Compile Data Set for Download or QSAR
Report error Found 3305 Enz. Inhib. hit(s) with Target = 'Procathepsin L'
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50176994(CHEMBL3813784)
Affinity DataEC50:  6.00E+3nMAssay Description:Activation of human liver cathepsin L using Z-FR-AMC as substrate measured for 120 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM23866(benzyl N-[(1S)-2-methyl-1-[(1-oxo-3-phenylpropan-2...)
Affinity DataEC50:  100nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM429284(med.21724, Compound 22)
Affinity DataEC50:  193nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50376204(CHEMBL401925 | med.21724, Compound 23)
Affinity DataEC50:  6.40E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM11318(1,3,8-trihydroxy-6-methylanthra-9,10-quinone | CHE...)
Affinity DataEC50:  2.00E+5nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM429289(med.21724, Compound 25)
Affinity DataEC50:  9.70E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM429290(med.21724, Compound 26)
Affinity DataEC50:  1.60E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataKoff:  9.00E+3s-1Assay Description:Irreversible inhibition of recombinant human cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50552672(CHEMBL4790628)
Affinity DataIC50: 0nMAssay Description:Inhibition of human recombinant Cathepsin L assessed as Kinact using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50602543(CHEMBL4598338)
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of human recombinant Cathepsin L assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50602544(CHEMBL4594757)
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of human recombinant Cathepsin L assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50602542(CHEMBL4594870)
Affinity DataIC50: 0.00900nMAssay Description:Inhibition of human recombinant Cathepsin L assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50602545(CHEMBL4596647)
Affinity DataIC50: 0.0170nMAssay Description:Inhibition of human recombinant Cathepsin L assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50: 0.0180nMAssay Description:Inhibition of human recombinant Cathepsin L assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50505559(CHEMBL4441303)
Affinity DataIC50: 0.0940nMAssay Description:Inhibition of human cathepsin L using fluorogenic substrate cbz-FR-AMC monitored for 90 to 120 mins by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50121902([(S)-1-((2S,3R)-2-Benzenesulfonyl-4-oxo-azetidin-3...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human Cathepsin LMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50121907([(S)-1-((3R,4S)-2-Oxo-4-phenylsulfanyl-azetidin-3-...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human Cathepsin LMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50069985({1-[(S)-(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of Cathepsin L (unknown origin) preincubated for 30 mins followed by fluorogenic substrate addition and measured for 15 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM19732(2-cyano-4-(cyclohexylamino)-N-[2-(4-methoxyphenyl)...)
Affinity DataIC50: 0.170nMpH: 5.5 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50229129(4-methyl-N-((S)-1-oxo-3-phenyl-1-((S)-5-phenyl-1-(...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human Cathepsin L using Cbz-Phe-Arg-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM419133(GC376 | BDBM429386)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM19733(2-cyano-4-(cyclohexylamino)-N-[2-(3-methoxyphenyl)...)
Affinity DataIC50: 0.310nMpH: 5.5 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM19741(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-(2-{4-[(4-...)
Affinity DataIC50: 0.330nMpH: 5.5 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM19736(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-[2-(4-meth...)
Affinity DataIC50: 0.340nMpH: 5.5 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50250152(3-acetyl-8-chloro-2-(4-chlorophenylamino)-6-nitroq...)
Affinity DataIC50: 0.437nMAssay Description:Inhibition of human liver cathepsin L after 30 mins by fluorometric end-point assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM19735(2-cyano-4-(cyclohexylamino)-N-{2-[4-(4-methylpiper...)
Affinity DataIC50: 0.450nMpH: 5.5 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM19743(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-(2-{4-[2-(...)
Affinity DataIC50: 0.520nMpH: 5.5 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50349198(CHEMBL1807649)
Affinity DataIC50: 0.530nMAssay Description:Inhibition of human recombinant cathepsin L using Z-LR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM19745(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-(2-{3-[2-(...)
Affinity DataIC50: 0.580nMpH: 5.5 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM642834(US11858905, Compound 34)
Affinity DataIC50: 0.600nMAssay Description:Human cathepsin L enzymatic assay was performed in assay buffer (50 mM MES pH 5.5, 2.5 mM DTT, 0.5 mM EDTA) to assess the inhibition of human CatL by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50505555(CHEMBL4447348)
Affinity DataIC50: 0.632nMAssay Description:Inhibition of human cathepsin L using fluorogenic substrate cbz-FR-AMC monitored for 90 to 120 mins by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM19744(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-(2-{3-[2-(...)
Affinity DataIC50: 0.680nMpH: 5.5 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50229129(4-methyl-N-((S)-1-oxo-3-phenyl-1-((S)-5-phenyl-1-(...)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of human recombinant Cathepsin L assessed as Kinact using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProcathepsin L(Rat)
Currently Naeja Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50121039([(S)-2-Cyclohexyl-1-((5S,6R)-4,4,7-trioxo-4lambda*...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50461249(CHEMBL1215628)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50163831((2S)-1-cyclohexylpropan-2-yl 1-cyanoazetidine-2-ca...)
Affinity DataIC50: 0.710nMAssay Description:Inhibitory concentration against human cathepsin L using 5 uM Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50084674([1-(1-Formyl-2-phenyl-ethylcarbamoyl)-2-phenyl-eth...)
Affinity DataIC50: 0.740nMAssay Description:Inhibitory activity against cathepsin L, lysosomal cysteine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50067612((S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-penta...)
Affinity DataIC50: 0.740nMAssay Description:Inhibition of human cathepsin L.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50505557(CHEMBL4527930)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of human cathepsin L using fluorogenic substrate cbz-FR-AMC monitored for 90 to 120 mins by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM642843(US11858905, Compound 43)
Affinity DataIC50: 0.800nMAssay Description:Human cathepsin L enzymatic assay was performed in assay buffer (50 mM MES pH 5.5, 2.5 mM DTT, 0.5 mM EDTA) to assess the inhibition of human CatL by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM19740(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-{2-[3-(4-m...)
Affinity DataIC50: 0.820nMpH: 5.5 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50084650({1-[1-Formyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-...)
Affinity DataIC50: 0.850nMAssay Description:Inhibitory activity against cathepsin L, lysosomal cysteine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM122528(US8729061, 58)
Affinity DataIC50: 0.900nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50067608((S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-penta...)
Affinity DataIC50: 0.950nMAssay Description:Inhibition of human cathepsin L.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50067606((S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-penta...)
Affinity DataIC50: 0.950nMAssay Description:Inhibition of human cathepsin L.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50067604((S)-N-[(R)-1-Formyl-2-(1H-indol-3-yl)-ethyl]-3-met...)
Affinity DataIC50: 0.970nMAssay Description:Inhibition of human cathepsin L.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376)
Affinity DataIC50: 0.990nMAssay Description:FRET-based enzymatic assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50349203(CHEMBL1807698)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant cathepsin L using Z-LR-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50505566(CHEMBL4582558)
Affinity DataIC50: 1nMAssay Description:Inhibition of human cathepsin L using fluorogenic substrate cbz-FR-AMC monitored for 90 to 120 mins by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM642846(US11858905, Compound 46)
Affinity DataIC50: 1nMAssay Description:Human cathepsin L enzymatic assay was performed in assay buffer (50 mM MES pH 5.5, 2.5 mM DTT, 0.5 mM EDTA) to assess the inhibition of human CatL by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

Displayed 1 to 50 (of 3305 total ) | Next | Last >>
Jump to: