Compile Data Set for Download or QSAR
Report error Found 754 Enz. Inhib. hit(s) with Target = 'Potassium-transporting ATPase alpha chain 1'
TargetPotassium-transporting ATPase alpha chain 1(Pig)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM394383(US10308605, Example 30 | N-methyl-1-[1-(phenylsulf...)
Affinity DataIC50: 4.20nMAssay Description:According to the method [Biochem. Biophys. Acta., 728, 31 (1983)] of Wallmark et al., a gastric mucous membrane microsomal fraction was prepared from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium-transporting ATPase alpha chain 1(Pig)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM394395(US10308605, Example 225 | 1-[5-(2,4-Difluorophenyl...)
Affinity DataIC50: 8.90nMAssay Description:According to the method [Biochem. Biophys. Acta., 728, 31 (1983)] of Wallmark et al., a gastric mucous membrane microsomal fraction was prepared from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium-transporting ATPase alpha chain 1(Pig)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM394391(US10308605, Example 165 | 1-{5-(2-Fluorophenyl)-1-...)
Affinity DataIC50: 9nMAssay Description:According to the method [Biochem. Biophys. Acta., 728, 31 (1983)] of Wallmark et al., a gastric mucous membrane microsomal fraction was prepared from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium-transporting ATPase alpha chain 1(Pig)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM394389(US10308605, Example 157 | Ethyl 1-(pyridazin-3-yls...)
Affinity DataIC50: 13nMAssay Description:According to the method [Biochem. Biophys. Acta., 728, 31 (1983)] of Wallmark et al., a gastric mucous membrane microsomal fraction was prepared from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032134(2-(4-Fluoro-2-methyl-phenylamino)-4-(methyl-phenyl...)
Affinity DataIC50: 18nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032124(N*4*-Methyl-N*4*-phenyl-N*2*-o-tolyl-thieno[3,2-d]...)
Affinity DataIC50: 19nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032135(4-[Methyl-(2-o-tolylamino-quinazolin-4-yl)-amino]-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Ortho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50367787(CHEMBL1202672)
Affinity DataIC50: 20nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032092(N*2*-(4-Fluoro-2-methyl-phenyl)-N*4*-methyl-N*4*-p...)
Affinity DataIC50: 21nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032123(8-(3-Dimethylamino-propoxy)-N*4*-methyl-N*4*-pheny...)
Affinity DataIC50: 21nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032137(N*4*-Methyl-N*4*-phenyl-N*2*-o-tolyl-quinazoline-2...)
Affinity DataIC50: 22nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1(Pig)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM394392(US10308605, Example 166 | 1-[5-(2-Fluorophenyl)-1-...)
Affinity DataIC50: 22nMAssay Description:According to the method [Biochem. Biophys. Acta., 728, 31 (1983)] of Wallmark et al., a gastric mucous membrane microsomal fraction was prepared from...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032090(4-(Methyl-phenyl-amino)-2-o-tolylamino-quinazolin-...)
Affinity DataIC50: 24nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032108(4-[(4-Methoxy-phenyl)-methyl-amino]-1-methyl-2-o-t...)
Affinity DataIC50: 28nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Ortho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50367813(CHEMBL1202661)
Affinity DataIC50: 30nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032116(N*2*-(4-Fluoro-2-methyl-phenyl)-8-methoxy-N*4*-met...)
Affinity DataIC50: 32nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1(Pig)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM394388(US10308605, Example 152 | 1-[1-(1-Benzothien-2-yls...)
Affinity DataIC50: 33nMAssay Description:According to the method [Biochem. Biophys. Acta., 728, 31 (1983)] of Wallmark et al., a gastric mucous membrane microsomal fraction was prepared from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032112(N*2*-(4-Fluoro-2-methyl-phenyl)-N*4*-methyl-N*4*-p...)
Affinity DataIC50: 34nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032119(N*4*-(4-Methoxy-phenyl)-N*4*-methyl-N*2*-o-tolyl-q...)
Affinity DataIC50: 34nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032131(2-[4-(Methyl-phenyl-amino)-2-o-tolylamino-quinazol...)
Affinity DataIC50: 35nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50031989(1-[8-Hydroxymethyl-4-(4-hydroxy-2-methyl-phenylami...)
Affinity DataIC50: 36nMpH: 7.0Assay Description:Inhibition of K+ -stimulated gastric ATPase activity was measured using lyophilized gastric vesicles at pH 7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032152(8-(3-Dimethylamino-propoxy)-N*2*-(4-fluoro-2-methy...)
Affinity DataIC50: 36nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1(Pig)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM394394(US10308605, Example 220 | N-Methyl-1-[5-(2-methylp...)
Affinity DataIC50: 36nMAssay Description:According to the method [Biochem. Biophys. Acta., 728, 31 (1983)] of Wallmark et al., a gastric mucous membrane microsomal fraction was prepared from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Ortho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM22893(CHEMBL512 | dimethyl[(5-{[(2-{[(E)-1-(methylamino)...)
Affinity DataIC50: 40nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032125(N*2*-(4-Chloro-2-methyl-phenyl)-N*4*-methyl-N*4*-p...)
Affinity DataIC50: 41nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032096(8-Methoxy-N*4*-methyl-N*4*-phenyl-N*2*-o-tolyl-qui...)
Affinity DataIC50: 42nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032148(N*4*-Methyl-N*2*,N*4*-di-o-tolyl-quinazoline-2,4-d...)
Affinity DataIC50: 46nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032145(N*2*-(4-Fluoro-2-methyl-phenyl)-N*4*-methyl-8-(3-m...)
Affinity DataIC50: 50nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Ortho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50367772(CHEMBL1202647)
Affinity DataIC50: 50nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Ortho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50367783(CHEMBL1202621)
Affinity DataIC50: 50nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1(Pig)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM394378(US10308605, Example 11 | Ethyl 1-[(4-methoxyphenyl...)
Affinity DataIC50: 51nMAssay Description:According to the method [Biochem. Biophys. Acta., 728, 31 (1983)] of Wallmark et al., a gastric mucous membrane microsomal fraction was prepared from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium-transporting ATPase alpha chain 1(Pig)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM394386(US10308605, Example 43 | N-Methyl-1-[5-phenyl-1-(3...)
Affinity DataIC50: 51nMAssay Description:According to the method [Biochem. Biophys. Acta., 728, 31 (1983)] of Wallmark et al., a gastric mucous membrane microsomal fraction was prepared from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032014(1-[8-(1-Hydroxy-ethyl)-4-(4-hydroxy-2-methyl-pheny...)
Affinity DataIC50: 61nMpH: 7.0Assay Description:Inhibition of K+ -stimulated gastric ATPase activity was measured using lyophilized gastric vesicles at pH 7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1(Pig)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM394390(US10308605, Example 161 | 1-[5-(2-Fluorophenyl)-1-...)
Affinity DataIC50: 62nMAssay Description:According to the method [Biochem. Biophys. Acta., 728, 31 (1983)] of Wallmark et al., a gastric mucous membrane microsomal fraction was prepared from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rat)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000672(CHEMBL298695 | 6-Methoxy-4-methyl-1-o-tolyl-1H-pyr...)
Affinity DataIC50: 64nMAssay Description:Inhibition of rat isolated gastric (H(+)/K(+))-ATPase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Ortho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008978(CHEMBL296482 | (+/-)-(2-Methyl-8-phenyl-7,8-dihydr...)
Affinity DataIC50: 64nMAssay Description:Inhibition of H+/K+ ATPase as reduced acid formation in rabbit gastric glandsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032149(N*4*-Methyl-N*2*,N*4*-diphenyl-quinazoline-2,4-dia...)
Affinity DataIC50: 65nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Ortho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008977((8-Benzyloxy-2-methyl-imidazo[1,2-a]pyridin-3-yl)-...)
Affinity DataIC50: 65nMAssay Description:Inhibition of H+/K+ ATPase as reduced acid formation in rabbit gastric glandsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032094(N*2*,N*4*-Dimethyl-N*2*,N*4*-diphenyl-quinazoline-...)
Affinity DataIC50: 67nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032000(1-[6-Hydroxy-4-(4-hydroxy-2-methyl-phenylamino)-qu...)
Affinity DataIC50: 71nMpH: 7.0Assay Description:Inhibition of K+ -stimulated gastric ATPase activity was measured using lyophilized gastric vesicles at pH 7More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032129(8-Methoxy-N*2*,N*4*-dimethyl-N*2*,N*4*-diphenyl-qu...)
Affinity DataIC50: 74nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1(Pig)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM394387(US10308605, Example 140)
Affinity DataIC50: 78nMAssay Description:According to the method [Biochem. Biophys. Acta., 728, 31 (1983)] of Wallmark et al., a gastric mucous membrane microsomal fraction was prepared from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Pig)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50032138(8-Methoxy-N*4*-o-tolyl-quinazoline-2,4-diamine | C...)
Affinity DataIC50: 80nMAssay Description:Inhibition of K+ stimulated gastric ATPase activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Ortho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50367787(CHEMBL1202672)
Affinity DataIC50: 80nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Ortho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50367772(CHEMBL1202647)
Affinity DataIC50: 80nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Ortho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50367790(CHEMBL1202681)
Affinity DataIC50: 80nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1(Pig)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM394393(US10308605, Example 204 | N-Methyl-3-({4-[(methyla...)
Affinity DataIC50: 86nMAssay Description:According to the method [Biochem. Biophys. Acta., 728, 31 (1983)] of Wallmark et al., a gastric mucous membrane microsomal fraction was prepared from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Ortho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50367801(CHEMBL1202667)
Affinity DataIC50: 90nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium-transporting ATPase alpha chain 1(Pig)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM394377(US10308605, Example 7 | N-Methyl-1-{5-(3-methylphe...)
Affinity DataIC50: 91nMAssay Description:According to the method [Biochem. Biophys. Acta., 728, 31 (1983)] of Wallmark et al., a gastric mucous membrane microsomal fraction was prepared from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Ortho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50008978(CHEMBL296482 | (+/-)-(2-Methyl-8-phenyl-7,8-dihydr...)
Affinity DataIC50: 92nMpH: 7.4Assay Description:Inhibition of purified H+/K+ ATPase at pH 7.4 as released inorganic phosphate from ATP using hog stomach gastric membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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