Compile Data Set for Download or QSAR
Found 209 Enz. Inhib. hit(s) with Target = 'Prolyl hydroxylase EGLN3'
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50446884(CHEMBL3115282)
Show SMILES OC(=O)CNC(=O)c1c(O)n(Cc2ccccc2C#N)c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H18N4O6/c23-10-15-8-4-5-9-16(15)13-26-21(31)18(19(29)24-11-17(27)28)20(30)25(22(26)32)12-14-6-2-1-3-7-14/h1-9,31H,11-13H2,(H,24,29)(H,27,28)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli after 30 minsMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385803(CHEMBL2041190)
Show SMILES Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccc(cc1C)C(O)=O)c1cnccn1
Show InChI InChI=1S/C32H30N6O4/c1-21-4-3-13-34-27(21)20-36-16-11-32(12-17-36)30(41)37(31(42)38(32)28-19-33-14-15-35-28)25-8-5-23(6-9-25)26-10-7-24(29(39)40)18-22(26)2/h3-10,13-15,18-19H,11-12,16-17,20H2,1-2H3,(H,39,40)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50446882(CHEMBL3115284)
Show SMILES CC(C)(C)c1ccc(Cn2nc(c(O)c(C(=O)NCC(O)=O)c2=O)-c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C24H24ClN3O5/c1-24(2,3)16-8-4-14(5-9-16)13-28-23(33)19(22(32)26-12-18(29)30)21(31)20(27-28)15-6-10-17(25)11-7-15/h4-11,31H,12-13H2,1-3H3,(H,26,32)(H,29,30)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli after 30 minsMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50446883(CHEMBL3115283)
Show SMILES CC(C)(C)c1ccc(Cn2c(nc(O)c(C(=O)NCC(O)=O)c2=O)-c2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C24H23Cl2N3O5/c1-24(2,3)14-9-7-13(8-10-14)12-29-20(18-15(25)5-4-6-16(18)26)28-22(33)19(23(29)34)21(32)27-11-17(30)31/h4-10,33H,11-12H2,1-3H3,(H,27,32)(H,30,31)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli after 30 minsMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50446905(CHEMBL3115291)
Show SMILES OC(=O)CNC(=O)c1c2ncn(Cc3ccccc3)c2cc2n(Cc3ccccc3)cnc12
Show InChI InChI=1S/C25H21N5O3/c31-21(32)12-26-25(33)22-23-19(29(15-27-23)13-17-7-3-1-4-8-17)11-20-24(22)28-16-30(20)14-18-9-5-2-6-10-18/h1-11,15-16H,12-14H2,(H,26,33)(H,31,32)
Affinity DataIC50: 1nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50317545(CHEMBL4173371)
Show SMILES COc1ccc(nc1OC)-n1c(=O)[nH]c2cc(sc2c1=O)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H17ClN4O5S/c1-30-14-7-8-16(25-19(14)31-2)26-20(28)17-13(24-21(26)29)9-15(32-17)18(27)23-10-11-3-5-12(22)6-4-11/h3-9H,10H2,1-2H3,(H,23,27)(H,24,29)
Affinity DataIC50: 1nMAssay Description:Inhibition of FLAG- tagged full length HIF-PHD3 (unknown origin) expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQ...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50446907(CHEMBL3115289)
Show SMILES OC(=O)CNC(=O)c1c(O)ccc2cc(cnc12)-c1ccccc1
Show InChI InChI=1S/C18H14N2O4/c21-14-7-6-12-8-13(11-4-2-1-3-5-11)9-19-17(12)16(14)18(24)20-10-15(22)23/h1-9,21H,10H2,(H,20,24)(H,22,23)
Affinity DataIC50: 1nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50446903(CHEMBL3115293)
Show SMILES COc1ccc(nc1OC)-n1c(=S)[nH]c2cc(sc2c1=O)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H17ClN4O4S2/c1-29-14-7-8-16(25-19(14)30-2)26-20(28)17-13(24-21(26)31)9-15(32-17)18(27)23-10-11-3-5-12(22)6-4-11/h3-9H,10H2,1-2H3,(H,23,27)(H,24,31)
Affinity DataIC50: 1nMAssay Description:Inhibition of FLAG- tagged full length HIF-PHD3 (unknown origin) expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQ...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50446904(CHEMBL3115292)
Show SMILES OC(=O)CNC(=O)c1c(O)c(Br)cc2n(Cc3ccccc3)cnc12
Show InChI InChI=1S/C17H14BrN3O4/c18-11-6-12-15(14(16(11)24)17(25)19-7-13(22)23)20-9-21(12)8-10-4-2-1-3-5-10/h1-6,9,24H,7-8H2,(H,19,25)(H,22,23)
Affinity DataIC50: 1nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50446903(CHEMBL3115293)
Show SMILES COc1ccc(nc1OC)-n1c(=S)[nH]c2cc(sc2c1=O)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H17ClN4O4S2/c1-29-14-7-8-16(25-19(14)30-2)26-20(28)17-13(24-21(26)31)9-15(32-17)18(27)23-10-11-3-5-12(22)6-4-11/h3-9H,10H2,1-2H3,(H,23,27)(H,24,31)
Affinity DataIC50: 1nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50446902(CHEMBL3115294)
Show SMILES COc1ccc(nc1OC)-n1c(=S)[nH]c2sc(C(=O)NCc3ccc(Cl)cc3)c(C)c2c1=O
Show InChI InChI=1S/C22H19ClN4O4S2/c1-11-16-20(33-17(11)18(28)24-10-12-4-6-13(23)7-5-12)26-22(32)27(21(16)29)15-9-8-14(30-2)19(25-15)31-3/h4-9H,10H2,1-3H3,(H,24,28)(H,26,32)
Affinity DataIC50: 1nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50446906(CHEMBL3115290)
Show SMILES OC(=O)CNC(=O)c1c(O)c(cc2nccnc12)-c1cccnc1
Show InChI InChI=1S/C16H12N4O4/c21-12(22)8-20-16(24)13-14-11(18-4-5-19-14)6-10(15(13)23)9-2-1-3-17-7-9/h1-7,23H,8H2,(H,20,24)(H,21,22)
Affinity DataIC50: 1nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50446901(CHEMBL3115296)
Show SMILES COc1ccc(nc1OC)-n1c(=O)[nH]c2cc(ncc2c1=O)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C22H18ClN5O5/c1-32-17-7-8-18(27-20(17)33-2)28-21(30)14-11-24-16(9-15(14)26-22(28)31)19(29)25-10-12-3-5-13(23)6-4-12/h3-9,11H,10H2,1-2H3,(H,25,29)(H,26,31)
Affinity DataIC50: 1nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50446887(CHEMBL3115295)
Show SMILES COc1ccc(nc1OC)-n1c(=O)[nH]c2cc(sc2c1=O)C(=O)NCc1ccc2OCOc2c1
Show InChI InChI=1S/C22H18N4O7S/c1-30-14-5-6-17(25-20(14)31-2)26-21(28)18-12(24-22(26)29)8-16(34-18)19(27)23-9-11-3-4-13-15(7-11)33-10-32-13/h3-8H,9-10H2,1-2H3,(H,23,27)(H,24,29)
Affinity DataIC50: 1nMAssay Description:Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Show SMILES Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccc(cc1C)C(O)=O)c1ccncn1
Show InChI InChI=1S/C32H30N6O4/c1-21-4-3-14-34-27(21)19-36-16-12-32(13-17-36)30(41)37(31(42)38(32)28-11-15-33-20-35-28)25-8-5-23(6-9-25)26-10-7-24(29(39)40)18-22(26)2/h3-11,14-15,18,20H,12-13,16-17,19H2,1-2H3,(H,39,40)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of FLAG- tagged full length HIF-PHD3 (unknown origin) expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQ...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Show SMILES Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccc(cc1C)C(O)=O)c1ccncn1
Show InChI InChI=1S/C32H30N6O4/c1-21-4-3-14-34-27(21)19-36-16-12-32(13-17-36)30(41)37(31(42)38(32)28-11-15-33-20-35-28)25-8-5-23(6-9-25)26-10-7-24(29(39)40)18-22(26)2/h3-11,14-15,18,20H,12-13,16-17,19H2,1-2H3,(H,39,40)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PHD3 (unknown origin) expressed in Sf9 cells using HIF-1alpha peptide as substrate preincubated for 30 mins followed by substrate addit...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Show SMILES Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccc(cc1C)C(O)=O)c1ccncn1
Show InChI InChI=1S/C32H30N6O4/c1-21-4-3-14-34-27(21)19-36-16-12-32(13-17-36)30(41)37(31(42)38(32)28-11-15-33-20-35-28)25-8-5-23(6-9-25)26-10-7-24(29(39)40)18-22(26)2/h3-11,14-15,18,20H,12-13,16-17,19H2,1-2H3,(H,39,40)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385788(CHEMBL2041175)
Show SMILES Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccc2scnc2c1)c1cc(=O)[nH]cn1
Show InChI InChI=1S/C31H27N7O3S/c1-20-3-2-12-32-25(20)17-36-13-10-31(11-14-36)29(40)37(30(41)38(31)27-16-28(39)34-18-33-27)23-7-4-21(5-8-23)22-6-9-26-24(15-22)35-19-42-26/h2-9,12,15-16,18-19H,10-11,13-14,17H2,1H3,(H,33,34,39)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385814(CHEMBL2043169)
Show SMILES COc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1cccc(c1)C(O)=O
Show InChI InChI=1S/C32H30N6O5/c1-21-5-4-14-33-26(21)19-36-15-12-32(13-16-36)30(41)37(31(42)38(32)27-18-28(43-2)35-20-34-27)25-10-8-22(9-11-25)23-6-3-7-24(17-23)29(39)40/h3-11,14,17-18,20H,12-13,15-16,19H2,1-2H3,(H,39,40)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385819(CHEMBL2043325)
Show SMILES COc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1ccc(cc1C)C(O)=O
Show InChI InChI=1S/C33H32N6O5/c1-21-5-4-14-34-27(21)19-37-15-12-33(13-16-37)31(42)38(32(43)39(33)28-18-29(44-3)36-20-35-28)25-9-6-23(7-10-25)26-11-8-24(30(40)41)17-22(26)2/h4-11,14,17-18,20H,12-13,15-16,19H2,1-3H3,(H,40,41)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385826(CHEMBL2041010)
Show SMILES COc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1ccc(s1)C(O)=O
Show InChI InChI=1S/C30H28N6O5S/c1-19-4-3-13-31-22(19)17-34-14-11-30(12-15-34)28(39)35(29(40)36(30)25-16-26(41-2)33-18-32-25)21-7-5-20(6-8-21)23-9-10-24(42-23)27(37)38/h3-10,13,16,18H,11-12,14-15,17H2,1-2H3,(H,37,38)
Affinity DataIC50: 2nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385830(CHEMBL2041185)
Show SMILES COc1nccnc1N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1ccc(cc1C)C(O)=O
Show InChI InChI=1S/C33H32N6O5/c1-21-5-4-14-34-27(21)20-37-17-12-33(13-18-37)31(42)38(32(43)39(33)28-29(44-3)36-16-15-35-28)25-9-6-23(7-10-25)26-11-8-24(30(40)41)19-22(26)2/h4-11,14-16,19H,12-13,17-18,20H2,1-3H3,(H,40,41)
Affinity DataIC50: 2nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385813(CHEMBL2043168)
Show SMILES COc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C32H30N6O5/c1-21-4-3-15-33-26(21)19-36-16-13-32(14-17-36)30(41)37(31(42)38(32)27-18-28(43-2)35-20-34-27)25-11-9-23(10-12-25)22-5-7-24(8-6-22)29(39)40/h3-12,15,18,20H,13-14,16-17,19H2,1-2H3,(H,39,40)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385805(CHEMBL2041192)
Show SMILES Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccc(cc1)C(O)=O)c1ccncn1
Show InChI InChI=1S/C31H28N6O4/c1-21-3-2-15-33-26(21)19-35-17-13-31(14-18-35)29(40)36(30(41)37(31)27-12-16-32-20-34-27)25-10-8-23(9-11-25)22-4-6-24(7-5-22)28(38)39/h2-12,15-16,20H,13-14,17-19H2,1H3,(H,38,39)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385801(CHEMBL2041188)
Show SMILES Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccc(cc1C)C(O)=O)c1ncccn1
Show InChI InChI=1S/C32H30N6O4/c1-21-5-3-14-33-27(21)20-36-17-12-32(13-18-36)29(41)37(31(42)38(32)30-34-15-4-16-35-30)25-9-6-23(7-10-25)26-11-8-24(28(39)40)19-22(26)2/h3-11,14-16,19H,12-13,17-18,20H2,1-2H3,(H,39,40)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385796(CHEMBL2041182)
Show SMILES Cc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1ccc(cc1C)C(O)=O
Show InChI InChI=1S/C33H32N6O4/c1-21-5-4-14-34-28(21)19-37-15-12-33(13-16-37)31(42)38(32(43)39(33)29-18-23(3)35-20-36-29)26-9-6-24(7-10-26)27-11-8-25(30(40)41)17-22(27)2/h4-11,14,17-18,20H,12-13,15-16,19H2,1-3H3,(H,40,41)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385811(CHEMBL2043010)
Show SMILES COc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1C(O)=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C32H30N6O5/c1-21-7-6-15-33-26(21)19-36-16-14-32(25(18-36)29(39)40)30(41)37(31(42)38(32)27-17-28(43-2)35-20-34-27)24-12-10-23(11-13-24)22-8-4-3-5-9-22/h3-13,15,17,20,25H,14,16,18-19H2,1-2H3,(H,39,40)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385782(CHEMBL2041169)
Show SMILES Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccc(cc1)-c1cc[nH]n1)c1cc(=O)[nH]cn1
Show InChI InChI=1S/C33H30N8O3/c1-22-3-2-15-34-28(22)20-39-17-13-33(14-18-39)31(43)40(32(44)41(33)29-19-30(42)36-21-35-29)26-10-8-24(9-11-26)23-4-6-25(7-5-23)27-12-16-37-38-27/h2-12,15-16,19,21H,13-14,17-18,20H2,1H3,(H,37,38)(H,35,36,42)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385818(CHEMBL2043324)
Show SMILES COc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1ccc(cc1F)C(O)=O
Show InChI InChI=1S/C32H29FN6O5/c1-20-4-3-13-34-26(20)18-37-14-11-32(12-15-37)30(42)38(31(43)39(32)27-17-28(44-2)36-19-35-27)23-8-5-21(6-9-23)24-10-7-22(29(40)41)16-25(24)33/h3-10,13,16-17,19H,11-12,14-15,18H2,1-2H3,(H,40,41)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385797(CHEMBL2041183)
Show SMILES Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccc(cc1C)C(O)=O)c1cc(ncn1)C(F)(F)F
Show InChI InChI=1S/C33H29F3N6O4/c1-20-4-3-13-37-26(20)18-40-14-11-32(12-15-40)30(45)41(31(46)42(32)28-17-27(33(34,35)36)38-19-39-28)24-8-5-22(6-9-24)25-10-7-23(29(43)44)16-21(25)2/h3-10,13,16-17,19H,11-12,14-15,18H2,1-2H3,(H,43,44)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM93422(PHD Inhibitor, 12{1,1,2})
Show SMILES CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C38H37N5O8/c1-22(44)41-30(19-24-12-14-26-10-6-7-11-27(26)16-24)36(49)42-29(18-23-8-4-3-5-9-23)35(48)39-20-25-13-15-31-28(17-25)34(47)33(38(51)43(31)2)37(50)40-21-32(45)46/h3-17,29-30,47H,18-21H2,1-2H3,(H,39,48)(H,40,50)(H,41,44)(H,42,49)(H,45,46)/t29-,30-/m0/s1
Affinity DataIC50: 4.5nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385802(CHEMBL2041189)
Show SMILES Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccc(cc1)C(O)=O)c1cnccn1
Show InChI InChI=1S/C31H28N6O4/c1-21-3-2-14-33-26(21)20-35-17-12-31(13-18-35)29(40)36(30(41)37(31)27-19-32-15-16-34-27)25-10-8-23(9-11-25)22-4-6-24(7-5-22)28(38)39/h2-11,14-16,19H,12-13,17-18,20H2,1H3,(H,38,39)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385799(CHEMBL2041186)
Show SMILES Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccc(cc1C)C(O)=O)c1nccnc1C
Show InChI InChI=1S/C33H32N6O4/c1-21-5-4-14-35-28(21)20-37-17-12-33(13-18-37)31(42)38(32(43)39(33)29-23(3)34-15-16-36-29)26-9-6-24(7-10-26)27-11-8-25(30(40)41)19-22(27)2/h4-11,14-16,19H,12-13,17-18,20H2,1-3H3,(H,40,41)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50507415(CHEMBL4451025)
Show SMILES OC(=O)CNC(=O)c1c(O)c2cc(OC(F)(F)F)cc3OC(Cn(c23)c1=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C22H14F3N3O7/c23-22(24,25)35-12-5-13-18-14(6-12)34-15(11-3-1-10(7-26)2-4-11)9-28(18)21(33)17(19(13)31)20(32)27-8-16(29)30/h1-6,15,31H,8-9H2,(H,27,32)(H,29,30)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of recombinant human HIF-PHD3 expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQL and 2-oxoglutarate as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM93419(PHD Inhibitor, 12{2,4,1})
Show SMILES Cn1c2ccc(CNC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NC(=O)c3ccccc3)cc2c(O)c(C(=O)NCC(O)=O)c1=O
Show InChI InChI=1S/C39H37N5O8/c1-44-31-18-17-26(19-28(31)34(47)33(39(44)52)38(51)41-23-32(45)46)22-40-36(49)29(20-24-11-5-2-6-12-24)43-37(50)30(21-25-13-7-3-8-14-25)42-35(48)27-15-9-4-10-16-27/h2-19,29-30,47H,20-23H2,1H3,(H,40,49)(H,41,51)(H,42,48)(H,43,50)(H,45,46)/t29-,30-/m1/s1
Affinity DataIC50: 5.30nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50317547(CHEMBL4163812)
Show SMILES OC(=O)CNC(=O)c1c(O)n(C2CCCCC2)c(=O)n(C2CCCCC2)c1=O
Show InChI InChI=1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,26H,1-11H2,(H,20,25)(H,23,24)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of PHD3 (unknown origin)More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50507408(CHEMBL4561977)
Show SMILES OC(=O)CNC(=O)c1c(O)c2COCc2n(Cc2ccc(OC(F)(F)F)cc2)c1=O
Show InChI InChI=1S/C18H15F3N2O7/c19-18(20,21)30-10-3-1-9(2-4-10)6-23-12-8-29-7-11(12)15(26)14(17(23)28)16(27)22-5-13(24)25/h1-4,26H,5-8H2,(H,22,27)(H,24,25)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of recombinant human HIF-PHD3 expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQL and 2-oxoglutarate as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385820(CHEMBL2043326)
Show SMILES COc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1ccc(C(O)=O)c(C)c1
Show InChI InChI=1S/C33H32N6O5/c1-21-5-4-14-34-27(21)19-37-15-12-33(13-16-37)31(42)38(32(43)39(33)28-18-29(44-3)36-20-35-28)25-9-6-23(7-10-25)24-8-11-26(30(40)41)22(2)17-24/h4-11,14,17-18,20H,12-13,15-16,19H2,1-3H3,(H,40,41)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385825(CHEMBL2040897)
Show SMILES Cc1nc(C)c(s1)-c1ccc(cc1)N1C(=O)N(c2cc(=O)[nH]cn2)C2(CCN(Cc3ncccc3C)CC2)C1=O
Show InChI InChI=1S/C29H29N7O3S/c1-18-5-4-12-30-23(18)16-34-13-10-29(11-14-34)27(38)35(28(39)36(29)24-15-25(37)32-17-31-24)22-8-6-21(7-9-22)26-19(2)33-20(3)40-26/h4-9,12,15,17H,10-11,13-14,16H2,1-3H3,(H,31,32,37)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50507409(CHEMBL4476576)
Show SMILES OC(=O)CNC(=O)c1c(O)c2COCc2n(Cc2ccn(n2)-c2ccccc2)c1=O
Show InChI InChI=1S/C20H18N4O6/c25-16(26)8-21-19(28)17-18(27)14-10-30-11-15(14)23(20(17)29)9-12-6-7-24(22-12)13-4-2-1-3-5-13/h1-7,27H,8-11H2,(H,21,28)(H,25,26)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human HIF-PHD3 expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQL and 2-oxoglutarate as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50507419(CHEMBL4462855)
Show SMILES OC(=O)CNC(=O)c1c(O)c2COCc2n(Cc2ccc(Cl)cc2)c1=O
Show InChI InChI=1S/C17H15ClN2O6/c18-10-3-1-9(2-4-10)6-20-12-8-26-7-11(12)15(23)14(17(20)25)16(24)19-5-13(21)22/h1-4,23H,5-8H2,(H,19,24)(H,21,22)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of recombinant human HIF-PHD3 expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQL and 2-oxoglutarate as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50507407(CHEMBL4590677)
Show SMILES OC(=O)CNC(=O)c1c(O)c2COCc2n(Cc2cnc(s2)C(F)(F)F)c1=O
Show InChI InChI=1S/C15H12F3N3O6S/c16-15(17,18)14-20-1-6(28-14)3-21-8-5-27-4-7(8)11(24)10(13(21)26)12(25)19-2-9(22)23/h1,24H,2-5H2,(H,19,25)(H,22,23)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of recombinant human HIF-PHD3 expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQL and 2-oxoglutarate as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM93430(PHD Inhibitor, 12{2,1,2})
Show SMILES CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C38H37N5O8/c1-22(44)41-30(19-24-12-14-26-10-6-7-11-27(26)16-24)36(49)42-29(18-23-8-4-3-5-9-23)35(48)39-20-25-13-15-31-28(17-25)34(47)33(38(51)43(31)2)37(50)40-21-32(45)46/h3-17,29-30,47H,18-21H2,1-2H3,(H,39,48)(H,40,50)(H,41,44)(H,42,49)(H,45,46)/t29-,30-/m1/s1
Affinity DataIC50: 6.40nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385778(CHEMBL2041164)
Show SMILES COc1cc(ncn1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1csc(c1)C(O)=O
Show InChI InChI=1S/C30H28N6O5S/c1-19-4-3-11-31-23(19)16-34-12-9-30(10-13-34)28(39)35(29(40)36(30)25-15-26(41-2)33-18-32-25)22-7-5-20(6-8-22)21-14-24(27(37)38)42-17-21/h3-8,11,14-15,17-18H,9-10,12-13,16H2,1-2H3,(H,37,38)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50507406(CHEMBL4452218)
Show SMILES OC(=O)CNC(=O)c1c(O)c2cccc3NC(Cn(c23)c1=O)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C20H15F3N4O5/c21-20(22,23)13-5-4-9(6-24-13)12-8-27-16-10(2-1-3-11(16)26-12)17(30)15(19(27)32)18(31)25-7-14(28)29/h1-6,12,26,30H,7-8H2,(H,25,31)(H,28,29)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of recombinant human HIF-PHD3 expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQL and 2-oxoglutarate as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50507411(CHEMBL4474474)
Show SMILES OC(=O)CNC(=O)c1c(O)c2COCc2n(Cc2nc3ccccc3o2)c1=O
Show InChI InChI=1S/C18H15N3O7/c22-14(23)5-19-17(25)15-16(24)9-7-27-8-11(9)21(18(15)26)6-13-20-10-3-1-2-4-12(10)28-13/h1-4,24H,5-8H2,(H,19,25)(H,22,23)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of recombinant human HIF-PHD3 expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQL and 2-oxoglutarate as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50507421(CHEMBL4462741)
Show SMILES OC(=O)CNC(=O)c1c(O)c2COCc2n(Cc2cc(F)c(F)cc2F)c1=O
Show InChI InChI=1S/C17H13F3N2O6/c18-9-2-11(20)10(19)1-7(9)4-22-12-6-28-5-8(12)15(25)14(17(22)27)16(26)21-3-13(23)24/h1-2,25H,3-6H2,(H,21,26)(H,23,24)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of recombinant human HIF-PHD3 expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQL and 2-oxoglutarate as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385812(CHEMBL2043011)
Show SMILES Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccc(cc1)C(O)=O)c1cc(=O)[nH]cn1
Show InChI InChI=1S/C31H28N6O5/c1-20-3-2-14-32-25(20)18-35-15-12-31(13-16-35)29(41)36(30(42)37(31)26-17-27(38)34-19-33-26)24-10-8-22(9-11-24)21-4-6-23(7-5-21)28(39)40/h2-11,14,17,19H,12-13,15-16,18H2,1H3,(H,39,40)(H,33,34,38)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50385798(CHEMBL2041184)
Show SMILES Cc1nccc(n1)N1C(=O)N(C(=O)C11CCN(Cc2ncccc2C)CC1)c1ccc(cc1)-c1ccc(cc1C)C(O)=O
Show InChI InChI=1S/C33H32N6O4/c1-21-5-4-15-35-28(21)20-37-17-13-33(14-18-37)31(42)38(32(43)39(33)29-12-16-34-23(3)36-29)26-9-6-24(7-10-26)27-11-8-25(30(40)41)19-22(27)2/h4-12,15-16,19H,13-14,17-18,20H2,1-3H3,(H,40,41)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of PHD3More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Janssen Research and Development LLC

Curated by ChEMBL
LigandPNGBDBM50507424(CHEMBL4452138)
Show SMILES OC(=O)CNC(=O)c1c(O)c2COCc2n(Cc2nc(cs2)C(F)(F)F)c1=O
Show InChI InChI=1S/C15H12F3N3O6S/c16-15(17,18)8-5-28-9(20-8)2-21-7-4-27-3-6(7)12(24)11(14(21)26)13(25)19-1-10(22)23/h5,24H,1-4H2,(H,19,25)(H,22,23)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of recombinant human HIF-PHD3 expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQL and 2-oxoglutarate as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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