds were dissolved in DMSO to a stock concentration of 10 mM and tested in 10-dose IC50 mode, in triplicate, with a 3-fold serial dilution star...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM687756(US20240246972, Compound 3 | Synthesis of N-(1-(3-m...)
Affinity DataKd:  8.90E+4nMAssay Description:Compounds were dissolved in DMSO to a stock concentration of 10 mM and tested in 10-dose IC50 mode, in triplicate, with a 3-fold serial dilution star...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50117930(N-(4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidi...)
Affinity DataKd:  33.3nMAssay Description:Compounds were dissolved in DMSO to a stock concentration of 10 mM and tested in 10-dose IC50 mode, in triplicate, with a 3-fold serial dilution star...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM687754(US20240246972, Compound 1 | Synthesis of N-(2-fluo...)
Affinity DataKd: >1.00E+5nMAssay Description:Compounds were dissolved in DMSO to a stock concentration of 10 mM and tested in 10-dose IC50 mode, in triplicate, with a 3-fold serial dilution star...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM687756(US20240246972, Compound 3 | Synthesis of N-(1-(3-m...)
Affinity DataKd:  8.90E+4nMAssay Description:Compounds were dissolved in DMSO to a stock concentration of 10 mM and tested in 10-dose IC50 mode, in triplicate, with a 3-fold serial dilution star...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50117930(N-(4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidi...)
Affinity DataKd:  33.3nMAssay Description:Compounds were dissolved in DMSO to a stock concentration of 10 mM and tested in 10-dose IC50 mode, in triplicate, with a 3-fold serial dilution star...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50182587(5-acetyl-4-(4'-chloro)benzyloxy-6-hydroxy-7-methox...)
Affinity DataEC50:  5.00E+3nMAssay Description:Effect on blockade of Kv11.1 channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50114845(CHEMBL3609759)
Affinity DataEC50:  1.50E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50148652(CHEMBL3770802 | US9518026, Example 57 | US9956214,...)
Affinity DataEC50:  1.41E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50095761(CHEMBL3093953)
Affinity DataKd:  86nMAssay Description:Binding affinity to human Kv11.1 expressed in HEK293 cell membranes assessed as binding affinity constant by [3H]dofetilide competition association a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50596273(CHEMBL5185133)
Affinity DataEC50:  2.50E+4nMAssay Description:Inhibition of hERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50095643(CHEMBL3590447)
Affinity DataKd:  41nMAssay Description:Binding affinity to human Kv11.1 expressed in HEK293 cell membranes assessed as binding affinity constant by [3H]dofetilide competition association a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50348732(CHEMBL1801504)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50114807(CHEMBL3608385)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM370572(US10233190, Example 1505 | N-((1r,4r)-4-(1-hydroxy...)
Affinity DataEC50:  3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50138819(CHEMBL3753837 | US10233190, Example 1357)
Affinity DataEC50:  2.30E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50095758(CHEMBL1464333)
Affinity DataKd:  1.81E+3nMAssay Description:Binding affinity to human Kv11.1 expressed in HEK293 cell membranes assessed as binding affinity constant by [3H]dofetilide competition association a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50095762(CHEMBL3590459)
Affinity DataKd:  1.19E+3nMAssay Description:Binding affinity to human Kv11.1 expressed in HEK293 cell membranes assessed as binding affinity constant by [3H]dofetilide competition association a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM370551(US10233190, Example 1484 | (1S,4s)-4-((R)-2-((S)-6...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM349513(US10207991, Ex. Cpd. No. 28 | US10611728, Example ...)
Affinity DataEC50:  9.60E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50095734(CHEMBL3590456)
Affinity DataKd:  36nMAssay Description:Binding affinity to human Kv11.1 expressed in HEK293 cell membranes assessed as binding affinity constant by [3H]dofetilide competition association a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50095769(CHEMBL3590465)
Affinity DataKd:  4nMAssay Description:Binding affinity to human Kv11.1 expressed in HEK293 cell membranes assessed as binding affinity constant by [3H]dofetilide competition association a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM370488(1-(4,4-difluorocyclohexyl)-2-(6-fluoro-5H- imidazo...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50577483(CHEMBL4869437)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50581623(CHEMBL5088467)
Affinity DataEC50:  1.27E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50275770(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(2,8-diazasp...)
Affinity DataEC50:  1.00E+4nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50517833(CHEMBL4472621)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50095767(CHEMBL3590462)
Affinity DataKd:  12nMAssay Description:Binding affinity to human Kv11.1 expressed in HEK293 cell membranes assessed as binding affinity constant by [3H]dofetilide competition association a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50577484(CHEMBL4863873)
Affinity DataEC50:  780nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50095768(CHEMBL3590463)
Affinity DataKd:  0.440nMAssay Description:Binding affinity to human Kv11.1 expressed in HEK293 cell membranes assessed as binding affinity constant by [3H]dofetilide competition association a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50095780(CHEMBL3590466)
Affinity DataKd:  37nMAssay Description:Binding affinity to human Kv11.1 expressed in HEK293 cell membranes assessed as binding affinity constant by [3H]dofetilide competition association a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50596264(CHEMBL5206355)
Affinity DataEC50: <3.00E+4nMAssay Description:Inhibition of hERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50596268(CHEMBL5203592)
Affinity DataEC50:  500nMAssay Description:Inhibition of hERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50596275(CHEMBL5176348)
Affinity DataEC50:  2.10E+4nMAssay Description:Inhibition of hERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50275886(8-(5-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)pyr...)
Affinity DataEC50:  5.00E+3nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50238419(CHEMBL4060134)
Affinity DataEC50:  3.98E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50275887(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(2-(methylsu...)
Affinity DataEC50:  3.30E+3nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50095789(CHEMBL3590468)
Affinity DataKd:  4.26E+3nMAssay Description:Binding affinity to human Kv11.1 expressed in HEK293 cell membranes assessed as binding affinity constant by [3H]dofetilide competition association a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50427961(CHEMBL2324239)
Affinity DataKd:  8.88E+3nMAssay Description:Binding affinity to human Kv11.1 expressed in HEK293 cell membranes assessed as binding affinity constant by [3H]dofetilide competition association a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM370460(4-(2-(6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)- 1-...)
Affinity DataEC50:  3.40E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50095833(CHEMBL3590500)
Affinity DataKd:  103nMAssay Description:Binding affinity to human Kv11.1 expressed in HEK293 cell membranes assessed as binding affinity constant by [3H]dofetilide competition association a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50148749(CHEMBL3770313 | US9518026, Example 70 | US9956214,...)
Affinity DataEC50:  2.28E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50365230(CHEMBL1956285 | US9238653, Table 5, Compound 10 | ...)
Affinity DataEC50:  7.00E+3nMAssay Description:Inhibition of human ERG by IonWorks patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50095763(CHEMBL3590460)
Affinity DataKd:  637nMAssay Description:Binding affinity to human Kv11.1 expressed in HEK293 cell membranes assessed as binding affinity constant by [3H]dofetilide competition association a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50394740(CHEMBL2165826)
Affinity DataEC50:  2.75E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential assessed as reduction in tail current amplitude by conventional patch c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50275986(6-(2-acetyl-2,7-diazaspiro[4.5]decan-7-yl)-N-(2-am...)
Affinity DataEC50:  1.00E+4nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50596261(CHEMBL5176134)
Affinity DataEC50:  1.70E+4nMAssay Description:Inhibition of hERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50182585(5-acetyl-7-(4'-bromo)benzyloxy-6-hydroxy-4-methoxy...)
Affinity DataEC50:  9.00E+3nMAssay Description:Effect on blockade of Kv11.1 channelMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM50596274(CHEMBL5204986)
Affinity DataEC50:  8.70E+4nMAssay Description:Inhibition of hERG by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
Displayed 1 to 50 (of 18634 total ) | Next | Last >>
Jump to: